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MGARAIFRGFNRPSRVLMINQFGINIGFYMLMPYLADYLAGPLGLAAWAVGLVMGVRNFSQQGMFFVGGT LADRFGYKPLIIAGCLIRTGGFALLVVAQSLPSVLIAAAATGFAGALFNPAVRGYLAAEAGERKIEAFAM FNVFYQSGILLGPLVGLVLLALDFRITVLAAAGVFGLLTVAQLVALPQHRADSEREKTSILQDWRVVVRN RPFLTLAAAMTGCYALSFQIYLALPMQASILMPRNQYLLIAAMFAVSGLVAVGGQLRITRWFAVRWGAER SLVVGATILAASFIPVAVIPNGQRFGVAVAVMALVLSASLLAVASAALFPFEMRAVVALSGDRLVATHYG FYSTIVGVGVLVGNLAIGSLMSAARRLNTDEIVWGGLILVGIVAVAGLRRLDTFTSGSQNMTGRWAAPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0849 | - | - | 100% (419) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. tuberculosis H37Rv | Rv2456c | - | 5e-07 | 24.24% (363) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv0783c | emrB | 2e-05 | 31.46% (89) | multidrug resistance integral membrane efflux protein EmrB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0872 | - | 0.0 | 100.00% (419) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_0900 | - | 1e-148 | 65.15% (396) | major facilitator transporter |
| M. leprae Br4923 | MLBr_01562 | - | 1e-05 | 27.01% (137) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_1274 | - | 1e-136 | 59.09% (396) | ABC transporter permease |
| M. marinum M | MMAR_4767 | - | 1e-180 | 75.60% (414) | integral membrane transport protein |
| M. avium 104 | MAV_1023 | - | 1e-07 | 23.77% (366) | MFS transporter |
| M. smegmatis MC2 155 | MSMEG_5047 | - | 2e-08 | 23.33% (433) | drug resistance transporter Bcr/CflA subfamily protein |
| M. thermoresistible (build 8) | TH_3412 | - | 6e-10 | 22.65% (393) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0338 | - | 1e-178 | 74.88% (414) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5855 | - | 1e-149 | 66.67% (396) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0849|M.tuberculosis_H37Rv -------------------------------------------MGARAIF
Mb0872|M.bovis_AF2122/97 -------------------------------------------MGARAIF
MMAR_4767|M.marinum_M -------------------------------------------MGFLAQF
MUL_0338|M.ulcerans_Agy99 -------------------------------------------MGFLAQF
Mflv_0900|M.gilvum_PYR-GCK -------------------------------------------MTLLSGF
Mvan_5855|M.vanbaalenii_PYR-1 -------------------------------------------MNLVSGF
MAB_1274|M.abscessus_ATCC_1997 ---------------------------MDQAHPRDRPDREEGVIQTLRQF
TH_3412|M.thermoresistible__bu -------------------------------------------MTQCAVR
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MAV_1023|M.avium_104 ----------------------------------------------MTAT
Rv0849|M.tuberculosis_H37Rv RGFNRPSRVLMINQFGINIGFYMLMPYLAD--YLAGPLGLAAWAVGLVMG
