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IDFAALPPEINSARIYAGPGSAPMMSAAAAWNTMAAEMRSAAASYGAVISELTSADWFGPSSMSMLAAVT PYLTWLTDTATRAEEAAAQANSAATAYEAAFAMTVPPAVVAANRAQLATLVATNVFGQNTPAIAATEAEY GQMWAQDAAAMNGYAVASTAATRLTPMTAPRSNTSPEGVAAQATSVTNAAQAPAGTVQSTVSSSGLAGLL SGSDNSAFGTFTNGNFFSTAVVNGSLAGGPFNPQFIISSVQGVLAAQHATTLGGLGDFAADAEGAATADL AASTGGSAPVAAGMGRAQLVGSLSVPQGWANAATINPGQAAVPATGVTGLTDAASAAGGPGGVAGPVGGT GRRLRRAIPKYGFRPVVMPRPPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2914 | - | - | 100% (376) | PPE family protein |
| M. avium 104 | MAV_2913 | - | 2e-85 | 48.77% (406) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 2e-83 | 44.99% (429) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 1e-87 | 46.81% (408) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-31 | 37.44% (203) | PPE protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 2e-88 | 46.52% (402) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-48 | 33.81% (420) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 7e-32 | 42.17% (166) | PPE family protein |
| M. marinum M | MMAR_2681 | - | 7e-88 | 44.86% (428) | PPE family protein, PPE31_1 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 6e-35 | 29.29% (420) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-36 | 32.71% (373) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3074 | - | 1e-81 | 45.78% (391) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-36 | 33.42% (389) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
Rv1807|M.tuberculosis_H37Rv -------------LDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
MUL_3074|M.ulcerans_Agy99 ---------MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAE
MMAR_2681|M.marinum_M -------------MDFAALPPEINSIRMYSGPGSAPMLAAVTAWDGLAAE
MAV_2914|M.avium_104 ------------MIDFAALPPEINSARIYAGPGSAPMMSAAAAWNTMAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
: .** :* : *.*...: :* * :. .
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
Rv1807|M.tuberculosis_H37Rv LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
MUL_3074|M.ulcerans_Agy99 LRVTVLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESA
MMAR_2681|M.marinum_M LRSTAAAYETVIAVLTGDGWLGPASESMEAAVFPYLAWMNITGMQAEQTA
MAV_2914|M.avium_104 MRSAAASYGAVISELTSADWFGPSSMSMLAAVTPYLTWLTDTATRAEEAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:. : : : * .: ** *: . . .
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
Rv1807|M.tuberculosis_H37Rv AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
MUL_3074|M.ulcerans_Agy99 VQAAAAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPTIAAVE
MMAR_2681|M.marinum_M RQAAAAAGAFEAAFAMTVPPAQVAANRTQLQTLVATNLLGQNTPAIAATE
MAV_2914|M.avium_104 AQANSAATAYEAAFAMTVPPAVVAANRAQLATLVATNVFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* ** *. :*:: . : *:: *: :*.:* *: .* *
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPV---------------
Rv1807|M.tuberculosis_H37Rv AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPV---------------
MUL_3074|M.ulcerans_Agy99 AQYCEMWAQDAMAMYGYAGSSAAAT-RLSEFLAPQ---------------
MMAR_2681|M.marinum_M AAYGEMWAQDAAAMYGYAVGSAAAS-TLTQFTQPA---------------
MAV_2914|M.avium_104 AEYGQMWAQDAAAMNGYAVASTAAT-RLTPMTAPR---------------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPP---------------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
* * .** * * :* * * .
Mb1836|M.bovis_AF2122/97 --------------------------------------------------
Rv1807|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3074|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2681|M.marinum_M --------------------------------------------------
MAV_2914|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Mb1836|M.bovis_AF2122/97 -----------------------QTTNASGLAAQSAAIAHATGASAG-AQ
Rv1807|M.tuberculosis_H37Rv -----------------------QTTNASGLAAQSAAIAHATGASAG-AQ
MUL_3074|M.ulcerans_Agy99 -----------------------HNTNPAGLLAQ----------------
MMAR_2681|M.marinum_M -----------------------QTTDPSGLASQSAAVTQAVGSTVGNLT
MAV_2914|M.avium_104 -----------------------SNTSPEGVAAQ----------------
MLBr_01182|M.leprae_Br4923 -----------------------LGVNEVGLAQEVVEEVVEEVVEEVVEA
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
.
