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MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAENYGSVIARLTGMHWWGPASTSMLAMSA PYVEWLERTAAQTKQTATQARAAAAAFEQAHAMTVPPALVTANRAELKALIASNLLGQNTAAIAAIEAQY AEMWAQDAAAMYGYATTSAAARQLTPFSSPQQTTNPAGLAAQNAAVTQAATNSAGNTPTALSQLSSFLSQ AVEAPTGWPNILPDDFTILDGILAAYATVGVTQDIESICAGIIGAENNLGLLGAASENPAELAPGAFGID AALSSAEKGAAASMHDAVLASAGRAGSIGPMSVPPSWATPSSTPVSALSGAGLTTLDGTDVAEHGTPGLP GVPAGTDKRASGVIPRYGVRLTVMSRPPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3159 | PPE50 | - | 100% (381) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3160 | PPE51 | e-134 | 64.36% (390) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3562 | PPE61 | e-106 | 52.35% (405) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-29 | 35.38% (212) | PPE protein |
| M. tuberculosis H37Rv | Rv3136 | PPE51 | 1e-134 | 64.36% (390) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-44 | 34.13% (419) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 3e-29 | 39.63% (164) | PPE family protein |
| M. marinum M | MMAR_1514 | - | 1e-148 | 68.24% (381) | PPE family protein, PPE51_1 |
| M. avium 104 | MAV_4015 | - | 1e-100 | 53.93% (382) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-31 | 35.27% (224) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 3e-33 | 40.51% (195) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2737 | - | 1e-146 | 67.45% (381) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-31 | 37.56% (213) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1514|M.marinum_M -------------MNYAFLPPEVNSARMYSGPGSASLLAAAASWDMVAIE
MUL_2737|M.ulcerans_Agy99 -------------MNYAFLPPEVNSARMYSGPGSASLLAAAASWDMVAIE
Mb3159|M.bovis_AF2122/97 -------------MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAE
Rv3136|M.tuberculosis_H37Rv -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
MAV_4015|M.avium_104 -------------MDFGFLPPEVNSARMYAGPGSGSLLAAAGSWDSLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
: .** :*: : ***. .:*.*. * :. .
MMAR_1514|M.marinum_M LASAAEGYRSVISTLSGMYWWGPASAAMLAATGPFIDWLEITGALASETA
MUL_2737|M.ulcerans_Agy99 LASAAEGYRSVISTLSGMYWWGPASAAMLAATGPFIGWLEITGALASETA
Mb3159|M.bovis_AF2122/97 LASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTA
Rv3136|M.tuberculosis_H37Rv LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
MAV_4015|M.avium_104 LSITAAVYESVLAGLTGLYWHGPASRAMAAGAAPYVGWLHTTAERAQQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
: :* : : : * :: *: ** . *
MMAR_1514|M.marinum_M NQAAAAAAAYEQAYAMTVPPIVVAANRALLVALVASNFFGQNTAAIEATE
MUL_2737|M.ulcerans_Agy99 NQAAAAAAAYEQAYAMTVPPIVVAANRALLVALVASNIFGQNTAAIEATE
Mb3159|M.bovis_AF2122/97 TQARAAAAAFEQAHAMTVPPALVTANRAELKALIASNLLGQNTAAIAAIE
Rv3136|M.tuberculosis_H37Rv IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
MAV_4015|M.avium_104 TQARAAAAAYELAHAMTVPPAAVAANRTQLAALVATNFFGQNTAAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
: .** *: * : . : *: *: :*::* *: .* *
MMAR_1514|M.marinum_M AEYAEMWAQDAGAMYDYAATSAMAT-ALVPFSAPGQDTNPA---------
MUL_2737|M.ulcerans_Agy99 AEYAEMWAQDAGAMYDYAATSAMAT-ALVPFSAPGQDTNPA---------
Mb3159|M.bovis_AF2122/97 AQYAEMWAQDAAAMYGYATTSAAAR-QLTPFSSPQQTTNPA---------
Rv3136|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPA---------
MAV_4015|M.avium_104 AQYAEYWAQDAAAMYAYSASSAAAA-QFSPFASPRRTTDPG---------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR---
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR---
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS---
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD---
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD--HDHGH---
*:*.. * * * :* * : * :..
MMAR_1514|M.marinum_M -------GLAAQSAAVSQAAGNAPASAQSVWSQLTSLVPDALPSLSNWPN
MUL_2737|M.ulcerans_Agy99 -------GLAAQSAAVSQAAGNAPASAQSVWSQLTSLVPDALPSLSNWPN
Mb3159|M.bovis_AF2122/97 -------GLAAQNAAVTQAATNSAGNTPTALSQLSSFLSQAVEAPTGWPN
Rv3136|M.tuberculosis_H37Rv -------GLTAQAAAVSQAT--------DPLSLLIETVTQALQALT-IPS
MAV_4015|M.avium_104 -------GVTAQQAAVAAAETG---------STGTDSGTQVIPPTA-GAS
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
Mflv_0325|M.gilvum_PYR-GCK ----AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIF
Mvan_0415|M.vanbaalenii_PYR-1 ----AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIF
MSMEG_0619|M.smegmatis_MC2_155 ----ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AIL
TH_3569|M.thermoresistible__bu ----AMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIV
MAB_0809c|M.abscessus_ATCC_199 ----DDHDHEHGHDDDHGHGDLDPTDP-EWWVHVAGEMVEHFELLLNNLL
:
MMAR_1514|M.marinum_M ILPDD-----FSILDGIFAMYATVGVTQDVESFCAGIIGAENNLG-----
MUL_2737|M.ulcerans_Agy99 ILPDD-----FSMLDGIFAMYATVGVTQDVESFCAGIIGAGNNLG-----
Mb3159|M.bovis_AF2122/97 ILPDD-----FTILDGILAAYATVGVTQDIESICAGIIGAENNLG-----
Rv3136|M.tuberculosis_H37Rv FIPED-----FTFLDAIFAGYATVGVTQDVESFVAGTIGAESNLG-----
MAV_4015|M.avium_104 EIPLD-----FRILDTILGAQTTFRSIFTTEGIPAGIIQADKNLG-----
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGS
Mflv_0325|M.gilvum_PYR-GCK NFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYP
Mvan_0415|M.vanbaalenii_PYR-1 DFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYP
MSMEG_0619|M.smegmatis_MC2_155 DFLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWG
TH_3569|M.thermoresistible__bu DFLRDPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWA
MAB_0809c|M.abscessus_ATCC_199 TDPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQPALALAIANLGWA
. .
