For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SMRRLNGMDAMLLYSETPNLHTHTLKVAVIDATGYSAEHGGEYGFDAFRQTIARRLHLLEPLRYRLIDIP WRLHHPMWLQDCPVDLDYHLRRVRVPAPGGRRELDRVIGEIASTPLDRTRPLWEFHFAEGMADNRFALIG KVHHTLADGVASANLLARLMDLVDAPQDEREDPPAGCDDPSTLDLLREAQLDHFRNIVELPSLVADAARG AARLRKRAKERREVPGLAKPFNAPPTFLNHVVSPVRTFATATLALSEVKETAKHLGVTFNDIVLAVAAGG LRELLLRYDGRADRPIMATVPVSTDKSTDRVTGNEIGGMMVSLPVHVDDPLERVELTAVATTRAKENNDL LGPTLQGRFLEYLPPPLAPTLFRAQSKRADHNRLMNVAISNVPGPRQRGHVGGAPVSEIYSVGVLSAGSA FNMTVWSYVDQLDIAVLSDDRTFNDPHEATDAMVHAFDELRQVCGLARPTTVDTAMAPAPAPQP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2428 | - | - | 100% (485) | hypothetical protein Mflv_2428 |
| M. gilvum PYR-GCK | Mflv_4091 | - | e-158 | 58.09% (482) | hypothetical protein Mflv_4091 |
| M. gilvum PYR-GCK | Mflv_0439 | - | e-145 | 54.62% (476) | hypothetical protein Mflv_0439 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0227 | - | 3e-68 | 51.43% (245) | hypothetical protein Mb0227 |
| M. tuberculosis H37Rv | Rv0221 | - | 1e-141 | 53.44% (479) | hypothetical protein Rv0221 |
| M. leprae Br4923 | MLBr_01244 | - | 3e-26 | 24.44% (495) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_1917 | - | 1e-66 | 33.91% (463) | hypothetical protein MAB_1917 |
| M. marinum M | MMAR_0464 | - | 1e-142 | 54.07% (479) | hypothetical protein MMAR_0464 |
| M. avium 104 | MAV_1847 | - | 1e-156 | 59.06% (469) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_0290 | - | 1e-146 | 53.12% (480) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_3760 | - | 1e-145 | 54.47% (481) | PUTATIVE Diacylglycerol O-acyltransferase |
| M. ulcerans Agy99 | MUL_1818 | - | 5e-62 | 32.91% (471) | hypothetical protein MUL_1818 |
| M. vanbaalenii PYR-1 | Mvan_4224 | - | 0.0 | 82.29% (480) | hypothetical protein Mvan_4224 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2428|M.gilvum_PYR-GCK --------MSMRRLNGMDAMLLYSET-PNLHTHTLKVAVIDATGYSAEHG
Mvan_4224|M.vanbaalenii_PYR-1 --MQVVAYPFMKRLNGMDAMLLYSET-PNLHTHTLKVAVIDAS--NCADG
MAV_1847|M.avium_104 ----------MKRLGGWDAVLLYNET-PNLHQHTLKIAVVDAT---DCDG
Mb0227|M.bovis_AF2122/97 ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELD----SDR
Rv0221|M.tuberculosis_H37Rv ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELD----SDR
MMAR_0464|M.marinum_M ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELD----PDR
MSMEG_0290|M.smegmatis_MC2_155 ----------MQRLSGWDAFLLYSET-PNVHMHTLKIAIIDLEG---IGD
TH_3760|M.thermoresistible__bu ----------VKRLQGWDAVLLYSET-PNVHMHTLKVAVIDLS----DVT
MAB_1917|M.abscessus_ATCC_1997 ----------MQRLSGLDASFLYLET-PTQPMHVCGVLELDTT----TIP
MUL_1818|M.ulcerans_Agy99 ----------MRRLSSVDAAFWSAET-AGWHMHVGALAICDPT----DAP
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTP------
. .* . * : *: . : :
Mflv_2428|M.gilvum_PYR-GCK GEYGFDAFRQTIARRLHLLEPLRYRLIDIPWRLHHPMWLQDCPVDLDYHL
Mvan_4224|M.vanbaalenii_PYR-1 --YDFDAFRRTVARRLPLLDPLRYRLIDIPWRLHHPMWLEDCPVDLDYHL
MAV_1847|M.avium_104 --FGFDLFRQTLARRLHLLEPLRYQLTEIRGRIHRAMWLENCDVDLDFHV
Mb0227|M.bovis_AF2122/97 QEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHI
Rv0221|M.tuberculosis_H37Rv QEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHI
MMAR_0464|M.marinum_M RAFGVDAFRAVIGERMAKLEPFGYQLVDIPFKFHHPMWREHCEVDLDYHI
MSMEG_0290|M.smegmatis_MC2_155 RTFGVEDFRKVLRGRLHKLDPFRFQLVDIPFKFHHPMWRENCDVDLEYHV
TH_3760|M.thermoresistible__bu HPFGLEDFRKVIASRLYKLDPFRYQLVEIPFKFHHPMWRENCEVDLDHHI
MAB_1917|M.abscessus_ATCC_1997 GGYSFEKLRTKLAERVEGIPSFREKLADSRLNLDHPVWVDDDDFDIDRHL
MUL_1818|M.ulcerans_Agy99 -DYSFQRLRELLIERLPEIPQLRWRVTGAPLGLDRPWFVEDQDLDVDFHV
MLBr_01244|M.leprae_Br4923 ---DWNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHV
. : :* : : : :: . : . .::: *:
Mflv_2428|M.gilvum_PYR-GCK RRVRVPAPGGRRELDRVIGEIASTPLDRTRPLWEFHFAEGMADNRFALIG
Mvan_4224|M.vanbaalenii_PYR-1 RRVRVPAPGRRRELDRVIGEIASTPLDRSRPLWEFHFAEGMADDRYALIG
MAV_1847|M.avium_104 RRTQIRSPGGRRELDAAIGEVASTPLDRSRPLWEFHFVEGMADNRFAIIG
Mb0227|M.bovis_AF2122/97 RPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVVA
Rv0221|M.tuberculosis_H37Rv RPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVVA
MMAR_0464|M.marinum_M RPWQLRPPGGRRELDEAIGEIASTPLDRRYPLWEMYFVEGLANHRVAVVG
MSMEG_0290|M.smegmatis_MC2_155 RPWQVRAPGGRRELDEAIGEIAGTPLDRSRPLWEMYFVEGLAGGRIAVVN
TH_3760|M.thermoresistible__bu RGMRVDPPGGRRELDEAVGRIASTPLDRRYPLWEMYFVEGLANGRVAVVG
MAB_1917|M.abscessus_ATCC_1997 HHVGLPAPGGKAEIADMCGHIASLPLDRARPLWEMWVIETGDTNRLVVMT
MUL_1818|M.ulcerans_Agy99 RRIGVPAPGGRRELEELVGRLMSYKLDRSRPLWELWVIEGVEGGRIATLT
MLBr_01244|M.leprae_Br4923 RRVRVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLL
: : ** *: : :: *** . * * . :
Mflv_2428|M.gilvum_PYR-GCK KVHHTLADGVASANLLARLMDLVDAPQDEREDPPAGCDDPSTLDLLRE--
Mvan_4224|M.vanbaalenii_PYR-1 KVHHTLADGVASANLLARLMDLTGTPPNHHADPVVVCEEPTRRELLWE--
MAV_1847|M.avium_104 KVHHALADGVASANLLARGLDLPNAPQPARDDYRADP-YPSNGVLIRA--
Mb0227|M.bovis_AF2122/97 KIHHALADGVASANMMARGMDLLPGPEVGR--YVPDP-APTKRQLLSA--
Rv0221|M.tuberculosis_H37Rv KIHHALADGVASANMMARGMDLLPGPEVGR--YVPDP-APTKRQLLSA--
MMAR_0464|M.marinum_M KIHHALADGVASANLMARGMDLLPGPEGDP--YVSDP-APTKRELMSS--
MSMEG_0290|M.smegmatis_MC2_155 KIHHALADGIASANLLARGMDLREGPQRDRDSYVTDP-EPSKGELVRT--
TH_3760|M.thermoresistible__bu KIHHALADGVASGNLMARGMDLQPGPQRDHTFYRTDP-PPGRSHLVRT--
MAB_1917|M.abscessus_ATCC_1997 KMHHASVDGVTGANLMSALCGLEPDAEAP-EPAPGVGGANS--LEIAV--
MUL_1818|M.ulcerans_Agy99 KMHHAIVDGVSGAGLGEILLDVTPEPRPPQEETVGFVGFQIPRLERRA--
MLBr_01244|M.leprae_Br4923 QISHAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQGI
:: *: .**: . : .: .
