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SYVIATPEMMATAAFDLARIGSQVSAASAVAAMPTTEVVAAGADEVSAGIAALFSAHAQEYQALSAQAAA FHDQFVHTLTAAARWYTATEIANAAAMRVVLGAVNAPTQTLLGRPLIGDGAHGTAPGQPGGAGGLLFGNG GNGAAGAVGQVGGAGGAAGLFGIGGAGGAGGAGAPGGTGGTGGWLAGGGGVGGMGGAGGGAGGAGGNAGL FGNGGAGGAGGAGGGAGGAGGNAGWFGHGGAGGVGGVGAAGANGATPGQDGAAGVAGSDDGAGGDGLAGS DGGDGGAGGVGGNGGRGGWLLGNGGAGGVGGVGGAGGAGAAGGAGGAGATGINGPAGISAAGGDGGAGGN GGAGGNGGVGGAGGAGGSAGLLGYVGRAGDGGAGGGGGLGGAPGDGGAGGNGGSWLAAGDGGAGGHGGDP GLGGAGGAGGASGGAGARAGANGLAAGNDGPVSGGNGGKGGNGAHAPVAGGHGGNGGAGGNGGLVGDGGA GGHGGDGAAGAGYADMTAIFLGSSGTPGEDGGNGGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAH GFNAVLVSDGGNGGDGGAGGRGGDGGAGGAGGDAPAGRAGSQGVGGDGGAGGAGGAPGNGGSGGRGDMAF KDGDGGAGGDGGDPGAGGKGGAGGAGATEGVTGATGATVHSGGNGGKGGNGADATVAGANGGKGGAGGNG GLVGDGGAGGDGGSGAAGANGANVGEDGADGTLSGQPGEGSEANGGQGGVGGGGAGGAGGDGGAGSSALG SGGNGGRGDAGQAGGAGGAGGAGGAGGSVSGDGGPGGKGGAGGAGGAGASGGGGGKGASGADSAEAVGGA GGKGGDGGVGGVGGDGGPGGDGGAGGAAPAGQVGSHGVGGVGGDGGLGGAGGNGGDGGHGSDGGDGGDGG DPGAGGLGGLGGDSGNGTRAASGVDASDHGPGSGGNGGNGGNGAQASVAGGAGGNGGDGGNAGRVGDGGA GGNGGDGAAGANGANSGAPGSDALALGQPGGNGGQGDAGQAGGAGGAGGAGGAGGSVSGDGGAGGNGGAG GNGGVGASGGAGARGANGIDSIGGTGGAGGGGGDGGAGGVGGHGGDGGVGGAAPSGTVGSHGTGGVGGDG GLGGAGGVGGAGGNGGIGITVGGAGGAGGNGGDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGG VGGNGAKAAAAGGDGGQGGDGGNAGLFGDGGAGGDGADGTAAEALGGDGGAGGAGGKGGDAGDIGDGGDG GKGGDGAHGALGGLTVAGGNGGAGGAGGAGGAGGAFLGDGGNGGAGGQGGAGRGGSPGGGGGVGGHGGAG GDAGMNGGGGTGGQGGNGAAGGAGWSPDSDLKGFDGFDGGSGGAGGDGGAGGAGGTQTGDGGDGGAGGLG GAGGVGGNGVDGFDINETTGRDGGDGGDGGYGGWGGAGGNGGAGGSAPAGEVGNRGVGGDGGDGGSGGDA GNGGLGGDGFTYLADFDGEPGGDGGDGGDGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGGDGGNGGHGG DGNGSFADAGDGGPGGNGGNGGLGGAGRDGGAPGGDGGDGGTGGSGGFGAPPPRSIGGGDGGDGGRGGDG GRGAGGLTSGGVGSSGESGGSGNGRGDPGSGGSGGEGGEGGPSISVNVT*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv2490c | PE_PGRS43 | - | 100% (1660) | PE-PGRS FAMILY PROTEIN |
M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 0.0 | 50.27% (1830) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv3514 | PE_PGRS57 | 0.0 | 52.63% (1577) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2517c | PE_PGRS43b | 0.0 | 99.65% (1154) | hypothetical protein Mb2517c |
M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 47.90% (833) | triple helix repeat-containing collagen |
M. leprae Br4923 | MLBr_01183 | - | 1e-10 | 34.78% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 6e-51 | 35.10% (453) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_2656 | - | 0.0 | 48.74% (1980) | PE-PGRS family protein, PE_PGRS50 |