Mb0872|M.bovis_AF2122/97 RGFNRPSRVLMINQFGINIGFYMLMPYLAD--YLAGPLGLAAWAVGLVMG
MMAR_4767|M.marinum_M RSFNRPSRVLMINQFGINVGFYMLMPYLAD--YLAGPLGLAAWAVGLVMG
MUL_0338|M.ulcerans_Agy99 RSFNRPSRVLMINQFGINVGFYMLMPYLAD--YLAGPLGLAAWAVGLVMG
Mflv_0900|M.gilvum_PYR-GCK GSFGWPSRMLMINQFGINLGFYMLMPYLAG--YLAGPLGLAAWAIGLVLG
Mvan_5855|M.vanbaalenii_PYR-1 RSFGWPSRMLMINQFGINLGFYMLMPYLAG--YLAGPLGLAAWAIGLVLG
MAB_1274|M.abscessus_ATCC_1997 RSFDRPSQILMVNQFAINVGFYMLMPYLAG--YLAGPLGLAAWMVGLVLG
TH_3412|M.thermoresistible__bu AGAREWAGLGVLAVPTVLLGLDVTVLYLVLP-AVAADLAPSPVQTLWIMD
MSMEG_5047|M.smegmatis_MC2_155 --MPSRTRMILVLGALITLGPLTIDMYLPALPKIGEELSVSSSVAQLTLT
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALP-KIQNELSLSDAGRSWGIT
MAV_1023|M.avium_104 PRACNRDRVALQAVHFFMADMEAGMGPFLG--VLLQSRGWTTGAIGAAMT
: : . . : . : :
Rv0849|M.tuberculosis_H37Rv VRNFSQQGMFFVGGTLADRFGYKP-LIIAGCLIRTGGFALLVVAQSLPSV
Mb0872|M.bovis_AF2122/97 VRNFSQQGMFFVGGTLADRFGYKP-LIIAGCLIRTGGFALLVVAQSLPSV
MMAR_4767|M.marinum_M VRNFSQQGMFFVGGTLADRFGYKP-LIVAGCLIRTGGFALLVVAQSLPSV
MUL_0338|M.ulcerans_Agy99 VRNFSQQGMFFVGGTLADRFGYKP-LIVAGCLIRTGGFALLVVAQSLPSV
Mflv_0900|M.gilvum_PYR-GCK VRNFSQQGMFIIGGTLADRLGFKP-LIVSGCVLRTAGFGLLVFADSLPAV
Mvan_5855|M.vanbaalenii_PYR-1 VRNFSQQGMFIIGGTLADRLGYKP-LIVAGCVLRTVGFGLLVLADSLPAV
MAB_1274|M.abscessus_ATCC_1997 VRNFSQQGMFLVGGTLADRFGYKP-LIVAGCFLRTAGFAMLAFVGTLPAI
TH_3412|M.thermoresistible__bu AYGFFIAGFLITMGTLGDRIGRRR-LLTIGVTAFAGASVLAALAPSAELL
MSMEG_5047|M.smegmatis_MC2_155 GTLAGLALGQLVVGSLSDSLGRRR-PLLAGIVLHMAASVLCFLAPNIAVL
MLBr_01562|M.leprae_Br4923 AYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTISSVLCAVAWDEVTL
MAV_1023|M.avium_104 LGAIVGMVTVAPAGALVDATRHKRGCVIVVGLAAVAASAVILTSRQFWTV
* * * : . . : :
Rv0849|M.tuberculosis_H37Rv LIAAAATGFAGALFNPAVRGYLA--AEAGERKIEAFAMFNVFYQSGILLG
Mb0872|M.bovis_AF2122/97 LIAAAATGFAGALFNPAVRGYLA--AEAGERKIEAFAMFNVFYQSGILLG
MMAR_4767|M.marinum_M LIASAATGFAGALFNPAVRAYVA--ADSGDRKLEAFAMFNIFYQAGILLG
MUL_0338|M.ulcerans_Agy99 LIAAAATGFAGALFNPAVRAYVA--ADSGDRKLEAFATFNIFYQAGILLG
Mflv_0900|M.gilvum_PYR-GCK LVASAATGFAGALFNPAVRAYLA--ADAGPRRLEAFALFNVFYQAGILAG
Mvan_5855|M.vanbaalenii_PYR-1 LIASAATGFAGALFNPAVRAYLA--VDAGPRRLEAFALFNVFYQGGILAG
MAB_1274|M.abscessus_ATCC_1997 LIASAATGFAGALFNPAVRAYLA--ADSGERRVEAFAVFNVFYQAGILFG
TH_3412|M.thermoresistible__bu IVARALLGVAGATLMPSTLSLISNMFVDAAQRALAIGVWATMFAVGMAAG
MSMEG_5047|M.smegmatis_MC2_155 GIARGLQGMGASAAAVVAIAVVG-DLYSGNTAATVMSRLMLVLGVAPVLA
MLBr_01562|M.leprae_Br4923 VIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMG
MAV_1023|M.avium_104 ATAQAVMCISGATIAPAMIGITLG-VVGQAAFTRQNGRNQAYNHAGNMAG
* ...: . . . .
