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MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAALAALFGAHAREYQAAAAQAA AYHEQFVHRLSAAATSYAVTEVTIATSLRGALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPI VNAPTNVLLGRDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYTGGNGGSAGLIGNGGTGGAGFAGGVGGMG GTGGWLMGNGGMGGAGGVGGNGGAGGQALLFGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNG QSIVIDFVRHGQTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIRTQQTAAPLA NLLGMAPQVLPGLNEIHAGIFEDLPQISPAGLLYLVGPIAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGA VQTIYDASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHPVPNTGAVVVQGNPEGGWTL VSWDGIPVGPASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVA DDVIDATGHPYLSGLPIGLPSLIP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv0754 | PE_PGRS11 | - | 100% (584) | PE-PGRS FAMILY PROTEIN |
M. tuberculosis H37Rv | Rv2490c | PE_PGRS43 | 3e-73 | 52.15% (303) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv3345c | PE_PGRS50 | 4e-70 | 51.74% (288) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0776 | PE_PGRS11 | 0.0 | 100.00% (584) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_4577 | - | 2e-54 | 44.60% (287) | phosphoglycerate mutase |
M. leprae Br4923 | MLBr_01183 | - | 3e-13 | 41.67% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_0321c | - | 7e-19 | 40.24% (164) | hypothetical protein MAB_0321c |
M. marinum M | MMAR_4953 | - | 0.0 | 66.95% (593) | PE-PGRS family protein |
M. avium 104 | MAV_4778 | - | 2e-77 | 63.03% (238) | pe_pgrs family protein |
M. smegmatis MC2 155 | MSMEG_6545 | - | 3e-43 | 46.70% (227) | phosphoglycerate mutase family protein |
M. thermoresistible (build 8) | TH_4040 | - | 4e-44 | 42.49% (273) | PUTATIVE Phosphoglycerate mutase |
M. ulcerans Agy99 | MUL_3507 | - | 1e-68 | 46.32% (326) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_5262 | - | 1e-65 | 50.00% (290) | phosphoglycerate mutase |
CLUSTAL 2.0.9 multiple sequence alignment Rv0754|M.tuberculosis_H37Rv MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAA Mb0776|M.bovis_AF2122/97 MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAA MMAR_4953|M.marinum_M MSFVLVAPDMLATAAADVVQIGSAVSAGNLAAAIPTTEVMAAAADEVSGA Mflv_4577|M.gilvum_PYR-GCK ----------------------------MPDPR--TCRVRRILIAALSAV TH_4040|M.thermoresistible__bu -----------------------------------------VVVAAISAA Mvan_5262|M.vanbaalenii_PYR-1 ----------------------------MRDVRRTARRLLTILAATLAAA MSMEG_6545|M.smegmatis_MC2_155 -----------------------------MTTHTRRTAAVAALVVALVAG MAV_4778|M.avium_104 ------------------------------MLRTPLCRAG-AVLASVVLL MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 MSFVSVTQEALAAAASDVGVIGSSLQAANMSVAAPTAGVLAAGADEVSVA Rv0754|M.tuberculosis_H37Rv LAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRG Mb0776|M.bovis_AF2122/97 LAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRG MMAR_4953|M.marinum_M IAALFGANAQEYQAAAAQAATFHEQFVRALSEAGASYASAEATIVTGLS- Mflv_4577|M.gilvum_PYR-GCK