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M. tuberculosis H37Rv Rv2490c (PE_PGRS43)

annotation: PE-PGRS FAMILY PROTEIN
coordinates: 2801254 - 2806236
length: 1660

SYVIATPEMMATAAFDLARIGSQVSAASAVAAMPTTEVVAAGADEVSAGIAALFSAHAQEYQALSAQAAA
FHDQFVHTLTAAARWYTATEIANAAAMRVVLGAVNAPTQTLLGRPLIGDGAHGTAPGQPGGAGGLLFGNG
GNGAAGAVGQVGGAGGAAGLFGIGGAGGAGGAGAPGGTGGTGGWLAGGGGVGGMGGAGGGAGGAGGNAGL
FGNGGAGGAGGAGGGAGGAGGNAGWFGHGGAGGVGGVGAAGANGATPGQDGAAGVAGSDDGAGGDGLAGS
DGGDGGAGGVGGNGGRGGWLLGNGGAGGVGGVGGAGGAGAAGGAGGAGATGINGPAGISAAGGDGGAGGN
GGAGGNGGVGGAGGAGGSAGLLGYVGRAGDGGAGGGGGLGGAPGDGGAGGNGGSWLAAGDGGAGGHGGDP
GLGGAGGAGGASGGAGARAGANGLAAGNDGPVSGGNGGKGGNGAHAPVAGGHGGNGGAGGNGGLVGDGGA
GGHGGDGAAGAGYADMTAIFLGSSGTPGEDGGNGGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAH
GFNAVLVSDGGNGGDGGAGGRGGDGGAGGAGGDAPAGRAGSQGVGGDGGAGGAGGAPGNGGSGGRGDMAF
KDGDGGAGGDGGDPGAGGKGGAGGAGATEGVTGATGATVHSGGNGGKGGNGADATVAGANGGKGGAGGNG
GLVGDGGAGGDGGSGAAGANGANVGEDGADGTLSGQPGEGSEANGGQGGVGGGGAGGAGGDGGAGSSALG
SGGNGGRGDAGQAGGAGGAGGAGGAGGSVSGDGGPGGKGGAGGAGGAGASGGGGGKGASGADSAEAVGGA
GGKGGDGGVGGVGGDGGPGGDGGAGGAAPAGQVGSHGVGGVGGDGGLGGAGGNGGDGGHGSDGGDGGDGG
DPGAGGLGGLGGDSGNGTRAASGVDASDHGPGSGGNGGNGGNGAQASVAGGAGGNGGDGGNAGRVGDGGA
GGNGGDGAAGANGANSGAPGSDALALGQPGGNGGQGDAGQAGGAGGAGGAGGAGGSVSGDGGAGGNGGAG
GNGGVGASGGAGARGANGIDSIGGTGGAGGGGGDGGAGGVGGHGGDGGVGGAAPSGTVGSHGTGGVGGDG
GLGGAGGVGGAGGNGGIGITVGGAGGAGGNGGDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGG
VGGNGAKAAAAGGDGGQGGDGGNAGLFGDGGAGGDGADGTAAEALGGDGGAGGAGGKGGDAGDIGDGGDG
GKGGDGAHGALGGLTVAGGNGGAGGAGGAGGAGGAFLGDGGNGGAGGQGGAGRGGSPGGGGGVGGHGGAG
GDAGMNGGGGTGGQGGNGAAGGAGWSPDSDLKGFDGFDGGSGGAGGDGGAGGAGGTQTGDGGDGGAGGLG
GAGGVGGNGVDGFDINETTGRDGGDGGDGGYGGWGGAGGNGGAGGSAPAGEVGNRGVGGDGGDGGSGGDA
GNGGLGGDGFTYLADFDGEPGGDGGDGGDGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGGDGGNGGHGG
DGNGSFADAGDGGPGGNGGNGGLGGAGRDGGAPGGDGGDGGTGGSGGFGAPPPRSIGGGDGGDGGRGGDG
GRGAGGLTSGGVGSSGESGGSGNGRGDPGSGGSGGEGGEGGPSISVNVT*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2490cPE_PGRS43-100% (1660)PE-PGRS FAMILY PROTEIN
M. tuberculosis H37RvRv3508PE_PGRS540.050.27% (1830) PE-PGRS family protein
M. tuberculosis H37RvRv3514PE_PGRS570.052.63% (1577) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2517cPE_PGRS43b0.099.65% (1154) hypothetical protein Mb2517c
M. gilvum PYR-GCKMflv_5091-0.047.90% (833) triple helix repeat-containing collagen
M. leprae Br4923MLBr_01183-1e-1034.78% (92) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-6e-5135.10% (453) hypothetical protein MAB_4284c
M. marinum MMMAR_2656-0.048.74% (1980) PE-PGRS family protein, PE_PGRS50
M. avium 104MAV_4827-7e-2544.71% (170) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-16640.31% (1089) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-5e-4642.86% (301) PUTATIVE -
M. ulcerans Agy99MUL_4367-0.047.36% (1191) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-1e-17645.15% (855) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


Rv2490c|M.tuberculosis_H37Rv        -MSYVIATPEMMATAAFDLARIGSQVSAASAVAAMPTTEVVAAGADEVSA
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               -MSLVTVSPELVAGAASDLARIGSSLGAANAAAAGPTTTVLSAAADEVSV
MUL_4367|M.ulcerans_Agy99           -MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDEVSA
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       MMFLAPPGGPGPISAAIQLTSTGSEATEP--------------------W
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPD
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GIAALFSAHAQEYQALSAQAAAFHDQFVHTLTAAARWYTATEIAN-----
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               AIATLFGTHAAEYQSLSARMAAFHEQFVQTLTSGAGIYVSTEATNASFIS
MUL_4367|M.ulcerans_Agy99           AIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALN---MW
Mflv_5091|M.gilvum_PYR-GCK          -MVTFGGGATPTPTSLGAAAVDLSG------TSCG---------------
Mvan_1264|M.vanbaalenii_PYR-1       YVVSFGGSGAPTPNNLAASLVDLSG------TSCG---------------
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTN------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQP---------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                RVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR-------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        --AAAMRVVLGAVNAPTQTLLGRPLIGDGAHGT-APGQPGGAGGLL-FGN
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               ALQLAEQNALNAINAPTQSWLGRPLIGNGVDATPGSGQAGGAGGLL-WGN
