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NYAFLPPEVNSARMYSGPGSASLLAAAASWDMVAIELASAAEGYRSVISTLSGMYWWGPASAAMLAATGP FIGWLEITGALASETANQAAAAAAAYEQAYAMTVPPIVVAANRALLVALVASNIFGQNTAAIEATEAEYA EMWAQDAGAMYDYAATSAMATALVPFSAPGQDTNPAGLAAQSAAVSQAAGNAPASAQSVWSQLTSLVPDA LPSLSNWPNILPDDFSMLDGIFAMYATVGVTQDVESFCAGIIGAGNNLGLLGAASENSAEVTPGALGLGA MFSSAERSAVGGATNAVTVSMSRAGSIGQLSVPPSWAAPSSGSASALSVSGLTTIPGTEVAEQGAPGMPG MPVGTGKRATSVIPRYGVRLTVMARPPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2737 | - | - | 100% (381) | PPE family protein |
| M. ulcerans Agy99 | MUL_2427 | - | 0.0 | 99.74% (381) | PPE family protein |
| M. ulcerans Agy99 | MUL_2428 | - | e-126 | 61.30% (385) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3159 | PPE50 | 1e-146 | 67.45% (381) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 5e-29 | 39.09% (197) | PPE protein |
| M. tuberculosis H37Rv | Rv3136 | PPE51 | 1e-124 | 60.77% (390) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-48 | 34.62% (416) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 5e-30 | 30.71% (407) | PPE family protein |
| M. marinum M | MMAR_1514 | - | 0.0 | 98.69% (381) | PPE family protein, PPE51_1 |
| M. avium 104 | MAV_4014 | - | 8e-90 | 48.61% (395) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-32 | 39.05% (210) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 6e-30 | 37.55% (229) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 7e-30 | 38.39% (211) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2737|M.ulcerans_Agy99 -------------MNYAFLPPEVNSARMYSGPGSASLLAAAASWDMVAIE
MMAR_1514|M.marinum_M -------------MNYAFLPPEVNSARMYSGPGSASLLAAAASWDMVAIE
Mb3159|M.bovis_AF2122/97 -------------MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAE
Rv3136|M.tuberculosis_H37Rv -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
MAV_4014|M.avium_104 -------------MDWAFLPPEINSARMYTGAGAASLLAAAGSWDALSAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
: .** :*: : *.*. .:*.*. * :. .
MUL_2737|M.ulcerans_Agy99 LASAAEGYRSVISTLSGMYWWGPASAAMLAATGPFIGWLEITGALASETA
MMAR_1514|M.marinum_M LASAAEGYRSVISTLSGMYWWGPASAAMLAATGPFIDWLEITGALASETA
Mb3159|M.bovis_AF2122/97 LASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTA
Rv3136|M.tuberculosis_H37Rv LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
MAV_4014|M.avium_104 LTATADGYESVLSGLG-LQWHGPAADAMAFAAARYLTWLRATAEQTKQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
:::* : : : * :: : ** . *
MUL_2737|M.ulcerans_Agy99 NQAAAAAAAYEQAYAMTVPPIVVAANRALLVALVASNIFGQNTAAIEATE
MMAR_1514|M.marinum_M NQAAAAAAAYEQAYAMTVPPIVVAANRALLVALVASNFFGQNTAAIEATE
Mb3159|M.bovis_AF2122/97 TQARAAAAAFEQAHAMTVPPALVTANRAELKALIASNLLGQNTAAIAAIE
Rv3136|M.tuberculosis_H37Rv IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
MAV_4014|M.avium_104 MQARTAAAAYEQAYAMTVPPPVIAANRTLLASLVATNIMGQNTAAIADTE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
: .** *: * : . : *: *: :*::* *: .* *
MUL_2737|M.ulcerans_Agy99 AEYAEMWAQDAGAMYDYAATSAMAT-ALVPFSAPG----QDTNPAGLAAQ
MMAR_1514|M.marinum_M AEYAEMWAQDAGAMYDYAATSAMAT-ALVPFSAPG----QDTNPAGLAAQ
Mb3159|M.bovis_AF2122/97 AQYAEMWAQDAAAMYGYATTSAAAR-QLTPFSSPQ----QTTNPAGLAAQ
Rv3136|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPR----QTTNPAGLTAQ
MAV_4014|M.avium_104 AQYADFWAQDTAAMAGYSASSTAAT-QLPRFASAN----NSTNESGVTAQ
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPP----LGVNEVGLAQE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD--HDHGHDDH
*:*. :* * : :* * : * :.. .
