For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VKRLSGWDAVLLYSETPNVHMHTLKVAVIELDSDRQEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHH PMWREHCQVDLNYHIRPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVVAKIHHA LADGVASANMMARGMDLLPGPEVGRYVPDPAPTKRQLLSAAFIDHLRHLGRIPATIRYTTQGLGRVRRSS RKLSPALTMPFTPPPTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGALRTLLLRYDG KAEPLLASVPVSYDFSPERISGNRFTGMLVALPADSDDPLQRVRVCHENAVSAKESHQLLGPELISRWAA YWPPAGAEALFRWLSERDGQNKVLNLNISNVPGPRERGRVGAALVTEIYSVGPLTAGSGLNITVWSYVDQ LNISVLTDGSTVQDPHEVTAGMIADFIEIRRAAGLSVELTVVESAMAQA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0221 | - | - | 100% (469) | hypothetical protein Rv0221 |
| M. tuberculosis H37Rv | Rv3087 | - | 1e-59 | 33.19% (464) | hypothetical protein Rv3087 |
| M. tuberculosis H37Rv | Rv1760 | - | 1e-55 | 32.59% (451) | hypothetical protein Rv1760 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0227 | - | 1e-135 | 98.29% (234) | hypothetical protein Mb0227 |
| M. gilvum PYR-GCK | Mflv_0439 | - | 0.0 | 71.06% (470) | hypothetical protein Mflv_0439 |
| M. leprae Br4923 | MLBr_01244 | - | 7e-23 | 25.92% (436) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_0507 | - | 7e-57 | 31.30% (476) | hypothetical protein MAB_0507 |
| M. marinum M | MMAR_0464 | - | 0.0 | 84.65% (469) | hypothetical protein MMAR_0464 |
| M. avium 104 | MAV_4952 | - | 0.0 | 80.38% (469) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_0290 | - | 0.0 | 71.46% (473) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_3760 | - | 0.0 | 71.55% (471) | PUTATIVE Diacylglycerol O-acyltransferase |
| M. ulcerans Agy99 | MUL_1818 | - | 1e-53 | 30.43% (470) | hypothetical protein MUL_1818 |
| M. vanbaalenii PYR-1 | Mvan_0228 | - | 0.0 | 70.74% (475) | hypothetical protein Mvan_0228 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0221|M.tuberculosis_H37Rv ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDS-----D
Mb0227|M.bovis_AF2122/97 ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDS-----D
MMAR_0464|M.marinum_M ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDP-----D
MAV_4952|M.avium_104 ----------MKRLSGWDSVLLYSEA-PNVHMHTIKAAVIELDA-----D
Mflv_0439|M.gilvum_PYR-GCK ----------MKRLRGWDAVLLYSET-PSVHMHTLKLAVIELDD----LG
Mvan_0228|M.vanbaalenii_PYR-1 ----------MKRLSGWDAVLLYSET-PNVHMHTLKLAVIELDDTFAREG
TH_3760|M.thermoresistible__bu ----------VKRLQGWDAVLLYSET-PNVHMHTLKVAVIDLSD-----V
MSMEG_0290|M.smegmatis_MC2_155 ----------MQRLSGWDAFLLYSET-PNVHMHTLKIAIIDLEG----IG
MAB_0507|M.abscessus_ATCC_1997 ----------MQRLSGVDAAFWHAET-AGWHMHIGGLSIYDPTD------
MUL_1818|M.ulcerans_Agy99 ----------MRRLSSVDAAFWSAET-AGWHMHVGALAICDPTD------
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTP------
. .* . * : .*: . : : :
