For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
HFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPF VRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDD FWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIAHSTVLVAPVSPSTASSRTDT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2430c | PPE41 | - | 100% (194) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1705c | PPE22 | 6e-27 | 34.87% (195) | PPE family protein |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | 1e-26 | 35.96% (178) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2456c | PPE41 | 1e-112 | 100.00% (194) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-17 | 32.54% (169) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-23 | 32.54% (169) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-18 | 32.35% (170) | PPE family protein |
| M. marinum M | MMAR_0685 | - | 3e-27 | 35.94% (192) | PPE family protein |
| M. avium 104 | MAV_2914 | - | 3e-29 | 39.05% (169) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-17 | 31.95% (169) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-17 | 28.80% (191) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1701 | - | 9e-28 | 33.85% (195) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-18 | 33.73% (169) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2430c|M.tuberculosis_H37Rv -------------MHFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVE
Mb2456c|M.bovis_AF2122/97 -------------MHFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVE
MMAR_0685|M.marinum_M -------------MDFGALPPEINSARMYAGPGSAPLVQAARAWGRLANE
MAV_2914|M.avium_104 ------------MIDFAALPPEINSARIYAGPGSAPMMSAAAAWNTMAAE
MUL_1701|M.ulcerans_Agy99 -------------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
: * .** :* : ***. .:. *. :* : *
Rv2430c|M.tuberculosis_H37Rv MTAVQRSFNRTLLSLMDA-WAGPVVMQLMEAAKPFVRWLTDLCVQLSEVE
Mb2456c|M.bovis_AF2122/97 MTAVQRSFNRTLLSLMDA-WAGPVVMQLMEAAKPFVRWLTDLCVQLSEVE
MMAR_0685|M.marinum_M LNATAASYSSVIAGLGAADWQGPSALSMAAAAAPYVAWMRSTAAQAEQAA
MAV_2914|M.avium_104 MRSAAASYGAVISELTSADWFGPSSMSMLAAVTPYLTWLTDTATRAEEAA
MUL_1701|M.ulcerans_Agy99 LSFTADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAERAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
. : : : * *: *: . .. .
Rv2430c|M.tuberculosis_H37Rv RQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLD
Mb2456c|M.bovis_AF2122/97 RQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLD
MMAR_0685|M.marinum_M AQAISAANAYESAHAAIVPPGQIAANRSTMLSLVRSNIFGQNTPAIATSE
MAV_2914|M.avium_104 AQANSAATAYEAAFAMTVPPAVVAANRAQLATLVATNVFGQNTPAIAATE
MUL_1701|M.ulcerans_Agy99 KQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
: . *: * . : *: *: * * : ** :
Rv2430c|M.tuberculosis_H37Rv QEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIAHSTVLVAPVSPS
Mb2456c|M.bovis_AF2122/97 QEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIAHSTVLVAPVSPS
MMAR_0685|M.marinum_M ADYSEMWAQDIVAMDGYAGTSAAATDLAPFTSPP-ATTTGTEALSAATVP
MAV_2914|M.avium_104 AEYGQMWAQDAAAMNGYAVASTAATRLTPMTAPR-SNTS-PEGVAAQATS
MUL_1701|M.ulcerans_Agy99 AQYAEMWAQDARAMYTYAGSSASATKITAFTPPPETANPAASALQSNATS
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
:* :* : * * : .