MUL_4367|M.ulcerans_Agy99           PLQELEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGIL-WGN
Mflv_5091|M.gilvum_PYR-GCK          ------------------------LICNGQDGT------GQNGGIL-FGN
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------LICNGQDGT------GQNGGIL-FGN
MSMEG_0868|M.smegmatis_MC2_155      ---TTDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------------------DGPSILSPSLLSPRDNDFLSHND
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---------------------------------DALAARRIDNVMLVSAF
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GGNGA-AGAVGQVGGAGGAAGLFGIGGAGGAGGAGAPGGTG---------
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               GGAGG-SGAAGQSGGAGGSAGLFGNGGAGGAGGISAAGNGGSGGVGGRGG
MUL_4367|M.ulcerans_Agy99           GGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGGVGAAGMTG---------
Mflv_5091|M.gilvum_PYR-GCK          GGSGWNSDVVGMDGGNGGNGGLFG--------------------------
Mvan_1264|M.vanbaalenii_PYR-1       GGSGWNSEIAGVSGGNGGNAGLFG--------------------------
MSMEG_0868|M.smegmatis_MC2_155      LGTTLIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTTVN--------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      TDFASHNPIASGNQVMSPSG------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                LAAAALAQNVGGAMGYERTAVLLVEP------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        ------------------------GTGGWLAGGGGVGGMGG----AGGGA
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               LVYGSGGAGGAGGQGALSGGAGGAGGGAWLWGAGGAGGSGGEGLASAGGV
MUL_4367|M.ulcerans_Agy99           ---GSGGAG---------------GGGGWLWGAGGSGGAAG-----AGGS
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GGAGGNAGLFGNGGAGGAGGAGGGAGGAGGNAGWFGHGGAGGVGGVGAAG
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               GGAGGNAGLIGTGGLGGAGGVGGQNGGAGGDGGNAPLLGRGGTGGVGGAS
MUL_4367|M.ulcerans_Agy99           GGSGG--WLWGN---------AGQTAGAG----------VGGAGGAGGAG
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      ---------------------------------------PQAQLPVPTVA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        ANGATPGQDGAAGVAGSDDGAGGDGLAGSDGGDGGAGGVGGNGGRGGWLL
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               D-GGNGGAGGDGGVGGGLFGSGGAGGSGGAGGVLGTGGDGGSGGAAAGLW
MUL_4367|M.ulcerans_Agy99           D-AGDQGVSG--------VAPGEAGAVGFAG-------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      SAVLDPTQIVNWLIYQPLHAAGQQFWVVSPIG------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GNGGAGGVGGVG---------------------GAGG-------AGAAGG
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               GAGGSGGAGGNGADGISGGIGESGGDGGNAGNGGAGGRGGRLIGAGGAGG
MUL_4367|M.ulcerans_Agy99           GAGGAGGAGGN----------------------GVGG------GVNGAGG
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      ------------------------------------------STLGGVIN
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        AGGAGATGINGPAGISAAGGDGGAGGNGGAGGNGGVGGAGGAGGSAGLLG
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               FGGVGGLGGAGGAGANG-IVAGSAGDGGGNGGSGGAGGVGGDGGKGGLIR
MUL_4367|M.ulcerans_Agy99           AGGAGGVGGGGGAGASG-VGAGVAGGDGGTGGAGGAAGVGG---------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      TISGQYLIGNGINGTADNPNGGTGGLLFGDGGHGYDGSAAG---------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        YVGRAGDGGAGGGGGLGGAPGDGGAGGNGGSWLAAGDGGAGGHGGDPGLG
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               FLGGRGAGGSGGEGGAGGAAGDGGDGAAGSFLTGTGAGGAGGQGGDPGLG
MUL_4367|M.ulcerans_Agy99           ------AAGTGGTGGAAGVAGTGGD-------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------LAGGNGGNAGLFGNGGN-------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GAGGAGGASGGAGARAGANGLAAGNDGPVSGGNGGKGGNGAHAPVAGGHG
Mb2517c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2656|M.marinum_M               GAGGAGGRGSVPGSHG------VTGQSPTSGGDGGNGGRGADAIDPATTA
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GNGGAGGNGGLVGDGGAGGHGGDGAAGAGYADMTAIFLGSSGTPGEDGGN
Mb2517c|M.bovis_AF2122/97           --------------------------------MTAIFLGSSGTPGEDGGN
MMAR_2656|M.marinum_M               GAGGVGGDGGRYGNGGVGGAGGDGYRGY----DGMSVVGGDGTVGGDGGA
MUL_4367|M.ulcerans_Agy99           --------------------------------------------GGDGGA
Mflv_5091|M.gilvum_PYR-GCK          ---------------------------------------------GNGGN