MUL_2737|M.ulcerans_Agy99 S----------------AAVSQAAGNAPA--SAQSVWSQLTS-----LVP
MMAR_1514|M.marinum_M S----------------AAVSQAAGNAPA--SAQSVWSQLTS-----LVP
Mb3159|M.bovis_AF2122/97 N----------------AAVTQAATNSAG--NTPTALSQLSS-----FLS
Rv3136|M.tuberculosis_H37Rv A----------------AAVSQAT----------DPLSLLIE-----TVT
MAV_4014|M.avium_104 N----------------AAVSAANANAAANKAVTQSFSPLADNPPGTTIN
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVA
Mflv_0325|M.gilvum_PYR-GCK DMSAFA------AQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFN
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFA------AQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFD
MSMEG_0619|M.smegmatis_MC2_155 SVQQMS------AQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILD
TH_3569|M.thermoresistible__bu TTQQIG------SQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVD
MAB_0809c|M.abscessus_ATCC_199 DHEHGH------DDDHGHGDLDPTDP-EWWVHVAGEMVEHFELLLNNLLT
. .
MUL_2737|M.ulcerans_Agy99 DALPSLSNWPNILPDDFS--MLDGIFAMYATVGVTQDVESFCAGIIGAGN
MMAR_1514|M.marinum_M DALPSLSNWPNILPDDFS--ILDGIFAMYATVGVTQDVESFCAGIIGAEN
Mb3159|M.bovis_AF2122/97 QAVEAPTGWPNILPDDFT--ILDGILAAYATVGVTQDIESICAGIIGAEN
Rv3136|M.tuberculosis_H37Rv QALQALT-IPSFIPEDFT--FLDAIFAGYATVGVTQDVESFVAGTIGAES
MAV_4014|M.avium_104 NYYVDASSTSAANSNAFR--VLDVIQGTGLGFSAPYNMEQFVSGIIGAEN
MLBr_01182|M.leprae_Br4923 TPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVN
Mflv_0325|M.gilvum_PYR-GCK FLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPS
Mvan_0415|M.vanbaalenii_PYR-1 FLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPS
MSMEG_0619|M.smegmatis_MC2_155 FLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGM
TH_3569|M.thermoresistible__bu FLRDPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAM
MAB_0809c|M.abscessus_ATCC_199 DPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQPALALAIANLGWAA
. .
MUL_2737|M.ulcerans_Agy99 NLG--LLGAASENSAEVTP-------------GALGLGAMFSSAERS---
MMAR_1514|M.marinum_M NLG--LLGAASENPAEVTP-------------GALGLGAMFSSAERS---
Mb3159|M.bovis_AF2122/97 NLG--LLGAASENPAELAP-------------GAFGIDAALSSAEKG---
Rv3136|M.tuberculosis_H37Rv NLG--LLNVGDENPAEVTP-------------GDFGIGELVSATSPGGGV
MAV_4014|M.avium_104 NLG--MLAKPGAAAANIAP-------------ALAAPALRGATAGLGG--
MLBr_01182|M.leprae_Br4923 GMGSAMKSLAPTTTKAAES-------------AFKAMGSAVQSTGRG---
Mflv_0325|M.gilvum_PYR-GCK LFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQ
Mvan_0415|M.vanbaalenii_PYR-1 LLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQ
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTD
TH_3569|M.thermoresistible__bu ILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---
MAB_0809c|M.abscessus_ATCC_199 GFAGLAGIQPSPEILAVEPGSVEDAPMA-ASAGTALAPSPPASAAAP---
: .