Rv2430c|M.tuberculosis_H37Rv TASSRTDT------------------------------------------
Mb2456c|M.bovis_AF2122/97 TASSRTDT------------------------------------------
MMAR_0685|M.marinum_M AAAAAAAPAETSILPLLQSFLPAPFNAIPNPFEDLDLLVLAAVVVSLGAL
MAV_2914|M.avium_104 VTNAAQAPAGT-----VQSTVSSSG--------------LAGLLSGSDNS
MUL_1701|M.ulcerans_Agy99 TAAATAAGAAQSTLAGVISQLPNALTS-----------LTSPIASALTSA
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
MAB_4783|M.abscessus_ATCC_1997 -------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITDPV
Rv2430c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2456c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0685|M.marinum_M GVSAIQLGEVYRHDIVDEDENAPLCGGEYDELPAAGLRNPDRDAITTPGG
MAV_2914|M.avium_104 AFGTFTNGNFFSTAVVN----GSLAGGPF---------NP-QFIISSVQG
MUL_1701|M.ulcerans_Agy99 ASPATWIDWLVNWYLPISQLFYNTVGLPYFAIG------IGSSLITSERA
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGS
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGPAA
Rv2430c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2456c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0685|M.marinum_M QRLASPPSPPVAALSGYSANIGGLSVPPAWNLPPAVRQVAAMFPGATPMY
MAV_2914|M.avium_104 -VLAAQHATTLGGLGDFAADAEG----------AATADLAASTGGSAP--
MUL_1701|M.ulcerans_Agy99 LGLIGPEAEAAAAGAGAAEAAAG--------------AAPAALGGAGP--
MLBr_01182|M.leprae_Br4923 AMKSLAPTTTKAAESAFKAMGSA------------VQSTGRGLLGSSS--
Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP------PAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP------AEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNN-----PVDVPAEDEAPQEVAAAPRTDQ
TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP----------PAEEAAPEEDVAAP----
MAB_4783|M.abscessus_ATCC_1997 GISIPLAITLASLSQMPEAPPV--------------DAPAETVPARIDQP
Rv2430c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2456c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0685|M.marinum_M LTGGSDGQYTGIAAAGIAGASLAGFAARGSGSAPAPTTGAPSAGGGGAAA
MAV_2914|M.avium_104 ------------VAAGMGRAQLVGSLSVPQGWANAATINP--------GQ
MUL_1701|M.ulcerans_Agy99 ------------IGAGLGNASALGKLSVPPSWPGSGLDVPPS-----VSA
MLBr_01182|M.leprae_Br4923 ---------GGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATR----AL
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPG---APAAAAATFVPYVVAG
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPG---APAAATASFVPYAVAG
MSMEG_0619|M.smegmatis_MC2_155 PLAVGISPAGVPGSAATAAAPAPAPAGTTVA---APAPAAATFVPYAVAN
TH_3569|M.thermoresistible__bu ---------------VRAEPQNPLPLTXXX--------------------
MAB_4783|M.abscessus_ATCC_1997 HAVAMGGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRG
Rv2430c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2456c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0685|M.marinum_M AARPAANTPSVPAAAAAANIPGLPSGLPPGVVANLAATLAAIPGATIIVV
MAV_2914|M.avium_104 AAVPATGVTGLTDAASAAGGPGGVAGPVGGTGRRLRRAIPKY-GFRPVVM
MUL_1701|M.ulcerans_Agy99 GGPLASDIVNPPEASAPGSLLGGMP-LAGGPGGAAAGAGPRY-GFRVTVM
MLBr_01182|M.leprae_Br4923 SPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVM
Mflv_0325|M.gilvum_PYR-GCK RDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIK
Mvan_0415|M.vanbaalenii_PYR-1 RDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIA
MSMEG_0619|M.smegmatis_MC2_155 RDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIE
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 DGPGFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTID
Rv2430c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2456c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0685|M.marinum_M PPDPNAAQ------------------------------------------
MAV_2914|M.avium_104 PRPPAAG-------------------------------------------
MUL_1701|M.ulcerans_Agy99 ARPPFAG-------------------------------------------
MLBr_01182|M.leprae_Br4923 PRNPAAG-------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQ
Mvan_0415|M.vanbaalenii_PYR-1 GRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQ
MSMEG_0619|M.smegmatis_MC2_155 ERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 DRGYRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVE
Rv2430c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2456c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0685|M.marinum_M --------------------------------------------------
MAV_2914|M.avium_104 --------------------------------------------------
MUL_1701|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 AGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 AAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 ATGLSTLDGDAEN--RTIPMLPGTWDVTDDDR------------------