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DFGALPPEINSARMYAGPGSAPLVQAARAWGRLANELNATAASYSSVIAGLGAADWQGPSALSMAAAAAP YVAWMRSTAAQAEQAAAQAISAANAYESAHAAIVPPGQIAANRSTMLSLVRSNIFGQNTPAIATSEADYS EMWAQDIVAMDGYAGTSAAATDLAPFTSPPATTTGTEALSAATVPAAAAAAAPAETSILPLLQSFLPAPF NAIPNPFEDLDLLVLAAVVVSLGALGVSAIQLGEVYRHDIVDEDENAPLCGGEYDELPAAGLRNPDRDAI TTPGGQRLASPPSPPVAALSGYSANIGGLSVPPAWNLPPAVRQVAAMFPGATPMYLTGGSDGQYTGIAAA GIAGASLAGFAARGSGSAPAPTTGAPSAGGGGAAAAARPAANTPSVPAAAAAANIPGLPSGLPPGVVANL AATLAAIPGATIIVVPPDPNAAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0685 | - | - | 100% (444) | PPE family protein |
| M. marinum M | MMAR_2928 | - | 1e-74 | 44.37% (435) | PPE family protein |
| M. marinum M | MMAR_2684 | - | 4e-70 | 42.13% (432) | PPE family protein, PPE32 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0394c | PPE9 | 1e-179 | 72.32% (448) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 9e-30 | 28.54% (417) | PPE protein |
| M. tuberculosis H37Rv | Rv0387c | - | 4e-94 | 70.16% (248) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 6e-37 | 47.37% (171) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 3e-34 | 29.85% (479) | PPE-family protein |
| M. avium 104 | MAV_2906 | - | 9e-70 | 41.18% (425) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 6e-31 | 35.09% (228) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-35 | 29.55% (440) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 3e-70 | 42.13% (432) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-34 | 31.29% (425) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0394c|M.bovis_AF2122/97 -------------MDFGALPPEINSARIYSGPGSRPLMQAAAAWQRLANE
Rv0387c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0685|M.marinum_M -------------MDFGALPPEINSARMYAGPGSAPLVQAARAWGRLANE
MAV_2906|M.avium_104 -------------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mb0394c|M.bovis_AF2122/97 LTATAASYSSVISGLTGDDWLGPSALSMAAAAVPYVAWMRATAASAEQAA
Rv0387c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0685|M.marinum_M LNATAASYSSVIAGLGAADWQGPSALSMAAAAAPYVAWMRSTAAQAEQAA
MAV_2906|M.avium_104 LYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVA
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
Mb0394c|M.bovis_AF2122/97 AQAVAAANAYESAYAATVPPTVIAANRRTMLSLVKTNVFGQNTPAIATSE
Rv0387c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0685|M.marinum_M AQAISAANAYESAHAAIVPPGQIAANRSTMLSLVRSNIFGQNTPAIATSE
MAV_2906|M.avium_104 TQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mb0394c|M.bovis_AF2122/97 AQYGAMWAQDIVAMEGYAGASAAASQLPPFTPPPATTSGAGSLSDAAATA
Rv0387c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0685|M.marinum_M ADYSEMWAQDIVAMDGYAGTSAAATDLAPFTSPPATTTGTEALS---AAT
MAV_2906|M.avium_104 AEYAEMWAQDAAAMYAYAAASAAAAELTPFTEPPRTTES--------SAA
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPPQTTNP--------VAG
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mb0394c|M.bovis_AF2122/97 AQAVVPA-------------------------------------------
Rv0387c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0685|M.marinum_M VPAAAAA-------------------------------------------
