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SGTVVAVPPRVARALDLLNFSLADVRDGLGPYLSIYLLLIHDWDQASIGFVMAVGGIAAIVAQTPIGALV DRTTAKRALVVAGAVLVTAAAVAMPLFAGLYSISVLQAVTGIASSVFAPALAAITLGAVGPQFFARRIGR NEAFNHAGNASAAGATGALAYFFGPVVVFWVLAGMALISVLATLRIPPDAVDHDLARGMDHAPGEPHPQP SRFTVLAHNRELVIFGAAVVAFHFANAAMLPLVGELLALHNRDEGTALMSSCIVAAQVVMVPVAYVVGTR ADAWGRKPIFLVGFAVLTARGFLYTLSDNSYWLVGVQLLDGIGAGIFGALFPLVVQDVTHGTGHFNISLG AVTTATGIGAALSNLVAGWIVVVAGYDAAFMSLGALAGAGFLLYLVAMPETVDSDVRVRSRPTLGGK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2456c | - | - | 100% (418) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. tuberculosis H37Rv | Rv1200 | - | 1e-07 | 30.18% (169) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv2265 | - | 2e-07 | 21.82% (362) | integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2483c | - | 0.0 | 100.00% (418) | putative integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1475 | - | 5e-11 | 28.21% (195) | major facilitator transporter |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3449c | - | 2e-15 | 28.16% (348) | putative transporter |
| M. marinum M | MMAR_3804 | - | 0.0 | 82.46% (399) | integral membrane transport protein |
| M. avium 104 | MAV_1023 | - | 3e-68 | 37.98% (387) | MFS transporter |
| M. smegmatis MC2 155 | MSMEG_2966 | - | 1e-08 | 22.03% (404) | major facilitator family protein transporter |
| M. thermoresistible (build 8) | TH_3714 | - | 3e-07 | 27.65% (340) | PUTATIVE major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_3727 | - | 0.0 | 81.70% (399) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_3219 | - | 2e-11 | 23.86% (373) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2456c|M.tuberculosis_H37Rv ---MSG-------------------TVVAVPPRVARALDLLNFSLADVRD
Mb2483c|M.bovis_AF2122/97 ---MSG-------------------TVVAVPPRVARALDLLNFSLADVRD
MMAR_3804|M.marinum_M MPGASGRKPASSTESSDAGFADSMAAYDALPRRVVHALDLVNFSLADVRD
MUL_3727|M.ulcerans_Agy99 MPGASGRKPASSTESSDAGFADSMAAYDALPRRVVHALDLVNFSLADVRD
MAV_1023|M.avium_104 -----------------------MTATPRACNRDRVALQAVHFFMADMEA
MAB_3449c|M.abscessus_ATCC_199 ----------------MSSCREGNADNATVKPRLPWEIWVLVVASLVIAL
Mflv_1475|M.gilvum_PYR-GCK ----------------------------MAPLSPTAQRAPLLAAGFTTAF
MSMEG_2966|M.smegmatis_MC2_155 ----------------MSAHQPHTVSSPRHVPIDDRPLTAFHKRLTVFSA
TH_3714|M.thermoresistible__bu ---------------------MSAEAATPTSRVTPRRVAVASFIGTTVEF
Mvan_3219|M.vanbaalenii_PYR-1 --------------------------MAESDRADRRSVLLTLCLTEITSW
Rv2456c|M.tuberculosis_H37Rv G--------LGPYLSIYLLLIHDWDQASIGFVMAVGGIAAI-VAQTPIGA
Mb2483c|M.bovis_AF2122/97 G--------LGPYLSIYLLLIHDWDQASIGFVMAVGGIAAI-VAQTPIGA
MMAR_3804|M.marinum_M G--------LGPYLSVYLLVTNNWDQASIGFVMAVGGIAAI-VAQTPMGA
MUL_3727|M.ulcerans_Agy99 G--------LGPYLSVYLLVTNNWDQASIGFVMAVGGIAAI-VAQTPMGA
MAV_1023|M.avium_104 G--------MGPFLGVLLQSR-GWTTGAIGAAMTLGAIVGM-VTVAPAGA
MAB_3449c|M.abscessus_ATCC_199 G--------FGVVAPALPQYARSFGVSVTAATAVVSSFAAFRLVFAPVAG
Mflv_1475|M.gilvum_PYR-GCK G--------AHAVAGTLGTTTTGTAASLLTLGAMLAIYDGAEVILKPLFG
MSMEG_2966|M.smegmatis_MC2_155 GGPFLDGFALTIIGIALISMVPALDMSTVDVGLVGASALIGIFVGGLVFG
TH_3714|M.thermoresistible__bu YDFLIYGTAAALVFPKLFFPTASPASGVLLSFATFGVGFFARPLGGIVFG
Mvan_3219|M.vanbaalenii_PYR-1 G------VLYYAFSVLSPAICADTGWSAPAVTAAFSAGLVISALLGIPVG
. . .
Rv2456c|M.tuberculosis_H37Rv LVDRTTAKRALVVAGAVLVTAAAVAMPLFAGLYSI--------SVLQAVT
Mb2483c|M.bovis_AF2122/97 LVDRTTAKRALVVAGAVLVTAAAVAMPLFAGLYSI--------SVLQAVT
MMAR_3804|M.marinum_M FVDRTKAKRALVITGALAVTASALAMPLFPELRSI--------SLLQVLT
MUL_3727|M.ulcerans_Agy99 FVDRTKAKRALVITGALAITASALAMPLFPELRSI--------SLLQVLT
MAV_1023|M.avium_104 LVDATRHKRGCVIVVGLAAVAASAVILTSRQFWTV--------ATAQAVM
MAB_3449c|M.abscessus_ATCC_199 ALVQRLGERWVYMSGLLIVAASTGICAFVHSYWQL--------LVFRSVG
Mflv_1475|M.gilvum_PYR-GCK TLADRIGARTVLIAGLAVFAVASLSFAVADETAWL--------WAARLGQ
MSMEG_2966|M.smegmatis_MC2_155 YVTDRVGRKVMYIADLTMLVVVSIASAFATEVWQL--------VALRFLL
TH_3714|M.thermoresistible__bu HFGDRLGRKRMLVYSLVGMGVATVLIGLLPTYAQIGMAAPALLTLLRLAQ
Mvan_3219|M.vanbaalenii_PYR-1 RWLDRHGPRWIMTGGSVLGSIALAGVAAAPDVVSFT-------AAWVVAG
: .
Rv2456c|M.tuberculosis_H37Rv GIASSVFAPALAAITLGAVGPQFFARRIGRNEAFNHAGNASAAGATGALA
Mb2483c|M.bovis_AF2122/97 GIASSVFAPALAAITLGAVGPQFFARRIGRNEAFNHAGNASAAGATGALA
MMAR_3804|M.marinum_M GIASSVFAPALAAITLGIVGPQLFARRIGRNESFNHAGNATAAAITGGLA
MUL_3727|M.ulcerans_Agy99 GIASSVFAPALAAITLGIVGPQLFARRIGRNESFNHAGNATAAAITGGLA
MAV_1023|M.avium_104 CISGATIAPAMIGITLGVVGQAAFTRQNGRNQAYNHAGNMAGAALGGVAG
MAB_3449c|M.abscessus_ATCC_199 GVGSTMFTVSAAALLVRIAPEEIRGRAQGLYGSSFLLGMVAGPALGSAVV
Mflv_1475|M.gilvum_PYR-GCK GIGAAAFSPAASALVARLAPASGQGRAFGTYGSYKSVGYTLGPLIGGAIV
MSMEG_2966|M.smegmatis_MC2_155 GVAIGADYPIASSLLAEFIPSRYRGRLLGALFVVWAGGAAAAAGVGWALS
TH_3714|M.thermoresistible__bu GFAMGGEWGGATLMAVEHASADRKG-FYGAFPQMGAPAGTATATLAFFAV
Mvan_3219|M.vanbaalenii_PYR-1 VAMSAVFYAPAFAALTRYFRPDAVRALTALTLAAGLASTVFAPLTAAISA
. . .
