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TATPRACNRDRVALQAVHFFMADMEAGMGPFLGVLLQSRGWTTGAIGAAMTLGAIVGMVTVAPAGALVDA TRHKRGCVIVVGLAAVAASAVILTSRQFWTVATAQAVMCISGATIAPAMIGITLGVVGQAAFTRQNGRNQ AYNHAGNMAGAALGGVAGWVFGYAGIFWLAAGFAVATIAAVLAIPGGDIDHHVARGEARAAGEAPVKAMR VLARSRPLLVLAAAMVLFHLGNAAMLPLYGLAVVATHANPFTTVASTVVVAQAVMVPASLLAMRIAATRG YWPAILIALTALPVRGVLAASVITSWGVIPVQVLDGIGAGMLSVAVPGLVARILDGTGHINVGQGAVMAA QGLGGALSPVLGGAVAQHLGFRAAFLLLAGLSLGALIIWVTFAPMLRRAARLPAAPSDRAGAPPTATADN QAK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1023 | - | - | 100% (424) | MFS transporter |
| M. avium 104 | MAV_3974 | - | 3e-07 | 22.47% (396) | permease of the major facilitator superfamily protein |
| M. avium 104 | MAV_1406 | - | 1e-06 | 24.94% (405) | transporter, major facilitator family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2483c | - | 3e-68 | 37.98% (387) | putative integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1475 | - | 4e-11 | 25.70% (358) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv2456c | - | 3e-68 | 37.98% (387) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3449c | - | 3e-12 | 27.08% (384) | putative transporter |
| M. marinum M | MMAR_3804 | - | 2e-67 | 37.82% (386) | integral membrane transport protein |
| M. smegmatis MC2 155 | MSMEG_1169 | - | 6e-09 | 26.28% (392) | integral membrane transport protein |
| M. thermoresistible (build 8) | TH_3965 | - | 3e-07 | 24.61% (191) | PUTATIVE drug transporter |
| M. ulcerans Agy99 | MUL_3727 | - | 2e-66 | 37.56% (386) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_1951 | - | 5e-10 | 24.30% (428) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3449c|M.abscessus_ATCC_199 MSSCRE------------GNADN-----ATVKPRLPWEIWVLVVASLVIA
Mvan_1951|M.vanbaalenii_PYR-1 MTSHTEGECPGADARSNSGTADAKSSSQSATKQPLPREVWVLVAANFVVA
Mb2483c|M.bovis_AF2122/97 -------MSG-------------------TVVAVPPRVARALDLLNFSLA
Rv2456c|M.tuberculosis_H37Rv -------MSG-------------------TVVAVPPRVARALDLLNFSLA
MMAR_3804|M.marinum_M ----MPGASGRKPASSTESSDAGFADSMAAYDALPRRVVHALDLVNFSLA
MUL_3727|M.ulcerans_Agy99 ----MPGASGRKPASSTESSDAGFADSMAAYDALPRRVVHALDLVNFSLA