Mflv_2428|M.gilvum_PYR-GCK ---AQLDHFRNIVELPSLVADAARGAARLRKRAK---ERREVPGLAKPFN
Mvan_4224|M.vanbaalenii_PYR-1 ---AQLDHFRNIAELPGLVADAASGLSRLRRRAK---ERNSVLDLAKPFN
MAV_1847|M.avium_104 ---ALRDHAEHVRELPRLVRDTVKGVRRVRRKS------RSAPGLARNFN
Mb0227|M.bovis_AF2122/97 ---AFIDHLRHLGRIPATIRYTTQGLGRVRRSS-----RKLSPALTMPFT
Rv0221|M.tuberculosis_H37Rv ---AFIDHLRHLGRIPATIRYTTQGLGRVRRSS-----RKLSPALTMPFT
MMAR_0464|M.marinum_M ---AFLDHLRHLGRIPATMRYTAQGLARVRRSS-----RKLSPELTRPFT
MSMEG_0290|M.smegmatis_MC2_155 ---AFADHMRQIGRIPATIRYTAQGVARVRRSS-----RKLSPELTRPFT
TH_3760|M.thermoresistible__bu ---AFVDHLRQIGRIPSVMRYTYDGLRRVHRST-----RKLSPELTRPFT
MAB_1917|M.abscessus_ATCC_1997 ---TGALKWA--SRPLKFAKLLPATIGVIPAWLE---RSKRGEAMSAPFS
MUL_1818|M.ulcerans_Agy99 ---VGALINVGIMTPFRIARLVEQTVRQQIAALG---VSARP---PRYFD
MLBr_01244|M.leprae_Br4923 NHLPVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQA
Mflv_2428|M.gilvum_PYR-GCK APPTFLNHVVSPVRTFATATLALSEVKETAKHLGVTFNDIVLAVAAGGLR
Mvan_4224|M.vanbaalenii_PYR-1 APSTFLNHVVSPVRTFATAALPLAEVKETAKHLGVTFNDVVLSLAAGGLR
MAV_1847|M.avium_104 PPATFLNHVVSPGRTFASTTLDLAAVKAVGKQLGVTINDMVLAITAGALR
Mb0227|M.bovis_AF2122/97 PPPTFMNR----------------------------------------IK
Rv0221|M.tuberculosis_H37Rv PPPTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGALR
MMAR_0464|M.marinum_M PPPTFMNHMLTPQRRFATATLALADVKQTGKQLGATINDMVLAMSTGALR
MSMEG_0290|M.smegmatis_MC2_155 PPPSFINHMITSKRKFATATIALADAKETSKKLGITLNDLVLAMSSGALR
TH_3760|M.thermoresistible__bu PPPTFLNHKIDATRTFATATLALSDVKATSRHLGVTINDLVLALSAGALR
MAB_1917|M.abscessus_ATCC_1997 APRTSFNSTITSRRNVGYAQLDLEDVRTVKNHFGVKVNDVVMAICAGALR
MUL_1818|M.ulcerans_Agy99 APKTRFNAHVSPHRRVSGCRIELARAKAVKDAFGVKLNDVVLATVAGAAR
MLBr_01244|M.leprae_Br4923 AEPSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALR
. : : :
Mflv_2428|M.gilvum_PYR-GCK ELLLRYDGRADRPIMATVPVSTDKSTDRVTG-NEIGGMMVSLPVHVDDPL
Mvan_4224|M.vanbaalenii_PYR-1 ELLLRYDGQADRPIMATVPVSTDKSTDRITG-NEIGGMMVSLPVHIDDPL
