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MQRLSGWDAFLLYSETPNVHMHTLKIAIIDLEGIGDRTFGVEDFRKVLRGRLHKLDPFRFQLVDIPFKFH HPMWRENCDVDLEYHVRPWQVRAPGGRRELDEAIGEIAGTPLDRSRPLWEMYFVEGLAGGRIAVVNKIHH ALADGIASANLLARGMDLREGPQRDRDSYVTDPEPSKGELVRTAFADHMRQIGRIPATIRYTAQGVARVR RSSRKLSPELTRPFTPPPSFINHMITSKRKFATATIALADAKETSKKLGITLNDLVLAMSSGALRTLQLR YDGRADHPLLASVPMSFDFSPDRIWGNRFSGVLVALPVDVADTGERVRRTREAANLAKESHQLIGPELVA RWAAYMPPVPVEALFKRLSSKDGQNKVLNLNISNVPGPRERGKVGGATVTELYSVGPITAGSGLNITVWS YVDQLNISVISDDATVDDPHEVTDAMLDEFREIRRTAGLSEKLTVVETAMPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0290 | - | - | 100% (472) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_4297 | - | 2e-64 | 35.31% (473) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_6322 | - | 2e-40 | 30.31% (452) | bifunctional wax ester synthase/acyl-CoA diacylglycerol |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0227 | - | 3e-98 | 71.06% (235) | hypothetical protein Mb0227 |
| M. gilvum PYR-GCK | Mflv_0439 | - | 0.0 | 72.82% (471) | hypothetical protein Mflv_0439 |
| M. tuberculosis H37Rv | Rv0221 | - | 0.0 | 71.46% (473) | hypothetical protein Rv0221 |
| M. leprae Br4923 | MLBr_01244 | - | 6e-27 | 27.01% (411) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_1917 | - | 1e-58 | 32.46% (456) | hypothetical protein MAB_1917 |
| M. marinum M | MMAR_0464 | - | 0.0 | 73.52% (472) | hypothetical protein MMAR_0464 |
| M. avium 104 | MAV_4952 | - | 0.0 | 71.49% (470) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_3760 | - | 0.0 | 72.13% (470) | PUTATIVE Diacylglycerol O-acyltransferase |
| M. ulcerans Agy99 | MUL_1818 | - | 1e-55 | 30.67% (463) | hypothetical protein MUL_1818 |
| M. vanbaalenii PYR-1 | Mvan_0228 | - | 0.0 | 73.84% (474) | hypothetical protein Mvan_0228 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0439|M.gilvum_PYR-GCK ----------MKRLRGWDAVLLYSET-PSVHMHTLKLAVIELDD----LG
Mvan_0228|M.vanbaalenii_PYR-1 ----------MKRLSGWDAVLLYSET-PNVHMHTLKLAVIELDDTFAREG
TH_3760|M.thermoresistible__bu ----------VKRLQGWDAVLLYSET-PNVHMHTLKVAVIDLSD-----V
MSMEG_0290|M.smegmatis_MC2_155 ----------MQRLSGWDAFLLYSET-PNVHMHTLKIAIIDLEG----IG
Mb0227|M.bovis_AF2122/97 ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDS-----D
Rv0221|M.tuberculosis_H37Rv ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDS-----D
MMAR_0464|M.marinum_M ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDP-----D
MAV_4952|M.avium_104 ----------MKRLSGWDSVLLYSEA-PNVHMHTIKAAVIELDA-----D
MAB_1917|M.abscessus_ATCC_1997 ----------MQRLSGLDASFLYLET-PTQPMHVCGVLELDTTTIPG---
MUL_1818|M.ulcerans_Agy99 ----------MRRLSSVDAAFWSAET-AGWHMHVGALAICDPTDAP----
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTP------
. .* . * : *: . :
