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MQVVAYPFMKRLNGMDAMLLYSETPNLHTHTLKVAVIDASNCADGYDFDAFRRTVARRLPLLDPLRYRLI DIPWRLHHPMWLEDCPVDLDYHLRRVRVPAPGRRRELDRVIGEIASTPLDRSRPLWEFHFAEGMADDRYA LIGKVHHTLADGVASANLLARLMDLTGTPPNHHADPVVVCEEPTRRELLWEAQLDHFRNIAELPGLVADA ASGLSRLRRRAKERNSVLDLAKPFNAPSTFLNHVVSPVRTFATAALPLAEVKETAKHLGVTFNDVVLSLA AGGLRELLLRYDGQADRPIMATVPVSTDKSTDRITGNEIGGMMVSLPVHIDDPLERVRLTSMATRRAKET NDLLGPTLQGRMLEYLPPPLAPALFRAQAKRADHNRLMNVAVSNVPGPRRRGHIGGAPVSEIYSVGVLSA GSAFNMTVWSYVDQVDIAVLSDDRTFDEPHEATSAVTRAFDELRRACGLARATAVESAMPPASAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4224 | - | - | 100% (485) | hypothetical protein Mvan_4224 |
| M. vanbaalenii PYR-1 | Mvan_2253 | - | e-151 | 58.30% (482) | hypothetical protein Mvan_2253 |
| M. vanbaalenii PYR-1 | Mvan_0228 | - | e-142 | 54.09% (477) | hypothetical protein Mvan_0228 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3114 | - | 3e-66 | 34.53% (472) | hypothetical protein Mb3114 |
| M. gilvum PYR-GCK | Mflv_2428 | - | 0.0 | 82.29% (480) | hypothetical protein Mflv_2428 |
| M. tuberculosis H37Rv | Rv0221 | - | 1e-137 | 52.42% (475) | hypothetical protein Rv0221 |
| M. leprae Br4923 | MLBr_01244 | - | 2e-29 | 24.05% (499) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_0507 | - | 3e-64 | 32.84% (472) | hypothetical protein MAB_0507 |
| M. marinum M | MMAR_0464 | - | 1e-141 | 53.47% (475) | hypothetical protein MMAR_0464 |
| M. avium 104 | MAV_1847 | - | 1e-147 | 56.50% (469) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_0290 | - | 1e-140 | 51.69% (474) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_3760 | - | 1e-140 | 53.15% (476) | PUTATIVE Diacylglycerol O-acyltransferase |
| M. ulcerans Agy99 | MUL_1818 | - | 1e-62 | 33.97% (471) | hypothetical protein MUL_1818 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_0507|M.abscessus_ATCC_1997 ----------MQRLSGVDAAFWHAET-AGWHMHIGGLSIYDPT----DAP
MUL_1818|M.ulcerans_Agy99 ----------MRRLSSVDAAFWSAET-AGWHMHVGALAICDPT----DAP
Mb3114|M.bovis_AF2122/97 ----------MRRLNGVDALMLYLDG-GSAYNHTLKISVLDPS----TDP
Mvan_4224|M.vanbaalenii_PYR-1 --MQVVAYPFMKRLNGMDAMLLYSET-PNLHTHTLKVAVIDAS--NCADG
Mflv_2428|M.gilvum_PYR-GCK --------MSMRRLNGMDAMLLYSET-PNLHTHTLKVAVIDATGYSAEHG