MAV_1847|M.avium_104 ALLLEYDGHADQPILAGVPMSIDTSLERISG-NALGTVVVSLPVHVADPL
Mb0227|M.bovis_AF2122/97 KPLSKPSGRPP-PHTNRAPSS----------------MPLAM--------
Rv0221|M.tuberculosis_H37Rv TLLLRYDGKAE-PLLASVPVSYDFSPERISG-NRFTGMLVALPADSDDPL
MMAR_0464|M.marinum_M NLLLRYDGRAE-PLLASVPVSYDFSPDRISG-NYFSGMMVALPTDCADPL
MSMEG_0290|M.smegmatis_MC2_155 TLQLRYDGRADHPLLASVPMSFDFSPDRIWG-NRFSGVLVALPVDVADTG
TH_3760|M.thermoresistible__bu KLLLRYDGHADHPLLASVPVSFDFSPDRICG-NYFTGMLVALPVDTAEPL
MAB_1917|M.abscessus_ATCC_1997 KYLDDRGELPDNSLVAMVPVSVHEKSDRPGR-NQVSGMFSRLETNVDDPV
MUL_1818|M.ulcerans_Agy99 EYLKKRDELPAKPLIAQIPVSTRTDQTKEDVGNQISSMTASLATHINDPA
MLBr_01244|M.leprae_Br4923 RYHEALG-VSISTLPMAVPVNVRTEADVVGS-NRFVGVTLAAPLGTNDPA
. . . * . :
Mflv_2428|M.gilvum_PYR-GCK ERVELTAVATTRAKENNDLLGPTLQGRFLEYLPP---PLAPTLFRAQSKR
Mvan_4224|M.vanbaalenii_PYR-1 ERVRLTSMATRRAKETNDLLGPTLQGRMLEYLPP---PLAPALFRAQAKR
MAV_1847|M.avium_104 EWVRLARIGATIGKENTALLGPDLVSRWAGYAPP---RLTERLFRRIATS
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
Rv0221|M.tuberculosis_H37Rv QRVRVCHENAVSAKESHQLLGPELISRWAAYWPP---AGAEALFRWLSER
MMAR_0464|M.marinum_M ERVQACHENALSAKESHQLLGPELISRWAAYWPP---GATEAAFRWASSR
MSMEG_0290|M.smegmatis_MC2_155 ERVRRTREAANLAKESHQLIGPELVARWAAYMPP---VPVEALFKRLSSK
TH_3760|M.thermoresistible__bu DRIRATRDAALLAKESHQLIGPELISRWSQYLPP---APAERLFGWLSRI
MAB_1917|M.abscessus_ATCC_1997 ERLNAIAAANNIAKDHTAVLGATLLQDWSQFAAPAVFGTAMRVYSRIRLA
MUL_1818|M.ulcerans_Agy99 ERLKAIHESTQNAKEMAKALSAHQIMGLTETTPPGLLHLAARAYTATGLS
MLBr_01244|M.leprae_Br4923 ARMQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPA----------SVLDFI
Mflv_2428|M.gilvum_PYR-GCK ADHNRLMNVAISNVPGPRQRGHVGGAPVSEIYSVGVLSAGSAFNMTVWSY
Mvan_4224|M.vanbaalenii_PYR-1 ADHNRLMNVAVSNVPGPRRRGHIGGAPVSEIYSVGVLSAGSAFNMTVWSY
MAV_1847|M.avium_104 GSGNKLINVPVSNVPGPRQPGRIACAPVVQFLSVGPLTFGAGVNITVWSY
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
