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MRRLNGVDALMLYLDGGSAYNHTLKISVLDPSTDPDGWSWPKARQMFEERAHLLPVFRLRYLPTPLGLHH PIWVEDPEFDLDAHVRRVVCPAPGGMAEFCALVEQIYAHPLDRDRPLWQTWVVEGLDGGRVALVTLLHHA YSDGVGVLDMLAAFYNDTPDEAPVVAPPWEPPPLPSTRQRLGWALRDLPSRLGKIAPTVRAVRDRVRIER EFAKDGDRRVPPTFDRSAPPGPFQRGLSRSRRFSCESFPLAEVREVSKTLGVTINDVFLACVAGAVRRYL ERCGSPPTDAMVATMPLAVTPAAERAHPGNYSSVDYVWLRADIADPLERLHATHLAAEATKQHFAQTKDA DVGAVVELLPERLISGLARANARTKGRFDTFKNVVVSNVPGPREPRYLGRWRVDQWFSTGQISHGATLNM TVWSYCDQFNLCVMADAVAVRNTWELLGGFRASHEELLAAARAQATPKEMAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3087 | - | - | 100% (472) | hypothetical protein Rv3087 |
| M. tuberculosis H37Rv | Rv0221 | - | 1e-59 | 33.19% (464) | hypothetical protein Rv0221 |
| M. tuberculosis H37Rv | Rv1760 | - | 2e-55 | 31.71% (473) | hypothetical protein Rv1760 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3114 | - | 0.0 | 99.58% (472) | hypothetical protein Mb3114 |
| M. gilvum PYR-GCK | Mflv_2428 | - | 3e-64 | 35.38% (455) | hypothetical protein Mflv_2428 |
| M. leprae Br4923 | MLBr_01244 | - | 2e-28 | 32.06% (287) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_1917 | - | 7e-59 | 33.76% (465) | hypothetical protein MAB_1917 |
| M. marinum M | MMAR_2599 | - | 1e-107 | 44.69% (452) | hypothetical protein MMAR_2599 |
| M. avium 104 | MAV_2240 | - | 1e-64 | 33.81% (488) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_0290 | - | 2e-59 | 32.04% (465) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_2477 | - | 5e-59 | 32.98% (473) | PUTATIVE acyltransferase, ws/dgat/mgat subfamily protein |
| M. ulcerans Agy99 | MUL_3161 | - | 1e-102 | 44.91% (432) | hypothetical protein MUL_3161 |
| M. vanbaalenii PYR-1 | Mvan_4224 | - | 2e-66 | 34.75% (472) | hypothetical protein Mvan_4224 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2428|M.gilvum_PYR-GCK --------MSMRRLNGMDAMLLYSET-PNLHTHTLKVAVIDATGYSAEHG
Mvan_4224|M.vanbaalenii_PYR-1 --MQVVAYPFMKRLNGMDAMLLYSET-PNLHTHTLKVAVIDAS--NCADG
MSMEG_0290|M.smegmatis_MC2_155 ----------MQRLSGWDAFLLYSET-PNVHMHTLKIAIIDLEG---IGD
Rv3087|M.tuberculosis_H37Rv ----------MRRLNGVDALMLYLDG-GSAYNHTLKISVLDPST----DP
Mb3114|M.bovis_AF2122/97 ----------MRRLNGVDALMLYLDG-GSAYNHTLKISVLDPST----DP