Rv0221|M.tuberculosis_H37Rv RQEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYH
Mb0227|M.bovis_AF2122/97 RQEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYH
MMAR_0464|M.marinum_M RRAFGVDAFRAVIGERMAKLEPFGYQLVDIPFKFHHPMWREHCEVDLDYH
MAV_4952|M.avium_104 RRSLDVAAFRQVIAGRLNKLDPFCYQLVEVPFSFHHPMWRENCEIDLDYH
Mflv_0439|M.gilvum_PYR-GCK GAKFGVEELRKVIHGRLYKLDPFRYELVDIPFKFHHPMWRENAEVDLDYH
Mvan_0228|M.vanbaalenii_PYR-1 GATFGVEELRKVIHGRLYKLDPFRYQLIDIPFKFHHPMWRENAEVDLEYH
TH_3760|M.thermoresistible__bu THPFGLEDFRKVIASRLYKLDPFRYQLVEIPFKFHHPMWRENCEVDLDHH
MSMEG_0290|M.smegmatis_MC2_155 DRTFGVEDFRKVLRGRLHKLDPFRFQLVDIPFKFHHPMWRENCDVDLEYH
MAB_0507|M.abscessus_ATCC_1997 APDYSFERVRALIVERLPSMPQLRWRVTDVPLGLDRPWFVEDEELDPDFH
MUL_1818|M.ulcerans_Agy99 APDYSFQRLRELLIERLPEIPQLRWRVTGAPLGLDRPWFVEDQDLDVDFH
MLBr_01244|M.leprae_Br4923 ----DWNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFH
. .* : : : .: .: * : . :.: :.*
Rv0221|M.tuberculosis_H37Rv IRPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVV
Mb0227|M.bovis_AF2122/97 IRPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVV
MMAR_0464|M.marinum_M IRPWQLRPPGGRRELDEAIGEIASTPLDRRYPLWEMYFVEGLANHRVAVV
MAV_4952|M.avium_104 IRPWRVSPPGGRRELDEAIGQIASTPLDRSRPLWEMYFVEGLANNRIAVV
Mflv_0439|M.gilvum_PYR-GCK VRSVRVDAPGGRRELDEAVGRIASTPLDRSRPLWEMYLIEGLADGRIAVL
Mvan_0228|M.vanbaalenii_PYR-1 VRSCRVDAPGGRRELDEAVGRIASTPLDRSRPLWEMYLIEGLAGGRIAVL
TH_3760|M.thermoresistible__bu IRGMRVDPPGGRRELDEAVGRIASTPLDRRYPLWEMYFVEGLANGRVAVV
MSMEG_0290|M.smegmatis_MC2_155 VRPWQVRAPGGRRELDEAIGEIAGTPLDRSRPLWEMYFVEGLAGGRIAVV
MAB_0507|M.abscessus_ATCC_1997 IRRIGVPAPGGRKELEELAGRLMSYKLDRSRPLWELWVIEGVEGGRVATL
MUL_1818|M.ulcerans_Agy99 VRRIGVPAPGGRRELEELVGRLMSYKLDRSRPLWELWVIEGVEGGRIATL
MLBr_01244|M.leprae_Br4923 VRRVRVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAML
:* : ** :*: : : :: *** .:**: * * :
Rv0221|M.tuberculosis_H37Rv AKIHHALADGVASANMMARGMDLLPGPEVGR--YVPDPAPTKRQLLSAAF
Mb0227|M.bovis_AF2122/97 AKIHHALADGVASANMMARGMDLLPGPEVGR--YVPDPAPTKRQLLSAAF
MMAR_0464|M.marinum_M GKIHHALADGVASANLMARGMDLLPGPEGDP--YVSDPAPTKRELMSSAF
MAV_4952|M.avium_104 GKIHHALADGVASANLLARGMDLQPGPEAGP--YVCDPPPTTRQLMVSAF
Mflv_0439|M.gilvum_PYR-GCK GKIHHALADGVASANLLARGMDLQDGPQVDRDSYATDPAPSKGELVRTAF
Mvan_0228|M.vanbaalenii_PYR-1 GKIHHALADGVASANLLARGMDLQDSPQADRDSYATDPAPTRGELVRSAF
TH_3760|M.thermoresistible__bu GKIHHALADGVASGNLMARGMDLQPGPQRDHTFYRTDPPPGRSHLVRTAF
MSMEG_0290|M.smegmatis_MC2_155 NKIHHALADGIASANLLARGMDLREGPQRDRDSYVTDPEPSKGELVRTAF
MAB_0507|M.abscessus_ATCC_1997 TKMHHAIVDGVSGAGLGEILLDIAPEPRPAPDDTVGSLVGLGLPSRERIL
MUL_1818|M.ulcerans_Agy99 TKMHHAIVDGVSGAGLGEILLDVTPEPRPPQEETVG-FVGFQIPRLERRA
MLBr_01244|M.leprae_Br4923 LQISHAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQG
:: **:.**:.. : *: *
Rv0221|M.tuberculosis_H37Rv IDHLRHLG------RIPATIRYTTQGLGRVRRSSRKLSPALTM-----PF