MMAR_1514|M.marinum_M -LLGAASENPAEVTPGALGLG------------------AMFSSAERS--
MUL_2737|M.ulcerans_Agy99 -LLGAASENSAEVTPGALGLG------------------AMFSSAERS--
Mb3159|M.bovis_AF2122/97 -LLGAASENPAELAPGAFGID------------------AALSSAEKG--
Rv3136|M.tuberculosis_H37Rv -LLNVGDENPAEVTPGDFGIG------------------ELVSATSPGGG
MAV_4015|M.avium_104 -ILPN-----LATIPAALPRT------------------PALSASPTG--
MLBr_01182|M.leprae_Br4923 AMKSLAPTTTKAAESAFKAMG------------------SAVQSTGRG--
Mflv_0325|M.gilvum_PYR-GCK SLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPD
Mvan_0415|M.vanbaalenii_PYR-1 SLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRAD
MSMEG_0619|M.smegmatis_MC2_155 MIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRT
TH_3569|M.thermoresistible__bu MILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--
MAB_0809c|M.abscessus_ATCC_199 AGFAGLAGIQPSPEILAVEPGSVEDAPMA-ASAGTALAPSPPASAAAP--
MMAR_1514|M.marinum_M -------AVGGATNAVTVSMSRAGSIGQLSVPPSWAAPSS---GSASALS
MUL_2737|M.ulcerans_Agy99 -------AVGGATNAVTVSMSRAGSIGQLSVPPSWAAPSS---GSASALS
Mb3159|M.bovis_AF2122/97 -------AAASMHDAVLASAGRAGSIGPMSVPPSWATPSS---TPVSALS
Rv3136|M.tuberculosis_H37Rv VSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWAAPST---RPVSALS
MAV_4015|M.avium_104 ------------LGRIDAVLARAARIGPMSVPAGWTAATG---NPVAAAP
MLBr_01182|M.leprae_Br4923 ------LLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALS
Mflv_0325|M.gilvum_PYR-GCK QQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGR
Mvan_0415|M.vanbaalenii_PYR-1 QPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGR
MSMEG_0619|M.smegmatis_MC2_155 DQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANR
TH_3569|M.thermoresistible__bu -----------------VRAEPQNPLPLTXXX------------------
MAB_0809c|M.abscessus_ATCC_199 -----------AAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGP
MMAR_1514|M.marinum_M VSGLTTIPGTEVAEQG---APGMPGMP-VGTGKRATSVIPRYGVRLTVMA
MUL_2737|M.ulcerans_Agy99 VSGLTTIPGTEVAEQG---APGMPGMP-VGTGKRATSVIPRYGVRLTVMA
Mb3159|M.bovis_AF2122/97 GAGLTTLDGTDVAEHG---TPGLPGVP-AGTDKRASGVIPRYGVRLTVMS
Rv3136|M.tuberculosis_H37Rv PAGLTTLPGTDVAEHG---MPGVPGVP-VAAG-RASGVLPRYGVRLTVMA
MAV_4015|M.avium_104 VTGWSEPSAADARPGVT--APGLPGIP-GATLRRAALVVPRYGVRITVMA
MLBr_01182|M.leprae_Br4923 PARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMP
Mflv_0325|M.gilvum_PYR-GCK DPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKG
Mvan_0415|M.vanbaalenii_PYR-1 DPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAG
MSMEG_0619|M.smegmatis_MC2_155 DPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEE
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 RLGTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQG
MMAR_1514|M.marinum_M RPPAAG--------------------------------------------
MUL_2737|M.ulcerans_Agy99 RPPAAG--------------------------------------------
Mb3159|M.bovis_AF2122/97 RPPAAG--------------------------------------------
Rv3136|M.tuberculosis_H37Rv HPPAAG--------------------------------------------
MAV_4015|M.avium_104 RPPAAG--------------------------------------------
MLBr_01182|M.leprae_Br4923 RNPAAG--------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK RGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAG
Mvan_0415|M.vanbaalenii_PYR-1 RAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAG
MSMEG_0619|M.smegmatis_MC2_155 RGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 RG-----IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATAS
MMAR_1514|M.marinum_M -------------------------------------------------
MUL_2737|M.ulcerans_Agy99 -------------------------------------------------
Mb3159|M.bovis_AF2122/97 -------------------------------------------------
Rv3136|M.tuberculosis_H37Rv -------------------------------------------------
MAV_4015|M.avium_104 -------------------------------------------------
MLBr_01182|M.leprae_Br4923 -------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 GLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 GLTTLT-GDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 GLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD-----------------