For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATGYASVIAELTGAPWVGAASLSMVAAAT PYVAWLSQAAARAEQAGMQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQY AEMWAQDAVAMYGYAAASASASRLIPFAAPPKTTNSAGVVAQAVASVSWSNPNDWWLVRLLGSITPTERT TIVRLLGQSYLATGMARFLTSIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGAGPAVSASLARAEPVGRLS VPPSWAVAAPAFAEKPEAGTPMSVIGEASSCGQGGLLRGIPLARAGRRTGAFAHRYGFRHSVITRSPSAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1818 | PPE27 | - | 100% (350) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1815 | PPE25 | e-167 | 83.33% (366) | PPE family protein |
| M. bovis AF2122 / 97 | Mb2916c | PPE45 | 5e-97 | 49.63% (409) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-29 | 37.63% (186) | PPE protein |
| M. tuberculosis H37Rv | Rv1790 | PPE27 | 0.0 | 99.71% (350) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-40 | 47.59% (187) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | 3e-28 | 35.35% (198) | PPE family protein |
| M. marinum M | MMAR_2669 | - | 6e-97 | 51.68% (416) | PPE family protein, PPE25 |
| M. avium 104 | MAV_2928 | - | 1e-102 | 51.07% (419) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 6e-31 | 39.13% (184) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 8e-31 | 39.67% (184) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3089 | - | 1e-95 | 50.96% (416) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 6e-33 | 40.86% (186) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1818|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
Rv1790|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
MMAR_2669|M.marinum_M ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
MUL_3089|M.ulcerans_Agy99 ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
MAV_2928|M.avium_104 ------------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_2254c|M.abscessus_ATCC_199 ----------MSAPIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHALSYE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
*:.** :* : ***...: :*. * :: *
Mb1818|M.bovis_AF2122/97 LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
Rv1790|M.tuberculosis_H37Rv LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
MMAR_2669|M.marinum_M LSSAASGYSSVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
MUL_3089|M.ulcerans_Agy99 LSSAASGYSLVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
MAV_2928|M.avium_104 LGIAASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_2254c|M.abscessus_ATCC_199 YSMAATELTQLLGVTAAGVWQGSSATQYVASHTPYLAWLTQQSATSAANA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
** : : * .: ** **: :* .
Mb1818|M.bovis_AF2122/97 MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
Rv1790|M.tuberculosis_H37Rv MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
MMAR_2669|M.marinum_M SQARAAAAAYETAFVMTVPPPVIAANRVLLMTLVATNFFGQNTPAIAATE
MUL_3089|M.ulcerans_Agy99 SQARAAAAAYETAFVMTVPPPVIAANRVLLMALVATNFFGQNTPAIAATE
MAV_2928|M.avium_104 SQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_2254c|M.abscessus_ATCC_199 ALHETSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.:* *. :*:. . : *:. *: :*::* *: .** *
Mb1818|M.bovis_AF2122/97 AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPPKTTN------SAGVV
Rv1790|M.tuberculosis_H37Rv AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPPKTTN------SAGVV
MMAR_2669|M.marinum_M AQYMEMWAQDAAAMYSYAGSSALAT-ELPRFAPPPDTTSVNAAGGQSAVV
MUL_3089|M.ulcerans_Agy99 AQYMEMWAQDAAAMYSYAGSSAPAT-ELPRFAPPPDTTSVNAAGGQSAVV
MAV_2928|M.avium_104 AQYMEMWAQDAAAMYGYAAASQTAS-TLSPFAAPPNTTAPEGESDQAAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVN--EVGLAQEVV
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_2254c|M.abscessus_ATCC_199 ADYVRMWVQAATTMGVYQGVSSTAVAAAAPTTTSPLIMPPGS-ELSRMAA
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:* .** * *.:* * . * ...*
Mb1818|M.bovis_AF2122/97 AQAVAS--------------------------------------------
Rv1790|M.tuberculosis_H37Rv AQAVAS--------------------------------------------
MMAR_2669|M.marinum_M AQAAATPAGDSAQTITATIPQ---------------------LLSSAGVP
MUL_3089|M.ulcerans_Agy99 AQAAATPAGDSAQTITATIPQ---------------------LLSSAGVP
MAV_2928|M.avium_104 SQAMAQPAGSTAQTAANTSSQ---------------------LATPQ---
MLBr_01182|M.leprae_Br4923 EEVVEEVVEEVVEAEQAISQA---------------------ALDQAVNE
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_2254c|M.abscessus_ATCC_199 DMSGFAAQAQATESGSALDSSNSVIDQL--------------LNFFRDPL
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FADALPDGLL
Mb1818|M.bovis_AF2122/97 ---------------VSWSNPNDWWLVR----------------------