Rv0221|M.tuberculosis_H37Rv DGQNKVLNLNISNVPGPRERGRVGAALVTEIYSVGPLTAGSGLNITVWSY
MMAR_0464|M.marinum_M DGQNKVLNLNISNVPGPREHGRVGGALVTEIYSVGPLTAGSGLNITVWSY
MSMEG_0290|M.smegmatis_MC2_155 DGQNKVLNLNISNVPGPRERGKVGGATVTELYSVGPITAGSGLNITVWSY
TH_3760|M.thermoresistible__bu DGQNKIQNLTVSNVMGPKERGRVGGALVTEIYSVGPLTAASGLNITVWSY
MAB_1917|M.abscessus_ATCC_1997 DRHPVIHNLVVSNVPGPQVPLYFLGAQVIGMYPLGPIFHGAALTVTVMSL
MUL_1818|M.ulcerans_Agy99 HNLAPIN-LVVSNVPGPQFPLYMAGARLDSLVPLGPPVMDVALNITCFSY
MLBr_01244|M.leprae_Br4923 VDSVASSDVNASNIPAYPGDTYFAGAKILRQYGIGPR-PGVAMMAVLMSR
Mflv_2428|M.gilvum_PYR-GCK VDQLDIAVLSDDRTFNDPHEATDAMVHAFDELRQVCGLARPTTVDTAMAP
Mvan_4224|M.vanbaalenii_PYR-1 VDQVDIAVLSDDRTFDEPHEATSAVTRAFDELRRACGLARATAVESAMPP
MAV_1847|M.avium_104 VDQLNISVLADDVTFEDPHQVTDTMVEAFDLVRQAAGMPAETRP------
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
Rv0221|M.tuberculosis_H37Rv VDQLNISVLTDGSTVQDPHEVTAGMIADFIEIRRAAGLSVELTVVESAMA
MMAR_0464|M.marinum_M VDQLNISVLTDGATVEDPHEVTEAMMADFVEIRRAAGLSAELTVIEAAMA
MSMEG_0290|M.smegmatis_MC2_155 VDQLNISVISDDATVDDPHEVTDAMLDEFREIRRTAGLSEKLTVVETAMP
TH_3760|M.thermoresistible__bu VDQLNISVLSDGSTFDDPHEVTDAMVGEFIEIRGAAGLPGELTVVETAMA
MAB_1917|M.abscessus_ATCC_1997 DGKLNVGLISCPDLMPDLGTLTDDFGVALEELKARI--------------
MUL_1818|M.ulcerans_Agy99 QEHLDFGFVTTPEVANDIDEMADLIEPALAELERAAGL------------
MLBr_01244|M.leprae_Br4923 GGFCTVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAA
Mflv_2428|M.gilvum_PYR-GCK APAPQP-------
Mvan_4224|M.vanbaalenii_PYR-1 ASAG---------
MAV_1847|M.avium_104 -------------
Mb0227|M.bovis_AF2122/97 -------------
Rv0221|M.tuberculosis_H37Rv QA-----------
MMAR_0464|M.marinum_M QARSMNEGAGSA-
MSMEG_0290|M.smegmatis_MC2_155 Q------------
TH_3760|M.thermoresistible__bu R------------
MAB_1917|M.abscessus_ATCC_1997 -------------
MUL_1818|M.ulcerans_Agy99 -------------
MLBr_01244|M.leprae_Br4923 RSSGSPAGWLSSS