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------------------------------GNGGN
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------GGVGWAGLDGGN
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAHGFN-AVLVSDGGN
Mb2517c|M.bovis_AF2122/97           GGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAHGFN-AVLVSDGGN
MMAR_2656|M.marinum_M               GGAGGAGGMGGALAGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGTD
MUL_4367|M.ulcerans_Agy99           GGAG-------------------------------------SDASLAGQA
Mflv_5091|M.gilvum_PYR-GCK          GGNG--------------------------------------LGGGNGGN
Mvan_1264|M.vanbaalenii_PYR-1       GGNG--------------------------------------LGSGDGGN
MSMEG_0868|M.smegmatis_MC2_155      GGSGG------------------LLMGIGGAGGAGGVGADGTSAHVDGGT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -----------------------------------------NVDSFNRGP
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------DTATLAVVETSD
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GGDGGAGG-RGGDGGAGGAGGDAPAG--RAGSQGVGGDGGAGGAGGAPGN
Mb2517c|M.bovis_AF2122/97           GGDGGAGG-RGGDGGAGGAGGDAPAG--RAGSQGVGGDGGAGGAGGAPGN
MMAR_2656|M.marinum_M               GGSGGMGG-VGGAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGD
MUL_4367|M.ulcerans_Agy99           GFAGGSGG-AGGVGGSAGAG-------------GVNGSGGDGGAGAAGGA
Mflv_5091|M.gilvum_PYR-GCK          GGNAGAFA-LFGNGGNGGNGG-----------VGVVGATGAVGAPGVAGA
Mvan_1264|M.vanbaalenii_PYR-1       GGDAGLFS-LFGRGGNGGNGG-----------VGIAGATGAVGAPGVAGA
MSMEG_0868|M.smegmatis_MC2_155      GGTGGTGGGTGGTGGIGGTGG---------GLFGLLGHSGSTGAAGAAGN
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LLDLSFGDLQFGNRDTTAIGD------------GAVAVGGSNSGPIASGQ
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                GSIPDVYKQQIRAESYGDAAG-----QLSAMVAGLEKLESLPGGLLLVGS
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GGSGGRGDMAFKDGDGGAGGDGGDPGAGGKGGAGGAGATEGVTGATGATV
Mb2517c|M.bovis_AF2122/97           GGSGGRGDMAFKDGDGGAGGDGGDPGAGGKGGAGGAGATEGVTGATGATV
MMAR_2656|M.marinum_M               GGDGANAPAASGLAGG-SGGHGGDPGVGGAGGAGGTGSVTGAHGTEGLTQ
MUL_4367|M.ulcerans_Agy99           GG-------ASATVAG-SGGVGGD--------------------------
Mflv_5091|M.gilvum_PYR-GCK          TG-------ATGVTSGVVGGNGED--------------------------
Mvan_1264|M.vanbaalenii_PYR-1       TG-------ATGVTSNVTGGNGAD--------------------------
MSMEG_0868|M.smegmatis_MC2_155      GGDGGNGGFGYVLIAGPNVTVGSETR------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GSTAVNGDVRDSNIINADHGSNVG--------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                GVDVAPLKQVLQTTTFLDVSVAEEPE------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        HSGGNGGKGGNGADATVAGANGGKGGAGGNGGLVGDGGAGGDGGSGAAGA
Mb2517c|M.bovis_AF2122/97           HSGGNGGKGGNGADATVAGANGGKGGAGGNGGLVGDGGAGGDGGSGAAGA
MMAR_2656|M.marinum_M               TTGGNGGDGGDGANASTVGASGGAGGAGGDGGRYGNGGVGGAGGDGYRGY
MUL_4367|M.ulcerans_Agy99           ---------------------GGAGGAAG-------GGVGAAS-------
Mflv_5091|M.gilvum_PYR-GCK          ------------------AVGYGATGAAGAAGAAG---------------
Mvan_1264|M.vanbaalenii_PYR-1       ------------------AVGYGATGAAGAAGAAG---------------
MSMEG_0868|M.smegmatis_MC2_155      ------------------GGTGGAGGTGGQSTAAGPGKGGGGGG------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------VDQSQTRVGGDYTNVS---------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----------------TALARGAALAAANAPLFAS--------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        NG-------ANVGEDGADGTLSGQPGEGSE--ANGGQGGVGG-GGAGGAG
Mb2517c|M.bovis_AF2122/97           NG-------ANVGEDGADGTLSGQPGEGSE--ANGGQGGVGG-GGAGGAG
MMAR_2656|M.marinum_M               DGMSVVGGDGTVGGDGGAGGAGGAGGMGGALAGHGGAGGAGGDGGTGGIG
MUL_4367|M.ulcerans_Agy99           -----------LGGDG----------------GHAGAGGAGGEGLSGGFN
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------AAGAAGAVGSAGAAGEAG
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------AAGKAGAVGSAGTAGSAG
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------GGGGAILIGANGGTVDGH
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------GHGSADIDKSVTVVDDHS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---------------------------------STAALAYAQDPGTGAVD
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GDGGAGSSALGSGGNGGRGDAGQAGGAGGAGGAGGAGGSVSGDGGPGGKG
Mb2517c|M.bovis_AF2122/97           GDGGAGSSALGSGGNGGRGDAGQAGGAGGAGGAGGAGGSVSGDGGPGGKG
