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MNFMMLPPEVNSALMFTGAGSAPTLAAATAWDGLAAELGEAAEAFSSVTSGLASGSWQGPAAAAMAAAAA PYAGWLSAAATRALGAATQAKAAAAVFESAQAATVHPELVLANRNQLVSLVLSNLFGQNAPAIAATESTY EELWAQDVAAMVGYHGGASAVAAQLAPWQQAIQALPGRVAAMATTGPAASAAAALASGPAAALGIGNNGS GNFLSIGNIGNNNLGSGNTGSANLGGGNIGNGNLGSGNTGNVNLGNGNNGFFNFGNGNLGDTNFGSGNSG NLNLGSGNRFGSGNIGFGNRFGDGNFGSGNAGSYNFGTGNNGSFNIGSGNNGDSNIGFGNFGTNNLGFGN NGSNNIGFGLSGSNQIGIGGLNAGIGNMGFGNAGDNNVGFFNSGSNNIGFFNSGDGNFGFANAGSTNTGF WNSGGTNTGFGNGGSLNFGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNTGFSNAGETNTGW ENSGNVNTGGYNSGGLNTGIGSPDTQAGPNSGFGHSGSGNSGFFNSGDGNSGFQNSNTGVSANGHSGVRN SGDATNVGFSNSGSNNTGIFNTGTFNTGIANSGSDSSGLLISGTNSSGALNSGDDQSGFNN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4319 | - | - | 100% (621) | PPE family protein |
| M. marinum M | MMAR_1139 | - | 0.0 | 65.02% (629) | PPE family protein |
| M. marinum M | MMAR_4320 | - | 0.0 | 62.31% (666) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1166c | PPE16 | 0.0 | 67.09% (635) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 2e-30 | 27.09% (609) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv1135c | PPE16 | 0.0 | 67.09% (635) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-30 | 43.98% (166) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 2e-24 | 36.90% (168) | PPE-family protein |
| M. avium 104 | MAV_4704 | - | 2e-53 | 55.44% (193) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 5e-31 | 29.55% (528) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-27 | 37.07% (205) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0964 | - | 0.0 | 98.71% (621) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-35 | 27.97% (615) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4319|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
Mb1166c|M.bovis_AF2122/97 --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MMAR_4319|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
Mb1166c|M.bovis_AF2122/97 --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MMAR_4319|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
Mb1166c|M.bovis_AF2122/97 --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MMAR_4319|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
Mb1166c|M.bovis_AF2122/97 --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MMAR_4319|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
Mb1166c|M.bovis_AF2122/97 --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MMAR_4319|M.marinum_M ------MN---FMMLPPEVNSALMFTGAGSAP---TLAAATAWDGLAAEL
MUL_0964|M.ulcerans_Agy99 ------MN---FMMLPPEVNSALMFTGAGSAP---TLAAATAWDGLVAEL
Mb1166c|M.bovis_AF2122/97 ------MS---FLVLPPEVNSALMFAGAGSGP---TLAAAAAWDGLAAEL
Rv1135c|M.tuberculosis_H37Rv ------MS---FLVLPPEVNSALMFAGAGSGP---TLAAAAAWDGLAAEL
MAV_4704|M.avium_104 ------MTNPHFAWLPPEVNSALIYSGPGPGP---LLAAAAAWDGLAEEL
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSP---ILTAAAAWVVLAKEL
MAB_0669|M.abscessus_ATCC_1997 ------MTAPIWMAEPPEVHSALLSAGPGPGA---VLAAAVQWQEIGNNY
TH_3569|M.thermoresistible__bu -----MMTAPIWMALPPEVHSALLSSGPGPGS---LLAAASAWHALSAEY
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
: .. * . :
MMAR_4319|M.marinum_M GEAAEAFSSVTSGLASGSWQGPAAAAMAAAAAPYAGWLSAAATRALGAAT
MUL_0964|M.ulcerans_Agy99 GEAAEAFSSVTSGLASGSWQGPAAAAMAAAAAPYAGWLSAAATRALGAAT
Mb1166c|M.bovis_AF2122/97 GQAANSFSSATAALADTAWQGPAATAMAAAAAPYASWLSTAATRALSAAA
Rv1135c|M.tuberculosis_H37Rv GQAANSFSSATAALADTAWQGPAATAMAAAAAPYASWLSTAATRALSAAA
