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DFGVLPPEINSGRMYAGPGSGPMMAAAAAWDSLAAELGLAAGGYRLAISELTGAYWAGPAAASMVAAVTP YVAWLSATAGQAEQAGMQARAAAAAYELAFAMTVPPPVVVANRALLVALVATNFFGQNTPAIAATEAQYA EMWAQDAAAMYAYAGSAAIATELTPFTAAPVTTSPAALAGQAAATVSSTVPPLATTAAVPQLLQQLSSTS LIPWYSALQQWLAENLLGLTPDNRMTIVRLLGISYFDEGLLQFEASLAQQAIPGTPGGAGDSGSSVLDSW GPTIFAGPRASPSVAGGGAVGGVQTPQPYWYWALDRESIGGSVSAALGKGSSAGSLSVPPDWAARARWAN PAAWRLPGDDVTALRGTAENALLRGFPMASAGQSTGGGFVHKYGFRLAVMQRPPFAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2892c | PPE45 | - | 100% (408) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1787 | PPE25 | e-102 | 50.98% (408) | PPE family protein |
| M. tuberculosis H37Rv | Rv1790 | PPE27 | 8e-97 | 49.63% (409) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2916c | PPE45 | 0.0 | 100.00% (408) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 8e-30 | 35.06% (231) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-45 | 33.73% (421) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 7e-31 | 41.04% (173) | PPE family protein |
| M. marinum M | MMAR_1905 | - | 1e-102 | 52.77% (415) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 2e-95 | 47.19% (445) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-30 | 35.89% (209) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-31 | 42.08% (183) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2129 | - | 1e-103 | 52.77% (415) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-35 | 30.89% (395) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2892c|M.tuberculosis_H37Rv -------------MDFGVLPPEINSGRMYAGPGSGPMMAAAAAWDSLAAE
Mb2916c|M.bovis_AF2122/97 -------------MDFGVLPPEINSGRMYAGPGSGPMMAAAAAWDSLAAE
MMAR_1905|M.marinum_M ----------MAHADYGARPPEINSALMYFGPGSRSMLAAAAAWDAVAFE
MUL_2129|M.ulcerans_Agy99 ----------MAHADYGARPPEINSALMYFGPGSRSMLAAAAAWDAVAFE
MAV_2928|M.avium_104 ------------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
. .** :* : ***. .: :*. * :. .
Rv2892c|M.tuberculosis_H37Rv LGLAAGGYRLAISELTGAYWAGPAAASMVAAVTPYVAWLSATAGQAEQAG
Mb2916c|M.bovis_AF2122/97 LGLAAGGYRLAISELTGAYWAGPAAASMVAAVTPYVAWLSATAGQAEQAG
MMAR_1905|M.marinum_M LGVLASGYTSVISELTSGPWVGPAAASMVGASAPYVAWLRASAIRAERTA
MUL_2129|M.ulcerans_Agy99 LGVLASGYTSVISELTSGPWVGPAAASMVGASAPYVAWLRASAIRAERTA
MAV_2928|M.avium_104 LGIAASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* : : * .: . ** ** : . .
Rv2892c|M.tuberculosis_H37Rv MQARAAAAAYELAFAMTVPPPVVVANRALLVALVATNFFGQNTPAIAATE
Mb2916c|M.bovis_AF2122/97 MQARAAAAAYELAFAMTVPPPVVVANRALLVALVATNFFGQNTPAIAATE
MMAR_1905|M.marinum_M SQARSAAAAYEAAFVMTVPPPVVAANRVLLTTLIVTNFFGQNTPAIAVTE
MUL_2129|M.ulcerans_Agy99 SQARSAAAAYEAAFVMTVPPPVVAANRVLLTTLIVTNFFGQNTPAIAVTE
MAV_2928|M.avium_104 SQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* ** *. *:. . : *:. *: :*::* *: .* .*
Rv2892c|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYAYAGSAAIAT-ELTPFTAAPVTTSPAALAGQAAAT
Mb2916c|M.bovis_AF2122/97 AQYAEMWAQDAAAMYAYAGSAAIAT-ELTPFTAAPVTTSPAALAGQAAAT
MMAR_1905|M.marinum_M AQYAEMWAQDAAAMYGYAASSATAT-RLTPFVPPPATTNLPGPLWQASAM
MUL_2129|M.ulcerans_Agy99 AQYAEMWAQDAAAMYGYAASSATAT-RLTPFVPPPATTNLPGPLWQASAM
MAV_2928|M.avium_104 AQYMEMWAQDAAAMYGYAAASQTAS-TLSPFAAPPNTTAPEGESDQAAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:* .** * *::* * * ...*
Rv2892c|M.tuberculosis_H37Rv VSSTVPPL---ATTAAVPQLLQQLS----STSLIPWYSALQQWLAEN---
Mb2916c|M.bovis_AF2122/97 VSSTVPPL---ATTAAVPQLLQQLS----STSLIPWYSALQQWLAEN---
MMAR_1905|M.marinum_M GKAATT-----TAVAGGSTLLAATR----RPVALPRLAALAQWLEAH---
MUL_2129|M.ulcerans_Agy99 GKAATT-----TAVAGGSTLLAATR----RPVALPRLAALAQWLEAH---
MAV_2928|M.avium_104 SQAMAQPAGSTAQTAANTSSQLATP----QALSAGTSQAATQASSSS---
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVAT---
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Rv2892c|M.tuberculosis_H37Rv ---------------LLGLTPDNRMT-IVRLLGISYFDEGLLQFE-----
Mb2916c|M.bovis_AF2122/97 ---------------LLGLTPDNRMT-IVRLLGISYFDEGLLQFE-----
MMAR_1905|M.marinum_M ---------------LPGITPAERTT-VVRLLGQSYFALGMVQFS-----
MUL_2129|M.ulcerans_Agy99 ---------------LPGITPAERTT-VVRLLGQSYFALGMVQFS-----
MAV_2928|M.avium_104 ---------------ASQTGPFTWLTSALQNLQQSGLPTPTNNYLG----
MLBr_01182|M.leprae_Br4923 ---------------PQTAVPDSSSAAAPQLWGGFAQHLSPIN-------
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
:
Rv2892c|M.tuberculosis_H37Rv ----------ASLAQQAIPGTPGG----------------------AGDS
Mb2916c|M.bovis_AF2122/97 ----------ASLAQQAIPGTPGG----------------------AGDS
MMAR_1905|M.marinum_M ----------TSIALQAIPGTASG----------------------AGAS
MUL_2129|M.ulcerans_Agy99 ----------TSIALQAIPGTASG----------------------AGGS
MAV_2928|M.avium_104 ---------LSPTFYTVMLKQTSG----------------------LGYF
MLBr_01182|M.leprae_Br4923 -------------DTLSMINNHAG----------------------MANA
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
Rv2892c|M.tuberculosis_H37Rv GSSVLDSWGPTIFAGPRASPSVAGGGAVGGVQTPQPYWYWALDRESIGGS
Mb2916c|M.bovis_AF2122/97 GSSVLDSWGPTIFAGPRASPSVAGGGAVGGVQTPQPYWYWALDRESIGGS
MMAR_1905|M.marinum_M GSSVVDNWG-SMLHG-------AHGGATAEFEE---------DLGTLTRP
MUL_2129|M.ulcerans_Agy99 GSSVVDNWG-SMLHG-------AHGGAAAEFEE---------DLGTLTRP
MAV_2928|M.avium_104 SNGITAFWSQLAQQLVSGPGGSTAGAGGAWYPTPQFASLGLGNLGSVGGA
MLBr_01182|M.leprae_Br4923 GLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRG--LLGSSSGG
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
Rv2892c|M.tuberculosis_H37Rv --VSAALGKGSSAGSLSVPPDWAARARWANPAAWRLP---GDDVTALRGT
Mb2916c|M.bovis_AF2122/97 --VSAALGKGSSAGSLSVPPDWAARARWANPAAWRLP---GDDVTALRGT
MMAR_1905|M.marinum_M --VSAAMGKARLTGSLSTPSSWGAGVREFANAAADEQ---LDLAGSVASA
MUL_2129|M.ulcerans_Agy99 --VSAAMGKARLTGSLSTPSSWGAGVREFANAAADEQ---LDLAGSVASA
MAV_2928|M.avium_104 SHVSAISAGAGRAGALSVPQQWATLTSAVSPAVSEEGSAVQAAAGGAPGG
MLBr_01182|M.leprae_Br4923 -HVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALS---PARVAVATES
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
.. .
Rv2892c|M.tuberculosis_H37Rv AENALLRG---------------------------------FPMASAG-Q
Mb2916c|M.bovis_AF2122/97 AENALLRG---------------------------------FPMASAG-Q
MMAR_1905|M.marinum_M KSNAYLQG---------------------------------MPMTAAG-R
MUL_2129|M.ulcerans_Agy99 KSNAYLQG---------------------------------MPMTAAG-R
MAV_2928|M.avium_104 AANGLLRG---------------------------------MPVGALGRR
MLBr_01182|M.leprae_Br4923 ESAPLLGGGL-----------------------------PMAPMVPGGGS
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
*
Rv2892c|M.tuberculosis_H37Rv STG-GGFVHKYGFRLAVMQRPPFAG-------------------------
Mb2916c|M.bovis_AF2122/97 STG-GGFVHKYGFRLAVMQRPPFAG-------------------------
MMAR_1905|M.marinum_M NT--AVAEQKYGFRYRVMQRTPAGG-------------------------
MUL_2129|M.ulcerans_Agy99 NT--AVAEQKYGFRYRVMQRTPAGG-------------------------
MAV_2928|M.avium_104 GAA-AGYVNKYGFRYSVLTRPPSAG-------------------------
MLBr_01182|M.leprae_Br4923 GTGGVNTALRLQPRAFVMPRNPAAG-------------------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
: . .
Rv2892c|M.tuberculosis_H37Rv ---------------
Mb2916c|M.bovis_AF2122/97 ---------------
MMAR_1905|M.marinum_M ---------------
MUL_2129|M.ulcerans_Agy99 ---------------
MAV_2928|M.avium_104 ---------------
MLBr_01182|M.leprae_Br4923 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------