MMAR_2656|M.marinum_M               GDGGRGVDGTDLSLDGTDGGSGGMGGVGGAGGDGGAGGLAQAAGFSDGIR
MUL_4367|M.ulcerans_Agy99           -----------------TGAAGGIGGAGGAGGTGGDSG------------
Mflv_5091|M.gilvum_PYR-GCK          ETG-------------TWGNAGLPGKAGDAGGAGAVGA-----------A
Mvan_1264|M.vanbaalenii_PYR-1       APG-------------VWGNAGLPGAAGAAGGAGAIGT-----------A
MSMEG_0868|M.smegmatis_MC2_155      AIG-------------GNGGNGGNGSTTAAGGNGGTGG-----------T
TH_3810|M.thermoresistible__bu      --------------------------VDGDGGSGGRTG------------
MAB_4284c|M.abscessus_ATCC_199      QRN------------TTNINDSFNTDRSTNIGSGNTTN------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                QYS---------------LPDYLYVPVDPEPGDDELAYS---------AV
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GAGGAGGAGASGGGGGKGASGADSAEAVG---GAGGKGGDGGVGGVGGDG
Mb2517c|M.bovis_AF2122/97           GAGGAGGAGASGGGGGKGASGADSAEAVG---GAGGKGGDGGVGGVGGDG
MMAR_2656|M.marinum_M               GVGGAGGDGGAGGGAGDGGDGANAPAASGLAGGSGGHGGDPGVGGAGGAG
MUL_4367|M.ulcerans_Agy99           GVGGVNGDGGAGGGGGRGGDGGSSTSTS-------------GVGGAGGAG
Mflv_5091|M.gilvum_PYR-GCK          GAAGTVGTAGATGGTGTGANGGAG-----------------GVGGVGGTG
Mvan_1264|M.vanbaalenii_PYR-1       GVAGAAGTAGATGGTGVGGNGGAG-----------------QAGGIGGTG
MSMEG_0868|M.smegmatis_MC2_155      GRVIAEGTGSTAEGTATGGDGGHSTG--------------TGIGGNGGIG
TH_3810|M.thermoresistible__bu      ----------LFSKLSRGGDGGDG-----------------GLGGNGGHG
MAB_4284c|M.abscessus_ATCC_199      TEIGSHNQANIGTSTSAGGSAAVG-------------------GNAGLAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                GEEDAESPTVVIEKLFLPEDSEPR------------------RRPVLLVG
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        -------------------GPGGDGGAGGAAPAGQVGSHGVGGVGGDGGL
Mb2517c|M.bovis_AF2122/97           -------------------GPGGDGGAGGAAPAGQVGSHGVGGVGGDGGL
MMAR_2656|M.marinum_M               GTGSVTGAHGTEGLTQTTGGNGGDGGDG-ANASTVGASGGAGGAGGDGGR
MUL_4367|M.ulcerans_Agy99           -------------------GNGGNAGFG-VSAGGTGGSAGDGGAGG----
Mflv_5091|M.gilvum_PYR-GCK          -------------------AAGAAGGAG--GLGETGTTGGAGGVGGQGTA
Mvan_1264|M.vanbaalenii_PYR-1       -------------------AAGAAGQAG--TAGETGVTGGVGGIGGQGTE
MSMEG_0868|M.smegmatis_MC2_155      -------------------SVYAYGNNGAVSGTATGGRGGDGIDGGTGGA
TH_3810|M.thermoresistible__bu      ------------------------GGTGIISLLSLAGN------------
MAB_4284c|M.abscessus_ATCC_199      -------------------NAGLAGNAGLAGNAGLAGNAGLAGN------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -------------------SGLAVVGISAVLALEIALAIGIRTTG-----
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GGAGGN-GGDGGHG--------------SDGGDGG-DGGDPGAGGLGG--
Mb2517c|M.bovis_AF2122/97           GGAGGN-GGDGGHG--------------SDGGDGG-DGGDPGAGGLGG--
MMAR_2656|M.marinum_M               YGNGGV-GGAGGDGYRGYDGMSVVGGDGTVGGDGG-AGGAGGAGGMGGAL
MUL_4367|M.ulcerans_Agy99           -GAGGV-DGVGG-----------------ASGNGG-AAGAGGAGGSG---
Mflv_5091|M.gilvum_PYR-GCK          GGTGGV-GGIGG-----------------AGSTGA-VGGVGGKGIQGG--
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGV-GGVGG-----------------VGATGG-AGGVGGKGIQGG--
MSMEG_0868|M.smegmatis_MC2_155      GGMGEIYSGADGEATG-----------ISAGGDGGSATGADSLGGRGG--
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        -----------------LGGDSGNGTR----AASGVDASDHG--------
Mb2517c|M.bovis_AF2122/97           -----------------LGGDSGNGTR----AASGVDASDHG--------
MMAR_2656|M.marinum_M               AGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGTDGGSGGMGGVGGAG
MUL_4367|M.ulcerans_Agy99           -----------------IG--------------AGIDGGAG---------
Mflv_5091|M.gilvum_PYR-GCK          ---------------------------------QGLQ-------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------------------QGLQ-------------
MSMEG_0868|M.smegmatis_MC2_155      -----------------TSWVQAGYGPTTGGKASGTAKAGHG--------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        ---------------------PGSGGNGGNGGNG----------AQASVA
Mb2517c|M.bovis_AF2122/97           ---------------------PGSGGNGGNGGNG----------AQASVA
MMAR_2656|M.marinum_M               GDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGDGGDGANAAAGSGAV
MUL_4367|M.ulcerans_Agy99           ----------------------GAGGTGGAAG-----------------F
Mflv_5091|M.gilvum_PYR-GCK          ------------------------GGKGGDGG-----------------A
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------GGQGGDGG-----------------T
