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MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAELSSAATGYETVITQLSSEGWLGPASAAMAEAVA PYVAWMSAAAAQAEQAATQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAEAQY GEMWAQDSAAMYAYAGSSASASAVTPFSTPPQIANPTAQGTQAAAVATAAGTAQSTLTEMITGLPNALQS LTSPLLQSSNGPLSWLWQILFGTPNFPTSISALLTDLQPYASFFYNTEGLPYFSIGMGNNFIQSAKTLGL IGSAAPAAVAAAGDAAKGLPGLGGMLGGGPVAAGLGNAASVGKLSVPPVWSGPLPGSVTPGAAPLPVSTV SAAPEAAPGSLLGGLPLAGAGGAGAGPRYGFRPTVMARPPFAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | - | 100% (393) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1705c | PPE22 | e-124 | 61.04% (403) | PPE family protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 6e-94 | 49.64% (411) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 0.0 | 99.75% (393) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 9e-34 | 30.05% (396) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 5e-53 | 35.68% (426) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-31 | 32.66% (398) | PPE family protein |
| M. marinum M | MMAR_1904 | - | 1e-134 | 61.54% (403) | PPE family protein |
| M. avium 104 | MAV_2924 | - | 1e-126 | 59.12% (411) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 8e-34 | 30.98% (410) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-35 | 30.90% (424) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1701 | - | 1e-120 | 57.99% (407) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-35 | 30.38% (418) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1789|M.tuberculosis_H37Rv -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
Mb1817|M.bovis_AF2122/97 -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
MMAR_1904|M.marinum_M -------------MDFGRRPPEVTSALMYMGPGSTSMTAAASVWNRVAAE
MAV_2924|M.avium_104 -------------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
MUL_1701|M.ulcerans_Agy99 -------------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.** * : ***. .: :*. .* :: *
Rv1789|M.tuberculosis_H37Rv LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
Mb1817|M.bovis_AF2122/97 LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
MMAR_1904|M.marinum_M LDSAATSYESLVIGLVEEGWLGPASVAMADAVAPYVVWMRATAAQAEHTA
MAV_2924|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
MUL_1701|M.ulcerans_Agy99 LSFTADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAERAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : * .: ** *: :. . ..
Rv1789|M.tuberculosis_H37Rv TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
Mb1817|M.bovis_AF2122/97 TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
MMAR_1904|M.marinum_M MQARASAAAYETAFGAVVPPPLISANRVRLAELIASNVFGQNTAVITALE
MAV_2924|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
MUL_1701|M.ulcerans_Agy99 KQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* .:. *. *: . : *: * *. * : *: *
Rv1789|M.tuberculosis_H37Rv AQYGEMWAQDSAAMYAYAGSSASAS-AVTPFSTPPQIANPTAQGTQAAAV
Mb1817|M.bovis_AF2122/97 AQYGEMWAQDSAAMYAYAGSSASAS-AVTPFSTPPQIANPTAQGTQAAAV
MMAR_1904|M.marinum_M TEYGQMWAQDAAAMYEYAAATSSAT-ELTPFTQPQQIVSPGAGSGQIAAV
MAV_2924|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASAS-KVTPFQKAPQVTNPSGQAAQSAAV
MUL_1701|M.ulcerans_Agy99 AQYAEMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPAASALQSNAT
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
::* . * * : .* * . : .
Rv1789|M.tuberculosis_H37Rv A----TAAGTAQSTLTEMITGLPNALQSLTSPLLQ---------------
Mb1817|M.bovis_AF2122/97 A----TAAGTAQSTLTEMITGLPNALQSLTSPLLQ---------------
MMAR_1904|M.marinum_M AHSAATLAGTSQTTLSRLISEIPKALHGIVAPLAA---------------
MAV_2924|M.avium_104 S--TATANSTSTNTTKALQSLAQPASSSTTATKAAT--------------
MUL_1701|M.ulcerans_Agy99 STAAATAAGAAQSTLAGVISQLPNALTSLTSPIAS---------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQ--------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFD-VSNIIADIIRLYG------EVLRFLFEPIF
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALD-LSNIIADLIRAYG------ELLRFLFEPIF
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLD-LSSIISDLLNQYL------QGVPGG-QAIL
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPD-PNDPIEMLLKNS-------QHFLGMYRALK
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Rv1789|M.tuberculosis_H37Rv ----------SSN--GPLSWLWQILFGTPNFPTSISALLTDLQPYAS---
Mb1817|M.bovis_AF2122/97 ----------SSN--GPLSWLWQILFGTPNFPTSISALLTDLQPYAS---
MMAR_1904|M.marinum_M ----------STTPDSPLGWLWQILFGTT-FPTSISALLTDLQPYAS---
MAV_2924|M.avium_104 -------TAASTTSTDPLSEIWFLLTGQTSLPTNLGTLVNGYSPFAG---
MUL_1701|M.ulcerans_Agy99 -----------------------ALTSAASPATWIDWLVNWYLPISQ---
MLBr_01182|M.leprae_Br4923 -------VDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLS
Mflv_0325|M.gilvum_PYR-GCK NFLR-------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 DFLR-------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 DFLK-------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_4783|M.abscessus_ATCC_1997 GLIT-------DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