Mb0227|M.bovis_AF2122/97 IDHLRHLG------RIPATIRYTTQGLGRVRRSSRKLSPALTM-----PF
MMAR_0464|M.marinum_M LDHLRHLG------RIPATMRYTAQGLARVRRSSRKLSPELTR-----PF
MAV_4952|M.avium_104 ADHLRHVG------RLPHTIRYTAQGLGRVRRSARKLSPELTR-----PF
Mflv_0439|M.gilvum_PYR-GCK TDHLRQIR------RFPDVVRYTAAGMRRVRSSGQKLSPELTR-----PF
Mvan_0228|M.vanbaalenii_PYR-1 TDHLRQIA------KLPGVVRYTAQGVRRVQRSERKLSPELTR-----PF
TH_3760|M.thermoresistible__bu VDHLRQIG------RIPSVMRYTYDGLRRVHRSTRKLSPELTR-----PF
MSMEG_0290|M.smegmatis_MC2_155 ADHMRQIG------RIPATIRYTAQGVARVRRSSRKLSPELTR-----PF
MAB_0507|M.abscessus_ATCC_1997 LSALVNVGV-----KTPYRVARLVQQTVRQQLAVFGMERKSPG-----YF
MUL_1818|M.ulcerans_Agy99 VGALINVGI-----MTPFRIARLVEQTVRQQIAALGVSARPPR-----YF
MLBr_01244|M.leprae_Br4923 INHLPVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQ
. : . * : :
Rv0221|M.tuberculosis_H37Rv TPPPTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGAL
Mb0227|M.bovis_AF2122/97 TPPPTFMNR----------------------------------------I
MMAR_0464|M.marinum_M TPPPTFMNHMLTPQRRFATATLALADVKQTGKQLGATINDMVLAMSTGAL
MAV_4952|M.avium_104 EPPPTFMNHKLTPERRFATATLALADVKETGKRLGATINDMVLAMSTGAL
Mflv_0439|M.gilvum_PYR-GCK TPPPSFMNHQIDATRKFATATLALDDVKQTGKHLGATINDMVLAMSAGTL
Mvan_0228|M.vanbaalenii_PYR-1 TPPPTFMNHMVDATRRFATATVALDDVKQTGKQLGVTINDMVLAMSAGAL
TH_3760|M.thermoresistible__bu TPPPTFLNHKIDATRTFATATLALSDVKATSRHLGVTINDLVLALSAGAL
MSMEG_0290|M.smegmatis_MC2_155 TPPPSFINHMITSKRKFATATIALADAKETSKKLGITLNDLVLAMSSGAL
MAB_0507|M.abscessus_ATCC_1997 EAPHTRFNAPVSPHRRISGARLDLARVKALKDAFGVKVNDVVLAIVAGAV
MUL_1818|M.ulcerans_Agy99 DAPKTRFNAHVSPHRRVSGCRIELARAKAVKDAFGVKLNDVVLATVAGAA
MLBr_01244|M.leprae_Br4923 AAEPSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGAL
. : :
Rv0221|M.tuberculosis_H37Rv RTLLLRYDGKAE-PLLASVPVSY-DFSPERISGNRFTGMLVALPADSDDP
Mb0227|M.bovis_AF2122/97 KKPLSKPSGRPP-PHTNRAPSS----------------MPLAM-------
MMAR_0464|M.marinum_M RNLLLRYDGRAE-PLLASVPVSY-DFSPDRISGNYFSGMMVALPTDCADP
MAV_4952|M.avium_104 RTLLLRYDGQAQ-PLLASVPVSF-DFSPERISGNRFTGMLVALPVDHDDP
Mflv_0439|M.gilvum_PYR-GCK RKLLLRYDGQADHPLLASVPVSF-DFSRDRISGNYFTGVLVSIPVELDDP
Mvan_0228|M.vanbaalenii_PYR-1 RKLLLRYDGRADHALLASVPVSF-DFSRDRISGNYFTGVLVSLPVDVEDP
TH_3760|M.thermoresistible__bu RKLLLRYDGHADHPLLASVPVSF-DFSPDRICGNYFTGMLVALPVDTAEP
MSMEG_0290|M.smegmatis_MC2_155 RTLQLRYDGRADHPLLASVPMSF-DFSPDRIWGNRFSGVLVALPVDVADT
MAB_0507|M.abscessus_ATCC_1997 RDYLAKRDEFPDKPLIVQIPVSVRTEETDGVVGNQVSSMTVSLATDIDDP
MUL_1818|M.ulcerans_Agy99 REYLKKRDELPAKPLIAQIPVSTRTDQTKEDVGNQISSMTASLATHINDP
MLBr_01244|M.leprae_Br4923 RRYHEALG-VSISTLPMAVPVNV-RTEADVVGSNRFVGVTLAAPLGTNDP
: . . . * . : :
Rv0221|M.tuberculosis_H37Rv LQRVRVCHENAVSAKESHQLLGPELISRWAAYWPPAGAEALFRWLSER--
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0464|M.marinum_M LERVQACHENALSAKESHQLLGPELISRWAAYWPPGATEAAFRWASSR--