MAV_2906|M.avium_104 ARQSAAV-------------------------------------------
MUL_3072|M.ulcerans_Agy99 AAQSAAV-------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQIMKMLQG---------------------------FQQWFEKM
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEEV-----------------------------------------
Mb0394c|M.bovis_AF2122/97 ------AAATDVSLLPTLQSFLP-------------------------PP
Rv0387c|M.tuberculosis_H37Rv -----------MSLLPTLQSFLP-------------------------PP
MMAR_0685|M.marinum_M ------AAPAETSILPLLQSFLP-------------------------AP
MAV_2906|M.avium_104 ------AQS----AASDLPAQLS-------------------------TL
MUL_3072|M.ulcerans_Agy99 ------AQASSTAASSDVVSQLA-------------------------GL
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGP------FLLAVVYQA----VSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGP------FLAAVAYQA----VSWVGASI
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWP------FLFGVAYQVFFNLVGWPTWGM
MAB_0669|M.abscessus_ATCC_1997 G--------FNPATSAVLAVIML------FLYDLLWYP---------YYA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 ------VEAEQAISQAALDQAVN---------------------------
:
Mb0394c|M.bovis_AF2122/97 FDAIPNPIEDLDVLVAAAVAVAAGSLGVSAAQLGEIYRHDVVDEAQKAPH
Rv0387c|M.tuberculosis_H37Rv FDAIPNPIEDLDVLVAAAVAVAAGSLGVSAAQLGEIYRHDVVDEAQKAPH
MMAR_0685|M.marinum_M FNAIPNPFEDLDLLVLAAVVVSLGALGVSAIQLGEVYRHDIVDEDENAPL
MAV_2906|M.avium_104 IDVTPTMLQGLATT---PSAAAA----TPAASIIEAIYPITAALRPFFAA
MUL_3072|M.ulcerans_Agy99 ITSVPNALQTLATTSAAPTAASI----LPEVSLPPWLATNLANWNTIMAT
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATT-------LAIVAGVGQHLLSLLNTPPAEEAAEEPAP
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATT-------LAIVLGVGAYLLENLPAPAEDAPAEEPAA
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALG-----ITGLVLLIDHVLNNPVDVPAEDEAPQEVAA
MAB_0669|M.abscessus_ATCC_1997 SYLLPFLIPALSGLS-----GLAALMHLRPAAPGPVPA-AALSPGDRPIR
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 EGMEATVVPQVDQQVN-----------VDVATPQTAVPDSSSAAAPQLWG
. :
Mb0394c|M.bovis_AF2122/97 CPAESDQTPAGAAGDGD---LPEVGG-RVTSPPQPPVAALTGYSANIGGL
Rv0387c|M.tuberculosis_H37Rv CPAESDQTPAGAAGDGD---LPEVGG-RVTSPPQPPVAALTGYSANIGGL
MMAR_0685|M.marinum_M CGGEYDELPAAGLRNPDRDAITTPGGQRLASPPSPPVAALSGYSANIGGL
MAV_2906|M.avium_104 VTGAYSPIGAIILPGGW---WLLSLQALGLAQNAPGVAELLGGGKAIAGG
MUL_3072|M.ulcerans_Agy99 LTGPFSLQGISSIPGGP---FLSFGQVYAYVQNAQGLNAFYSP-KAITGT
Mflv_0325|M.gilvum_PYR-GCK AQSAPSRPDQQSFPATM--SAPPPPSGAPIAANTVSAGSPPAPGAPAAAA
Mvan_0415|M.vanbaalenii_PYR-1 SSPAPTRADQPSPAIAV--SAPPPPSSAAATVGTVATGTAPAPGAPAAAT
MSMEG_0619|M.smegmatis_MC2_155 AP----RTDQP-LAVGI--SPAGVPGSAATAAAPAPAPAGTTVAAPAPAA
MAB_0669|M.abscessus_ATCC_1997 RPTQHVEPNLAALPLPT--SSVVPSGGSSVPVSTPTAPAHTVSSVPAPSA
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGS--SAPPAPTG-SAAPTTGTAPGGAGSPPPAGHS
MLBr_01182|M.leprae_Br4923 GFAQHLSPINDTLSMIN---NHAGMANAGLSLVNGMGSAMKSLAPTTTKA
Mb0394c|M.bovis_AF2122/97 SVPHSWNLPPAVRQVAAMFPGATPMYMTGSSDGSYAGLAAAGLAGTGLAG
Rv0387c|M.tuberculosis_H37Rv SVPHSWNLPPAVRQVAAMFPGATPMYMTGSSDGSYAGLAAAGLAGTGLAG
MMAR_0685|M.marinum_M SVPPAWNLPPAVRQVAAMFPGATPMYLTGGSDGQYTGIAAAGIAGASLAG