Rv0849|M.tuberculosis_H37Rv PLVG-----------LVLLALDFRITVLAAAGVFGLLTVAQLVALPQHRA
Mb0872|M.bovis_AF2122/97 PLVG-----------LVLLALDFRITVLAAAGVFGLLTVAQLVALPQHRA
MMAR_4767|M.marinum_M PLVG-----------LALLTLDFRMTVLGASAVFAVLTAAQLMALPQHLA
MUL_0338|M.ulcerans_Agy99 PLVG-----------LALLTLDFRMTVLGASAVFAVLTAAQLMALPQHLA
Mflv_0900|M.gilvum_PYR-GCK PLVG-----------LALMFVDFKITAAAAALVFAVLTVAQLFALPQRAV
Mvan_5855|M.vanbaalenii_PYR-1 PLVG-----------LALMFVDFRATAAAAAMVFAVLTVAQLFALPQRTA
MAB_1274|M.abscessus_ATCC_1997 PIVG-----------LALTAWDFRITCAVAAAVFAFLTVIQLMALPPNRA
TH_3412|M.thermoresistible__bu PVVGGALVDRFWWGAAFLLAVPVAAAVLLGARLLPEYADPQAGRLDLRSV
MSMEG_5047|M.smegmatis_MC2_155 PSLG----------AAVLLKASWHWVFVALVILAGLLLVMAALALPETLP
MLBr_01562|M.leprae_Br4923 LVVGG-ALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAGA
MAV_1023|M.avium_104 AALGG------VAGWVFGYAGIFWLAAGFAVATIAAVLAIPGGDIDHHVA
:* . :
Rv0849|M.tuberculosis_H37Rv DSER---EKTSILQDWRVVVRNRPFLTLAAAMTGCYALSFQIYLALPMQA
Mb0872|M.bovis_AF2122/97 DSER---EKTSILQDWRVVVRNRPFLTLAAAMTGCYALSFQIYLALPMQA
MMAR_4767|M.marinum_M DPGT---KNESILQGWKAIVRNRSFLGFAAAMTGAYVLSFQVYLALPMQA
MUL_0338|M.ulcerans_Agy99 DPDT---KNESILQGWKAIVCNRSFLGFAAAMTGAYVLSFQVYLALPIQA
Mflv_0900|M.gilvum_PYR-GCK APTP---EKTSVLQDWRAVAANRSFLLFAAAMIGSYVLSFQVYLAMPLQA
Mvan_5855|M.vanbaalenii_PYR-1 APAE---AKTSVLDDWRVVAANRSFLLFAAAMIGSYVLSFQVYLALPLQA
MAB_1274|M.abscessus_ATCC_1997 ESERN-ADRAPVLTSWRSVVSNKAFLLFSGAMIGSYVLTFQVYLALPLQA
TH_3412|M.thermoresistible__bu ALSLL-AILAAIYAVKHVAVHGVDGVAVAACALAAAAATVFVHRQRRLDA
MSMEG_5047|M.smegmatis_MC2_155 TSHRRPLKVGGIMRTYGRLLHDARFVILVLVAALGMSGLFAYISAAPFVL
MLBr_01562|M.leprae_Br4923 ILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAEN
MAV_1023|M.avium_104 RGEAR-AAGEAPVKAMRVLARSRPLLVLAAAMVLFHLGNAAMLPLYGLAV
.
