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MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATGYASVIAELTGAPWVGAASLSMVAAAT PYVAWLSQAAARAEQAGMQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQY AEMWAQDAVAMYGYAAASASASRLIPFAAPPKTTNSAGVVAQAVASVSWPNPNDWWLVRLLGSITPTERT TIVRLLGQSYLATGMARFLTSIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGAGPAVSASLARAEPVGRLS VPPSWAVAAPAFAEKPEAGTPMSVIGEASSCGQGGLLRGIPLARAGRRTGAFAHRYGFRHSVITRSPSAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1790 | PPE27 | - | 100% (350) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1787 | PPE25 | e-167 | 83.88% (366) | PPE family protein |
| M. tuberculosis H37Rv | Rv2892c | PPE45 | 7e-97 | 49.63% (409) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1818 | PPE27 | 0.0 | 99.71% (350) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-29 | 37.63% (186) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-40 | 47.59% (187) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 9e-29 | 28.10% (395) | PPE family protein |
| M. marinum M | MMAR_2669 | - | 2e-96 | 51.44% (416) | PPE family protein, PPE25 |
| M. avium 104 | MAV_2928 | - | 1e-102 | 51.07% (419) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 6e-31 | 39.13% (184) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 8e-31 | 39.67% (184) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3089 | - | 3e-95 | 50.72% (416) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 6e-33 | 40.86% (186) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1790|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
Mb1818|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
MMAR_2669|M.marinum_M ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
MUL_3089|M.ulcerans_Agy99 ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
MAV_2928|M.avium_104 ------------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
* .** :* : ***...: :*. * :. .
Rv1790|M.tuberculosis_H37Rv LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
Mb1818|M.bovis_AF2122/97 LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
MMAR_2669|M.marinum_M LSSAASGYSSVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
MUL_3089|M.ulcerans_Agy99 LSSAASGYSLVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
MAV_2928|M.avium_104 LGIAASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : * .: ** ** : .
Rv1790|M.tuberculosis_H37Rv MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
Mb1818|M.bovis_AF2122/97 MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
MMAR_2669|M.marinum_M SQARAAAAAYETAFVMTVPPPVIAANRVLLMTLVATNFFGQNTPAIAATE
MUL_3089|M.ulcerans_Agy99 SQARAAAAAYETAFVMTVPPPVIAANRVLLMALVATNFFGQNTPAIAATE
MAV_2928|M.avium_104 SQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* .** *. :*:. . : *:. *: :*::* *: .* *
Rv1790|M.tuberculosis_H37Rv AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPP------KTTN-----
Mb1818|M.bovis_AF2122/97 AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPP------KTTN-----
MMAR_2669|M.marinum_M AQYMEMWAQDAAAMYSYAGSSALAT-ELPRFAPPP------DTTSVNAAG
MUL_3089|M.ulcerans_Agy99 AQYMEMWAQDAAAMYSYAGSSAPAT-ELPRFAPPP------DTTSVNAAG
MAV_2928|M.avium_104 AQYMEMWAQDAAAMYGYAAASQTAS-TLSPFAAPP------NTTAPEGES
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPP------LGVN--EVG
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:* .** * *.:* * * ...*
Rv1790|M.tuberculosis_H37Rv -SAGVVAQAVAS--------------------------------------
Mb1818|M.bovis_AF2122/97 -SAGVVAQAVAS--------------------------------------
MMAR_2669|M.marinum_M GQSAVVAQAAATPAGDSAQTITATIPQLLSSAGVPGLQQLSLSSVSS---
MUL_3089|M.ulcerans_Agy99 GQSAVVAQAAATPAGDSAQTITATIPQLLSSAGVPGLQQRSLSSVSS---
MAV_2928|M.avium_104 DQAAAVSQAMAQPAGSTAQTAANTSSQLATPQ---ALSAGTSQAATQ---
MLBr_01182|M.leprae_Br4923 LAQEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQ---
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
:
Rv1790|M.tuberculosis_H37Rv --------------------------VSWPNPNDWWLVR-----LLG---
Mb1818|M.bovis_AF2122/97 --------------------------VSWSNPNDWWLVR-----LLG---
MMAR_2669|M.marinum_M -----------------------MSPSAASSPTVWQIIQTQVQNFLTYGL
MUL_3089|M.ulcerans_Agy99 -----------------------MSPSAASSPTVWQIIQTQVQNFLTYGL
MAV_2928|M.avium_104 -----------------------ASSSSASQTGPFTWLTSALQNLQQSGL
MLBr_01182|M.leprae_Br4923 -----------------------QVNVDVATPQTAVPDSSSAAAPQLWGG
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
Rv1790|M.tuberculosis_H37Rv --------SITPTERTTIVRLLG-QSYLATGMA-----------------
Mb1818|M.bovis_AF2122/97 --------SITPTERTTIVRLLG-QSYLATGMA-----------------
MMAR_2669|M.marinum_M PTPDNNYAGLYPGMYNALRQTLQ--AYFGVGIG-----------------
MUL_3089|M.ulcerans_Agy99 PTPDNNYAGLYPGMYNALRQTLQ--AYFGVGIG-----------------
MAV_2928|M.avium_104 PTPTNNYLGLSPTFYTVMLKQTSGLGYFSNGIT-----------------
MLBr_01182|M.leprae_Br4923 FAQHLSPINDTLSMINNHAGMANAGLSLVNGMG-----------------
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
.