LLVLVSAIP----------------------------------------- TH_4040|M.thermoresistible__bu LLFIVSAIP----------------------------------------- Mvan_5262|M.vanbaalenii_PYR-1 VLFAASAFA----------------------------------------- MSMEG_6545|M.smegmatis_MC2_155 MLTAPNAVA----------------------------------------- MAV_4778|M.avium_104 CSASATASA----------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 MANIIS-------------------------------------------- MUL_3507|M.ulcerans_Agy99 MAALFSGHGQAYQTLSAQANAFHAQFLQALTNAGGAYAAAEVANLSPLQG Rv0754|M.tuberculosis_H37Rv ALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLG Mb0776|M.bovis_AF2122/97 ALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLG MMAR_4953|M.marinum_M ------SAVADGFQTAVYGPIRAAGQAWISSPAGEVVDPVINAPTEALFG Mflv_4577|M.gilvum_PYR-GCK -------------------------------------------------- TH_4040|M.thermoresistible__bu -------------------------------------------------- Mvan_5262|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6545|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4778|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 ------------------------------NGPDGDAG------------ MUL_3507|M.ulcerans_Agy99 VEQGVLGVVNAPAQALLGRPLIGDGAAGTAASPNGGAGGLLYGNGGAGYS Rv0754|M.tuberculosis_H37Rv RDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYT---------GGNGGSAGL Mb0776|M.bovis_AF2122/97 RDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYT---------GGNGGSAGL MMAR_4953|M.marinum_M RGLISNGAAGTAAHPNGGAGGILFGDGGPGYTPTGGIGAVAGGIGGDAGL Mflv_4577|M.gilvum_PYR-GCK -------------------------------------------------- TH_4040|M.thermoresistible__bu -------------------------------------------------- Mvan_5262|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6545|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4778|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 ----ATGAQGSQG------------------------------------- MUL_3507|M.ulcerans_Agy99 YTSGATAEAGGNGGAAGLIGN----------------------------- Rv0754|M.tuberculosis_H37Rv IGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLF Mb0776|M.bovis_AF2122/97 IGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLF MMAR_4953|M.marinum_M IGNGGLGGNGFGGGTGGMGGTGGWLMGNGGGGGVGGVGG---VGGQALFF Mflv_4577|M.gilvum_PYR-GCK -------------------------------------------------- TH_4040|M.thermoresistible__bu -------------------------------------------------- Mvan_5262|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6545|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4778|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- Rv0754|M.tuberculosis_H37Rv GNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHG Mb0776|M.bovis_AF2122/97 GNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHG MMAR_4953|M.marinum_M GNGGAGGGSALG------GRAGLFIGEPGTGWVADPGNGQSIVIDFVRHG Mflv_4577|M.gilvum_PYR-GCK --------------------------------------SWAMTLTFVRHA TH_4040|M.thermoresistible__bu --------------------------------------AWSMTVTFVRHG Mvan_5262|M.vanbaalenii_PYR-1 --------------------------------------AADIVLTFVRHG MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------QRIITLTLVRHA MAV_4778|M.avium_104 --------------------------------------DESIVIDLVRHG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 ---------------------------------ATGAAGAMANCNWIDDD MUL_3507|M.ulcerans_Agy99 -------------------------GGAGGSGWAGGAGGAGGNGGWLYGN Rv0754|M.tuberculosis_H37Rv QTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIR Mb0776|M.bovis_AF2122/97 QTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIR MMAR_4953|M.marinum_M QTASNVAELIDTNVPGPPLTAEGHLQADIIAGQLFAKGPYAGIFDSELLR Mflv_4577|M.gilvum_PYR-GCK ESLANEAGIIDTRVPGPGLSEAGELQARAIAPVLAGMG-FDGIYVSSMLR TH_4040|M.thermoresistible__bu ESQANAAHIIETDIPGRGLTERGHAEAAAVAEILARNG-HDKAYSSPLLR Mvan_5262|M.vanbaalenii_PYR-1 QSQANADGIINTEVPGPHITALGQQQAALVAGVLAAGG-YQGIYASDMVR MSMEG_6545|M.smegmatis_MC2_155 QSEGNASGLIDTSTPGPPLTALGREQAETAAQKLAAGHTFDGIYASTMIR MAV_4778|M.avium_104 QSVANAAGLIDTAVPGASLTQLGQQQAQTVAGVLAARGPVAAIFASQLIR MLBr_01183|M.leprae_Br4923 ------MPLFLNAEP-QALTAAANTLEGLSAATVASNA-------AAAQL MAB_0321c|M.abscessus_ATCC_199 CATR------------GGTGGTGGNGGPGGAGGPGGHG-GVIDFEVET-- MUL_3507|M.ulcerans_Agy99 GGAGGLGGAAAGDYTAGGVGGAGGNAGLWGDGGAGGNGSATYDYDQNFSR . Rv0754|M.tuberculosis_H37Rv ---------------------------------TQQTAAPLANL------ Mb0776|M.bovis_AF2122/97 ---------------------------------TQQTAAPLANL------ MMAR_4953|M.marinum_M ---------------------------------TQQTAAPLAAL------ Mflv_4577|M.gilvum_PYR-GCK ---------------------------------TQLTAQPMLDL------ TH_4040|M.thermoresistible__bu ---------------------------------TLETARHFAD------- Mvan_5262|M.vanbaalenii_PYR-1 ---------------------------------TQETAAPLAD------- MSMEG_6545|M.smegmatis_MC2_155 ---------------------------------TQQTAQPLAD------- MAV_4778|M.avium_104 ---------------------------------TQQTAAPLAS------- MLBr_01183|M.leprae_Br4923 ---------------------------------TTEIAPPAAD------- MAB_0321c|M.abscessus_ATCC_199 -----------------FMDG------------VTLQAK----------- MUL_3507|M.ulcerans_Agy99 LGALEGAGGNGGHGGLLFGNGGGGGDAGANNKFVTAQATPNGAAGGYGGN . * Rv0754|M.tuberculosis_H37Rv --------------LGMAPQ-VLPGLNEIHAGIFEDLPQ-ISPAGLLYLV Mb0776|M.bovis_AF2122/97 --------------LGMAPQ-VLPGLNEIHAGIFEDLPQ-ISPAGLLYLV MMAR_4953|M.marinum_M --------------YGITDVPALSGLNEISAGIFDGLQQ-ITPAGLLYLI Mflv_4577|M.gilvum_PYR-GCK --------------LPGSSYQVLPGLREISAGIFEGSSENEGLGRLGYAL TH_4040|M.thermoresistible__bu ---------------DDSEITRLEGMREIPGGWFEGARDDSGLERLLYGL Mvan_5262|M.vanbaalenii_PYR-1 --------------ILGESVTVLPGLREIDAGIYEGSSETDGLGRLGYGL MSMEG_6545|M.smegmatis_MC2_155 --------------LSREPVTVLPGLREIEAGIYEGQPE--ALAGFTYYE MAV_4778|M.avium_104 --------------ALGMNVQVLPGLNEIDAGIFNGQPQ-FSLGGLAYLL MLBr_01183|M.leprae_Br4923 ------------------------DVSILLAHFFSGHGR-------QYQA MAB_0321c|M.abscessus_ATCC_199 ------------------------GGRGGNG----GHGGAGGTGGTG--- MUL_3507|M.ulcerans_Agy99 AGLWGNGGAGGDGGFGGTATVIGDGGTGGNGGLLSGDGGAGGVGGTGGIQ . . . Rv0754|M.tuberculosis_H37Rv GPIAWTLGFPIVPMLAPGSTDVNGI------------VFNRAFTGAVQTI Mb0776|M.bovis_AF2122/97 GPIAWTLGFPIVPMLAPGSTDVNGI------------VFNRAFTGAVQTI MMAR_4953|M.marinum_M GPMAWTLGYPIVPMLTPGSLDFNGV------------VFNQDFTHAMDTM Mflv_4577|M.gilvum_PYR-GCK APVTWMLGAR--FVPVPGGEDGN--------------AFDARVDGAIAEI TH_4040|M.thermoresistible__bu PGIAWALGLR--FIPVLGSEDGN--------------AFDARVDAALRQI Mvan_5262|M.vanbaalenii_PYR-1 TPALWTLGLRSAWIPDSTDTNGN--------------VFSDRMSEAVQII MSMEG_6545|M.smegmatis_MC2_155 APTRWLQGDR--TARIPGSIDGD--------------EFDARFDEAVREI MAV_4778|M.avium_104 APIAWMLGLRIVPMLAPGSADANGY------------EFRRRFDGALQTV MLBr_01183|M.leprae_Br4923 H-------------ASQGATNHQ-----------------DLIQSLLTS- MAB_0321c|M.abscessus_ATCC_199 --------------GKGGDG-------------------DDCEFGRTGGN MUL_3507|M.ulcerans_Agy99 IYSGGGIGGVGGIGGNGGAGGTSGLIGDGGAGGAGGTGGGNAGVGGVGGV Rv0754|M.tuberculosis_H37Rv YDASLAN------------------PVVAADGNITSVAYSSAFTIGVGTM Mb0776|M.bovis_AF2122/97 YDASLAN------------------PVVAADGNITSVAYSSAFTIGVGTM MMAR_4953|M.marinum_M YSAALAN------------------PVLAANGKITDVAYSSAFTIGVGTM Mflv_4577|M.gilvum_PYR-GCK ADN----------------------------GDENAVAFAHGATIMFWVM TH_4040|M.thermoresistible__bu HADYLA------------------------GETQNPVVFGHGGTIMFWTM Mvan_5262|M.vanbaalenii_PYR-1 YED----------------------------GWARPVAFSHGATIMFWTM MSMEG_6545|M.smegmatis_MC2_155 YDS----------------------------EDTDPVAFSHAGAIMTWVA MAV_4778|M.avium_104 YGSAAASAGGFGDVLQAVYAGAVTNPVRAANGRITGVAFSSEFAIGVGTM MLBr_01183|M.leprae_Br4923 -----------------------------------SSAYAG--------- MAB_0321c|M.abscessus_ATCC_199 GGTG------------------------GRGGDGNFAGTGGN-----GGA MUL_3507|M.ulcerans_Agy99 GGTGGAA------------------RLFGSGGSGGIGGTGGHSLINSGGG . Rv0754|M.tuberculosis_H37Rv MNVDNPHPLLLLTHPVPNTGAVVVQGNPEGG------------WTLVSWD Mb0776|M.bovis_AF2122/97 MNVDNPHPLLLLTHPVPNTGAVVVQGNPEGG------------WTLVSWD MMAR_4953|M.marinum_M MNVDNPDPLLLLTHPLPNTGVVEVQGSPANG------------WTMVSWD Mflv_4577|M.gilvum_PYR-GCK MNVDNPDLLLMLRHQLDNVESVVVEGSPEEG------------WTLVSWA TH_4040|M.thermoresistible__bu MNVDNPDLLLMLTHTLGNTETVVIEGSPDEG------------WTLVSWA Mvan_5262|M.vanbaalenii_PYR-1 MNVDNPDLGLLLSHQLPNTGVVVLEGNPEDG------------WTLVSWD MSMEG_6545|M.smegmatis_MC2_155 MNVDNPDLGLLSRHPLGNTGHAVVKGNPTGG------------WTLVDWG MAV_4778|M.avium_104 MTVKNPDPLVLLFDPLPNTGIVVIQGSPRDG------------WTLISWN MLBr_01183|M.leprae_Br4923 TETANHDSL----------------------------------------- MAB_0321c|M.abscessus_ATCC_199 ILVKCQHDLSLGTHPMDVSAGTGGNGG-------------------IGGG MUL_3507|M.ulcerans_Agy99 IGGKGGGGGAAGLIGDGGAGGAGGNGGDGTGAGGLGGNGASADWIGNGGS Rv0754|M.tuberculosis_H37Rv GIPVGP-ASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINAVRD Mb0776|M.bovis_AF2122/97 GIPVGP-ASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINAVRD MMAR_4953|M.marinum_M GIPVAP-ATLPTQLFVDVRNLITAPQYAGWDIFYSLFTGNPTTILTAVRD Mflv_4577|M.gilvum_PYR-GCK GQAVSADPSLATKLLVNVRDLVVAPQTALYNVGTAFSSGDFETLVNAVRD TH_4040|M.thermoresistible__bu GVEVSRTPSLPTTLFVRTRDLLVAPQTALYNLGQALRTGDVVTVVEALRD