MAV_1023|M.avium_104 ---------------------------MTATPRACNRDRVALQAVHFFMA
Mflv_1475|M.gilvum_PYR-GCK -----------------------------MAPLSPTAQRAPLLAAGFTTA
TH_3965|M.thermoresistible__bu ---------VTSVDAGRSTMSEVFTAYAPRSAAANPWHALWAMLIGFFMI
MSMEG_1169|M.smegmatis_MC2_155 -----------------------MTPPSLSAGPGLRWVLITLCVTEITSW
:
MAB_3449c|M.abscessus_ATCC_199 LGFGVVAPALPQYARSFGVSVTAAT-AVVSSFAAFRLVFAPVAGALVQR-
Mvan_1951|M.vanbaalenii_PYR-1 LGYGVVAPVLPQYARHFGVSISAAT-FVITAFAVMRLVGAPPAGMLVQR-
Mb2483c|M.bovis_AF2122/97 DVRDGLGPYLSIYLLLIHDWDQASIGFVMAVGGIAAIVAQTPIGALVDRT
Rv2456c|M.tuberculosis_H37Rv DVRDGLGPYLSIYLLLIHDWDQASIGFVMAVGGIAAIVAQTPIGALVDRT
MMAR_3804|M.marinum_M DVRDGLGPYLSVYLLVTNNWDQASIGFVMAVGGIAAIVAQTPMGAFVDRT
MUL_3727|M.ulcerans_Agy99 DVRDGLGPYLSVYLLVTNNWDQASIGFVMAVGGIAAIVAQTPMGAFVDRT
MAV_1023|M.avium_104 DMEAGMGPFLGVLLQSR-GWTTGAIGAAMTLGAIVGMVTVAPAGALVDAT
Mflv_1475|M.gilvum_PYR-GCK FGAHAVAGTLGTTTTGTAASLLTLG-AMLAIYDGAEVILKPLFGTLADR-
TH_3965|M.thermoresistible__bu LVDATIVPVANLEIMADLGADYTAVIWVTSAYLLAYAVPLLIAGRLGDR-
MSMEG_1169|M.smegmatis_MC2_155 GVLYYAFTVLSASISSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDR-
: : * :
MAB_3449c|M.abscessus_ATCC_199 LGERWVYMSGLLIVAASTGICAFVHSYWQLLVFRSVGGVGST-MFTVSAA
Mvan_1951|M.vanbaalenii_PYR-1 LGERRVYISGLIIVALSTAACAFAETYWQLLLFRSLGGIGSA-MFTVSSL
Mb2483c|M.bovis_AF2122/97 TAKRALVVAGAVLVTAAAVAMPLFAGLYSISVLQAVTGIASS-VFAPALA
Rv2456c|M.tuberculosis_H37Rv TAKRALVVAGAVLVTAAAVAMPLFAGLYSISVLQAVTGIASS-VFAPALA
MMAR_3804|M.marinum_M KAKRALVITGALAVTASALAMPLFPELRSISLLQVLTGIASS-VFAPALA
MUL_3727|M.ulcerans_Agy99 KAKRALVITGALAITASALAMPLFPELRSISLLQVLTGIASS-VFAPALA
MAV_1023|M.avium_104 RHKRGCVIVVGLAAVAASAVILTSRQFWTVATAQAVMCISGA-TIAPAMI
Mflv_1475|M.gilvum_PYR-GCK IGARTVLIAGLAVFAVASLSFAVADETAWLWAARLGQGIGAA-AFSPAAS
TH_3965|M.thermoresistible__bu FGPRTMYLIGLAIFTAASLWCGLAGTIGMLIAARVLQGLGAA-LLTPQTL
MSMEG_1169|M.smegmatis_MC2_155 YGPRWIMTIGSVLGVVAVLAVVVAPNYACFVAAWILAGVAMSGVFYAPAF
* . : . :. : :
MAB_3449c|M.abscessus_ATCC_199 ALLVRIAPEEIRGRAQGLYGSSFLLGMVAGPALGSAVVGLSLSAPFIIYA
Mvan_1951|M.vanbaalenii_PYR-1 GLMIRISPPDARGRVAGLFSSGFMVGSVGGPILGALTAGFGLSAPFLIYG
Mb2483c|M.bovis_AF2122/97 AITLGAVGPQFFARRIGRNEAFNHAGNASAAGATGALAYFFGPVVVFWVL
