For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PSRTRMILVLGALITLGPLTIDMYLPALPKIGEELSVSSSVAQLTLTGTLAGLALGQLVVGSLSDSLGRR RPLLAGIVLHMAASVLCFLAPNIAVLGIARGLQGMGASAAAVVAIAVVGDLYSGNTAATVMSRLMLVLGV APVLAPSLGAAVLLKASWHWVFVALVILAGLLLVMAALALPETLPTSHRRPLKVGGIMRTYGRLLHDARF VILVLVAALGMSGLFAYISAAPFVLQGRYGLDQQMFAAVFAAGAVALIGSTQFNVVLLRRFTPQAITVAA LASATVVGAVFVGLTIADVGGLIGFLVPVMAILTAMGFVIPNAPAVALSRHSEAAGTAAALLGAAQFGIG ALVAPLVGALGNGALALSGVMTAGMAIALVALLLVGGSHADDETHDGNEDGPGSDDVVAEAVAEPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5047 | - | - | 100% (417) | drug resistance transporter Bcr/CflA subfamily protein |
| M. smegmatis MC2 155 | MSMEG_2991 | - | 1e-63 | 37.41% (401) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2619 | - | 5e-19 | 26.77% (325) | efflux protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1908 | - | 4e-19 | 37.14% (175) | hypothetical protein Mb1908 |
| M. gilvum PYR-GCK | Mflv_2220 | - | 1e-162 | 73.80% (416) | Bcr/CflA subfamily drug resistance transporter |
| M. tuberculosis H37Rv | Rv1877 | - | 1e-19 | 29.17% (384) | integral membrane protein |
| M. leprae Br4923 | MLBr_01562 | - | 4e-19 | 26.88% (413) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_1395 | - | 1e-130 | 62.14% (383) | Bcr/CflA family multidrug resistance transporter |
| M. marinum M | MMAR_3524 | - | 1e-36 | 30.85% (363) | hypothetical protein MMAR_3524 |
| M. avium 104 | MAV_2832 | - | 2e-17 | 30.07% (286) | drug transporter |
| M. thermoresistible (build 8) | TH_0755 | - | 2e-56 | 68.12% (160) | drug resistance transporter Bcr/CflA subfamily protein |
| M. ulcerans Agy99 | MUL_3826 | - | 2e-17 | 25.55% (411) | hypothetical protein MUL_3826 |
| M. vanbaalenii PYR-1 | Mvan_4475 | - | 1e-160 | 72.60% (416) | Bcr/CflA subfamily drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2220|M.gilvum_PYR-GCK ----------------MSLINFMAISPDVKLKAQSPESAGPPS-------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------MAPPG-------
MSMEG_5047|M.smegmatis_MC2_155 ----------------------------------------MPS-------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 ----------------MRALSTEVTSAPGKTTVDDPATDRTPAGSVSPPA
MAV_2832|M.avium_104 ------------------------MNAPARADTGSGGERISPQR------
MUL_3826|M.ulcerans_Agy99 ----------------MMRPRATVAAATPTTDLAAGRALITPRR------
Rv1877|M.tuberculosis_H37Rv ----------------MAGP---TAPTTAPTAIRAGGPLLSPVR------
Mb1908|M.bovis_AF2122/97 ----------------MAGP---TAPTTAPTAIRAGGPLLSPVR------
MMAR_3524|M.marinum_M ------------------------------------MKASAPSR------