Mflv_0439|M.gilvum_PYR-GCK GAKFGVEELRKVIHGRLYKLDPFRYELVDIPFKFHHPMWRENAEVDLDYH
Mvan_0228|M.vanbaalenii_PYR-1 GATFGVEELRKVIHGRLYKLDPFRYQLIDIPFKFHHPMWRENAEVDLEYH
TH_3760|M.thermoresistible__bu THPFGLEDFRKVIASRLYKLDPFRYQLVEIPFKFHHPMWRENCEVDLDHH
MSMEG_0290|M.smegmatis_MC2_155 DRTFGVEDFRKVLRGRLHKLDPFRFQLVDIPFKFHHPMWRENCDVDLEYH
Mb0227|M.bovis_AF2122/97 RQEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYH
Rv0221|M.tuberculosis_H37Rv RQEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYH
MMAR_0464|M.marinum_M RRAFGVDAFRAVIGERMAKLEPFGYQLVDIPFKFHHPMWREHCEVDLDYH
MAV_4952|M.avium_104 RRSLDVAAFRQVIAGRLNKLDPFCYQLVEVPFSFHHPMWRENCEIDLDYH
MAB_1917|M.abscessus_ATCC_1997 --GYSFEKLRTKLAERVEGIPSFREKLADSRLNLDHPVWVDDDDFDIDRH
MUL_1818|M.ulcerans_Agy99 --DYSFQRLRELLIERLPEIPQLRWRVTGAPLGLDRPWFVEDQDLDVDFH
MLBr_01244|M.leprae_Br4923 ----DWNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFH
. :* : : : .: : * : . :.::: *
Mflv_0439|M.gilvum_PYR-GCK VRSVRVDAPGGRRELDEAVGRIASTPLDRSRPLWEMYLIEGLADGRIAVL
Mvan_0228|M.vanbaalenii_PYR-1 VRSCRVDAPGGRRELDEAVGRIASTPLDRSRPLWEMYLIEGLAGGRIAVL
TH_3760|M.thermoresistible__bu IRGMRVDPPGGRRELDEAVGRIASTPLDRRYPLWEMYFVEGLANGRVAVV
MSMEG_0290|M.smegmatis_MC2_155 VRPWQVRAPGGRRELDEAIGEIAGTPLDRSRPLWEMYFVEGLAGGRIAVV
Mb0227|M.bovis_AF2122/97 IRPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVV
Rv0221|M.tuberculosis_H37Rv IRPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVV
MMAR_0464|M.marinum_M IRPWQLRPPGGRRELDEAIGEIASTPLDRRYPLWEMYFVEGLANHRVAVV
MAV_4952|M.avium_104 IRPWRVSPPGGRRELDEAIGQIASTPLDRSRPLWEMYFVEGLANNRIAVV
MAB_1917|M.abscessus_ATCC_1997 LHHVGLPAPGGKAEIADMCGHIASLPLDRARPLWEMWVIETGDTNRLVVM
MUL_1818|M.ulcerans_Agy99 VRRIGVPAPGGRRELEELVGRLMSYKLDRSRPLWELWVIEGVEGGRIATL
MLBr_01244|M.leprae_Br4923 VRRVRVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAML
:: : ** *: : : :: *** .:* * . :
Mflv_0439|M.gilvum_PYR-GCK GKIHHALADGVASANLLARGMDLQDGPQVDRDSYATDP--------APSK
Mvan_0228|M.vanbaalenii_PYR-1 GKIHHALADGVASANLLARGMDLQDSPQADRDSYATDP--------APTR
TH_3760|M.thermoresistible__bu GKIHHALADGVASGNLMARGMDLQPGPQRDHTFYRTDP--------PPGR
MSMEG_0290|M.smegmatis_MC2_155 NKIHHALADGIASANLLARGMDLREGPQRDRDSYVTDP--------EPSK
Mb0227|M.bovis_AF2122/97 AKIHHALADGVASANMMARGMDLLPGPEVGR--YVPDP--------APTK
Rv0221|M.tuberculosis_H37Rv AKIHHALADGVASANMMARGMDLLPGPEVGR--YVPDP--------APTK
MMAR_0464|M.marinum_M GKIHHALADGVASANLMARGMDLLPGPEGDP--YVSDP--------APTK
MAV_4952|M.avium_104 GKIHHALADGVASANLLARGMDLQPGPEAGP--YVCDP--------PPTT
MAB_1917|M.abscessus_ATCC_1997 TKMHHASVDGVTGANLMSALCGLEPDAEAP-EPAPGVGGANS--LEIAVT
MUL_1818|M.ulcerans_Agy99 TKMHHAIVDGVSGAGLGEILLDVTPEPRPPQEETVGFVGFQIPRLERRAV
MLBr_01244|M.leprae_Br4923 LQISHAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIP------QDLSRN
:: ** .**: . : .: .