MSMEG_0868|M.smegmatis_MC2_155      -------------------GKASDGGKGGNGGD-----------ALVMAA
TH_3810|M.thermoresistible__bu      ------------------------GGNGGNGYR-----------------
MAB_4284c|M.abscessus_ATCC_199      ------------------------AGLAGNAG-----------------L
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ------------------------------------------------TV
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GGAGGNGGDGGNAGRVGDG-------------------------------
Mb2517c|M.bovis_AF2122/97           GGAGGNGGDGGNAGRVGDG-------------------------------
MMAR_2656|M.marinum_M               GGKGGDGGDPGVGGAGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGNGGSG
MUL_4367|M.ulcerans_Agy99           PGGGGTTGAWGTGGAGGAG-------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGKGGDADSMGSAGATGGKG------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGDATSMGEAGATGGKG------------------------------
MSMEG_0868|M.smegmatis_MC2_155      GATGVATGNTAIGGNGGAAS------------------------------
TH_3810|M.thermoresistible__bu      -----TTDNNALDG------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGNAGLAGNAGLAGNAGLAG------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ALQPTPNQHLIVPTEQAPAPP-----------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        ---------GAGGNGGDGAAGANGANSGAPGSDALALGQP----GGNGGQ
Mb2517c|M.bovis_AF2122/97           ---------GAGGNGGDGAAGANGANSGAPGSDALALGQP----GGNGGQ
MMAR_2656|M.marinum_M               TTGTTGSKGGAGGAGGDGGRYGNGGNGGTGGTGSTGTAGSSDVMGANGGA
MUL_4367|M.ulcerans_Agy99           ---------GAGGAGDHGGVGVNPGDSGT---------------------
Mflv_5091|M.gilvum_PYR-GCK          ---------GNGGNGGRGGLFGKGGNAGN---------------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------GNGGNGGRGSLFGRGGNAGN---------------------
MSMEG_0868|M.smegmatis_MC2_155      ---------ANGAVGGNGGFTNIAAIHGSITDSSATSGHG----------
TH_3810|M.thermoresistible__bu      ---------GHGGNGGNVGFFSLFN-------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------NAGLAGNAGLAGNAG-------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---------PVQASAPQPKISVPEPVAAP---------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GDAGQAGGAGGAGGAGGAGGSVSGDGGAGGNGGAGGNGGVGASGGAGARG
Mb2517c|M.bovis_AF2122/97           GDAGQAGGAG---GAGGAGGSVSGDGGAGGNGGAGGNGGVGASGGAGARG
MMAR_2656|M.marinum_M               GGSGWAGGDG---GAGGMGGTLAGHGGDGGDGGSGGTGGTGGRGGNGFNG
MUL_4367|M.ulcerans_Agy99           --AGWAGGAG---GAGGAGGSAA------------------------FN-
Mflv_5091|M.gilvum_PYR-GCK          ---GADGGTG---GAGGAG-------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ---GGNGGTG---GNGGNG-------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --GAAQGGNG---GNGGNGWVQAYDPNGPAGTTIDKGK------------
TH_3810|M.thermoresistible__bu      -----LGGAG---GWGGSG-------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----LAGNAG---LAGNAG-------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        ANGIDSIG-------------------------------GTGGAGGGGGD
Mb2517c|M.bovis_AF2122/97           ANGIDSIG-------------------------------GTGGAGGGGGD
MMAR_2656|M.marinum_M               STKAGLNGGDAGDGGAGGVGGAGGNGGAAGLAQAAGFSDGIQGAGGAGGD
MUL_4367|M.ulcerans_Agy99           ---------------------------------------GVNGAGGAGGN
Mflv_5091|M.gilvum_PYR-GCK          ---------------------------------------GTGGTGGAGGT
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------------------------GTGGTGGNGGT
MSMEG_0868|M.smegmatis_MC2_155      ---------------------------------------AAGGNGGDGGF
TH_3810|M.thermoresistible__bu      ----------------------------------------VDGVDVVGGN
MAB_4284c|M.abscessus_ATCC_199      ----------------------------------------LAGNAGLAGN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---------------------------------------KPLSPPVAAPL
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GGAGG-----------------------------VGGHGGDGGVGGAAPS
Mb2517c|M.bovis_AF2122/97           GGAGG-----------------------------VGGHGGDGGVGGAAPS
MMAR_2656|M.marinum_M               GGAGGGAGDGGDGANAAAGSGAVGGNGGDGGDPGLGGGGGAGGTGATTGA
MUL_4367|M.ulcerans_Agy99           GGAGG------------------------------GGGAGASGIGAG---
Mflv_5091|M.gilvum_PYR-GCK          GGTGG-----------------------------TGGIGGAG--------
Mvan_1264|M.vanbaalenii_PYR-1       GGTGG-----------------------------TGGIGGAG--------
MSMEG_0868|M.smegmatis_MC2_155      NGTGG----------------------------ATGGRGGDGAGASVWKA