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
Mflv_2220|M.gilvum_PYR-GCK ----RTRMIIVLGLLVALGPLTIDMYLPALPKIGEELSVSSSVAQLTLTG
Mvan_4475|M.vanbaalenii_PYR-1 ----RTRMILVLGLLVALGPLTIDMYLPALPKIAEELSVSSSVAQLTLTG
MSMEG_5047|M.smegmatis_MC2_155 ----RTRMILVLGALITLGPLTIDMYLPALPKIGEELSVSSSVAQLTLTG
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 TRLGRAWLITVLGAMVALGPLTIDMYLPALPDIGSDLHVNSTLTQLTLTG
MAV_2832|M.avium_104 ----RNLIFVAIVLGMLLAALDQTIVATALPTIVANLGDAG-HQSWVVTS
MUL_3826|M.ulcerans_Agy99 ----RNFIFVALVLGILLSSLDQTIVAIALPTIVADLGEAG-RQSWVVTS
Rv1877|M.tuberculosis_H37Rv ----RNIIFTALVFGVLVAATGQTIVVPALPTIVAELGSTV-DQSWAVTS
Mb1908|M.bovis_AF2122/97 ----RNIIFTALVFGVLVAATGQTIVVPALPTIVAELGSTV-DQSWAVTS
MMAR_3524|M.marinum_M ------RIVAVLLCVVPLNQIPMDAYTPALPQMETSIGTTATALQSTVTV
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
Mflv_2220|M.gilvum_PYR-GCK TLAGLAIGQLVIGPLSDSLGRRKPLFAGIVLHMVASLLCMFAPTITVLGI
Mvan_4475|M.vanbaalenii_PYR-1 TLAGLAIGQLVIGPLSDSLGRRRPLFAGIVLHMLASLLCLLAPNITVLGV
MSMEG_5047|M.smegmatis_MC2_155 TLAGLALGQLVVGSLSDSLGRRRPLLAGIVLHMAASVLCFLAPNIAVLGI
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 TLVGLGLGQLLVGPLSDSLGRRLPLIAGAILHIVASLAITIAPNIVVLGV
MAV_2832|M.avium_104 YLLASTIVTALVGKLGDLYGRKRVFQAAVLFFVAGSVLCGLAQSMAMLVG
MUL_3826|M.ulcerans_Agy99 YLLASTIATALVGKLGDMFGRKRVFQVAVLLFVAGSVSCGLTQSMTMLVA
Rv1877|M.tuberculosis_H37Rv YLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVFVVGSVLCGLSQTMTMLAI
Mb1908|M.bovis_AF2122/97 YLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVFVVGSVLCGLSQTMTMLAI
MMAR_3524|M.marinum_M FMIGMALSYLAVGIMSDSWGRKPVLMGCAAALTVTSLACAAANNVAMLLV
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
Mflv_2220|M.gilvum_PYR-GCK ARGLQGMGAAAGMVVAIAVVGDLYK-DNAAATVMSRLMLVLGVAPVLAPS
Mvan_4475|M.vanbaalenii_PYR-1 ARCLQGMGAAAGMVVAIAVVGDLYK-DNVAATVMSRLMLVLGVAPVLAPS
MSMEG_5047|M.smegmatis_MC2_155 ARGLQGMGASAAAVVAIAVVGDLYS-GNTAATVMSRLMLVLGVAPVLAPS
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 LRAVEGMGAAAAMVVAMAVVRDLYT-DKAAATVISRLTLVIGIAPILAPS
MAV_2832|M.avium_104 ARALQGIGGGGITVTASALIGEVVP-LRERGRYQGILGAVFGVTTVIGPL
MUL_3826|M.ulcerans_Agy99 SRALQGVGGGAITVTAIALIGEVVP-LRDRGRYQGILGAVIGIATIGGPL
Rv1877|M.tuberculosis_H37Rv SRALQGVGAGAISVTAYALAAEVVP-LRDRGRYQGVLGAVFGVNTVTGPL
Mb1908|M.bovis_AF2122/97 SRALQGVGAGAISVTAYALAAEVVP-LRDRGRYQGVLGAVFGVNTVTGPL
MMAR_3524|M.marinum_M LRFLQGGACSAFIVVAIAIAADCFE-GARLRSVNGLLGAAWSAAPILAPA
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
Mflv_2220|M.gilvum_PYR-GCK LGAAVLLHGSWHWVFAALVVVAAALLVMAVLALPETLPVDHRRPLKVRGI