MAV_4704|M.avium_104 ASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVSH
MLBr_01182|M.leprae_Br4923 TAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTAT
MAB_0669|M.abscessus_ATCC_1997 ANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIAA
TH_3569|M.thermoresistible__bu ASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATAG
Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
. : * . : :
MMAR_4319|M.marinum_M QAKAAAAVFESAQAATVHPELVLANRNQLVSLVLSN-------------L
MUL_0964|M.ulcerans_Agy99 QAKAAAAVFESAQAATVHPELVLANRNQLVSLVLSN-------------L
Mb1166c|M.bovis_AF2122/97 QAKAAAAVYEAARAATVDPLLVAANRHQLVSLVLSN-------------L
Rv1135c|M.tuberculosis_H37Rv QAKAAAAVYEAARAATVDPLLVAANRHQLVSLVLSN-------------L
MAV_4704|M.avium_104 QASAIATAFEVALAATVQPAVVAANRALVQALAATN-------------W
MLBr_01182|M.leprae_Br4923 QLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSN-------------I
MAB_0669|M.abscessus_ATCC_1997 QHETTAAAYNSALAAMPTLAELAANHITHGVLVGTN-------------F
TH_3569|M.thermoresistible__bu RHETAAAAYSTALATMPTMAELTLNKTTHAVLVATN-------------F
Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
MMAR_4319|M.marinum_M FGQNAPAIAATESTYEELWAQDVAAMVGYHGGASAVAAQLAPWQ------
MUL_0964|M.ulcerans_Agy99 FGQNAPAIAATESTYEELWAQDVAATVGYHGGASAVAAQLAPWQ------
Mb1166c|M.bovis_AF2122/97 FGQNAPAIAATEAAYEQLWAADVAAMVSYHSGASAVAAQLAPWA------
Rv1135c|M.tuberculosis_H37Rv FGQNAPAIAATEAAYEQLWAADVAAMVSYHSGASAVAAQLAPWA------
MAV_4704|M.avium_104 LGQNTPAIADIEAAYEQMWASDVAAMFGYHADASAAVAKLPPWN------
MLBr_01182|M.leprae_Br4923 FGQNSTAIAEKEAEYTEMWIQDAAAMTSYQASVLEAVGATKAFT------
MAB_0669|M.abscessus_ATCC_1997 FGINTIPIALNEADYVRMWVQAAATMSAYQATTEAMTSAIPPTQ------
TH_3569|M.thermoresistible__bu LGINTIPIALNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASS------
Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG------
Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG------
MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
.* . . .
MMAR_4319|M.marinum_M -----------------------------------QAIQALPGRVAAMAT
MUL_0964|M.ulcerans_Agy99 -----------------------------------QAIQALPGRVAAMAT
Mb1166c|M.bovis_AF2122/97 -----------------------------------QAVRALPNPTAPALA
Rv1135c|M.tuberculosis_H37Rv -----------------------------------QAVRALPNPTAPALA
MAV_4704|M.avium_104 -----------------------------------EVLQNLGFSNASTAV
MLBr_01182|M.leprae_Br4923 -----------------------------------APPLGVNEVGLAQEV
MAB_0669|M.abscessus_ATCC_1997 -----------------------------------QPPAILSPGGEARSD
TH_3569|M.thermoresistible__bu -----------------------------------PAPLLLAPG---VSE
Mflv_5091|M.gilvum_PYR-GCK -AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGLG
Mvan_1264|M.vanbaalenii_PYR-1 -VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTAG
MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
MMAR_4319|M.marinum_M TGPAASAAAALASG------------------------------------
MUL_0964|M.ulcerans_Agy99 TGPAASAAAALASG------------------------------------
Mb1166c|M.bovis_AF2122/97 SGPAALAIPALG--------------------------------------
Rv1135c|M.tuberculosis_H37Rv SGPAALAIPALG--------------------------------------
MAV_4704|M.avium_104 TRPAGSGAVARG--------------------------------------
MLBr_01182|M.leprae_Br4923 VEEVVEEVVEEV--------------------------------------
MAB_0669|M.abscessus_ATCC_1997 QSDVPGSPDQIMK-------------------------------------
TH_3569|M.thermoresistible__bu AADAMATTQQIGS-------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGAG
Mvan_1264|M.vanbaalenii_PYR-1 ETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGVG
MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
MMAR_4319|M.marinum_M ------------------PAAALGIGNNGSGNFLSIGNIGNNNLGSGNTG
MUL_0964|M.ulcerans_Agy99 ------------------PAAALDIGNNGSGNFLSIGNIGNNNLGSGNTG
Mb1166c|M.bovis_AF2122/97 ------------------------IGNTGIGNIFSIGNIGDYNLGNGNTG
Rv1135c|M.tuberculosis_H37Rv ------------------------IGNTGIGNIFSIGNIGDYNLGNGNTG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 ------------------------------------------------VE
MAB_0669|M.abscessus_ATCC_1997 -----------------------------------------------MLQ
TH_3569|M.thermoresistible__bu -----------------------------------------------QAT
Mflv_5091|M.gilvum_PYR-GCK ----------STGAVGG-------VGGKG----IQGGQG-----------
Mvan_1264|M.vanbaalenii_PYR-1 ----------ATGGAGG-------VGGKG----IQGGQG-----------
MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA
MMAR_4319|M.marinum_M SANLGGGNIGNGNLGSGNTGNVNLG--------------------NGNNG
MUL_0964|M.ulcerans_Agy99 SANLGGGNIGNGNLGSGNTGNVNLG--------------------NGNNG
Mb1166c|M.bovis_AF2122/97 NANLGSGNTGQANLGSGNTGFFNFG--------------------SGNTA
Rv1135c|M.tuberculosis_H37Rv NANLGSGNTGQANLGSGNTGFFNFG--------------------SGNTA
MAV_4704|M.avium_104 -------------YTSRIAGFLAPR--------------------APQ--
MLBr_01182|M.leprae_Br4923 AEQAISQAALDQAVNEGMEATVVPQ--------------------VDQQV
MAB_0669|M.abscessus_ATCC_1997 GFQQWFEKMGFNPATSAVLAVIMLF--------------------LYDLL
TH_3569|M.thermoresistible__bu ------------AADSGTALNLSDL--------------------IANLL
Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK
Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK
MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV
MMAR_4319|M.marinum_M FFNFGNGNLGDTNF------------------------------------
MUL_0964|M.ulcerans_Agy99 FFNFGNGNLGDTNF------------------------------------
Mb1166c|M.bovis_AF2122/97 NTNFGSGNLGNLNL------------------------------------
Rv1135c|M.tuberculosis_H37Rv NTNFGSGNLGNLNL------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 NVDVATPQTAVP--------------------------------------
MAB_0669|M.abscessus_ATCC_1997 WYPYYASYLLPFLI------------------------------------
TH_3569|M.thermoresistible__bu QY--YQDYLDQLFG------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD-----------
Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN-----------
MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP
MMAR_4319|M.marinum_M ---------------------GSGNSGNLNLGSGNRFGSGNIGFGNRFGD
MUL_0964|M.ulcerans_Agy99 ---------------------GSGNSGNLNLGSGNRFGSGNIGFGNRFGD
Mb1166c|M.bovis_AF2122/97 ---------------------GSGNDGNGNFGLGN-IGDGNRGSGN-VGS
Rv1135c|M.tuberculosis_H37Rv ---------------------GSGNDGNGNFGLGN-IGDGNRGSGN-VGS
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 ---------------------PALSGLSGLAALMH---------------
TH_3569|M.thermoresistible__bu ---------------------PIVDFLR----------------------
Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG---------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG---------------
MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ
MMAR_4319|M.marinum_M GNFGSGNAGSYNFGTGNNGSFNIGSGNNGDSNIGFGNFGTNNLGFGNNGS
MUL_0964|M.ulcerans_Agy99 GNFGSGNAGSYNFGTGNNGSFNIGSGNNGDSNIGFGNLGTNNLGFGNNGS
Mb1166c|M.bovis_AF2122/97 FNFGTANAGSFNVGSANHGSPNVGFANLGNNNLGIANLGNNNLGIANLGN
Rv1135c|M.tuberculosis_H37Rv FNFGTANAGSFNVGSANHGSPNVGFANLGNNNLGIANLGNNNLGIANLGN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 -DSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAM
MAB_0669|M.abscessus_ATCC_1997 -LRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSSVVPSGGSS
TH_3569|M.thermoresistible__bu -------------------DPIGNLFQLIDDFLTN---PAGALVT----W
Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG
MMAR_4319|M.marinum_M NNIGFGLSGSNQ-----IGIGGLNAGIGNMG-------------------
MUL_0964|M.ulcerans_Agy99 NNIGFGLSGSNQ-----IGIGGLNAGIGNMG-------------------
Mb1166c|M.bovis_AF2122/97 NNIGIGLTGDNM-----IGIGALNSGIGNLG-------------------
Rv1135c|M.tuberculosis_H37Rv NNIGIGLTGDNM-----IGIGALNSGIGNLG-------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 KSLAPTTTKAAE-----SAFKAMGSAVQSTG-------------------
MAB_0669|M.abscessus_ATCC_1997 VPVSTPTAPAHT-----VSSVPAPSAAISYA-------------------
TH_3569|M.thermoresistible__bu WPLLFAVAYQVF-----TNLVGWPTWAMILA-------------------
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155 GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGG
MMAR_4319|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
Mb1166c|M.bovis_AF2122/97 --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AG-----------DGTGGTGGTGG----TGGQGGQGGQGG----------
Mvan_1264|M.vanbaalenii_PYR-1 AG-----------DGLGGTGGTGG----TGGFGGQGGQGG----------
MSMEG_0868|M.smegmatis_MC2_155 AGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIG
MMAR_4319|M.marinum_M -------------------------------------------------F
MUL_0964|M.ulcerans_Agy99 -------------------------------------------------F
Mb1166c|M.bovis_AF2122/97 -------------------------------------------------F
Rv1135c|M.tuberculosis_H37Rv -------------------------------------------------F
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 -------------------------------------------------R
MAB_0669|M.abscessus_ATCC_1997 -------------------------------------------------I
TH_3569|M.thermoresistible__bu -------------------------------------------------S
Mflv_5091|M.gilvum_PYR-GCK -------TGGTGGQGG-LGGGGGTG-----------------------GQ
Mvan_1264|M.vanbaalenii_PYR-1 -------TGGTGGQGG-LGGVGGTG-----------------------GT
MSMEG_0868|M.smegmatis_MC2_155 SNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGH
MMAR_4319|M.marinum_M GNAGDNNVGFFNSGSNNIGFFNSGDGNFGFANAGSTNTGFWNSGGTNTGF
MUL_0964|M.ulcerans_Agy99 GNAGDNNVGFFNSGSNNIGFFNSGDGNFGFAHAGSTNTGFWNSGGTNTGF
Mb1166c|M.bovis_AF2122/97 GNSGNNNIGLFNSGNNNIGFFNSGDSNFGFFNSGDTNTGFGNAGFTNTGF
Rv1135c|M.tuberculosis_H37Rv GNSGNNNIGLFNSGNNNIGFFNSGDSNFGFFNSGDTNTGFGNAGFTNTGF
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 GLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPAR--
MAB_0669|M.abscessus_ATCC_1997 PGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRLRGKNKA
TH_3569|M.thermoresistible__bu PVLIPLAITLG------------------VAGLVMIADQAQP--------
Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGS
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGV
MSMEG_0868|M.smegmatis_MC2_155 GGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGD
MMAR_4319|M.marinum_M GNGGSLNFGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNTGF
MUL_0964|M.ulcerans_Agy99 GNGGSLNFGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNTGF
Mb1166c|M.bovis_AF2122/97 GNAGSGNFGFGNAGNNNFGFGNSGFENMGVGNSGAYNTGSFNSGTLNTGD
Rv1135c|M.tuberculosis_H37Rv GNAGSGNFGFGNAGNNNFGFGNSGFENMGVGNSGAYNTGSFNSGTLNTGD
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 -------------------------------------------VAVATES
MAB_0669|M.abscessus_ATCC_1997 EAGGRRHEYLEE-----------------------------TAGMGATAT
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKA
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTA
MSMEG_0868|M.smegmatis_MC2_155 GVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTL
MMAR_4319|M.marinum_M SNAGETNTGWENSGNVNTGGYNSGG----------LNTGIGSPDTQAGPN
MUL_0964|M.ulcerans_Agy99 SNAAETNTGWENSGNVNTGGYNSGG----------LNTGIGSPDTQAGPN
Mb1166c|M.bovis_AF2122/97 LNSGDFNTGWANSGDINTGGFHSGD----------LNTGFGSPVDQPVMN
Rv1135c|M.tuberculosis_H37Rv LNSGDFNTGWANSGDINTGGFHSGD----------LNTGFGSPVDQPVMN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 ESAPLLGGGLPMAPMVPGGGSGTGG----------VNTALRLQPRAFVMP
MAB_0669|M.abscessus_ATCC_1997 ADVPAYAATGRGTGPLGFAGTAPAA----------ASTHVAATVRLSSDE
TH_3569|M.thermoresistible__bu -------------------PAEEAA----------PEEDVAAPVRAEPQN
Mflv_5091|M.gilvum_PYR-GCK GATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATG
Mvan_1264|M.vanbaalenii_PYR-1 GVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGSAG
MSMEG_0868|M.smegmatis_MC2_155 GGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGG
MMAR_4319|M.marinum_M SGFGHSGSGNSG------------------FFNSGDGNSGFQNSNTGVSA
MUL_0964|M.ulcerans_Agy99 SGFGHSGSGNSG------------------FFNSGDGNSGFENSNTCVSA
Mb1166c|M.bovis_AF2122/97 SGFGNIGTGNSG------------------FNNSGDANSGFQNTNTGAFF
Rv1135c|M.tuberculosis_H37Rv SGFGNIGTGNSG------------------FNNSGDANSGFQNTNTGAFF
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 RNPAAG--------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 ARQVIPMLPSTW------------------DADGGDQN------------
TH_3569|M.thermoresistible__bu P------LPLTX------------------XX------------------
Mflv_5091|M.gilvum_PYR-GCK AAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA
Mvan_1264|M.vanbaalenii_PYR-1 SAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA
MSMEG_0868|M.smegmatis_MC2_155 AATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWV
MMAR_4319|M.marinum_M NGHSGVRNSGDATNVGFSNSGS-NNTGIFNTGTFNTGIANSGS-----DS
MUL_0964|M.ulcerans_Agy99 NGHSGVRNSGDATNVGFSNSGS-NNTGIFNTGTFNTGIANSGS-----DS
Mb1166c|M.bovis_AF2122/97 IGHSGLLNSGGGQHVGISNSGTGFNTGLFNTGFNNTGIGNSATNAAFTTT
Rv1135c|M.tuberculosis_H37Rv IGHSGLLNSGGGQHVGISNSGTGFNTGLFNTGFNNTGIGNSATNAAFTTT
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG-------
Mvan_1264|M.vanbaalenii_PYR-1 GATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG-------
MSMEG_0868|M.smegmatis_MC2_155 QAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKS
MMAR_4319|M.marinum_M SGLLISGTNSSGALNSGDDQSGFNN-------------------------
MUL_0964|M.ulcerans_Agy99 SGLLISGTNSSGALNSGDDQSGFNN-------------------------
Mb1166c|M.bovis_AF2122/97 SGVANSGDNSSGGFNAGNDQSGFFDG------------------------
Rv1135c|M.tuberculosis_H37Rv SGVANSGDNSSGGFNAGNDQSGFFDG------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGAG-
Mvan_1264|M.vanbaalenii_PYR-1 ----AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGAG-
MSMEG_0868|M.smegmatis_MC2_155 GGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGN
MMAR_4319|M.marinum_M ---------------------------
MUL_0964|M.ulcerans_Agy99 ---------------------------
Mb1166c|M.bovis_AF2122/97 ---------------------------
Rv1135c|M.tuberculosis_H37Rv ---------------------------
MAV_4704|M.avium_104 ---------------------------
MLBr_01182|M.leprae_Br4923 ---------------------------
MAB_0669|M.abscessus_ATCC_1997 ---------------------------
TH_3569|M.thermoresistible__bu ---------------------------
Mflv_5091|M.gilvum_PYR-GCK -GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1 -GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGNGGADGTPGTAGTTGANNP