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SFLVLPPEVNSALMFAGAGSGPTLAAAAAWDGLAAELGQAANSFSSATAALADTAWQGPAATAMAAAAAP YASWLSTAATRALSAAAQAKAAAAVYEAARAATVDPLLVAANRHQLVSLVLSNLFGQNAPAIAATEAAYE QLWAADVAAMVSYHSGASAVAAQLAPWAQAVRALPNPTAPALASGPAALAIPALGIGNTGIGNIFSIGNI GDYNLGNGNTGNANLGSGNTGQANLGSGNTGFFNFGSGNTANTNFGSGNLGNLNLGSGNDGNGNFGLGNI GDGNRGSGNVGSFNFGTANAGSFNVGSANHGSPNVGFANLGNNNLGIANLGNNNLGIANLGNNNIGIGLT GDNMIGIGALNSGIGNLGFGNSGNNNIGLFNSGNNNIGFFNSGDSNFGFFNSGDTNTGFGNAGFTNTGFG NAGSGNFGFGNAGNNNFGFGNSGFENMGVGNSGAYNTGSFNSGTLNTGDLNSGDFNTGWANSGDINTGGF HSGDLNTGFGSPVDQPVMNSGFGNIGTGNSGFNNSGDANSGFQNTNTGAFFIGHSGLLNSGGGQHVGISN SGTGFNTGLFNTGFNNTGIGNSATNAAFTTTSGVANSGDNSSGGFNAGNDQSGFFDG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1135c | PPE16 | - | 100% (618) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3159c | PPE53 | 0.0 | 64.02% (617) | PPE family protein |
| M. tuberculosis H37Rv | Rv2356c | PPE40 | 0.0 | 59.27% (626) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1166c | PPE16 | 0.0 | 100.00% (618) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-22 | 34.68% (173) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-32 | 43.39% (189) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 6e-26 | 40.00% (165) | PPE family protein |
| M. marinum M | MMAR_4319 | - | 0.0 | 67.09% (635) | PPE family protein |
| M. avium 104 | MAV_4704 | - | 6e-50 | 52.58% (194) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-25 | 37.95% (166) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 5e-26 | 38.14% (194) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0964 | - | 0.0 | 66.14% (635) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-26 | 39.42% (208) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
Rv1135c|M.tuberculosis_H37Rv ----------MS---FLVLPPEVNSALMFAGAGSGPTLAAAAAWDGLAAE
Mb1166c|M.bovis_AF2122/97 ----------MS---FLVLPPEVNSALMFAGAGSGPTLAAAAAWDGLAAE
MMAR_4319|M.marinum_M ----------MN---FMMLPPEVNSALMFTGAGSAPTLAAATAWDGLAAE
MUL_0964|M.ulcerans_Agy99 ----------MN---FMMLPPEVNSALMFTGAGSAPTLAAATAWDGLVAE
MAV_4704|M.avium_104 ----------MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEE
MLBr_01182|M.leprae_Br4923 ----------MFD--FAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.**.:*: : *.*... :*. * * .
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
Rv1135c|M.tuberculosis_H37Rv LGQAANSFSSATAALADTAWQGPAATAMAAAAAPYASWLSTAATRALSAA
Mb1166c|M.bovis_AF2122/97 LGQAANSFSSATAALADTAWQGPAATAMAAAAAPYASWLSTAATRALSAA
MMAR_4319|M.marinum_M LGEAAEAFSSVTSGLASGSWQGPAAAAMAAAAAPYAGWLSAAATRALGAA
MUL_0964|M.ulcerans_Agy99 LGEAAEAFSSVTSGLASGSWQGPAAAAMAAAAAPYAGWLSAAATRALGAA
MAV_4704|M.avium_104 LASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVS
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
:* : : ::.* .: * ** : . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
Rv1135c|M.tuberculosis_H37Rv AQAKAAAAVYEAARAATVDPLLVAANRHQLVSLVLSNLFGQNAPAIAATE
Mb1166c|M.bovis_AF2122/97 AQAKAAAAVYEAARAATVDPLLVAANRHQLVSLVLSNLFGQNAPAIAATE
MMAR_4319|M.marinum_M TQAKAAAAVFESAQAATVHPELVLANRNQLVSLVLSNLFGQNAPAIAATE
MUL_0964|M.ulcerans_Agy99 TQAKAAAAVFESAQAATVHPELVLANRNQLVSLVLSNLFGQNAPAIAATE
MAV_4704|M.avium_104 HQASAIATAFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
* . * .. * : : *: * :* :* *: .* *
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
Rv1135c|M.tuberculosis_H37Rv AAYEQLWAADVAAMVSYHSGASAVAAQLAPWAQAVRALPNPTAPALASGP
Mb1166c|M.bovis_AF2122/97 AAYEQLWAADVAAMVSYHSGASAVAAQLAPWAQAVRALPNPTAPALASGP
MMAR_4319|M.marinum_M STYEELWAQDVAAMVGYHGGASAVAAQLAPWQQAIQALPGRVAAMATTGP
MUL_0964|M.ulcerans_Agy99 STYEELWAQDVAATVGYHGGASAVAAQLAPWQQAIQALPGRVAAMATTGP
MAV_4704|M.avium_104 AAYEQMWASDVAAMFGYHADASAAVAKLPPWNEVLQNLGFSNASTAVTRP
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
: * .:* .:: *. . . :
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQP-----------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQA-----------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQA-----------------------------------------
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDD-----------------------------------------
TH_3113|M.thermoresistible__bu TGAHVTAEL-----------------------------------------
Rv1135c|M.tuberculosis_H37Rv AALAIPALG--------IGNTGIGNIFSIGNIGDYNLGNGNTGNANLGSG
Mb1166c|M.bovis_AF2122/97 AALAIPALG--------IGNTGIGNIFSIGNIGDYNLGNGNTGNANLGSG
MMAR_4319|M.marinum_M AASAAAALASGPAAALGIGNNGSGNFLSIGNIGNNNLGSGNTGSANLGGG
MUL_0964|M.ulcerans_Agy99 AASAAAALASGPAAALDIGNNGSGNFLSIGNIGNNNLGSGNTGSANLGGG
MAV_4704|M.avium_104 AGSGAVARG-----------------------------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEV-----------------------------------------
Mflv_0325|M.gilvum_PYR-GCK --MAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR----------
Mvan_0415|M.vanbaalenii_PYR-1 --QAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR----------
MSMEG_0619|M.smegmatis_MC2_155 --TAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK----------
MAB_0809c|M.abscessus_ATCC_199 --HDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG----------
TH_3113|M.thermoresistible__bu --RAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLLAPLLPGA
Rv1135c|M.tuberculosis_H37Rv NTGQANLGSGNTGFFNFGSGNTANTNFGSGNLGNLNLGSGNDGNGNFGLG
Mb1166c|M.bovis_AF2122/97 NTGQANLGSGNTGFFNFGSGNTANTNFGSGNLGNLNLGSGNDGNGNFGLG
MMAR_4319|M.marinum_M NIGNGNLGSGNTGNVNLGNGNNGFFNFGNGNLGDTNFGSGNSGNLNLGSG
MUL_0964|M.ulcerans_Agy99 NIGNGNLGSGNTGNVNLGNGNNGFFNFGNGNLGDTNFGSGNSGNLNLGSG
MAV_4704|M.avium_104 ------YTSRIAGFLAPRAPQ-----------------------------
MLBr_01182|M.leprae_Br4923 -VEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVPDS---
Mflv_0325|M.gilvum_PYR-GCK ----DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGAS
Mvan_0415|M.vanbaalenii_PYR-1 ----DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGAS
MSMEG_0619|M.smegmatis_MC2_155 ----DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWG
MAB_0809c|M.abscessus_ATCC_199 ----EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----AQLASTI
TH_3113|M.thermoresistible__bu TGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAVSGMLAQL
Rv1135c|M.tuberculosis_H37Rv N-IGDGNRGSGN-VGSFNFGTANAGSFNVGSANHGSPNVGFANLGNNNLG
Mb1166c|M.bovis_AF2122/97 N-IGDGNRGSGN-VGSFNFGTANAGSFNVGSANHGSPNVGFANLGNNNLG
MMAR_4319|M.marinum_M NRFGSGNIGFGNRFGDGNFGSGNAGSYNFGTGNNGSFNIGSGNNGDSNIG
MUL_0964|M.ulcerans_Agy99 NRFGSGNIGFGNRFGDGNFGSGNAGSYNFGTGNNGSFNIGSGNNGDSNIG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 -------------------SSAAAPQLWGGFAQHLSPINDTLSMINNHAG
Mflv_0325|M.gilvum_PYR-GCK ILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEAAEEPAPA
Mvan_0415|M.vanbaalenii_PYR-1 ILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAPAEEPAAS
MSMEG_0619|M.smegmatis_MC2_155 MIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEAPQEVAAA
MAB_0809c|M.abscessus_ATCC_199 GQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPM
TH_3113|M.thermoresistible__bu VPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGGASAAPVP
Rv1135c|M.tuberculosis_H37Rv IANLGNNNLGIANLGNNNIGIGLTGDNMIGIGALNSGIGNLGFGNSGNNN
Mb1166c|M.bovis_AF2122/97 IANLGNNNLGIANLGNNNIGIGLTGDNMIGIGALNSGIGNLGFGNSGNNN
MMAR_4319|M.marinum_M FGNFGTNNLGFGNNGSNNIGFGLSGSNQIGIGGLNAGIGNMGFGNAGDNN
MUL_0964|M.ulcerans_Agy99 FGNLGTNNLGFGNNGSNNIGFGLSGSNQIGIGGLNAGIGNMGFGNAGDNN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 MANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSS
Mflv_0325|M.gilvum_PYR-GCK QSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATF
Mvan_0415|M.vanbaalenii_PYR-1 SPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASF
MSMEG_0619|M.smegmatis_MC2_155 P----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATF
MAB_0809c|M.abscessus_ATCC_199 AASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PPVGDPGFS
TH_3113|M.thermoresistible__bu AGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPPAPHSAPP
Rv1135c|M.tuberculosis_H37Rv IGLFNSGNNNIGFFNSGDSNFGFFNSGDTNTGFGNAGFTNTGFGNAGSGN
Mb1166c|M.bovis_AF2122/97 IGLFNSGNNNIGFFNSGDSNFGFFNSGDTNTGFGNAGFTNTGFGNAGSGN
MMAR_4319|M.marinum_M VGFFNSGSNNIGFFNSGDGNFGFANAGSTNTGFWNSGGTNTGFGNGGSLN
MUL_0964|M.ulcerans_Agy99 VGFFNSGSNNIGFFNSGDGNFGFAHAGSTNTGFWNSGGTNTGFGNGGSLN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 GGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPAR---------
Mflv_0325|M.gilvum_PYR-GCK VPYVVAGRD----------------------PYEGFSPTVRDSTGAKAPA
Mvan_0415|M.vanbaalenii_PYR-1 VPYAVAGRD----------------------PGTGFSPTVRDSTSAKAPA
MSMEG_0619|M.smegmatis_MC2_155 VPYAVANRD----------------------PGEGFTPTLGNKSQVAAPA