. :
Rv1789|M.tuberculosis_H37Rv FFYNTEGLPYFSIGMGNN-------------------FIQSAKTLGLIGS
Mb1817|M.bovis_AF2122/97 FFYNTEGLPYFSIGMGNN-------------------FIQAAKTLGLIGS
MMAR_1904|M.marinum_M FFYNTEGLPYFSIGMANN-------------------FIQMSKTLGLLSG
MAV_2924|M.avium_104 LFYNTEGLPYFSTGMANT-------------------FTQIAKSVGAIGG
MUL_1701|M.ulcerans_Agy99 LFYNTVGLPYFAIGIGSS-------------------LITSERALGLIGP
MLBr_01182|M.leprae_Br4923 MINNHAGMANAGLSLVNG-------------------MGSAMKSLAPTTT
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT--LAIVAGVGQ---HLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT--LAIVLGVGA---YLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGITGLVLLIDH---VLNNPVDVPAEDEA
MAB_4783|M.abscessus_ATCC_1997 -TFAVMGTPIYAAIMGPAAGISIPLAITLAS------LSQMPEAPPVDAP
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
: :
Rv1789|M.tuberculosis_H37Rv AAPAAVAAAGDAAKGLPGLGGML--GGGPVAAG----LGNAASVG---KL
Mb1817|M.bovis_AF2122/97 AAPAAVAAAGDAAKGLPGLGGML--GGGPVAAG----LGNAASVG---KL
MMAR_1904|M.marinum_M TT---AAATGGAASGLAGLGGLID-GGGQVSAH----LGHAASLG---RL
MAV_2924|M.avium_104 AAP----AAAKALPGLGGLGGML--GGGAAAAHPVAALGGAGSIGG--KL
MUL_1701|M.ulcerans_Agy99 EAEAAAAGAGAAEAAAGAAPAALG-GAGPIGAG----LGNASALG---KL
MLBr_01182|M.leprae_Br4923 KAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQ----LGRAASIG---SL
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSP-----P
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTA-----P
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAG-----T
MAB_4783|M.abscessus_ATCC_1997 AETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSA-----P
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
. .
Rv1789|M.tuberculosis_H37Rv SVPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAA--PGSLLGGLPLAG--A
Mb1817|M.bovis_AF2122/97 SVPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAA--PGSLLGGLPLAG--A
MMAR_1904|M.marinum_M SVPPSWAQSVP-DLESMPARMPIETLKFAPDGGG-AGNLLGGMPLGGPGL
MAV_2924|M.avium_104 SVPVAWSGAPA--TPALGHAIPVSSISAAPEAAGGPGNLLGGMPLAGAGA
MUL_1701|M.ulcerans_Agy99 SVPPSWPGSGLDVPPSVSAGGPLASDIVNPPEASAPGSLLGGMPLAGGPG
MLBr_01182|M.leprae_Br4923 RVPQTWTTASQPVTAATRALSPARVAVATESES--APLLGGGLPMAPMVP
Mflv_0325|M.gilvum_PYR-GCK APGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGI
Mvan_0415|M.vanbaalenii_PYR-1 APGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGV
MSMEG_0619|M.smegmatis_MC2_155 TVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGV
MAB_4783|M.abscessus_ATCC_1997 AP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQ-PAPGVARRSAGARRAASIVEPAGSAAAAA
. * .
Rv1789|M.tuberculosis_H37Rv GGAGA-------------------------------------GPRYGFRP
Mb1817|M.bovis_AF2122/97 GGAGA-------------------------------------GPRYGFRP
MMAR_1904|M.marinum_M GASGS-------------------------------------GPRYGVRP
MAV_2924|M.avium_104 GGHGAA------------------------------------GPKYGFRP
MUL_1701|M.ulcerans_Agy99 GAAAGA------------------------------------GPRYGFRV
MLBr_01182|M.leprae_Br4923 GGGSGTGGVNT-------------------------------ALRLQPRA
Mflv_0325|M.gilvum_PYR-GCK AASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTAST
Mvan_0415|M.vanbaalenii_PYR-1 AASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATE
MSMEG_0619|M.smegmatis_MC2_155 AASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASE
MAB_4783|M.abscessus_ATCC_1997 LACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-----------AATAPSA
.
Rv1789|M.tuberculosis_H37Rv TVMARPPFAG----------------------------------------
Mb1817|M.bovis_AF2122/97 TVMARPPFAG----------------------------------------
MMAR_1904|M.marinum_M TVMARPPFAG----------------------------------------
MAV_2924|M.avium_104 TVMARPPFAG----------------------------------------
MUL_1701|M.ulcerans_Agy99 TVMARPPFAG----------------------------------------
MLBr_01182|M.leprae_Br4923 FVMPRNPAAG----------------------------------------
Mflv_0325|M.gilvum_PYR-GCK RGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATD
Mvan_0415|M.vanbaalenii_PYR-1 RGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEP
MSMEG_0619|M.smegmatis_MC2_155 RGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENP
MAB_4783|M.abscessus_ATCC_1997 TGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDD
TH_3113|M.thermoresistible__bu AGIRVLGGAGRISRT-RGSVPHAEITPGDPTE--PSSPTDRAHRPAEPN-
:*
Rv1789|M.tuberculosis_H37Rv -------------------
Mb1817|M.bovis_AF2122/97 -------------------
MMAR_1904|M.marinum_M -------------------
MAV_2924|M.avium_104 -------------------
MUL_1701|M.ulcerans_Agy99 -------------------
MLBr_01182|M.leprae_Br4923 -------------------
Mflv_0325|M.gilvum_PYR-GCK DRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 D------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 AP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 R------------------
TH_3113|M.thermoresistible__bu -------------------