MMAR_2599|M.marinum_M MTAPIKGVTRPQRLSGADAFMLGMET-PRAYMHTFKVAIIDPST----DA
MUL_3161|M.ulcerans_Agy99 -------------------------------MHTFKVAIIDPST----DA
MAV_2240|M.avium_104 -------MLRMQRLSGLDASFLYLET-SSQPMHVCSIIELDTST----VP
TH_2477|M.thermoresistible__bu --VPPPYDRGMQRLSGLDASFLYLET-PDQPLHVCSILELDTST----IP
MAB_1917|M.abscessus_ATCC_1997 ----------MQRLSGLDASFLYLET-PTQPMHVCGVLELDTTT----IP
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTP------
: :*
Mflv_2428|M.gilvum_PYR-GCK GEYGFDAFRQTIARRLHLLEPLRYRLIDIPWRLHHPMWLQDCPVDLDYHL
Mvan_4224|M.vanbaalenii_PYR-1 --YDFDAFRRTVARRLPLLDPLRYRLIDIPWRLHHPMWLEDCPVDLDYHL
MSMEG_0290|M.smegmatis_MC2_155 RTFGVEDFRKVLRGRLHKLDPFRFQLVDIPFKFHHPMWRENCDVDLEYHV
Rv3087|M.tuberculosis_H37Rv DGWSWPKARQMFEERAHLLPVFRLRYLPTPLGLHHPIWVEDPEFDLDAHV
Mb3114|M.bovis_AF2122/97 DGWSWPKARQMFEERAHLLPVFRLRYLPTPLGLHHPIWVEDPEFDLDAHV
MMAR_2599|M.marinum_M QGWSFDRFYAEAARRIHLLPMLRWKCVESPLGLNHPYWVEDPDFELHNHI
MUL_3161|M.ulcerans_Agy99 QGWSFDRFYAEAARRIHLLPMLRWKCVESPLGLNHPYWVEDPDFELHNHI
MAV_2240|M.avium_104 GGYTFERLRDALVRRIRAVPPFREKLADSPLNLDHPVWVDDEDFDVDRHL
TH_2477|M.thermoresistible__bu GGYDFHQLREALLLRIKAMPEFREKLADNRFNLDHPVWVEDADFDVDRHL
MAB_1917|M.abscessus_ATCC_1997 GGYSFEKLRTKLAERVEGIPSFREKLADSRLNLDHPVWVDDDDFDIDRHL
MLBr_01244|M.leprae_Br4923 ---DWNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHV
: :* : * * : .::. *:
Mflv_2428|M.gilvum_PYR-GCK RRVRVPAPGGRRELDRVIGEIASTPLDRTRPLWEFHFAEGMADN------
Mvan_4224|M.vanbaalenii_PYR-1 RRVRVPAPGRRRELDRVIGEIASTPLDRSRPLWEFHFAEGMADD------
MSMEG_0290|M.smegmatis_MC2_155 RPWQVRAPGGRRELDEAIGEIAGTPLDRSRPLWEMYFVEGLAGG------
Rv3087|M.tuberculosis_H37Rv RRVVCPAPGGMAEFCALVEQIYAHPLDRDRPLWQTWVVEGLDGG------
Mb3114|M.bovis_AF2122/97 RRVVCPAPGGMAEFCALVEQIYAHPLDRDRPLWQTWVVEGLDGG------
MMAR_2599|M.marinum_M HRVACPAPGDHKSLCAVMTTIYSAQLERDRPLWLMWVVEGLAEG------
MUL_3161|M.ulcerans_Agy99 HRVACPAPGDHKSLCAVMTTIYSAQLERDRPLWLMWVVEGLAEG------
MAV_2240|M.avium_104 HRIAVPAPGGRAELSQICGHIAQTPLDRRRPLWEMWVIEGVAGTDCHRDG
TH_2477|M.thermoresistible__bu HRIGLPAPGGPAELAEICGHLAALPLDRSRPLWEMWVIENIDGTDPRSGG
MAB_1917|M.abscessus_ATCC_1997 HHVGLPAPGGKAEIADMCGHIASLPLDRARPLWEMWVIETGDTN------
MLBr_01244|M.leprae_Br4923 RRVRVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAG------
: ** .. : :: **** . *