MUL_2737|M.ulcerans_Agy99 ------AVGGATNAVTVSMSRAGSIGQLSVPPSWAAPSS---GSASALSV
MMAR_1514|M.marinum_M ------AVGGATNAVTVSMSRAGSIGQLSVPPSWAAPSS---GSASALSV
Mb3159|M.bovis_AF2122/97 ------AAASMHDAVLASAGRAGSIGPMSVPPSWATPSS---TPVSALSG
Rv3136|M.tuberculosis_H37Rv SASGAGGAASVGNTVLASVGRANSIGQLSVPPSWAAPST---RPVSALSP
MAV_4014|M.avium_104 ------GLGGGLGNVTATLSHAGTIGPMSVPATWSAPTS---THVSPLAP
MLBr_01182|M.leprae_Br4923 -----LLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSP
Mflv_0325|M.gilvum_PYR-GCK QSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRD
Mvan_0415|M.vanbaalenii_PYR-1 PSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRD
MSMEG_0619|M.smegmatis_MC2_155 QPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRD
TH_3569|M.thermoresistible__bu ----------------VRAEPQNPLPLTXXX-------------------
MAB_0809c|M.abscessus_ATCC_199 ----------AAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGPR
.
MUL_2737|M.ulcerans_Agy99 SGLTTIPGTEV---AEQGAPGMPGMPVGTGKRATSV--IPRYG-------
MMAR_1514|M.marinum_M SGLTTIPGTEV---AEQGAPGMPGMPVGTGKRATSV--IPRYG-------
Mb3159|M.bovis_AF2122/97 AGLTTLDGTDV---AEHGTPGLPGVPAGTDKRASGV--IPRYG-------
Rv3136|M.tuberculosis_H37Rv AGLTTLPGTDV---AEHGMPGVPGVPVAAG-RASGV--LPRYG-------
MAV_4014|M.avium_104 AGFTTLPGTEEP--MASGYPGYPGMPGGGAARSAGVGVPPRYG-------
MLBr_01182|M.leprae_Br4923 ARVAVATESESAPLLGGGLPMAPMVP-GGGSGTGGVNTALRLQ-------
Mflv_0325|M.gilvum_PYR-GCK PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGR
Mvan_0415|M.vanbaalenii_PYR-1 PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGR
MSMEG_0619|M.smegmatis_MC2_155 PGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEER
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 LGTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGR
MUL_2737|M.ulcerans_Agy99 --------------------VRLTVMARPPAAG-----------------
MMAR_1514|M.marinum_M --------------------VRLTVMARPPAAG-----------------
Mb3159|M.bovis_AF2122/97 --------------------VRLTVMSRPPAAG-----------------
Rv3136|M.tuberculosis_H37Rv --------------------VRLTVMAHPPAAG-----------------
MAV_4014|M.avium_104 --------------------VRLTVMPRPPAAG-----------------
MLBr_01182|M.leprae_Br4923 --------------------PRAFVMPRNPAAG-----------------
Mflv_0325|M.gilvum_PYR-GCK GYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGG
Mvan_0415|M.vanbaalenii_PYR-1 AYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGG
MSMEG_0619|M.smegmatis_MC2_155 GYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAG
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 G-----IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASG
MUL_2737|M.ulcerans_Agy99 ------------------------------------------------
MMAR_1514|M.marinum_M ------------------------------------------------
Mb3159|M.bovis_AF2122/97 ------------------------------------------------
Rv3136|M.tuberculosis_H37Rv ------------------------------------------------
MAV_4014|M.avium_104 ------------------------------------------------
MLBr_01182|M.leprae_Br4923 ------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK LTTLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 LTTLP-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 LTTLT-GDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 LAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD-----------------