Rv1790|M.tuberculosis_H37Rv ---------------VSWPNPNDWWLVR----------------------
MMAR_2669|M.marinum_M GLQQLSLSSVSSMSPSAASSPTVWQIIQTQVQ------------------
MUL_3089|M.ulcerans_Agy99 GLQQRSLSSVSSMSPSAASSPTVWQIIQTQVQ------------------
MAV_2928|M.avium_104 ALSAGTSQAATQASSSSASQTGPFTWLTSALQ------------------
MLBr_01182|M.leprae_Br4923 GMEATVVPQVDQQVNVDVATPQTAVPDSSSAA------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_2254c|M.abscessus_ATCC_199 GTLRQIIEDFIRNPGAALATWLPFLLVLASMT---YVLFAQVFWLFWAAL
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
Mb1818|M.bovis_AF2122/97 ---------------------LLG-----------SITPTERTTIVRLLG
Rv1790|M.tuberculosis_H37Rv ---------------------LLG-----------SITPTERTTIVRLLG
MMAR_2669|M.marinum_M --------------------NFLTYGLPTPDNNYAGLYPGMYNALRQTLQ
MUL_3089|M.ulcerans_Agy99 --------------------NFLTYGLPTPDNNYAGLYPGMYNALRQTLQ
MAV_2928|M.avium_104 --------------------NLQQSGLPTPTNNYLGLSPTFYTVMLKQTS
MLBr_01182|M.leprae_Br4923 --------------------APQLWGGFAQHLSPINDTLSMINNHAGMAN
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_2254c|M.abscessus_ATCC_199 LSAPLWLP--LLILAAWQYLQPPAVDAAPADEIRPELGSTVNGQREHIEP
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
Mb1818|M.bovis_AF2122/97 -QSYLATGMARFLTSIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGAGPA-
Rv1790|M.tuberculosis_H37Rv -QSYLATGMARFLTSIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGAGPA-
MMAR_2669|M.marinum_M --AYFGVGIGNSGWSIAQQLTFGPGGTTAGAGGAWYPTPEFAALGADTW-
MUL_3089|M.ulcerans_Agy99 --AYFGVGIGNFGWSIAQQLTLGPGGTTAGAGGAWYPTPEFAALGADTW-
MAV_2928|M.avium_104 GLGYFSNGITAFWSQLAQQLVSGPGGSTAGAGGAWYPTPQFASLGLGNLG
MLBr_01182|M.leprae_Br4923 AGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGG-
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
MAB_2254c|M.abscessus_ATCC_199 LPAIALAPTATPVPTASASAPSAPAPAPAPTAAGAGFAPYLVGAIPDEPP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
. . . : .
Mb1818|M.bovis_AF2122/97 -------VSASLARAEPVGRLSVPPSWAVAAPAFAEKPEAGTPMSVIGEA
Rv1790|M.tuberculosis_H37Rv -------VSASLARAEPVGRLSVPPSWAVAAPAFAEKPEAGTPMSVIGEA
MMAR_2669|M.marinum_M ----HWHPMASFASSSKVGGLSVPASWGTAPGAVEQASTKLVSTNFTTSP
MUL_3089|M.ulcerans_Agy99 ----HWHPMASFASSSKVGGLSVPASWGTTPGAVEQASTKLVSTNFTTSP
MAV_2928|M.avium_104 SVGGASHVSAISAGAGRAGALSVPQQWATLTSAVSPAVSEEGSAVQAAAG
MLBr_01182|M.leprae_Br4923 ------HVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVAT
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
MAB_2254c|M.abscessus_ATCC_199 AIQFGPTLNEGNKAQAPASGISAAAA-AAASARSRARRKRGARVKDPAPQ
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAG
. .
Mb1818|M.bovis_AF2122/97 S----SCGQGGLLRGIPLARAG-RRTGA-FAHRYGFRHSVITRSPSAG--
Rv1790|M.tuberculosis_H37Rv S----SCGQGGLLRGIPLARAG-RRTGA-FAHRYGFRHSVITRSPSAG--
MMAR_2669|M.marinum_M GEANPANGLNAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG--
MUL_3089|M.ulcerans_Agy99 GEANPANGLNAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG--
MAV_2928|M.avium_104 G--APGGAANGLLRGMPVGALGRRGAAAGYVNKYGFRYSVLTRPPSAG--
MLBr_01182|M.leprae_Br4923 ESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG--
Mflv_0325|M.gilvum_PYR-GCK YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGL
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGL
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGL
MAB_2254c|M.abscessus_ATCC_199 YMDMNVTVDADYGEPPGSAQR-QSTASARGAGHLGLAGTSPKTTATAAGL
TH_3113|M.thermoresistible__bu SAAAAAAARESAPIRRRRGQKDGLHG--HRHEHQQPASMSAATAPSAAGI
*.
Mb1818|M.bovis_AF2122/97 --------------------------------------------------
Rv1790|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2669|M.marinum_M --------------------------------------------------
MUL_3089|M.ulcerans_Agy99 --------------------------------------------------
MAV_2928|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TTLA-----GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1 TTLP-----GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MSMEG_0619|M.smegmatis_MC2_155 TTLT-----GDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPR
MAB_2254c|M.abscessus_ATCC_199 VARGSAGSDTDVPETARIVPMIPTTWSTDSDEAID---------------
TH_3113|M.thermoresistible__bu RVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN-------
Mb1818|M.bovis_AF2122/97 -
Rv1790|M.tuberculosis_H37Rv -
MMAR_2669|M.marinum_M -
MUL_3089|M.ulcerans_Agy99 -
MAV_2928|M.avium_104 -
MLBr_01182|M.leprae_Br4923 -
Mflv_0325|M.gilvum_PYR-GCK P
Mvan_0415|M.vanbaalenii_PYR-1 Q
MSMEG_0619|M.smegmatis_MC2_155 R
MAB_2254c|M.abscessus_ATCC_199 -
TH_3113|M.thermoresistible__bu -