Mflv_2428|M.gilvum_PYR-GCK RFALIGKVHHTLADGVASANLLARLMDLVDAPQDEREDPPAGCDDPSTLD
Mvan_4224|M.vanbaalenii_PYR-1 RYALIGKVHHTLADGVASANLLARLMDLTGTPPNHHADPVVVCEEPTRRE
MSMEG_0290|M.smegmatis_MC2_155 RIAVVNKIHHALADGIASANLLARGMDLREGPQRDR-DSYVTDPEPSKGE
Rv3087|M.tuberculosis_H37Rv RVALVTLLHHAYSDGVGVLDMLAAFYNDTPDEAPVVAPPWEPPPLPSTRQ
Mb3114|M.bovis_AF2122/97 RVALVTLLHHAYSDGVGVLDMLAAFYNDAPDEAPVVAPPWEPPPLPSTRQ
MMAR_2599|M.marinum_M KVALVMLVHHAYVDGVGAAWLMQQFYQPHRGVGAAEAPDYRPAPLPSWPT
MUL_3161|M.ulcerans_Agy99 KVALVMLVHHAYVDGVGAAWLMQQFYQPHRGVGAAEAPDYRPAPLPSWPT
MAV_2240|M.avium_104 RLAVMTKVHHAGVDGVTGANLMSQLCATEPDAAPPEPAAG-VGGGAGWRI
TH_2477|M.thermoresistible__bu PLVVLTKVHHAAVDGVTGANLLSQVCTTEADTPPPEPVQG-AGTASDLEI
MAB_1917|M.abscessus_ATCC_1997 RLVVMTKMHHASVDGVTGANLMSALCGLEPDAEAPEPAPG-VGGANSLEI
MLBr_01244|M.leprae_Br4923 RAAMLLQISHAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRND
.:: : *: **: ::
Mflv_2428|M.gilvum_PYR-GCK LLREAQLDHFR-NIVELPSLVADAARGAARLRKRAKERRE-------VPG
Mvan_4224|M.vanbaalenii_PYR-1 LLWEAQLDHFR-NIAELPGLVADAASGLSRLRRRAKERNS-------VLD
MSMEG_0290|M.smegmatis_MC2_155 LVRTAFADHMR-QIGRIPATIRYTAQGVARVRRSS--RKL-------SPE
Rv3087|M.tuberculosis_H37Rv RLGWALRDLPS-RLGKIAPTVRAVRDRVRIEREFAKDGDR-------RVP
Mb3114|M.bovis_AF2122/97 RLGWALRDLPS-RLGKIAPTVRAVRDRVRIEREFAKDGDR-------RVP
MMAR_2599|M.marinum_M RLGWAVRDWPETVIGNVPKVATGLWRKFLFDRKRKSAG---------LPP
MUL_3161|M.ulcerans_Agy99 RLGWAVRDWPETVIGNVPKVATGLWRKFLFDRKRKSAG---------LPP
MAV_2240|M.avium_104 AAGGLVRFAAR--PLRLASVVPDTAASVLATVRRALDG----------AA
TH_2477|M.thermoresistible__bu ALSGAVRFATR--PLKLLNVLPTTANSVLDTVRRARAG----------RT
MAB_1917|M.abscessus_ATCC_1997 AVTGALKWASR--PLKFAKLLPATIGVIPAWLERSKRG----------EA
MLBr_01244|M.leprae_Br4923 LMLQGINHLPVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGI
.
Mflv_2428|M.gilvum_PYR-GCK LAKPFNAPPTFLNHVVSPVRTFATATLALSEVKETAKHLGVTFNDIVLAV
Mvan_4224|M.vanbaalenii_PYR-1 LAKPFNAPSTFLNHVVSPVRTFATAALPLAEVKETAKHLGVTFNDVVLSL
MSMEG_0290|M.smegmatis_MC2_155 LTRPFTPPPSFINHMITSKRKFATATIALADAKETSKKLGITLNDLVLAM
Rv3087|M.tuberculosis_H37Rv PTFDRSAPPGPFQRGLSRSRRFSCESFPLAEVREVSKTLGVTINDVFLAC
Mb3114|M.bovis_AF2122/97 PTFDRSAPPGPFQRGLSRSRRFSCESFPLAEVREVSKTLGVTINDVFLAC
MMAR_2599|M.marinum_M HPSARQMQRTPINVNLSAARTFVCDSVPLQHFSAVAKALGVTINDVFSSC