Mvan_4475|M.vanbaalenii_PYR-1 FGAAVLLHGSWHWVFAALVVVAGALLVMSVLALPETLPADHRRPLKARGI
MSMEG_5047|M.smegmatis_MC2_155 LGAAVLLKASWHWVFVALVILAGLLLVMAALALPETLPTSHRRPLKVGGI
TH_0755|M.thermoresistible__bu ---------------------------MSEEPLGEXX-------------
MAB_1395|M.abscessus_ATCC_1997 LGAAVLVHGSWQNVFAALSCLGVLLLILAVVALPETLPPSARRPLRAGAI
MAV_2832|M.avium_104 LGGYFTDYLSWRWAFWVNVPVSVIVIFVAAAAIPALAASAKPVIDYAGIV
MUL_3826|M.ulcerans_Agy99 LGGYFTDCLGWRWAFWINLPVSAVVICVATAAIPALAATTRPVIDYAGIM
Rv1877|M.tuberculosis_H37Rv LGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDYLGIL
Mb1908|M.bovis_AF2122/97 LGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDYLGIL
MMAR_3524|M.marinum_M VGGFIVEYASWRYVFVLIAALSVVVGLAVTWALPETLDQESRTRFELGQT
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKER-MKLDAAGAI
.:
Mflv_2220|M.gilvum_PYR-GCK AATYLELVRDARFVILVLVAALGMSGLFAYIAGASFVLQGRFGLDQTAFA
Mvan_4475|M.vanbaalenii_PYR-1 ALTYLELLRDVRFVILVFVGALGMSGLFAYIAGASFVLQGRFGLDQTAFA
MSMEG_5047|M.smegmatis_MC2_155 MRTYGRLLHDARFVILVLVAALGMSGLFAYISAAPFVLQGRYGLDQQMFA
TH_0755|M.thermoresistible__bu ----------------------------XYISGAAFVLQDGYGLNQQAFA
MAB_1395|M.abscessus_ATCC_1997 LRTYRDLLRDKVFVVLVLVAGLSLSGLFAYISGASFVLQGQYGMNQQVFA
MAV_2832|M.avium_104 FVGLGAAGLTLATSWGGSRYPWGSPTIIGLFAAAAVALGVFVVVERRAAE
MUL_3826|M.ulcerans_Agy99 FIGLSLAALTLATSLGGSVYAWGSAPIIGLFTAAGVTLAVFVWVETIAAQ
Rv1877|M.tuberculosis_H37Rv VIAVATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGRAAA
Mb1908|M.bovis_AF2122/97 VIAVATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGRARC
MMAR_3524|M.marinum_M WQVLTATARNRVFLALAAIFGLLAGPQLSFGVAAPFLYQDEMGFSPSAYG
MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEK-GWISLTTIGSGLVALVAAIAFAVVERTAEN
* . ..
Mflv_2220|M.gilvum_PYR-GCK LVFGAGAVALIGTTQCNVILLKR---------------------------
Mvan_4475|M.vanbaalenii_PYR-1 LVFGAGAIALIGTTQFNVVLLKR---------------------------
MSMEG_5047|M.smegmatis_MC2_155 AVFAAGAVALIGSTQFNVVLLRR---------------------------
TH_0755|M.thermoresistible__bu LVFGAGAIALIGATQFNVVLLRR---------------------------
MAB_1395|M.abscessus_ATCC_1997 LAFGAGAIAFVAASQLNVVLLKR---------------------------
MAV_2832|M.avium_104 PILPVRLFASPVFTVCCVLSFVVGFAMLGAMTFLPTYMQYVDGVSATTSG
MUL_3826|M.ulcerans_Agy99 PILPIRLFAAPVFSVCCVLAFVVGFAMLGALIFVPTFMQYVNGVSATASG
Rv1877|M.tuberculosis_H37Rv AILPPRLFGSPVFAVCCVLSFVVGFAMLGALTFVPIYLGYVDGASATASG
Mb1908|M.bovis_AF2122/97 GHPAAQAVWQP--SICRVLRPVLRGRIR----------------DAGCTD
MMAR_3524|M.marinum_M LIALVVGVAVLLGSFSTGMLATR---------------------------
MLBr_01562|M.leprae_Br4923 PVVPFDLFRDRNRLVTFIAIFLAGGVIFS---------------------
.