TH_3810|M.thermoresistible__bu      PDG-----------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGLAG---------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                PAAPP---------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GTVG---SHGTGGVGGDGGLGGAGGVGGAGGNGGIGITVGGAGGAG-GNG
Mb2517c|M.bovis_AF2122/97           GTVG---SHGTGGVGGDGGLGGAGGVGGAGGNGGIGITVGGAGGAG-GNG
MMAR_2656|M.marinum_M               HGADGL-SPTTGGNGGKGGNGGSGAIGVAGGAGGA----GGDGGLY-GDG
MUL_4367|M.ulcerans_Agy99           ---------VAGGDGGTGGTGGAAGTGGAAGTGGT----GGAAGAA-GSA
Mflv_5091|M.gilvum_PYR-GCK          ---------STGGTGGTGGTGGTGGTGGTGGTGGT----GGTGGTG-GKG
Mvan_1264|M.vanbaalenii_PYR-1       ---------STGGTGGTGGTGGTGGTGGTGGTGGT----GGTGGTG-GKG
MSMEG_0868|M.smegmatis_MC2_155      NGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGA----GGAGGVSEGEG
TH_3810|M.thermoresistible__bu      --------------GTPGAHGESHTPGVYTDRQGE----DGEDGTG---T
MAB_4284c|M.abscessus_ATCC_199      ----------NAGLAGNAGLAGNAGLAGNAGLAGNAAVAGNAAVAG--NA
MLBr_01183|M.leprae_Br4923          -----------------MPLFLNAEPQALTAAANT------LEGLS--AA
MAV_4827|M.avium_104                ----------------PAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPV
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGGVGGNG------
Mb2517c|M.bovis_AF2122/97           GDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGGVGGNG------
MMAR_2656|M.marinum_M               GDGGSGGNGGAGKAGAAGVSAGSNGEAGGQAG-AGGVGGAGGNGGANAGN
MUL_4367|M.ulcerans_Agy99           GDGGAGGAGGAGDDGSAGVVSGDPGTAGKAGG-AGGAGGVGGNG------
Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGAGGTGGDGGTGGTGGTGGTGG-----TGGTGGTGGAG------
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGDGGTGGTGGTGGTGGTGGTGG-----TGGTGGTGGAG------
MSMEG_0868|M.smegmatis_MC2_155      GTGGHGGDGGRGGDGALGGNGGTGGVGLGNGG-KGGNGGNGGNG------
TH_3810|M.thermoresistible__bu      GIGGRGGNGGSSSGTHPMAEDGEHVKALD-----GRPGLDGGNG------
MAB_4284c|M.abscessus_ATCC_199      AVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLGGSGSVGGST------
MLBr_01183|M.leprae_Br4923          TVASNAAAAQLTTEIAPPAADDVSILLA---------HFFSGHG------
MAV_4827|M.avium_104                RIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVPQPPSPPQVGGTVP-----
                                            .                               .*        

Rv2490c|M.tuberculosis_H37Rv        ---------------------AKAAAAGGDGGQGGDGGNAGLFGDGGAGG
Mb2517c|M.bovis_AF2122/97           ---------------------AKAAAAGGDGGQGGDGGNAGLFGDGGAGG
MMAR_2656|M.marinum_M               GGTGGNGGDGGVGGTGGAGKVGTTGPAGGAGGEGGDGGKGGTGGRGGNGG
MUL_4367|M.ulcerans_Agy99           -------------------------VAGGVNGSGGAGGAGGAGGTGGAGA
Mflv_5091|M.gilvum_PYR-GCK          ---------------------------DGTGGTGGTGGTGGQGGQGGQGG
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------------DGLGGTGGTGGTGGFGGQGGQGG
MSMEG_0868|M.smegmatis_MC2_155      ----------------------GTYVDPSHTGAGGNGGNGGAGRIRVNNG
TH_3810|M.thermoresistible__bu      ----------------------------SHGGNGGHGGRGGFLGIGGSGG
MAB_4284c|M.abscessus_ATCC_199      -------------------------AVGGGAHTGVGGGVSTGVGVGSHVG
MLBr_01183|M.leprae_Br4923          ---------------------------RQYQAHASQGATNHQDLIQSLLT
MAV_4827|M.avium_104                ------------------------QSPPQHQTPPGEGTPPKPDGPGNYGG
                                                                        *             

Rv2490c|M.tuberculosis_H37Rv        DGADGTAAEALGGDGGAGGAGGKGGDAGDIG-DGGDGGKGGD--GAHGAL
Mb2517c|M.bovis_AF2122/97           DGADGTAAEALGGDGGAGGAGGKGGDAGDIG-DGGDGGKGGD--GAHGAL
MMAR_2656|M.marinum_M               AGGTAQAAGYSDGSQGVGGDGGAGGTGGTAG-NGGKGGAGTW--AVNNGI
MUL_4367|M.ulcerans_Agy99           SGVPASVD---------GGDGGAGGAGGAAG-TGGSGGS-----------
Mflv_5091|M.gilvum_PYR-GCK          TGGT-------------GGQGGLGGGGGTGG-QGGTGGT-----------
Mvan_1264|M.vanbaalenii_PYR-1       TGGT-------------GGQGGLGGVGGTGG-TGGTGGT-----------
MSMEG_0868|M.smegmatis_MC2_155      TATGTATG-------GNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSN
TH_3810|M.thermoresistible__bu      ----------------WGGHGGNGGDTDADGGNGGDGGN-----------
MAB_4284c|M.abscessus_ATCC_199      GGISES----------LGGSGSVGGSTAVGG--GAHTGVG----------
MLBr_01183|M.leprae_Br4923          SS---------------SAYAGTETANHDSL-------------------
MAV_4827|M.avium_104                GHVPTPG---------AGGSGGSGGGHVPTPGAGGSGGSG----------
                                                     .. ..                            