Mflv_0439|M.gilvum_PYR-GCK GELVRTAFTDHLRQIRRFPDVVRYTAAGMRRVRSSGQKLSPELTRPFTP-
Mvan_0228|M.vanbaalenii_PYR-1 GELVRSAFTDHLRQIAKLPGVVRYTAQGVRRVQRSERKLSPELTRPFTP-
TH_3760|M.thermoresistible__bu SHLVRTAFVDHLRQIGRIPSVMRYTYDGLRRVHRSTRKLSPELTRPFTP-
MSMEG_0290|M.smegmatis_MC2_155 GELVRTAFADHMRQIGRIPATIRYTAQGVARVRRSSRKLSPELTRPFTP-
Mb0227|M.bovis_AF2122/97 RQLLSAAFIDHLRHLGRIPATIRYTTQGLGRVRRSSRKLSPALTMPFTP-
Rv0221|M.tuberculosis_H37Rv RQLLSAAFIDHLRHLGRIPATIRYTTQGLGRVRRSSRKLSPALTMPFTP-
MMAR_0464|M.marinum_M RELMSSAFLDHLRHLGRIPATMRYTAQGLARVRRSSRKLSPELTRPFTP-
MAV_4952|M.avium_104 RQLMVSAFADHLRHVGRLPHTIRYTAQGLGRVRRSARKLSPELTRPFEP-
MAB_1917|M.abscessus_ATCC_1997 GALKWA--SRPLKFAKLLPATIGVIPAWLERSKRGE-----AMSAPFSA-
MUL_1818|M.ulcerans_Agy99 GALINVGIMTPFRIARLVEQTVRQQIAALGVSARP--------PRYFDA-
MLBr_01244|M.leprae_Br4923 DLMLQGINHLPVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSG
: . . : . .
Mflv_0439|M.gilvum_PYR-GCK --------PPSFMNHQIDATRKFATATLALDDVKQTGKHLGATINDMVLA
Mvan_0228|M.vanbaalenii_PYR-1 --------PPTFMNHMVDATRRFATATVALDDVKQTGKQLGVTINDMVLA
TH_3760|M.thermoresistible__bu --------PPTFLNHKIDATRTFATATLALSDVKATSRHLGVTINDLVLA
MSMEG_0290|M.smegmatis_MC2_155 --------PPSFINHMITSKRKFATATIALADAKETSKKLGITLNDLVLA
Mb0227|M.bovis_AF2122/97 --------PPTFMNR-----------------------------------
Rv0221|M.tuberculosis_H37Rv --------PPTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLA
MMAR_0464|M.marinum_M --------PPTFMNHMLTPQRRFATATLALADVKQTGKQLGATINDMVLA
MAV_4952|M.avium_104 --------PPTFMNHKLTPERRFATATLALADVKETGKRLGATINDMVLA
MAB_1917|M.abscessus_ATCC_1997 --------PRTSFNSTITSRRNVGYAQLDLEDVRTVKNHFGVKVNDVVMA
MUL_1818|M.ulcerans_Agy99 --------PKTRFNAHVSPHRRVSGCRIELARAKAVKDAFGVKLNDVVLA
MLBr_01244|M.leprae_Br4923 IRVLSQAAEPSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLA
: :
Mflv_0439|M.gilvum_PYR-GCK MSAGTLRKLLLRYDGQADHPLLASVPVSFDFSRDRISG-NYFTGVLVSIP
Mvan_0228|M.vanbaalenii_PYR-1 MSAGALRKLLLRYDGRADHALLASVPVSFDFSRDRISG-NYFTGVLVSLP