MAV_1847|M.avium_104 ----------MKRLGGWDAVLLYNET-PNLHQHTLKIAVVDAT---DCDG
Rv0221|M.tuberculosis_H37Rv ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELD----SDR
MMAR_0464|M.marinum_M ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELD----PDR
MSMEG_0290|M.smegmatis_MC2_155 ----------MQRLSGWDAFLLYSET-PNVHMHTLKIAIIDLEG---IGD
TH_3760|M.thermoresistible__bu ----------VKRLQGWDAVLLYSET-PNVHMHTLKVAVIDLS----DVT
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTP------
. .* . * : : : : :
MAB_0507|M.abscessus_ATCC_1997 D-YSFERVRALIVERLPSMPQLRWRVTDVPLGLDRPWFVEDEELDPDFHI
MUL_1818|M.ulcerans_Agy99 D-YSFQRLRELLIERLPEIPQLRWRVTGAPLGLDRPWFVEDQDLDVDFHV
Mb3114|M.bovis_AF2122/97 DGWSWPKARQMFEERAHLLPVFRLRYLPTPLGLHHPIWVEDPEFDLDAHV
Mvan_4224|M.vanbaalenii_PYR-1 --YDFDAFRRTVARRLPLLDPLRYRLIDIPWRLHHPMWLEDCPVDLDYHL
Mflv_2428|M.gilvum_PYR-GCK GEYGFDAFRQTIARRLHLLEPLRYRLIDIPWRLHHPMWLQDCPVDLDYHL
MAV_1847|M.avium_104 --FGFDLFRQTLARRLHLLEPLRYQLTEIRGRIHRAMWLENCDVDLDFHV
Rv0221|M.tuberculosis_H37Rv QEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHI
MMAR_0464|M.marinum_M RAFGVDAFRAVIGERMAKLEPFGYQLVDIPFKFHHPMWREHCEVDLDYHI
MSMEG_0290|M.smegmatis_MC2_155 RTFGVEDFRKVLRGRLHKLDPFRFQLVDIPFKFHHPMWRENCDVDLEYHV
TH_3760|M.thermoresistible__bu HPFGLEDFRKVIASRLYKLDPFRYQLVEIPFKFHHPMWRENCEVDLDHHI
MLBr_01244|M.leprae_Br4923 ---DWNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHV
. * . : : : . : . .: : *:
MAB_0507|M.abscessus_ATCC_1997 RRIGVPAPGGRKELEELAGRLMSYKLDRSRPLWELWVIEGVEGGRVATLT
MUL_1818|M.ulcerans_Agy99 RRIGVPAPGGRRELEELVGRLMSYKLDRSRPLWELWVIEGVEGGRIATLT
Mb3114|M.bovis_AF2122/97 RRVVCPAPGGMAEFCALVEQIYAHPLDRDRPLWQTWVVEGLDGGRVALVT
Mvan_4224|M.vanbaalenii_PYR-1 RRVRVPAPGRRRELDRVIGEIASTPLDRSRPLWEFHFAEGMADDRYALIG
Mflv_2428|M.gilvum_PYR-GCK RRVRVPAPGGRRELDRVIGEIASTPLDRTRPLWEFHFAEGMADNRFALIG
MAV_1847|M.avium_104 RRTQIRSPGGRRELDAAIGEVASTPLDRSRPLWEFHFVEGMADNRFAIIG
Rv0221|M.tuberculosis_H37Rv RPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVVA
MMAR_0464|M.marinum_M RPWQLRPPGGRRELDEAIGEIASTPLDRRYPLWEMYFVEGLANHRVAVVG
MSMEG_0290|M.smegmatis_MC2_155 RPWQVRAPGGRRELDEAIGEIAGTPLDRSRPLWEMYFVEGLAGGRIAVVN
TH_3760|M.thermoresistible__bu RGMRVDPPGGRRELDEAVGRIASTPLDRRYPLWEMYFVEGLANGRVAVVG
MLBr_01244|M.leprae_Br4923 RRVRVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLL
* ** *. : :: *** . **: * * :
MAB_0507|M.abscessus_ATCC_1997 KMHHAIVDGVSGAGLGEILLDIAPEPRPAPDDTVGSLVGLGLPSRERILL
MUL_1818|M.ulcerans_Agy99 KMHHAIVDGVSGAGLGEILLDVTPEPRPPQEETVG-FVGFQIPRLERRAV
Mb3114|M.bovis_AF2122/97 LLHHAYSDGVGVLDMLAAFYNDAPDEAPVVAPPWEPPPLPSTRQRLGWAL
Mvan_4224|M.vanbaalenii_PYR-1 KVHHTLADGVASANLLARLMDLTGTPPNHHADPVVVCEEPTRRELLWEAQ
Mflv_2428|M.gilvum_PYR-GCK KVHHTLADGVASANLLARLMDLVDAPQDEREDPPAGCDDPSTLDLLREAQ
MAV_1847|M.avium_104 KVHHALADGVASANLLARGLDLPNAPQPARDDYRADP-YPSNGVLIRAAL
Rv0221|M.tuberculosis_H37Rv KIHHALADGVASANMMARGMDLLPGPEVGR--YVPDP-APTKRQLLSAAF
MMAR_0464|M.marinum_M KIHHALADGVASANLMARGMDLLPGPEGDP--YVSDP-APTKRELMSSAF
MSMEG_0290|M.smegmatis_MC2_155 KIHHALADGIASANLLARGMDLREGPQRDRDSYVTDP-EPSKGELVRTAF
TH_3760|M.thermoresistible__bu KIHHALADGVASGNLMARGMDLQPGPQRDHTFYRTDP-PPGRSHLVRTAF
MLBr_01244|M.leprae_Br4923 QISHAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQGI
: *: **:. : :
MAB_0507|M.abscessus_ATCC_1997 --------SALVN-VGVKTPYRVARLVQQTVRQQLAVFGMERKSPGY-FE
MUL_1818|M.ulcerans_Agy99 --------GALIN-VGIMTPFRIARLVEQTVRQQIAALGVSARPPRY-FD
Mb3114|M.bovis_AF2122/97 --------RDLPSRLGKIAPTVRAVRDRVRIEREFAKDGDRRVPPTFDRS
Mvan_4224|M.vanbaalenii_PYR-1 --------LDHFRNIAELPGLVADAASGLSRLRRRAKERNSVLDLAKPFN
Mflv_2428|M.gilvum_PYR-GCK --------LDHFRNIVELPSLVADAARGAARLRKRAKERREVPGLAKPFN
MAV_1847|M.avium_104 --------RDHAEHVRELPRLVRDTVKGVRRVRRKS---RSAPGLARNFN
Rv0221|M.tuberculosis_H37Rv --------IDHLRHLGRIPATIRYTTQGLGRVRRSS--RKLSPALTMPFT
MMAR_0464|M.marinum_M --------LDHLRHLGRIPATMRYTAQGLARVRRSS--RKLSPELTRPFT
MSMEG_0290|M.smegmatis_MC2_155 --------ADHMRQIGRIPATIRYTAQGVARVRRSS--RKLSPELTRPFT
TH_3760|M.thermoresistible__bu --------VDHLRQIGRIPSVMRYTYDGLRRVHRST--RKLSPELTRPFT
MLBr_01244|M.leprae_Br4923 NHLPVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQA
: .
MAB_0507|M.abscessus_ATCC_1997 APHTRFNAPVSPHRRISGARLDLARVKALKDAFGVKVNDVVLAIVAGAVR
MUL_1818|M.ulcerans_Agy99 APKTRFNAHVSPHRRVSGCRIELARAKAVKDAFGVKLNDVVLATVAGAAR
Mb3114|M.bovis_AF2122/97 APPGPFQRGLSRSRRFSCESFPLAEVREVSKTLGVTINDVFLACVAGAVR
Mvan_4224|M.vanbaalenii_PYR-1 APSTFLNHVVSPVRTFATAALPLAEVKETAKHLGVTFNDVVLSLAAGGLR
Mflv_2428|M.gilvum_PYR-GCK APPTFLNHVVSPVRTFATATLALSEVKETAKHLGVTFNDIVLAVAAGGLR