Mflv_2220|M.gilvum_PYR-GCK ---------------------FTPQQIMVWALAASSVFGLVFVALAAAGV
Mvan_4475|M.vanbaalenii_PYR-1 ---------------------FAPQQIMVWALVAASLSGAVFVALAAAHI
MSMEG_5047|M.smegmatis_MC2_155 ---------------------FTPQAITVAALASATVVGAVFVGLTIADV
TH_0755|M.thermoresistible__bu ---------------------FDPSTIVVTALAVASVLGFVFVGLAVTGV
MAB_1395|M.abscessus_ATCC_1997 ---------------------FEPQQIVRWCLSLALIPAVVLLVLAGFGI
MAV_2832|M.avium_104 LRTLPMVVGMLFTSTGSGTIVGRTGRYKIFPVAGTALMALAFLLMSRMQP
MUL_3826|M.ulcerans_Agy99 LRILPMVIGMLITSIGSGSMVGRTGRYKIFPVLGTALMTLAFLLMSRTDE
Rv1877|M.tuberculosis_H37Rv LRTLPMVIGLLIASTGTGVLVGRTGRYKIFPVAGMALMAVAFLLMSQMDE
Mb1908|M.bovis_AF2122/97 LR-----------TDLSGVRGRRVGDRVRSAHVADGDRPADRLDRDGCPG
MMAR_3524|M.marinum_M ---------------------MAFRRLAFADWTLYMVGAALLLGSAPVVG
MLBr_01562|M.leprae_Br4923 ---------------LTVSIGLYIQDILGYSALRAGIGFIPFVIAMGIGL
:
Mflv_2220|M.gilvum_PYR-GCK GGVFGFVIPVWAILAAMGLVIPNAPAVALTRHPDAAGTAAALLG------
Mvan_4475|M.vanbaalenii_PYR-1 GGLWGFVIPVWAILAAMGLVIPNAPAVALTRHPDAAGTAAALLG------
MSMEG_5047|M.smegmatis_MC2_155 GGLIGFLVPVMAILTAMGFVIPNAPAVALSRHSEAAGTAAALLG------
TH_0755|M.thermoresistible__bu GGLAGFVLPVWGVLGAMGFVLPNAPALALSRHPEASGTAAALLG------
MAB_1395|M.abscessus_ATCC_1997 GGLVGFVAPVWTLMALMGFVIPNAPALALSRHGEAAGTSAAVLG------
MAV_2832|M.avium_104 STSAVIQSLYLFILGAGIGLSMQVLILIVQNTSDFEDLGVATSGVTFFRT
MUL_3826|M.ulcerans_Agy99 STSAAVQSVYLLILGSAIGMSSQVLVIIVQNTSEFEDLGVATSGVSLFRT
Rv1877|M.tuberculosis_H37Rv WTPPLLQSLYLVVLGAGIGLSMQVLVLIVQNTSSFEDLGVATSGVTFFRV
Mb1908|M.bovis_AF2122/97 RPDGPLQDLPGRGDGADGGC---VPADVADGRVDATAAAIAVPGRPRCRH
MMAR_3524|M.marinum_M VNPWAITLAVSLAVAGCGALVPQAQAAALGAFSRNLGLVSGLFG------
MLBr_01562|M.leprae_Br4923 GVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRGVPYFPNLLAPIVV
.
Mflv_2220|M.gilvum_PYR-GCK -AVQFGGGAAIAPVVGVLGNDELAMAVVMAAG---------------VII
Mvan_4475|M.vanbaalenii_PYR-1 -AVQFGMGAAIAPVVGVLGNDELAMAVVMAAG---------------VIV
MSMEG_5047|M.smegmatis_MC2_155 -AAQFGIGALVAPLVGALGNGALALSGVMTAG---------------MAI
TH_0755|M.thermoresistible__bu -CGQFGLGAVISPLVGVLGNSAPAMAAVMTGG---------------VLI
MAB_1395|M.abscessus_ATCC_1997 -AAQFGVGAVIAPLVGALGNNALAVAIVMMIG---------------VVL
MAV_2832|M.avium_104 IGSSFGAAIFGSLFVNFLNRR---IGPALAASGAPPGAVSSPGALHRQPH
MUL_3826|M.ulcerans_Agy99 IGGSFGAAIFGSLFVNFLNSR---LASALTAT----EVASSPEALHRQSP
Rv1877|M.tuberculosis_H37Rv VGASFGTATFGALFVNFLDRR---LGSALTSGAVPVPAVPSPAVLHQLPQ
Mb1908|M.bovis_AF2122/97 RIVHAGARSHRAEHVVFRRPRRRNIGCDLLPG-------GRRLVWYRNIR
MMAR_3524|M.marinum_M -TLTYLIIAAIMAIVGVSPER-----TQAPLG---------------WLY
MLBr_01562|M.leprae_Br4923 GGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIA--------------LMLQ
Mflv_2220|M.gilvum_PYR-GCK ALGALLVTG-AHRNTEPAR----------VPDEAVAEPA-----------