Rv2456c|M.tuberculosis_H37Rv AITLGAVGPQFFARRIGRNEAFNHAGNASAAGATGALAYFFGPVVVFWVL
MMAR_3804|M.marinum_M AITLGIVGPQLFARRIGRNESFNHAGNATAAAITGGLAFFFGPVVVFWVL
MUL_3727|M.ulcerans_Agy99 AITLGIVGPQLFARRIGRNESFNHAGNATAAAITGGLAFFFGPVVVFWVL
MAV_1023|M.avium_104 GITLGVVGQAAFTRQNGRNQAYNHAGNMAGAALGGVAGWVFGYAGIFWLA
Mflv_1475|M.gilvum_PYR-GCK ALVARLAPASGQGRAFGTYGSYKSVGYTLGPLIGGAIVTFGGLQALFAVM
TH_3965|M.thermoresistible__bu SMITRIFPADRRGVPMGVWGATAGVATLIGPLAGGVLVDGLGWQWIFIVN
MSMEG_1169|M.smegmatis_MC2_155 AALTRYFAPNAVRALTVLTLVAGLSSTVFAPLTAALGSHLSWRQTYLVLA
. . .. . :
MAB_3449c|M.abscessus_ATCC_199 AALVIVVMLVYFGLRRST--------------------------------
Mvan_1951|M.vanbaalenii_PYR-1 AALLVAATVVFVSLRHST--------------------------------
Mb2483c|M.bovis_AF2122/97 AGMALISVLATLRIPPDA--------------------------------
Rv2456c|M.tuberculosis_H37Rv AGMALISVLATLRIPPDA--------------------------------
MMAR_3804|M.marinum_M ATMAAMSVVATLRIPHDA--------------------------------
MUL_3727|M.ulcerans_Agy99 ATMAAMSVVATLRIPHDA--------------------------------
MAV_1023|M.avium_104 AGFAVATIAAVLAIPGGD--------------------------------
Mflv_1475|M.gilvum_PYR-GCK AALAAAVAVWAAVAVPRL--------------------------------
TH_3965|M.thermoresistible__bu VPIGIAGLVLGARLMPRLPRQDQGFDVLGMVLSAVGLFLIVFALQEAQTH
MSMEG_1169|M.smegmatis_MC2_155 ALLAVITIPAHLFGLRRP--------------------------------
. :
MAB_3449c|M.abscessus_ATCC_199 --------LLDVADE--------HHGTPVRLTSALRHRTFLAALMSNFSA
Mvan_1951|M.vanbaalenii_PYR-1 --------VVGQQDE--------DPEEPVPFRTVFRHRAYRAALFSNFAT
Mb2483c|M.bovis_AF2122/97 --------VDHDLARGMDHAPGEPHPQPSRFTVLAHNRELVIFGAAVVAF
Rv2456c|M.tuberculosis_H37Rv --------VDHDLARGMDHAPGEPHPQPSRFTVLAHNRELVIFGAAVVAF
MMAR_3804|M.marinum_M --------IDHDLARGMDHAPGEPHAQPSGFGVLLHNRTLMIFAAAVVAF
MUL_3727|M.ulcerans_Agy99 --------IDHDLARGMDHAPGEPQAQPSGFGVLLHNRTLMIFAAAVVAF
MAV_1023|M.avium_104 --------IDHHVARGEARAAG--EAPVKAMRVLARSRPLLVLAAAMVLF
Mflv_1475|M.gilvum_PYR-GCK --------AVLPRTR-------------QTLLDTVRRFSESSFVTPTLAL
TH_3965|M.thermoresistible__bu RWAPWIWGTLAGGAGVMAMFVIWQSANRRHPLVPLQIFADRNFMLANVGV
MSMEG_1169|M.smegmatis_MC2_155 ---------------------WPPVQHHHNVEAPTRTARSAPFLALMVSF
: .