Rv2490c|M.tuberculosis_H37Rv        GGLTVAGGNGGAGGAGG---------------------------------
Mb2517c|M.bovis_AF2122/97           GGLTVAGGNGGAGGAGG---------------------------------
MMAR_2656|M.marinum_M               GGKGGNGGNAGTGGTGGSFGTGSQIGNHGSTGHLGDGGDGGTGGAGVNAT
MUL_4367|M.ulcerans_Agy99           ------AGNTGAGGAGG---------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ------GGQGGTGGTGG---------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ------GGQGGTGGTGG---------------------------------
MSMEG_0868|M.smegmatis_MC2_155      ASGTATGGDGGNGGTLG---------------------------------
TH_3810|M.thermoresistible__bu      ------GGSAGRGGTGG---------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------GGVSTGVGVG----------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ------GGHVPTPGTGG---------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        -------AGGAGG--AFLGDGGNGGAGGQGGAGRGGSP------------
Mb2517c|M.bovis_AF2122/97           -------AGGAGG--AFLGDGGNGGAGGQGGAGRGGSP------------
MMAR_2656|M.marinum_M               APGQDGAAGGVGGNGGIVGDGGVGGKGGDGAAGTTGSSGTASGEAGKDGG
MUL_4367|M.ulcerans_Agy99           -------AGGAGG-----------------SAASTGVN-----------G
Mflv_5091|M.gilvum_PYR-GCK          -------TGGTGG-------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------TGGTGG-------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      ------ATNGTGGAATIVAYNVVQANPQASGTATDG--------------
TH_3810|M.thermoresistible__bu      -------LRGVFG-------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -SHVGG--------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        -GGGGGVGGHGGAGG--------------DAGMNGGGGTGGQGGNGAAGG
Mb2517c|M.bovis_AF2122/97           -GGGGGVGGHGGAGG--------------DAGMNGGGGTGGQGGNGAAGG
MMAR_2656|M.marinum_M               DGGKGGAGGAGGNGGT-------------SRGDGGAGGAGGTGGVGGSGG
MUL_4367|M.ulcerans_Agy99           DGGAGGAGGVGGLGGD-------------SAATAGGGGAGGDGGKGGAGG
Mflv_5091|M.gilvum_PYR-GCK          TGGAGGDGGLGGLGG-----------------FGGSGGTGGQGGLGGPGG
Mvan_1264|M.vanbaalenii_PYR-1       TGGAGGDGGLGGLGG-----------------FGGVGGTGGQGGQGGPGG
MSMEG_0868|M.smegmatis_MC2_155      HGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGG
TH_3810|M.thermoresistible__bu      --------------------------------INGGNGRAGLGGRGX---
MAB_4284c|M.abscessus_ATCC_199      ------------------------------GISESLGGSGSVGGSTAVGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----------------------------------PGGTGGSGGGHVPTP
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        AGWSPDSDLKG-----FDGFDGGSGG-AGGDGGAGGAGG---------TQ
Mb2517c|M.bovis_AF2122/97           AGWSPDSDLKG-----FDGFDGGSGG-AGGDGGAGGAGG---------TQ
MMAR_2656|M.marinum_M               DGADGTSGLFGG-ADGTAGGAGGDGG-DGGAGGAGGAGGKAVSGVGQNGS
MUL_4367|M.ulcerans_Agy99           AGVNGVG--------------GGDGG-KGGTGGAGGAG------------
Mflv_5091|M.gilvum_PYR-GCK          S-------------------TGGAGG-AGGQAGTAGKGG---------LF
Mvan_1264|M.vanbaalenii_PYR-1       S-------------------TGGAGG-AGGQAGVAGKGG---------LF
MSMEG_0868|M.smegmatis_MC2_155      DGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPS------WVQ
TH_3810|M.thermoresistible__bu      ---------------------XXXGG---GVGAAVRSGN-----------
MAB_4284c|M.abscessus_ATCC_199      G-----------------AHTGVGGGVNTGVGVGSHVGG-----------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                G-------------------AGTPGGSGGGHLPFPGAGS-----------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        TGDGGDGGAGGLG-GAGGVGGNGVDGFDINETTG---RDGGDGGDGGYGG
Mb2517c|M.bovis_AF2122/97           TGDGGDGGAGGLG-GAGGVGGNGVDGFDINETTG---RDG-DGGDGGYGG
MMAR_2656|M.marinum_M               QGAGGNGGAAGDG-GDGGNGGNGHDGNNGSVPSGGTDRDGGDGQGGGDGG
MUL_4367|M.ulcerans_Agy99           -GAGSDGIIPSNG-GLGGNGGNGGNG----------------GQAFGDG-
Mflv_5091|M.gilvum_PYR-GCK          GGSGSAGKAGATG-AAGASGGKGAQG--------------ATGAQGATGA
Mvan_1264|M.vanbaalenii_PYR-1       GGSGSAGTAGVTG-ASGASGGKGAQG--------------ATGAQGATGA
MSMEG_0868|M.smegmatis_MC2_155      SGYGSTLGGNATGTATAGKGGEASNG--------------GVAGNGGNAL
TH_3810|M.thermoresistible__bu      ------------G-VFSGGGGTPSAG---------------FGVPTTIQF
MAB_4284c|M.abscessus_ATCC_199      ------GISESLG-GSGSVGGSTAVG----------------GGAHTSAI
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------TPGGSGGGHLPTP---------------GAGTPGGG
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        WGGAGGNGGAGGSAPAGE--VGNRGVGGDGGDGGSGGDAGNGGLGGDGFT
Mb2517c|M.bovis_AF2122/97           WGGAGGNGGAGGSAPAGE--VGNRGVGGDGGDGGSGGDAGNGGLGGDGFT
MMAR_2656|M.marinum_M               AGGAGGAGGNGGAAGAGG--GGTRGAGGDGGDGGNGGFAGDGGLGMDGLD
MUL_4367|M.ulcerans_Agy99           VGGAGGIGGKGGNAAIGT--IVIN--GGVGGAGGSGGLGG----------
Mflv_5091|M.gilvum_PYR-GCK          QGATGATGAAGKAGATGA--AGAAGAAGSAGTTGAQGSAGTN--------