Rv0849|M.tuberculosis_H37Rv SILMP-----RNQYLLIAAMFAVSGLVAVGG----------------QLR
Mb0872|M.bovis_AF2122/97 SILMP-----RNQYLLIAAMFAVSGLVAVGG----------------QLR
MMAR_4767|M.marinum_M SLLAP-----GHQSVLVAAMFAVSGLIAIAG----------------QLR
MUL_0338|M.ulcerans_Agy99 SLLAP-----GHQSVLLAAMFAVSGLIAIAG----------------QLR
Mflv_0900|M.gilvum_PYR-GCK RYLFP-----QNDSVVTAMIFVVSGVVAVLG----------------QMR
Mvan_5855|M.vanbaalenii_PYR-1 RDLFP-----GSDSVVTAMIFVVSGLVAVMG----------------QMR
MAB_1274|M.abscessus_ATCC_1997 ALLTDDK---KSETALVTSIFVVSGLVAIAG----------------QVR
TH_3412|M.thermoresistible__bu PLLDVTLF--ADRAFTAALTVLLIGLIGVGGTMYLVTQFLQLVEGLTPVR
MSMEG_5047|M.smegmatis_MC2_155 QGRYG------LDQQMFAAVFAAGAVALIGS---------------TQFN
MLBr_01562|M.leprae_Br4923 PVVPFDLFRDRNRLVTFIAIFLAGGVIFSLT-----------------VS
MAV_1023|M.avium_104 VATHAN-----PFTTVASTVVVAQAVMVPAS------------------L
. .:
Rv0849|M.tuberculosis_H37Rv ITRWFAVRWGAERS-LVVGATILAASFIPVAVIPNGQ----------RFG
Mb0872|M.bovis_AF2122/97 ITRWFAVRWGAERS-LVVGATILAASFIPVAVIPNGQ----------RFG
MMAR_4767|M.marinum_M ITRWFAAHWRVSRS-LVVGAAILAIAFVPLAMVPNAQ----------RFG
MUL_0338|M.ulcerans_Agy99 ITRWVAAHWRVSRS-LVVGAAILAMAFVPLAMVPNAQ----------RFG
Mflv_0900|M.gilvum_PYR-GCK ITRWFGRRWGSGRS-LAIGMLILALSFLPLIALPDDE----------RAG
Mvan_5855|M.vanbaalenii_PYR-1 ITRWFAKRWGAGRS-LMIGMLILAVSFVPLMALPDDT----------RAG
MAB_1274|M.abscessus_ATCC_1997 LTGWLSARFGPSRS-LVLGMLVIGTAFVPLVLLPTAA----------SAG
TH_3412|M.thermoresistible__bu AGWWMGPPALAMFV-AAIGAPLIARRVRPGVVMAATLGVSVLGYAVLASA
MSMEG_5047|M.smegmatis_MC2_155 VVLLRRFTPQAITV-AALASATVVGAVFVGLTIADVGG---------LIG
MLBr_01562|M.leprae_Br4923 IGLYIQDILGYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGG
MAV_1023|M.avium_104 LAMRIAATRGYWPAILIALTALPVRGVLAASVITSWG----------VIP
. :.
Rv0849|M.tuberculosis_H37Rv VAVAVMALVLSASLLAVASAALFPFEMRAVVALSGDRLVATHYGFYSTIV
Mb0872|M.bovis_AF2122/97 VAVAVMALVLSASLLAVASAALFPFEMRAVVALSGDRLVATHYGFYSTIV
MMAR_4767|M.marinum_M TGAAVAALLVSASLLAVASAALFPFEMRTVVVLAEDKLVATHYGFYSTIV
MUL_0338|M.ulcerans_Agy99 TGAAVAALLVSASLLAVASAALFPFEMRTVVVLAEDKLVATNYGFYSTIV
Mflv_0900|M.gilvum_PYR-GCK RVAAATALLIATAVLAVGSAAVFPFEMDTVVSLADNRLVGTHYGFYNTIV
Mvan_5855|M.vanbaalenii_PYR-1 RVAAATALLGATAVLAVGSAAVFPFEMDTVVSLAGNRLVGTHYGFYNTIV
MAB_1274|M.abscessus_ATCC_1997 QLAAIAALLFSAALLAVGTIATFPFEMDTVVRLADNRLVATQYGLYNTIV
TH_3412|M.thermoresistible__bu GRGDGPAVVVAFAFVYLGLGAIAALGTDIVVGAAPAAKSGSAAAMSETVQ
MSMEG_5047|M.smegmatis_MC2_155 FLVPVMAILTAMGFVIPNAPAVALSRHSEAAGTAAALLGAAQFGIGALVA
MLBr_01562|M.leprae_Br4923 GWLLMVAMLYGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAG
MAV_1023|M.avium_104 VQVLDGIGAGMLSVAVPGLVARILDGTGHINVGQGAVMAAQGLGGALSPV
..