MAV_2906|M.avium_104 LSP----LAPLRG-GYVSAVTPDAG-GVAGSMGRSTLVGSLSVPPGWTTA
MUL_3072|M.ulcerans_Agy99 LAP----LVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQA
Mflv_0325|M.gilvum_PYR-GCK ATFVPYVVAGRDP-YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERR
Mvan_0415|M.vanbaalenii_PYR-1 ASFVPYAVAGRDP-GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERR
MSMEG_0619|M.smegmatis_MC2_155 ATFVPYAVANRDP-GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRR
MAB_0669|M.abscessus_ATCC_1997 A--ISYAIPGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARR
TH_3113|M.thermoresistible__bu VPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAA
MLBr_01182|M.leprae_Br4923 AESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTA
.:
Mb0394c|M.bovis_AF2122/97 LAARG-GSAPTPAAAAPAGAGGAGPAATRPAAQQTPAVPAAAAGSAIPGL
Rv0387c|M.tuberculosis_H37Rv LAARG-GSAPTPAAAAPAGAGGAGPAATRPAAQQTPAVPAAAAGSAIPGL
MMAR_0685|M.marinum_M FAARGSGSAPAPTTGAPSAGGGGAAAAARPAAN-TPSVPAAAAAANIPGL
MAV_2906|M.avium_104 APVLRTVASVLPAASSATAAAMPASGGAVFGEMAAASLAGRALAGAGVRT
MUL_3072|M.ulcerans_Agy99 APAMRLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFGS
Mflv_0325|M.gilvum_PYR-GCK KRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGF
Mvan_0415|M.vanbaalenii_PYR-1 KRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGF
MSMEG_0619|M.smegmatis_MC2_155 KRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGF
MAB_0669|M.abscessus_ATCC_1997 RLRGKNKAEAGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGF
TH_3113|M.thermoresistible__bu AAAARESAPIRRRRGQKDGLHGHRHEHQQPASMS-AATAPSAAGIRVLGG
MLBr_01182|M.leprae_Br4923 SQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNT
. .
Mb0394c|M.bovis_AF2122/97 PPGLPPGV--VANLAATLAAIPGATIIVVPPSPNANQ-------------
Rv0387c|M.tuberculosis_H37Rv PPGLPPGV--VANLAATLAAIPGATIIVVPPSPNANQ-------------
MMAR_0685|M.marinum_M PSGLPPGV--VANLAATLAAIPGATIIVVPPDPNAAQ-------------
MAV_2906|M.avium_104 VGNGTTG---AATAAAADGAATTATIIVVPAD------------------
MUL_3072|M.ulcerans_Agy99 SSGGAVAN--SLGGVVAEADPAAATIIVIPALDE----------------
Mflv_0325|M.gilvum_PYR-GCK AGTVSRGD-EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRD
Mvan_0415|M.vanbaalenii_PYR-1 AGTVSRDA-AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------E
MSMEG_0619|M.smegmatis_MC2_155 TGTVTRHD-VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------
MAB_0669|M.abscessus_ATCC_1997 AGTAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDAD-----------
TH_3113|M.thermoresistible__bu AGRISRTR-GSVPHAEITPGDPTEPSSPTDRAHRPAEPN-----------
MLBr_01182|M.leprae_Br4923 ALRLQPRA------------------FVMPRNPAAG--------------
Mb0394c|M.bovis_AF2122/97 -----------
Rv0387c|M.tuberculosis_H37Rv -----------
MMAR_0685|M.marinum_M -----------
MAV_2906|M.avium_104 -----------
MUL_3072|M.ulcerans_Agy99 -----------
Mflv_0325|M.gilvum_PYR-GCK GHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 RHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 SPDDPEGGPRR
MAB_0669|M.abscessus_ATCC_1997 ------GGDQN
TH_3113|M.thermoresistible__bu -----------
MLBr_01182|M.leprae_Br4923 -----------