Rv1790|M.tuberculosis_H37Rv --------------------------RFLTSIAQQLTFGPGGTTAGSGGA
Mb1818|M.bovis_AF2122/97 --------------------------RFLTSIAQQLTFGPGGTTAGSGGA
MMAR_2669|M.marinum_M --------------------------NSGWSIAQQLTFGPGGTTAGAGGA
MUL_3089|M.ulcerans_Agy99 --------------------------NFGWSIAQQLTLGPGGTTAGAGGA
MAV_2928|M.avium_104 --------------------------AFWSQLAQQLVSGPGGSTAGAGGA
MLBr_01182|M.leprae_Br4923 --------------------------SAMKSLAPTTTKAAESAFKAMGSA
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
. . . .
Rv1790|M.tuberculosis_H37Rv WYPTPQFAGLGAGPA--------VSASLARAEPVGRLSVPPSWAVAAPAF
Mb1818|M.bovis_AF2122/97 WYPTPQFAGLGAGPA--------VSASLARAEPVGRLSVPPSWAVAAPAF
MMAR_2669|M.marinum_M WYPTPEFAALGADTW-----HWHPMASFASSSKVGGLSVPASWGTAPGAV
MUL_3089|M.ulcerans_Agy99 WYPTPEFAALGADTW-----HWHPMASFASSSKVGGLSVPASWGTTPGAV
MAV_2928|M.avium_104 WYPTPQFASLGLGNLGSVGGASHVSAISAGAGRAGALSVPQQWATLTSAV
MLBr_01182|M.leprae_Br4923 VQSTGRGLLGSSSGG-------HVTAQLGRAASIGSLRVPQTWTTASQPV
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
. . .
Rv1790|M.tuberculosis_H37Rv AEKPEAGT-----------------------------PMSVIGEAS----
Mb1818|M.bovis_AF2122/97 AEKPEAGT-----------------------------PMSVIGEAS----
MMAR_2669|M.marinum_M EQASTKLV-----------------------------STNFTTSPGEANP
MUL_3089|M.ulcerans_Agy99 EQASTKLV-----------------------------STNFTTSPGEANP
MAV_2928|M.avium_104 SPAVSEEG-----------------------------SAVQAAAGG--AP
MLBr_01182|M.leprae_Br4923 TAATRALS-----------------------------PARVAVATESESA
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
Rv1790|M.tuberculosis_H37Rv SCGQGGLLRGIPLARAG-RRTGA-FAHRYGFRHSVITRSPSAG-------
Mb1818|M.bovis_AF2122/97 SCGQGGLLRGIPLARAG-RRTGA-FAHRYGFRHSVITRSPSAG-------
MMAR_2669|M.marinum_M ANGLNAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG-------
MUL_3089|M.ulcerans_Agy99 ANGLNAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG-------
MAV_2928|M.avium_104 GGAANGLLRGMPVGALGRRGAAAGYVNKYGFRYSVLTRPPSAG-------
MLBr_01182|M.leprae_Br4923 PLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
.
Rv1790|M.tuberculosis_H37Rv ---------------
Mb1818|M.bovis_AF2122/97 ---------------
MMAR_2669|M.marinum_M ---------------
MUL_3089|M.ulcerans_Agy99 ---------------
MAV_2928|M.avium_104 ---------------
MLBr_01182|M.leprae_Br4923 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------