MAB_0809c|M.abscessus_ATCC_199 FPYAVGGGPR---------------------LGTGLALAAQVRRGTSAAA
TH_3113|M.thermoresistible__bu VGTSGPPYLI---------------------AAQPAPGVARRSAGARRAA
Rv1135c|M.tuberculosis_H37Rv FGFGNAGNNNFGFGNSGFENMGVGNSGAYNTGSFNSGTLNTGDLNSGDFN
Mb1166c|M.bovis_AF2122/97 FGFGNAGNNNFGFGNSGFENMGVGNSGAYNTGSFNSGTLNTGDLNSGDFN
MMAR_4319|M.marinum_M FGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNTGFSNAGETN
MUL_0964|M.ulcerans_Agy99 FGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNTGFSNAAETN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 ------------------------------------VAVATESESAPLLG
Mflv_0325|M.gilvum_PYR-GCK GTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPE
Mvan_0415|M.vanbaalenii_PYR-1 SGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPV
MSMEG_0619|M.smegmatis_MC2_155 SGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAP
MAB_0809c|M.abscessus_ATCC_199 RSSAREQAAAAETAAARQARRRRDKGKQQGRG-----IEYMDMNATARCE
TH_3113|M.thermoresistible__bu SIVEPAGSAAAAAAARESAPIRRRRGQKDGLHG--------HRHEHQQPA
Rv1135c|M.tuberculosis_H37Rv TGWANSGDINTGGFHSGDLNTGFGSPVDQPVMNSGFGNIGTGNSGFNNSG
Mb1166c|M.bovis_AF2122/97 TGWANSGDINTGGFHSGDLNTGFGSPVDQPVMNSGFGNIGTGNSGFNNSG
MMAR_4319|M.marinum_M TGWENSGNVNTGGYNSGGLNTGIGSPDTQAGPNSGFGHSGSGNSGFFNSG
MUL_0964|M.ulcerans_Agy99 TGWENSGNVNTGGYNSGGLNTGIGSPDTQAGPNSGFGHSGSGNSGFFNSG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 GGLPMAPMVPGGGSGTGGVNTALR----------------LQPRAFVMPR
Mflv_0325|M.gilvum_PYR-GCK QPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPML
Mvan_0415|M.vanbaalenii_PYR-1 RQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPML
MSMEG_0619|M.smegmatis_MC2_155 QPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPML
MAB_0809c|M.abscessus_ATCC_199 EPAPDTTASHRGAGTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMV
TH_3113|M.thermoresistible__bu SMSAATAPSAAGIRVLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRA
Rv1135c|M.tuberculosis_H37Rv DANSGFQNTNTGAFFIGHSGLLNSGGGQHVGISNSGTGFNTGLFNTGFNN
Mb1166c|M.bovis_AF2122/97 DANSGFQNTNTGAFFIGHSGLLNSGGGQHVGISNSGTGFNTGLFNTGFNN
MMAR_4319|M.marinum_M DGNSGFQNSNTGVSANGHSGVRNSGDATNVGFSNSGS-NNTGIFNTGTFN
MUL_0964|M.ulcerans_Agy99 DGNSGFENSNTCVSANGHSGVRNSGDATNVGFSNSGS-NNTGIFNTGTFN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 NPAAG---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK PGTWDPDATDDRHTDGRDGHDGHDGKEKP------------
Mvan_0415|M.vanbaalenii_PYR-1 PGTWDPDTEPD------ERHNHHDGKDSQ------------
MSMEG_0619|M.smegmatis_MC2_155 PGTWDGDENPAP------SPDDPEGGPRR------------
MAB_0809c|M.abscessus_ATCC_199 PNTWDP------------EHGRQD-----------------
TH_3113|M.thermoresistible__bu HRPAEPN----------------------------------
Rv1135c|M.tuberculosis_H37Rv TGIGNSATNAAFTTTSGVANSGDNSSGGFNAGNDQSGFFDG
Mb1166c|M.bovis_AF2122/97 TGIGNSATNAAFTTTSGVANSGDNSSGGFNAGNDQSGFFDG
MMAR_4319|M.marinum_M TGIANSGS-----DSSGLLISGTNSSGALNSGDDQSGFNN-
MUL_0964|M.ulcerans_Agy99 TGIANSGS-----DSSGLLISGTNSSGALNSGDDQSGFNN-
MAV_4704|M.avium_104 -----------------------------------------
MLBr_01182|M.leprae_Br4923 -----------------------------------------