Mvan_1264|M.vanbaalenii_PYR-1       QGATGATGASGAQGSAGS--AGSAGVAGSAGTTGAQGSAGTN--------
MSMEG_0868|M.smegmatis_MC2_155      VMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTA
TH_3810|M.thermoresistible__bu      PAGSCTSRAVSREGIMPS---SRAASARAGAACASS--------------
MAB_4284c|M.abscessus_ATCC_199      NDALGGSGSVGGSTAVGG---GAHTSAINESMNSSIN-------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                LGGFGGGHAPAPGGGLGG--GGGHAPAPGGGLGGFGG-------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        YLADFDGEPGGDGGDGGDGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGG
Mb2517c|M.bovis_AF2122/97           YLADFDGEPGGDGGDGGDGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGG
MMAR_2656|M.marinum_M               ATLTNRAGDGGDGGGGGQAFAGGAGGAGGTGSTQGSAGTTGAWRAGGDGG
MUL_4367|M.ulcerans_Agy99           ---------ATEDGVGGVGCAGGAGGNGGRG--------DMLFTVGGSGG
Mflv_5091|M.gilvum_PYR-GCK          ---------GANGANGSQGAAGKAGATGTTG-------------ATGAAG
Mvan_1264|M.vanbaalenii_PYR-1       ---------GANGANGSQGAAGKAGATGTTG-------------ATGAAG
MSMEG_0868|M.smegmatis_MC2_155      ISGHGGAGNGGNGGKGADGWVQAYDPAGPVG-----SKIANSSAVAGNGG
TH_3810|M.thermoresistible__bu      -----------TSRSRRSFCCSRA--------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------ASHSSSMNESFGSSMGSHGAAG-----------TGFEAQGH
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ----------GHSGGGLGGLGGGHK-------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        DGGNGGHG--------GDGNGSFADAGDGG------PGGNGGNG------
Mb2517c|M.bovis_AF2122/97           DGGNGGHG--------GDGNGSFADAGDGG------PGGNGGNG------
MMAR_2656|M.marinum_M               SGGDGGDGFGLWNPGEGGRGGSGGDGGTGG------DGGDGGNGRVEIWE
MUL_4367|M.ulcerans_Agy99           TGGDGGG------------GGSASGSGTGG------SGGTGG--------
Mflv_5091|M.gilvum_PYR-GCK          EDGDAGSG------------GSGINGGAGG------AGGAGG--------
Mvan_1264|M.vanbaalenii_PYR-1       DAGDPGSE------------AVDINGGAGG------AGGAGG--------
MSMEG_0868|M.smegmatis_MC2_155      DGGVNGTG-----------GASGGDGGNGGNTSVWKSGGQTADG------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AQG-----------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        -------------------------------------GLGGAGRDGGAPG
Mb2517c|M.bovis_AF2122/97           -------------------------------------GLGGAGRDGGAPG
MMAR_2656|M.marinum_M               GRGGNGGNGAIGPGGDGGDGGDAPNQQRVSSSSPGYEGADGGNGGNGTIG
MUL_4367|M.ulcerans_Agy99           ------------------------------------------------VG
Mflv_5091|M.gilvum_PYR-GCK          ------------------------------------------------EG
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------------------EG
MSMEG_0868|M.smegmatis_MC2_155      ------------------------------------------EHNTGGNG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------------------HA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        GDGGDGGTGGSGGFGAPPPRSIGGGDGGDGGRGGDGGRGAGG--------
Mb2517c|M.bovis_AF2122/97           GDGGDGGTGGSGGFGAPPPRSIGGGDGGDGGRGGDGGRGAGG--------
MMAR_2656|M.marinum_M               GNGGNGGTGGPGYDASLGGEATAGGEGGDGGDGGKGFNGAGGAGGDGGAG
MUL_4367|M.ulcerans_Agy99           GIGGDGKLGG------------FGGDGGDGGDGG----------------
Mflv_5091|M.gilvum_PYR-GCK          GEGGDGGKGGAG---------AEGGAGGGGGAGG----------------
Mvan_1264|M.vanbaalenii_PYR-1       GEGGAGGAGGDG---------SEGGAGGSGGAGG----------------
MSMEG_0868|M.smegmatis_MC2_155      GNGGDGSEPGPGG-------NGAGGAGGNGGTGG----------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SETAHTTLPGAEHH------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        --------------LTSGGVGSSGESGGSGNGRGDPGSGGSGGEGGEGGP
Mb2517c|M.bovis_AF2122/97           --------------LTSGGVGSSGESGGSGNGRGDPGSGGSGGEGGEGGP
MMAR_2656|M.marinum_M               GAGGSGAPAPFGSGGAYGGTGGQGGTGGSG-VIGGIGEGGKIGDAGFGGN
MUL_4367|M.ulcerans_Agy99           ----------------FGVIGGQGGGGGFG-GLGGTGAGGAPSDKGINGE
Mflv_5091|M.gilvum_PYR-GCK          -----------------SGAGGAGGAGGSG------GSGGSGGSGGSGGA
Mvan_1264|M.vanbaalenii_PYR-1       -----------------SGTGGAGGAGGSG------GSGGSGGAGGSGGA
MSMEG_0868|M.smegmatis_MC2_155      ---------------TTAGGSGNGGNGGNG------GNGGADGTPGTAGT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2490c|M.tuberculosis_H37Rv        SISVNVT-------------------
Mb2517c|M.bovis_AF2122/97           SISVNVT-------------------
MMAR_2656|M.marinum_M               PPNSQTGEGGSGGAGGAGGAGGDPSN
MUL_4367|M.ulcerans_Agy99           PGNPG---------------------
Mflv_5091|M.gilvum_PYR-GCK          AGDSDD--------------------
Mvan_1264|M.vanbaalenii_PYR-1       AGDSD---------------------
MSMEG_0868|M.smegmatis_MC2_155      TGANNP--------------------
TH_3810|M.thermoresistible__bu      --------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------
MLBr_01183|M.leprae_Br4923          --------------------------
MAV_4827|M.avium_104                --------------------------