MUL_3161|M.ulcerans_Agy99 HPSARQMQRTPINVNLSAARTFVCDSVPLQHFSAVAKALGVTINDVFSSC
MAV_2240|M.avium_104 MARPFAAPTTVFNARISNRRCIAYAELNLDDVKAVKNHFGVKVNDVVMAL
TH_2477|M.thermoresistible__bu MARPFAAPSTPFNANVTGRRNVAFTQLDLEDVKRIKDHFGVKVNDVVMAL
MAB_1917|M.abscessus_ATCC_1997 MSAPFSAPRTSFNSTITSRRNVGYAQLDLEDVRTVKNHFGVKVNDVVMAI
MLBr_01244|M.leprae_Br4923 RVLSQAAEPSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAG
: : . * . . . ..** :
Mflv_2428|M.gilvum_PYR-GCK AAGGLRELLLRYD-GRADRPIMATVPVSTDKSTDRVTG-NEIGGMMVSLP
Mvan_4224|M.vanbaalenii_PYR-1 AAGGLRELLLRYD-GQADRPIMATVPVSTDKSTDRITG-NEIGGMMVSLP
MSMEG_0290|M.smegmatis_MC2_155 SSGALRTLQLRYD-GRADHPLLASVPMSFDFSPDRIWG-NRFSGVLVALP
Rv3087|M.tuberculosis_H37Rv VAGAVRRYLERCG-SPPTDAMVATMPLAVTPAAERAHPGNYSSVDYVWLR
Mb3114|M.bovis_AF2122/97 VAGAVRRYLERCG-SPPTDAMVATMPLAVTPAAERAHPGNYSSVDYVWLR
MMAR_2599|M.marinum_M AAGALRRLLVDLNYDPDTHPLIGATPFAGERPLGMQGLGNYATLDYCWLR
MUL_3161|M.ulcerans_Agy99 AAGALRRLLVDLDYDPDTHPLIGATPFAGERPLGMQGLGNYATVDYCWLR
MAV_2240|M.avium_104 VSGVLRQYLAERN-ALPDSSLVASVPISVHGKSDRPGR-NQVSAMFASLH
TH_2477|M.thermoresistible__bu TSGALRSYLLERD-QLPDSPLIAMVPVSVHDKTDRPGR-NHVSGMFSRLE
MAB_1917|M.abscessus_ATCC_1997 CAGALRKYLDDRG-ELPDNSLVAMVPVSVHEKSDRPGR-NQVSGMFSRLE
MLBr_01244|M.leprae_Br4923 LVGALRRYHEALG--VSISTLPMAVPVNVRTEADVVGS-NRFVGVTLAAP
* :* . .: *. *
Mflv_2428|M.gilvum_PYR-GCK VHVDDPLERVELTAVATTRAKENNDLLGPTLQGRFLEYLPPPLAPTLFRA
Mvan_4224|M.vanbaalenii_PYR-1 VHIDDPLERVRLTSMATRRAKETNDLLGPTLQGRMLEYLPPPLAPALFRA
MSMEG_0290|M.smegmatis_MC2_155 VDVADTGERVRRTREAANLAKESHQLIGPELVARWAAYMPPVPVEALFKR
Rv3087|M.tuberculosis_H37Rv ADIADPLERLHATHLAAEATKQHFAQTKDA--DVGAVVELLPERLISGLA
Mb3114|M.bovis_AF2122/97 ADIADPLERLHATHLAAEATKQHFAQTKDA--DVGAVVELLPERLISGLA
MMAR_2599|M.marinum_M SDIADPSARLQASREANTQMKEHIKAVKEAGADFNSVMQVLPPWGIKIIR
MUL_3161|M.ulcerans_Agy99 SDIADPSARLQASREANTQMKENIKAVKEAGADFNSVMQVLPPWGIKIIR
MAV_2240|M.avium_104 TEIADPVQRLKAIAHANSLAKEHSSAIGASLLQDWTQFAAPAVFGIAMRL
TH_2477|M.thermoresistible__bu TTIEDPAERLRAIANANSVAKQHSSAIAASLLQDWTQFAAPAVFGVAMRV
MAB_1917|M.abscessus_ATCC_1997 TNVDDPVERLNAIAAANNIAKDHTAVLGATLLQDWSQFAAPAVFGTAMRV
MLBr_01244|M.leprae_Br4923 LGTNDPAARMQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPASVLDFIVDS
*. *:. ::
Mflv_2428|M.gilvum_PYR-GCK QSKR---ADHNRLMNVAISNVPGPRQRGHVGGAPVSEIYSVGVLSAGSAF