Rv0849|M.tuberculosis_H37Rv GVGVLVGNLAIGSLMSAARR------------LNTDEIVWGGLILVGIVA
Mb0872|M.bovis_AF2122/97 GVGVLVGNLAIGSLMSAARR------------LNTDEIVWGGLILVGIVA
MMAR_4767|M.marinum_M GVGILVGNLVVGSLMSVAHR------------FGADEIVWGGLILIGLAT
MUL_0338|M.ulcerans_Agy99 GVGILVGNLAVGSLMSVAHR------------FGADEIVWGGLILIGLAT
Mflv_0900|M.gilvum_PYR-GCK GVGILVGNLATGSLMQLARE------------LGRPEFLWVLLTVIGMLS
Mvan_5855|M.vanbaalenii_PYR-1 GVGILVGNLATGYLMQAAKR------------VGAPELLWVLLCAIGAVS
MAB_1274|M.abscessus_ATCC_1997 GIGILAGNLLTGSVFGYSQR------------RGVPSLLWVSLVVVGLVC
TH_3412|M.thermoresistible__bu ELGIAVGVALLGSVTAAVYRSRMTGPEGVAEGVGGPDAERLAESLPAAVS
MSMEG_5047|M.smegmatis_MC2_155 PLVGALGNGALALSGVMTAG---------------MAIALVALLLVGGSH
MLBr_01562|M.leprae_Br4923 VGFDRIGPVSAIALMLQSLGG------PLVLAVIQAVITSRTLYLGGTTG
MAV_1023|M.avium_104 LGGAVAQHLGFRAAFLLLAG-------------LSLGALIIWVTFAPMLR
Rv0849|M.tuberculosis_H37Rv VAGLRRLDTFT-SGSQNMTGRWAAPR------------------------
Mb0872|M.bovis_AF2122/97 VAGLRRLDTFT-SGSQNMTGRWAAPR------------------------
MMAR_4767|M.marinum_M VAGLYQLDRQA-TRADRLSRRHPPAQLCQQAA------------------
MUL_0338|M.ulcerans_Agy99 VAGLYQLDRQA-TRAERLSRRHPPAQLCQQAA------------------
Mflv_0900|M.gilvum_PYR-GCK AAALYRLDQRGRLGSTPKAVDDATPR------------------------
Mvan_5855|M.vanbaalenii_PYR-1 ALALYRLDRRGLLQPAKSTPDRAVAR------------------------
MAB_1274|M.abscessus_ATCC_1997 AAALFALRRAGLLDRGREVAPAARA-------------------------
TH_3412|M.thermoresistible__bu VADRVPGEAVRLAQDAFAAGVNIAALIGGAAVVVVAVVCATALRHLRPLD
MSMEG_5047|M.smegmatis_MC2_155 ADDETHDGNEDGPGSDDVVAEAVAEPA-----------------------
MLBr_01562|M.leprae_Br4923 PVKFMNDAQLRALDHGYTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQE
MAV_1023|M.avium_104 RAARLPAAPSDRAGAPPTATADNQAK------------------------
Rv0849|M.tuberculosis_H37Rv ----------
Mb0872|M.bovis_AF2122/97 ----------
MMAR_4767|M.marinum_M ----------
MUL_0338|M.ulcerans_Agy99 ----------
Mflv_0900|M.gilvum_PYR-GCK ----------
Mvan_5855|M.vanbaalenii_PYR-1 ----------
MAB_1274|M.abscessus_ATCC_1997 ----------
TH_3412|M.thermoresistible__bu ----------
MSMEG_5047|M.smegmatis_MC2_155 ----------
MLBr_01562|M.leprae_Br4923 VKEAVDAGEL
MAV_1023|M.avium_104 ----------