TH_3760|M.thermoresistible__bu LSAGALRKLLLRYDGHADHPLLASVPVSFDFSPDRICG-NYFTGMLVALP
MSMEG_0290|M.smegmatis_MC2_155 MSSGALRTLQLRYDGRADHPLLASVPMSFDFSPDRIWG-NRFSGVLVALP
Mb0227|M.bovis_AF2122/97 -----IKKPLSKPSGRPP-PHTNRAPSS----------------MPLAM-
Rv0221|M.tuberculosis_H37Rv MSTGALRTLLLRYDGKAE-PLLASVPVSYDFSPERISG-NRFTGMLVALP
MMAR_0464|M.marinum_M MSTGALRNLLLRYDGRAE-PLLASVPVSYDFSPDRISG-NYFSGMMVALP
MAV_4952|M.avium_104 MSTGALRTLLLRYDGQAQ-PLLASVPVSFDFSPERISG-NRFTGMLVALP
MAB_1917|M.abscessus_ATCC_1997 ICAGALRKYLDDRGELPDNSLVAMVPVSVHEKSDRPGR-NQVSGMFSRLE
MUL_1818|M.ulcerans_Agy99 TVAGAAREYLKKRDELPAKPLIAQIPVSTRTDQTKEDVGNQISSMTASLA
MLBr_01244|M.leprae_Br4923 GLVGALRRYHEALG-VSISTLPMAVPVNVRTEADVVGS-NRFVGVTLAAP
: . . . * . :
Mflv_0439|M.gilvum_PYR-GCK VELDDPVERVRAAHDAAVAGKESNNLLGPELVSQWSAYLPPAPAEALFRW
Mvan_0228|M.vanbaalenii_PYR-1 VDVEDPLERVSAAHTAAAAGKESNNLIGPELVSRWSAYFPPAPAEAMFRW
TH_3760|M.thermoresistible__bu VDTAEPLDRIRATRDAALLAKESHQLIGPELISRWSQYLPPAPAERLFGW
MSMEG_0290|M.smegmatis_MC2_155 VDVADTGERVRRTREAANLAKESHQLIGPELVARWAAYMPPVPVEALFKR
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
Rv0221|M.tuberculosis_H37Rv ADSDDPLQRVRVCHENAVSAKESHQLLGPELISRWAAYWPPAGAEALFRW
MMAR_0464|M.marinum_M TDCADPLERVQACHENALSAKESHQLLGPELISRWAAYWPPGATEAAFRW
MAV_4952|M.avium_104 VDHDDPLERVAACHQNAISAKESHQLMGPELVSRWAAYMPPAPTRAFFQW
MAB_1917|M.abscessus_ATCC_1997 TNVDDPVERLNAIAAANNIAKDHTAVLGATLLQDWSQFAAPAVFGTAMRV
MUL_1818|M.ulcerans_Agy99 THINDPAERLKAIHESTQNAKEMAKALSAHQIMGLTETTPPGLLHLAARA
MLBr_01244|M.leprae_Br4923 LGTNDPAARMQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPASVLDFIVDS
Mflv_0439|M.gilvum_PYR-GCK LGTK---DGQNKVMNLPISNVPGPRERARVGGALVTEIYSVGPLTVGSGI
Mvan_0228|M.vanbaalenii_PYR-1 LSNK---DGQNKVMNLPISNVPGPRERARVGGALVTEIYSVGPLTAGSGL
TH_3760|M.thermoresistible__bu LSRI---DGQNKIQNLTVSNVMGPKERGRVGGALVTEIYSVGPLTAASGL
MSMEG_0290|M.smegmatis_MC2_155 LSSK---DGQNKVLNLNISNVPGPRERGKVGGATVTELYSVGPITAGSGL