MAV_1847|M.avium_104 PPATFLNHVVSPGRTFASTTLDLAAVKAVGKQLGVTINDMVLAITAGALR
Rv0221|M.tuberculosis_H37Rv PPPTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGALR
MMAR_0464|M.marinum_M PPPTFMNHMLTPQRRFATATLALADVKQTGKQLGATINDMVLAMSTGALR
MSMEG_0290|M.smegmatis_MC2_155 PPPSFINHMITSKRKFATATIALADAKETSKKLGITLNDLVLAMSSGALR
TH_3760|M.thermoresistible__bu PPPTFLNHKIDATRTFATATLALSDVKATSRHLGVTINDLVLALSAGALR
MLBr_01244|M.leprae_Br4923 AEPSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALR
. : : * : . ..** *: *. *
MAB_0507|M.abscessus_ATCC_1997 DYLAKRDEFPDKPLIVQIPVSVRTEETDGVVGNQVSSMTVSLATDIDDPA
MUL_1818|M.ulcerans_Agy99 EYLKKRDELPAKPLIAQIPVSTRTDQTKEDVGNQISSMTASLATHINDPA
Mb3114|M.bovis_AF2122/97 RYLERCGSPPTDAMVATMPLAVTPAAERAHPGNYSSVDYVWLRADIADPL
Mvan_4224|M.vanbaalenii_PYR-1 ELLLRYDGQADRPIMATVPVSTDKSTDR-ITGNEIGGMMVSLPVHIDDPL
Mflv_2428|M.gilvum_PYR-GCK ELLLRYDGRADRPIMATVPVSTDKSTDR-VTGNEIGGMMVSLPVHVDDPL
MAV_1847|M.avium_104 ALLLEYDGHADQPILAGVPMSIDTSLER-ISGNALGTVVVSLPVHVADPL
Rv0221|M.tuberculosis_H37Rv TLLLRYDGKAE-PLLASVPVSYDFSPER-ISGNRFTGMLVALPADSDDPL
MMAR_0464|M.marinum_M NLLLRYDGRAE-PLLASVPVSYDFSPDR-ISGNYFSGMMVALPTDCADPL
MSMEG_0290|M.smegmatis_MC2_155 TLQLRYDGRADHPLLASVPMSFDFSPDR-IWGNRFSGVLVALPVDVADTG
TH_3760|M.thermoresistible__bu KLLLRYDGHADHPLLASVPVSFDFSPDR-ICGNYFTGMLVALPVDTAEPL
MLBr_01244|M.leprae_Br4923 RYHEALG-VSISTLPMAVPVNVRTEADV-VGSNRFVGVTLAAPLGTNDPA
. . .: :*: .* :.
MAB_0507|M.abscessus_ATCC_1997 ERIQAIYEGTQGAKEMARAMSAHQIMGLTDTTPPGLLQLAARAYTASGLS
MUL_1818|M.ulcerans_Agy99 ERLKAIHESTQNAKEMAKALSAHQIMGLTETTPPGLLHLAARAYTATGLS
Mb3114|M.bovis_AF2122/97 ERLHATHLAAEATKQHFAQTKDADVGAVVELLPERLISGLARANART-KG
Mvan_4224|M.vanbaalenii_PYR-1 ERVRLTSMATRRAKETNDLLGPTLQGRMLEYLPPPLAPALFRAQAKR--A
Mflv_2428|M.gilvum_PYR-GCK ERVELTAVATTRAKENNDLLGPTLQGRFLEYLPPPLAPTLFRAQSKR--A
MAV_1847|M.avium_104 EWVRLARIGATIGKENTALLGPDLVSRWAGYAPPRLTERLFRRIATS--G
Rv0221|M.tuberculosis_H37Rv QRVRVCHENAVSAKESHQLLGPELISRWAAYWPPAGAEALFRWLSER--D
MMAR_0464|M.marinum_M ERVQACHENALSAKESHQLLGPELISRWAAYWPPGATEAAFRWASSR--D
MSMEG_0290|M.smegmatis_MC2_155 ERVRRTREAANLAKESHQLIGPELVARWAAYMPPVPVEALFKRLSSK--D
TH_3760|M.thermoresistible__bu DRIRATRDAALLAKESHQLIGPELISRWSQYLPPAPAERLFGWLSRI--D
MLBr_01244|M.leprae_Br4923 ARMQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPASVLDFIVDSVASS---
:. :: * :
MAB_0507|M.abscessus_ATCC_1997 RNLAPINLVLSNVPGPSFPLYMAGARLESMIPLGPPVMDVALNITCFSYL
MUL_1818|M.ulcerans_Agy99 HNLAPINLVVSNVPGPQFPLYMAGARLDSLVPLGPPVMDVALNITCFSYQ
Mb3114|M.bovis_AF2122/97 RFDTFKNVVVSNVPGPREPRYLGRWRVDQWFSTGQISHGATLNMTVWSYC
Mvan_4224|M.vanbaalenii_PYR-1 DHNRLMNVAVSNVPGPRRRGHIGGAPVSEIYSVGVLSAGSAFNMTVWSYV
Mflv_2428|M.gilvum_PYR-GCK DHNRLMNVAISNVPGPRQRGHVGGAPVSEIYSVGVLSAGSAFNMTVWSYV
MAV_1847|M.avium_104 SGNKLINVPVSNVPGPRQPGRIACAPVVQFLSVGPLTFGAGVNITVWSYV
Rv0221|M.tuberculosis_H37Rv GQNKVLNLNISNVPGPRERGRVGAALVTEIYSVGPLTAGSGLNITVWSYV
MMAR_0464|M.marinum_M GQNKVLNLNISNVPGPREHGRVGGALVTEIYSVGPLTAGSGLNITVWSYV
MSMEG_0290|M.smegmatis_MC2_155 GQNKVLNLNISNVPGPRERGKVGGATVTELYSVGPITAGSGLNITVWSYV
TH_3760|M.thermoresistible__bu GQNKIQNLTVSNVMGPKERGRVGGALVTEIYSVGPLTAASGLNITVWSYV
MLBr_01244|M.leprae_Br4923 ------DVNASNIPAYPGDTYFAGAKILRQYGIGPR-PGVAMMAVLMSRG
:: **: . .. : * . . *
MAB_0507|M.abscessus_ATCC_1997 EHMDFGFVTTPEVAADIDEMADGLEAALVELEHAVGI-------------
MUL_1818|M.ulcerans_Agy99 EHLDFGFVTTPEVANDIDEMADLIEPALAELERAAGL-------------
Mb3114|M.bovis_AF2122/97 DQFNLCVMADAVAVRNTWELVGGFRASHEELLAAARAQATPKEMAT----
Mvan_4224|M.vanbaalenii_PYR-1 DQVDIAVLSDDRTFDEPHEATSAVTRAFDELRRACGLARATAVESAMPPA
Mflv_2428|M.gilvum_PYR-GCK DQLDIAVLSDDRTFNDPHEATDAMVHAFDELRQVCGLARPTTVDTAMAPA
MAV_1847|M.avium_104 DQLNISVLADDVTFEDPHQVTDTMVEAFDLVRQAAGMPAETRP-------
Rv0221|M.tuberculosis_H37Rv DQLNISVLTDGSTVQDPHEVTAGMIADFIEIRRAAGLSVELTVVESAMAQ
MMAR_0464|M.marinum_M DQLNISVLTDGATVEDPHEVTEAMMADFVEIRRAAGLSAELTVIEAAMAQ
MSMEG_0290|M.smegmatis_MC2_155 DQLNISVISDDATVDDPHEVTDAMLDEFREIRRTAGLSEKLTVVETAMPQ
TH_3760|M.thermoresistible__bu DQLNISVLSDGSTFDDPHEVTDAMVGEFIEIRGAAGLPGELTVVETAMAR
MLBr_01244|M.leprae_Br4923 GFCTVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAAR
. . . . . :
MAB_0507|M.abscessus_ATCC_1997 ------------
MUL_1818|M.ulcerans_Agy99 ------------
Mb3114|M.bovis_AF2122/97 ------------
Mvan_4224|M.vanbaalenii_PYR-1 SAG---------
Mflv_2428|M.gilvum_PYR-GCK PAPQP-------
MAV_1847|M.avium_104 ------------
Rv0221|M.tuberculosis_H37Rv A-----------
MMAR_0464|M.marinum_M ARSMNEGAGSA-
MSMEG_0290|M.smegmatis_MC2_155 ------------
TH_3760|M.thermoresistible__bu ------------
MLBr_01244|M.leprae_Br4923 SSGSPAGWLSSS