Mvan_4475|M.vanbaalenii_PYR-1 ALTALLVTG-VHRNTAPAA----------VPGEAVAEPA-----------
MSMEG_5047|M.smegmatis_MC2_155 ALVALLLVGGSHADDETHDGNEDGPGSDDVVAEAVAEPA-----------
TH_0755|M.thermoresistible__bu ALVALLAAG-VRPGAEHRD-----------TADMLVEHA-----------
MAB_1395|M.abscessus_ATCC_1997 ALAGLAVVR-----------------------NRVAA-------------
MAV_2832|M.avium_104 EVAAPIVAAYAESLTEVFFWAAPVALVGFVLALFLREIPLRDIHDSTVDL
MUL_3826|M.ulcerans_Agy99 AVAAPIVHAYAGSLAQVFLCAAPVAAIGFVLALFMREVPLRDIHN-----
Rv1877|M.tuberculosis_H37Rv SMAAPIVRAYAESLTQVFLCAVSVTVVGFILALLLREVPLTDIHDDADDL
Mb1908|M.bovis_AF2122/97 CVVRKLPGPKTRFRADVGRRACPGSAISGCLASAAPEHGRPDRAG-----
MMAR_3524|M.marinum_M VLCGALVFAALAWVTPRVQ-------------GEKPTPG-----------
MLBr_01562|M.leprae_Br4923 SLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYG---
:
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2832|M.avium_104 GDAFGMPTTETPDQMLENAIARMLRGETGMRLRSIAMRPDCRLDVAGLWG
MUL_3826|M.ulcerans_Agy99 --------------------------------RDHDAR------------
Rv1877|M.tuberculosis_H37Rv GDGFGVPRAESPEDVLEIAVRRMLPN--GVRLRDIATQPGCGLGVAELWA
Mb1908|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3524|M.marinum_M --------------------------------------------------
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2832|M.avium_104 VLRINRYTQMYGTARLTDMAEYLRIPFEVLEPTFSRLVTAGYAGSDGDRL
MUL_3826|M.ulcerans_Agy99 -------------------------------------VPSGDGSGQQNKL
Rv1877|M.tuberculosis_H37Rv LLRIYQYQRLFEAVRLTDIGRHLHVPYQVFEPVFDRLVQTGYAARDGDIL
Mb1908|M.bovis_AF2122/97 ---------------------------------------ICRVAHPGVPL
MMAR_3524|M.marinum_M --------------------------------------------------
MLBr_01562|M.leprae_Br4923 -----------------------------------LLWVAGAVVIVGVAA
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2832|M.avium_104 WLTPAGAQQVGYVHSLLLAWLVDKLGRSPGFEGRPDRQAVQAALERVAYR
MUL_3826|M.ulcerans_Agy99 EGDLDTGQSVG------------APGKEPDFG-------VDPAMGPVR--
Rv1877|M.tuberculosis_H37Rv TLTPSGHRQVDSLAVLIRQWLLDHLAVAPGLKRQPD-HQFEAALQHVTDA
Mb1908|M.bovis_AF2122/97 RGLGHGGRFHP--------------GAVAARG---------TAHRHPR--
MMAR_3524|M.marinum_M --------------------------------------------------
MLBr_01562|M.leprae_Br4923 LFIGYTPEQVAYAQEVKEAVDAGEL-------------------------
Mflv_2220|M.gilvum_PYR-GCK ------------------------
Mvan_4475|M.vanbaalenii_PYR-1 ------------------------
MSMEG_5047|M.smegmatis_MC2_155 ------------------------
TH_0755|M.thermoresistible__bu ------------------------
MAB_1395|M.abscessus_ATCC_1997 ------------------------
MAV_2832|M.avium_104 VLAQRDWHDAQPTAAITAAAR---
MUL_3826|M.ulcerans_Agy99 ------------------------
Rv1877|M.tuberculosis_H37Rv VLVQRDWYEDLGDLSESRQLAATT
Mb1908|M.bovis_AF2122/97 ------------------------
MMAR_3524|M.marinum_M ------------------------
MLBr_01562|M.leprae_Br4923 ------------------------