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
Rv0221|M.tuberculosis_H37Rv LSER---DGQNKVLNLNISNVPGPRERGRVGAALVTEIYSVGPLTAGSGL
MMAR_0464|M.marinum_M ASSR---DGQNKVLNLNISNVPGPREHGRVGGALVTEIYSVGPLTAGSGL
MAV_4952|M.avium_104 ASAR---DGHNKILNLNISNVPGPRERGRVGGALVTEIYSVGPLTAGSGL
MAB_1917|M.abscessus_ATCC_1997 YSRIRLADRHPVIHNLVVSNVPGPQVPLYFLGAQVIGMYPLGPIFHGAAL
MUL_1818|M.ulcerans_Agy99 YTATGLSHNLAPIN-LVVSNVPGPQFPLYMAGARLDSLVPLGPPVMDVAL
MLBr_01244|M.leprae_Br4923 VASS----------DVNASNIPAYPGDTYFAGAKILRQYGIGPR-PGVAM
Mflv_0439|M.gilvum_PYR-GCK NITVWSYVDQLNISVLTDGKTLEDPHELTSAMLDDFVEIRRAAGLSEELT
Mvan_0228|M.vanbaalenii_PYR-1 NITVWSYVDQINISVLSDGKTLDDPHELTTAMVDEFIEIRRAAGLSTELT
TH_3760|M.thermoresistible__bu NITVWSYVDQLNISVLSDGSTFDDPHEVTDAMVGEFIEIRGAAGLPGELT
MSMEG_0290|M.smegmatis_MC2_155 NITVWSYVDQLNISVISDDATVDDPHEVTDAMLDEFREIRRTAGLSEKLT
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
Rv0221|M.tuberculosis_H37Rv NITVWSYVDQLNISVLTDGSTVQDPHEVTAGMIADFIEIRRAAGLSVELT
MMAR_0464|M.marinum_M NITVWSYVDQLNISVLTDGATVEDPHEVTEAMMADFVEIRRAAGLSAELT
MAV_4952|M.avium_104 NITVWSYVDQLNISVLTDGATCKDPHEVTEAMVQDFIEIRRAAGFSEDLT
MAB_1917|M.abscessus_ATCC_1997 TVTVMSLDGKLNVGLISCPDLMPDLGTLTDDFGVALEELKARI-------
MUL_1818|M.ulcerans_Agy99 NITCFSYQEHLDFGFVTTPEVANDIDEMADLIEPALAELERAAGL-----
MLBr_01244|M.leprae_Br4923 MAVLMSRGGFCTVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHA
Mflv_0439|M.gilvum_PYR-GCK VVETALPN------------
Mvan_0228|M.vanbaalenii_PYR-1 VIETAMAN------------
TH_3760|M.thermoresistible__bu VVETAMAR------------
MSMEG_0290|M.smegmatis_MC2_155 VVETAMPQ------------
Mb0227|M.bovis_AF2122/97 --------------------
Rv0221|M.tuberculosis_H37Rv VVESAMAQA-----------
MMAR_0464|M.marinum_M VIEAAMAQARSMNEGAGSA-
MAV_4952|M.avium_104 VVEAAMAPA-----------
MAB_1917|M.abscessus_ATCC_1997 --------------------
MUL_1818|M.ulcerans_Agy99 --------------------
MLBr_01244|M.leprae_Br4923 VPASFAARSSGSPAGWLSSS