MAB_3449c|M.abscessus_ATCC_199 GWAIFGIRGALL-PLLVVEALHQRPGAAGLVFAAFAAGDVSTAFLAGSWS
Mvan_1951|M.vanbaalenii_PYR-1 GWASFGLRIALV-PLFIVEVLGQSPGAAGLALTAFAVGNISVVIPSGHLS
Mb2483c|M.bovis_AF2122/97 HFANAAMLPLVG-ELLALHNRDEGTALMSSCIVAAQVVMVPVAYVVGTRA
Rv2456c|M.tuberculosis_H37Rv HFANAAMLPLVG-ELLALHNRDEGTALMSSCIVAAQVVMVPVAYVVGTRA
MMAR_3804|M.marinum_M HFANAAMLPLVG-QVLALHNRDEGTALMSWCIVAAQVVMVPVAYVTGSRA
MUL_3727|M.ulcerans_Agy99 HFANAAMLPLVG-QVLALHNRDEGTALMSWCIVAAQVVMVPVAYVTGSRA
MAV_1023|M.avium_104 HLGNAAMLPLYG-LAVVATHANPFTTVAS-TVVVAQAVMVPASLLAMRIA
Mflv_1475|M.gilvum_PYR-GCK AAATAALSAGVG-FLPVLGTDFGLSPVVTGAVVSVLALTTAVVQPLAGRA
TH_3965|M.thermoresistible__bu ATIGFVVTAMVLPAMFFAQAVCGLSPTGSALLIAPMAVASGVLAPMAGRI
MSMEG_1169|M.smegmatis_MC2_155 ALAALASYAVIVNLVPLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMA
. . .
MAB_3449c|M.abscessus_ATCC_199 DDIGR-KPLVVAGLV--VCGSTVVAMGFVSSLPVLVVLSLIGGIGAGLYA
Mvan_1951|M.vanbaalenii_PYR-1 DRLGR-RKLMIFGLT--LAAASTALVGFTTSLPVFLVAAYIAGAATGIFV
Mb2483c|M.bovis_AF2122/97 DAWGR-KPIFLVGFA--VLTARGFLYTLSDNSYWLVGVQLLDGIGAGIFG
Rv2456c|M.tuberculosis_H37Rv DAWGR-KPIFLVGFA--VLTARGFLYTLSDNSYWLVGVQLLDGIGAGIFG
MMAR_3804|M.marinum_M DAWGR-KPIFLVAFA--VLTARGFLYTLSDNSYWLVGVQLLDGIGAGIFG
MUL_3727|M.ulcerans_Agy99 DAWGR-KPIFLVAFA--VLTACGFLYTLSDNSYWLVGVQLLDGIGAGIFG
MAV_1023|M.avium_104 ATRGY-WPAILIALT--ALPVRGVLAASVITSWGVIPVQVLDGIGAGMLS
Mflv_1475|M.gilvum_PYR-GCK ADSGR-ISLTSGLFTGVVVTAAGVAAAALPGLVGLLGGAVVIGVGCGLIT
TH_3965|M.thermoresistible__bu VDRSHPTPVVGFGFSVVAVGLTWLAVEMAPTTPIWRLVLPFVAVGVGMAF
MSMEG_1169|M.smegmatis_MC2_155 RRIGVVPRTVLIMAA---VAVTTALLGVFTTLAALVAASIVAGMARGIMT
. . . . *:
MAB_3449c|M.abscessus_ATCC_199 SPQQAAVADVVGSRGRAGTA-LATFQMTSDIGLVVG--------------
Mvan_1951|M.vanbaalenii_PYR-1 SPQQAAVADVVGNKSRGGTA-VATFQMMADFGSIGG--------------
Mb2483c|M.bovis_AF2122/97 ALFPLVVQDVTHGTGHFNIS-LGAVTTATGIGAALS--------------
Rv2456c|M.tuberculosis_H37Rv ALFPLVVQDVTHGTGHFNIS-LGAVTTATGIGAALS--------------
MMAR_3804|M.marinum_M ALFPLIVQDLTHGTGHFNIS-LGAITTAVGVGAALS--------------
MUL_3727|M.ulcerans_Agy99 ALFPLIVQDLTHGTGHFNIS-LGAITTAVGVGAALS--------------
MAV_1023|M.avium_104 VAVPGLVARILDGTGHINVG-QGAVMAAQGLGGALS--------------
Mflv_1475|M.gilvum_PYR-GCK PLAFTMLARSTPEE-RLGQT-MGAAEIGRECGDAAG--------------
TH_3965|M.thermoresistible__bu IWSPLATTATRQLPLHLSGAGSGVYNTTRQIGSVLGSAGMAAFLTGRLSA
MSMEG_1169|M.smegmatis_MC2_155 LLQATAVTDRWGTTHYGHLS--GMLMAPIMITTALG--------------
. .