Mvan_5262|M.vanbaalenii_PYR-1 GVAVDPDPSFLTKTFVNVRELITTPQTAVYNVKKAFATGDLAAITDSFAQ MSMEG_6545|M.smegmatis_MC2_155 GINTE--------------------------------------------- MAV_4778|M.avium_104 GKPVHPGWSATRNGRGANGLCLMLDPSTRTGVCAAKPPGPASAPVAAR-- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 GGGGGS--------VGANG------------ATTGVFSSSSDCSGPGPQ- MUL_3507|M.ulcerans_Agy99 GGAGGSGGLGAHAGAGGNGGSLYGNDGSGGAGGTGASGAGGNGGGGGAAG Rv0754|M.tuberculosis_H37Rv GADEVG-------------------AAVVQFPHAVADDVIDATGHPYLSG Mb0776|M.bovis_AF2122/97 GADEVG-------------------AAVVQFPHAVADDVIDATGHPYLSG MMAR_4953|M.marinum_M GIEEVG-------------------SAVINFPIEVTEDVVNAICG-ATDG Mflv_4577|M.gilvum_PYR-GCK GLIEVTRAVVRFIPDTVRDIVDEFRPSVTEDSLDVTELHRAVVTAAPQDD TH_4040|M.thermoresistible__bu GILDVVX-----------------XPGTSPTMMRAATHRR---------- Mvan_5262|M.vanbaalenii_PYR-1 AVIDVVLAPVRFVGAVATDVLELVFPPAPSVQVEAPMSAESTTD---ESD MSMEG_6545|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4778|M.avium_104 -------------------------PGLS--------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 --PNPGS------------------PGDPGTSVAVSGAQGNPGQAQFL-- MUL_3507|M.ulcerans_Agy99 MMGDGGA------------------GGDGGDGSAAGGLGGDGGNADWLGN Rv0754|M.tuberculosis_H37Rv LPIGLPSLIP---------------------------------------- Mb0776|M.bovis_AF2122/97 LPIGLPSLIP---------------------------------------- MMAR_4953|M.marinum_M LTAGAPSLVG---------------------------------------- Mflv_4577|M.gilvum_PYR-GCK DEAEPQSVAVAEAETRNGSGVAPAGSTPPSGDEVTGSTDDDEATASDVVL TH_4040|M.thermoresistible__bu -------------------------------------------------- Mvan_5262|M.vanbaalenii_PYR-1 VPADVPDDVVAVAPSEDVESRTPEPASDEAETREESAAPESEATEPEISA MSMEG_6545|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4778|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 ---------IVP-------------------------------------- MUL_3507|M.ulcerans_Agy99 GGGGTGGFGLPPATGGFGGRGGRLFGSPGAQGRRALMCLSAACRC----- Rv0754|M.tuberculosis_H37Rv -------------------------------------------------- Mb0776|M.bovis_AF2122/97 -------------------------------------------------- MMAR_4953|M.marinum_M -------------------------------------------------- Mflv_4577|M.gilvum_PYR-GCK EDTVDVDTIDVDTVEEDTGASDHAVGNHPDAEADDAAPANGSAKSSDDDG TH_4040|M.thermoresistible__bu -------------------------------------------------- Mvan_5262|M.vanbaalenii_PYR-1 SQSEESE-VETETTEETTTAG---------------------TTGDDDTD MSMEG_6545|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4778|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_0321c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- Rv0754|M.tuberculosis_H37Rv ------------ Mb0776|M.bovis_AF2122/97 ------------ MMAR_4953|M.marinum_M ------------ Mflv_4577|M.gilvum_PYR-GCK DSDDDASERAAA TH_4040|M.thermoresistible__bu ------------ Mvan_5262|M.vanbaalenii_PYR-1 ETDDGAAVKEAA MSMEG_6545|M.smegmatis_MC2_155 ------------ MAV_4778|M.avium_104 ------------ MLBr_01183|M.leprae_Br4923 ------------ MAB_0321c|M.abscessus_ATCC_199 ------------ MUL_3507|M.ulcerans_Agy99 ------------