Mb1836|M.bovis_AF2122/97 QTTLSQLIAAIPSVLQGLSSSTAATSASGP--SGLLG--ILGSGSSWLDK
Rv1807|M.tuberculosis_H37Rv QTTLSQLIAAIPSVLQGLSSSTAATFASGP--SGLLG--IVGSGSSWLDK
MUL_3074|M.ulcerans_Agy99 QSTLAQLMSAVPNVLQGLASSN--TSASAP--SGLLSTLLSGNGQSWLAT
MMAR_2681|M.marinum_M QTELPQLMSAVPASLQGLASPAAASPIDAIPGSGLLAA-LLNFLDGNDGN
MAV_2914|M.avium_104 ATSVTNAAQAPAGTVQSTVSSSG----------------LAGLLSGSDNS
MLBr_01182|M.leprae_Br4923 EQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQ
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
. :
Mb1836|M.bovis_AF2122/97 LWALLDPNSNFWNTIASSGLFLPSNT-IAPFLGLLGGVAAADAAGDVLGE
Rv1807|M.tuberculosis_H37Rv LWALLDPNSNFWNTIASSGLFLPSNT-IAPFLGLLGGVAAADAAGDVLGE
MUL_3074|M.ulcerans_Agy99 LWSEFGPNANIWNTIASTGFLLPSNM-VTPFLGMLDTAAVADAAEDALRT
MMAR_2681|M.marinum_M PYGVF-LNSSLVNGFVSAGYVSPAVVGPAIWAAMADINAVALGAQESAAV
MAV_2914|M.avium_104 AFGTF-TNGNFFSTAVVNGSLAGGPFNPQFIISSVQGVLAAQHATTLGGL
MLBr_01182|M.leprae_Br4923 LWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKA
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
Mb1836|M.bovis_AF2122/97 ATSG-GLGGALVAPLGSAGGLG---------------GTVAAGLGNAATV
Rv1807|M.tuberculosis_H37Rv ATSG-GLGGALVAPLGSAGGLG---------------GTVAAGLGNAATV
MUL_3074|M.ulcerans_Agy99 TGSG-ALGGALSAPLGSVGGQA---------------GLAAA--GNAAIV
MMAR_2681|M.marinum_M PPMGSGEGNPSWIPAASPASPESLPVLGEETAATLGTGGISAGMNQAELV
MAV_2914|M.avium_104 GDFAADAEGAATADLAASTGGS---------------APVAAGMGRAQLV
MLBr_01182|M.leprae_Br4923 AESAFKAMGSAVQSTGRGLLGSS------------SGGHVTAQLGRAASI
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
*
Mb1836|M.bovis_AF2122/97 GTLSVPPSWTAAAPLASPLGSAL--GGTPMVAP---PPAVAAGMPGMP--
Rv1807|M.tuberculosis_H37Rv GTLSVPPSWTAAAPLASPLGSAL--GGTPMVAP---PPAVAAGMPGMP--
MUL_3074|M.ulcerans_Agy99 GKLSVPPSWTGAAPLASPLGSAL--GGTPMVAP---PPTAAAGMPGMP--
MMAR_2681|M.marinum_M GRMSVPQSWGVATAVANHAGAAAPGGGWTSTAV---VPEAAVGMPGIPGM
MAV_2914|M.avium_104 GSLSVPQGWANAATIN-PGQAAVPATGVTGLTD---AASAAGGPGGVAG-
MLBr_01182|M.leprae_Br4923 GSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMV
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
.
Mb1836|M.bovis_AF2122/97 FGTMGGQGFGRAVPQYGFRPNFVARPPAAG--------------------
Rv1807|M.tuberculosis_H37Rv FGTMGGQGFGRAVPQYGFRPNFVARPPAAG--------------------
MUL_3074|M.ulcerans_Agy99 FGNMAGQPFGRALPQYGFRPTFVARPPAAG--------------------
MMAR_2681|M.marinum_M PAGIYGHNLG-NAPRYGFRPTIMGRPPAAG--------------------
MAV_2914|M.avium_104 PVGGTGRRLRRAIPKYGFRPVVMPRPPAAG--------------------
MLBr_01182|M.leprae_Br4923 PGGGSGTGGVNTALRLQPRAFVMPRNPAAG--------------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
*
Mb1836|M.bovis_AF2122/97 ---------------
Rv1807|M.tuberculosis_H37Rv ---------------
MUL_3074|M.ulcerans_Agy99 ---------------
MMAR_2681|M.marinum_M ---------------
MAV_2914|M.avium_104 ---------------
MLBr_01182|M.leprae_Br4923 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------