MAB_3449c|M.abscessus_ATCC_199 -----------------------PVVAGAIAEHTS-YGWAFVVGGAMPLI
Mvan_1951|M.vanbaalenii_PYR-1 -----------------------SLLVGLIAQYTS-FGWAFLISGVILAV
Mb2483c|M.bovis_AF2122/97 -----------------------NLVAGWIVVVAG-YDAAFMSLGALAGA
Rv2456c|M.tuberculosis_H37Rv -----------------------NLVAGWIVVVAG-YDAAFMSLGALAGA
MMAR_3804|M.marinum_M -----------------------NFASGWVVVTAG-YNVAFMSLGAIAGA
MUL_3727|M.ulcerans_Agy99 -----------------------NFASGWVVVTAG-YNVAFMSLGAIAGA
MAV_1023|M.avium_104 -----------------------PVLGGAVAQHLG-FRAAFLLLAGLSLG
Mflv_1475|M.gilvum_PYR-GCK -----------------------PLVVAAIAAAST-VPFGFLGLAAVVAA
TH_3965|M.thermoresistible__bu ELPFGATAVPAGEQTRVLPEFLHAPYAAAMAQSML-LPAFVALFGVLAAI
MSMEG_1169|M.smegmatis_MC2_155 -----------------------PFVGAALASLLDGYDAMFLVLGVVAAV
. :. . . :
MAB_3449c|M.abscessus_ATCC_199 AAVAWVFAPETLGRLASPQVRSMQEVAEDVGGPER---------------
Mvan_1951|M.vanbaalenii_PYR-1 AAVGWIFAPETRPR-ASTEHTQARPLGPEAGGEVP---------------
Mb2483c|M.bovis_AF2122/97 GFLLYLVAMPETVDSDVRVRSRPTLGGK----------------------
Rv2456c|M.tuberculosis_H37Rv GFLLYLVAMPETVDSDVRVRSRPTLGGK----------------------
MMAR_3804|M.marinum_M GFILYLLAMPETASARLAGR------------------------------
MUL_3727|M.ulcerans_Agy99 GFILYLLAMPETASARLAGR------------------------------
MAV_1023|M.avium_104 ALIIWVTFAPMLRRAARLPAAPSDRAGAPPTATADNQAK-----------
Mflv_1475|M.gilvum_PYR-GCK SGVGVRRGRGRVGGVG----------------------------------
TH_3965|M.thermoresistible__bu FLAGIVLSTPQPDADAQYLDEHDDYLVIELARPDPNPRTDIAVTAVIPAL
MSMEG_1169|M.smegmatis_MC2_155 AAALAAATGVRPTSGSADPSAAGDRRPPCSAEH-----------------
MAB_3449c|M.abscessus_ATCC_199 -----------------------------
Mvan_1951|M.vanbaalenii_PYR-1 -----------------------------
Mb2483c|M.bovis_AF2122/97 -----------------------------
Rv2456c|M.tuberculosis_H37Rv -----------------------------
MMAR_3804|M.marinum_M -----------------------------
MUL_3727|M.ulcerans_Agy99 -----------------------------
MAV_1023|M.avium_104 -----------------------------
Mflv_1475|M.gilvum_PYR-GCK -----------------------------
TH_3965|M.thermoresistible__bu RPTLRPTLRPSLGPPGGPVVQPNNTAALR
MSMEG_1169|M.smegmatis_MC2_155 -----------------------------