Rv2456c|M.tuberculosis_H37Rv YFFGPVVVFWVLAGMALISVLATLRI-----------------PPDAVDH
Mb2483c|M.bovis_AF2122/97 YFFGPVVVFWVLAGMALISVLATLRI-----------------PPDAVDH
MMAR_3804|M.marinum_M FFFGPVVVFWVLATMAAMSVVATLRI-----------------PHDAIDH
MUL_3727|M.ulcerans_Agy99 FFFGPVVVFWVLATMAAMSVVATLRI-----------------PHDAIDH
MAV_1023|M.avium_104 WVFGYAGIFWLAAGFAVATIAAVLAI-----------------PGGDIDH
MAB_3449c|M.abscessus_ATCC_199 GLSLSAPFIIYAAALVIVVMLVYFGL-----------------RRS----
Mflv_1475|M.gilvum_PYR-GCK TFGGLQALFAVMAALAAAVAVWAAVA-----------------VPR----
MSMEG_2966|M.smegmatis_MC2_155 TMGPDAWRWMLASPAVFGVVTLMLRAGTPESPRWLLSRGRTEEAQRVCRK
TH_3714|M.thermoresistible__bu SRLPDGQFLSWGWRLPFLLSAVLIGIG----------------LAVRLTL
Mvan_3219|M.vanbaalenii_PYR-1 HMDWRETYLVLAAAMAVITVPAHFFG------------------------
Rv2456c|M.tuberculosis_H37Rv DLARGMDHAPGEPHPQPSRFTVLAHNRELVIFGAAVVAFHFANAAMLPLV
Mb2483c|M.bovis_AF2122/97 DLARGMDHAPGEPHPQPSRFTVLAHNRELVIFGAAVVAFHFANAAMLPLV
MMAR_3804|M.marinum_M DLARGMDHAPGEPHAQPSGFGVLLHNRTLMIFAAAVVAFHFANAAMLPLV
MUL_3727|M.ulcerans_Agy99 DLARGMDHAPGEPQAQPSGFGVLLHNRTLMIFAAAVVAFHFANAAMLPLV
MAV_1023|M.avium_104 HVARGEARAAG--EAPVKAMRVLARSRPLLVLAAAMVLFHLGNAAMLPLY
MAB_3449c|M.abscessus_ATCC_199 ----TLLDVADEHHGTPVRLTSALRHRTFLAALMSNFSAGWAIFGIRGAL
Mflv_1475|M.gilvum_PYR-GCK ---------LAVLPRTRQTLLDTVRRFSESSFVTPTLALAAATAALSAGV
MSMEG_2966|M.smegmatis_MC2_155 VWGNDADIAMIPAEPAHTPFTALFRGIYLRRVVFVGVFFTAHVIPLFAVY
TH_3714|M.thermoresistible__bu TESPDFAAVQARSAVHRMPIAEAFRRHRRQILLVAGAYLSQGVFAYICVA
Mvan_3219|M.vanbaalenii_PYR-1 ---LRRPWPHIEHHHLVEPPTRIARSRQFVALTVAFAMAGLASYAVIVNL
:
Rv2456c|M.tuberculosis_H37Rv GELLALHNRDEGTALMSSCIVAAQVVMVPVAYVVGTR-----ADAWGRKP
Mb2483c|M.bovis_AF2122/97 GELLALHNRDEGTALMSSCIVAAQVVMVPVAYVVGTR-----ADAWGRKP
MMAR_3804|M.marinum_M GQVLALHNRDEGTALMSWCIVAAQVVMVPVAYVTGSR-----ADAWGRKP
MUL_3727|M.ulcerans_Agy99 GQVLALHNRDEGTALMSWCIVAAQVVMVPVAYVTGSR-----ADAWGRKP
MAV_1023|M.avium_104 GLAVVATHANPFTTVAS-TVVVAQAVMVPASLLAMRI-----AATRGYWP
MAB_3449c|M.abscessus_ATCC_199 LPLLVVEALHQRPGAAGLVFAAFAAGDVSTAFLAGSW-----SDDIGRKP
Mflv_1475|M.gilvum_PYR-GCK GFLPVLGTDFGLSPVVTGAVVSVLALTTAVVQPLAGR-----AADSGRIS
MSMEG_2966|M.smegmatis_MC2_155 TFGPDILREMG-VGAHGSHHVYVAELVISLLFLVGGVPGLLLVDRIGRKP
TH_3714|M.thermoresistible__bu YLVSYGTSVAGIDRTATLFGVSVAAVLAVVMYPLFGS----LSDTFGRKP
Mvan_3219|M.vanbaalenii_PYR-1 VPLMTAHGISTQAAALALGLGGAGQVLGRLGYQRMVR----HLSVVPRTA
.