MAV_4952|M.avium_104 LERVAACHQNAISAKESHQLMGPELVSRWAAYMPPAPTRAFFQWASAR--
Mflv_0439|M.gilvum_PYR-GCK VERVRAAHDAAVAGKESNNLLGPELVSQWSAYLPPAPAEALFRWLGTK--
Mvan_0228|M.vanbaalenii_PYR-1 LERVSAAHTAAAAGKESNNLIGPELVSRWSAYFPPAPAEAMFRWLSNK--
TH_3760|M.thermoresistible__bu LDRIRATRDAALLAKESHQLIGPELISRWSQYLPPAPAERLFGWLSRI--
MSMEG_0290|M.smegmatis_MC2_155 GERVRRTREAANLAKESHQLIGPELVARWAAYMPPVPVEALFKRLSSK--
MAB_0507|M.abscessus_ATCC_1997 AERIQAIYEGTQGAKEMARAMSAHQIMGLTDTTPPGLLQLAARAYTASGL
MUL_1818|M.ulcerans_Agy99 AERLKAIHESTQNAKEMAKALSAHQIMGLTETTPPGLLHLAARAYTATGL
MLBr_01244|M.leprae_Br4923 AARMQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPASVLDFIVDSVASS--
Rv0221|M.tuberculosis_H37Rv DGQNKVLNLNISNVPGPRERGRVGAALVTEIYSVGPLTAGSGLNITVWSY
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0464|M.marinum_M DGQNKVLNLNISNVPGPREHGRVGGALVTEIYSVGPLTAGSGLNITVWSY
MAV_4952|M.avium_104 DGHNKILNLNISNVPGPRERGRVGGALVTEIYSVGPLTAGSGLNITVWSY
Mflv_0439|M.gilvum_PYR-GCK DGQNKVMNLPISNVPGPRERARVGGALVTEIYSVGPLTVGSGINITVWSY
Mvan_0228|M.vanbaalenii_PYR-1 DGQNKVMNLPISNVPGPRERARVGGALVTEIYSVGPLTAGSGLNITVWSY
TH_3760|M.thermoresistible__bu DGQNKIQNLTVSNVMGPKERGRVGGALVTEIYSVGPLTAASGLNITVWSY
MSMEG_0290|M.smegmatis_MC2_155 DGQNKVLNLNISNVPGPRERGKVGGATVTELYSVGPITAGSGLNITVWSY
MAB_0507|M.abscessus_ATCC_1997 SRNLAPINLVLSNVPGPSFPLYMAGARLESMIPLGPPVMDVALNITCFSY
MUL_1818|M.ulcerans_Agy99 SHNLAPINLVVSNVPGPQFPLYMAGARLDSLVPLGPPVMDVALNITCFSY
MLBr_01244|M.leprae_Br4923 -------DVNASNIPAYPGDTYFAGAKILRQYGIGPR-PGVAMMAVLMSR
Rv0221|M.tuberculosis_H37Rv VDQLNISVLTDGSTVQDPHEVTAGMIADFIEIRRAAGLSVELTVVESAMA
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0464|M.marinum_M VDQLNISVLTDGATVEDPHEVTEAMMADFVEIRRAAGLSAELTVIEAAMA
MAV_4952|M.avium_104 VDQLNISVLTDGATCKDPHEVTEAMVQDFIEIRRAAGFSEDLTVVEAAMA
Mflv_0439|M.gilvum_PYR-GCK VDQLNISVLTDGKTLEDPHELTSAMLDDFVEIRRAAGLSEELTVVETALP
Mvan_0228|M.vanbaalenii_PYR-1 VDQINISVLSDGKTLDDPHELTTAMVDEFIEIRRAAGLSTELTVIETAMA
TH_3760|M.thermoresistible__bu VDQLNISVLSDGSTFDDPHEVTDAMVGEFIEIRGAAGLPGELTVVETAMA
MSMEG_0290|M.smegmatis_MC2_155 VDQLNISVISDDATVDDPHEVTDAMLDEFREIRRTAGLSEKLTVVETAMP
MAB_0507|M.abscessus_ATCC_1997 LEHMDFGFVTTPEVAADIDEMADGLEAALVELEHAVGI------------
MUL_1818|M.ulcerans_Agy99 QEHLDFGFVTTPEVANDIDEMADLIEPALAELERAAGL------------
MLBr_01244|M.leprae_Br4923 GGFCTVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAA
Rv0221|M.tuberculosis_H37Rv QA-----------
Mb0227|M.bovis_AF2122/97 -------------
MMAR_0464|M.marinum_M QARSMNEGAGSA-
MAV_4952|M.avium_104 PA-----------
Mflv_0439|M.gilvum_PYR-GCK N------------
Mvan_0228|M.vanbaalenii_PYR-1 N------------
TH_3760|M.thermoresistible__bu R------------
MSMEG_0290|M.smegmatis_MC2_155 Q------------
MAB_0507|M.abscessus_ATCC_1997 -------------
MUL_1818|M.ulcerans_Agy99 -------------
MLBr_01244|M.leprae_Br4923 RSSGSPAGWLSSS