Mvan_4224|M.vanbaalenii_PYR-1 QAKR---ADHNRLMNVAVSNVPGPRRRGHIGGAPVSEIYSVGVLSAGSAF
MSMEG_0290|M.smegmatis_MC2_155 LSSK---DGQNKVLNLNISNVPGPRERGKVGGATVTELYSVGPITAGSGL
Rv3087|M.tuberculosis_H37Rv RANARTKGRFDTFKNVVVSNVPGPREPRYLGRWRVDQWFSTGQISHGATL
Mb3114|M.bovis_AF2122/97 RANARTKGRFDTFKNVVVSNVPGPREPRYLGRWRVDQWFSTGQISHGATL
MMAR_2599|M.marinum_M KAIHRSRGRFGFFGNVVLSNVPGPKETLYLDHWKVSNWFSTGQIADGTAL
MUL_3161|M.ulcerans_Agy99 KAIHRSRGRFGFFGNVVLSNVPGPKETLYLDHWKVSNWFSTGQIADGTAL
MAV_2240|M.avium_104 YARTRFTDSMP-VHNLVVSNVPGPQLPLYLLGCEVKAMYPLGPIFHGSGL
TH_2477|M.thermoresistible__bu YAASRLGEAKP-VHNLVVSNVPGPQVPLYFLGAEVKAMYPLGPIFHGSGL
MAB_1917|M.abscessus_ATCC_1997 YSRIRLADRHPVIHNLVVSNVPGPQVPLYFLGAQVIGMYPLGPIFHGAAL
MLBr_01244|M.leprae_Br4923 VASS----------DVNASNIPAYPGDTYFAGAKILRQYGIGPR-PGVAM
: :: **:*. . : : * * :
Mflv_2428|M.gilvum_PYR-GCK NMTVWSYVDQLDIAVLSDDRTFNDPHEATDAMVHAFDELRQVCGLAR-PT
Mvan_4224|M.vanbaalenii_PYR-1 NMTVWSYVDQVDIAVLSDDRTFDEPHEATSAVTRAFDELRRACGLAR-AT
MSMEG_0290|M.smegmatis_MC2_155 NITVWSYVDQLNISVISDDATVDDPHEVTDAMLDEFREIRRTAGLSEKLT
Rv3087|M.tuberculosis_H37Rv NMTVWSYCDQFNLCVMADAVAVRNTWELLGGFRASHEELLAAARAQATPK
Mb3114|M.bovis_AF2122/97 NMTVWSYCDQFNLCVMADAVAVRNTWELVGGFRASHEELLAAARAQATPK
MMAR_2599|M.marinum_M NITMWSYCGQANICILADRAVLDDGWRMFD----YLVDELNSLTAVASTK
MUL_3161|M.ulcerans_Agy99 NITMWSYCGQANICVLADRAVLDDGWRMFD----YLVDELNSLTAVASTK
MAV_2240|M.avium_104 NITAMSLRGKLDVGLIGCPDLVPDLWELADEFAVAMEELRAAAR------
TH_2477|M.thermoresistible__bu NITVMSLTGRLNVGMVSCPELMPDLWELAEGFERALRELLDTVG------
MAB_1917|M.abscessus_ATCC_1997 TVTVMSLDGKLNVGLISCPDLMPDLGTLTDDFGVALEELKARI-------
MLBr_01244|M.leprae_Br4923 MAVLMSRGGFCTVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHA
. * . : : . . :
Mflv_2428|M.gilvum_PYR-GCK TVDTAMAPAPAPQP------
Mvan_4224|M.vanbaalenii_PYR-1 AVESAMPPASAG--------
MSMEG_0290|M.smegmatis_MC2_155 VVETAMPQ------------
Rv3087|M.tuberculosis_H37Rv EMAT----------------
Mb3114|M.bovis_AF2122/97 EMAT----------------
MMAR_2599|M.marinum_M EAA-----------------
MUL_3161|M.ulcerans_Agy99 EAA-----------------
MAV_2240|M.avium_104 --------------------
TH_2477|M.thermoresistible__bu --------------------
MAB_1917|M.abscessus_ATCC_1997 --------------------
MLBr_01244|M.leprae_Br4923 VPASFAARSSGSPAGWLSSS