Rv2456c|M.tuberculosis_H37Rv IFLVGFA--VLTARGFLYTLSDNSYWLVGVQLLDGIGAGIFGA--LFPLV
Mb2483c|M.bovis_AF2122/97 IFLVGFA--VLTARGFLYTLSDNSYWLVGVQLLDGIGAGIFGA--LFPLV
MMAR_3804|M.marinum_M IFLVAFA--VLTARGFLYTLSDNSYWLVGVQLLDGIGAGIFGA--LFPLI
MUL_3727|M.ulcerans_Agy99 IFLVAFA--VLTACGFLYTLSDNSYWLVGVQLLDGIGAGIFGA--LFPLI
MAV_1023|M.avium_104 AILIALT--ALPVRGVLAASVITSWGVIPVQVLDGIGAGMLSV--AVPGL
MAB_3449c|M.abscessus_ATCC_199 LVVAGLV--VCGSTVVAMGFVSSLPVLVVLSLIGGIGAGLYAS--PQQAA
Mflv_1475|M.gilvum_PYR-GCK LTSGLFTGVVVTAAGVAAAALPGLVGLLGGAVVIGVGCGLITP--LAFTM
MSMEG_2966|M.smegmatis_MC2_155 LLLWTFA--VMSAAFIAMAVVPGAPAQILFALLALYAVTSGACN-FIEII
TH_3714|M.thermoresistible__bu LFLAGVIAMGVSIGPAFALIDTGRPALFLVALVLVFGLAMAPAAGVTGAL
Mvan_3219|M.vanbaalenii_PYR-1 LIMAGVA-----VTTALLGLLTSVATLITVAVVAGVVRGVMTL---LQAT
. . ::
Rv2456c|M.tuberculosis_H37Rv VQDVTHGTGHFNISLGAVTTATGIGAALSNLVAGWIVVVAG-YDAAFMSL
Mb2483c|M.bovis_AF2122/97 VQDVTHGTGHFNISLGAVTTATGIGAALSNLVAGWIVVVAG-YDAAFMSL
MMAR_3804|M.marinum_M VQDLTHGTGHFNISLGAITTAVGVGAALSNFASGWVVVTAG-YNVAFMSL
MUL_3727|M.ulcerans_Agy99 VQDLTHGTGHFNISLGAITTAVGVGAALSNFASGWVVVTAG-YNVAFMSL
MAV_1023|M.avium_104 VARILDGTGHINVGQGAVMAAQGLGGALSPVLGGAVAQHLG-FRAAFLLL
MAB_3449c|M.abscessus_ATCC_199 VADVVGSRGRAGTALATFQMTSDIGLVVGPVVAGAIAEHTS-YGWAFVVG
Mflv_1475|M.gilvum_PYR-GCK LARSTPEE-RLGQTMGAAEIGRECGDAAGPLVVAAIAAAST-VPFGFLGL
MSMEG_2966|M.smegmatis_MC2_155 YPNELFPTSVRASATGTVVAISRVGSAVSTFVLPLVLSGTG-LGGVMWLL
TH_3714|M.thermoresistible__bu FAMTFDADVRYSGVSIGYTLSQVLGSAFAPTIAAALYAATESSGSIVAYL
Mvan_3219|M.vanbaalenii_PYR-1 AVTERWGITHYGQLSGILSAPVMLSTALGPFVGAGLATLLGGYGAMFVVL
. . . : .
Rv2456c|M.tuberculosis_H37Rv GALAGAGFLLYLVAMPETVDSDVRVRSRPTLGGK-----------
Mb2483c|M.bovis_AF2122/97 GALAGAGFLLYLVAMPETVDSDVRVRSRPTLGGK-----------
MMAR_3804|M.marinum_M GAIAGAGFILYLLAMPETASARLAGR-------------------
MUL_3727|M.ulcerans_Agy99 GAIAGAGFILYLLAMPETASARLAGR-------------------
MAV_1023|M.avium_104 AGLSLGALIIWVTFAPMLRRAARLPAAPSDRAGAPPTATADNQAK
MAB_3449c|M.abscessus_ATCC_199 GAMPLIAAVAWVFAPETLGRLASPQVRSMQEVAEDVGGPER----
Mflv_1475|M.gilvum_PYR-GCK AAVVAASGVGVRRGRGRVGGVG-----------------------
MSMEG_2966|M.smegmatis_MC2_155 AGVNVVGLLVTLVLGEETRGRALSETSAATRLTEPETRSDPVDA-
TH_3714|M.thermoresistible__bu IGVSVISAVSVCLLPGGWGRTGDQPATEVPASVRPMVSGPD----
Mvan_3219|M.vanbaalenii_PYR-1 GAVALAAALLATATRVRPVDADG----------------------
.: . :