M. avium 104 | MAV_4827 | - | 7e-25 | 44.71% (170) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-166 | 40.31% (1089) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 5e-46 | 42.86% (301) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 47.36% (1191) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-176 | 45.15% (855) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Rv2490c|M.tuberculosis_H37Rv -MSYVIATPEMMATAAFDLARIGSQVSAASAVAAMPTTEVVAAGADEVSA Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M -MSLVTVSPELVAGAASDLARIGSSLGAANAAAAGPTTTVLSAAADEVSV MUL_4367|M.ulcerans_Agy99 -MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDEVSA Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 MMFLAPPGGPGPISAAIQLTSTGSEATEP--------------------W MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPD Rv2490c|M.tuberculosis_H37Rv GIAALFSAHAQEYQALSAQAAAFHDQFVHTLTAAARWYTATEIAN----- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M AIATLFGTHAAEYQSLSARMAAFHEQFVQTLTSGAGIYVSTEATNASFIS MUL_4367|M.ulcerans_Agy99 AIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALN---MW Mflv_5091|M.gilvum_PYR-GCK -MVTFGGGATPTPTSLGAAAVDLSG------TSCG--------------- Mvan_1264|M.vanbaalenii_PYR-1 YVVSFGGSGAPTPNNLAASLVDLSG------TSCG--------------- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTN------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQP--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 RVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR------------- Rv2490c|M.tuberculosis_H37Rv --AAAMRVVLGAVNAPTQTLLGRPLIGDGAHGT-APGQPGGAGGLL-FGN Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M ALQLAEQNALNAINAPTQSWLGRPLIGNGVDATPGSGQAGGAGGLL-WGN MUL_4367|M.ulcerans_Agy99 PLQELEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGIL-WGN Mflv_5091|M.gilvum_PYR-GCK ------------------------LICNGQDGT------GQNGGIL-FGN Mvan_1264|M.vanbaalenii_PYR-1 ------------------------LICNGQDGT------GQNGGIL-FGN MSMEG_0868|M.smegmatis_MC2_155 ---TTDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------DGPSILSPSLLSPRDNDFLSHND MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------------------DALAARRIDNVMLVSAF Rv2490c|M.tuberculosis_H37Rv GGNGA-AGAVGQVGGAGGAAGLFGIGGAGGAGGAGAPGGTG--------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M GGAGG-SGAAGQSGGAGGSAGLFGNGGAGGAGGISAAGNGGSGGVGGRGG MUL_4367|M.ulcerans_Agy99 GGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGGVGAAGMTG--------- Mflv_5091|M.gilvum_PYR-GCK GGSGWNSDVVGMDGGNGGNGGLFG-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GGSGWNSEIAGVSGGNGGNAGLFG-------------------------- MSMEG_0868|M.smegmatis_MC2_155 LGTTLIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTTVN-------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TDFASHNPIASGNQVMSPSG------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 LAAAALAQNVGGAMGYERTAVLLVEP------------------------ Rv2490c|M.tuberculosis_H37Rv ------------------------GTGGWLAGGGGVGGMGG----AGGGA Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M LVYGSGGAGGAGGQGALSGGAGGAGGGAWLWGAGGAGGSGGEGLASAGGV MUL_4367|M.ulcerans_Agy99 ---GSGGAG---------------GGGGWLWGAGGSGGAAG-----AGGS Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GGAGGNAGLFGNGGAGGAGGAGGGAGGAGGNAGWFGHGGAGGVGGVGAAG Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M GGAGGNAGLIGTGGLGGAGGVGGQNGGAGGDGGNAPLLGRGGTGGVGGAS MUL_4367|M.ulcerans_Agy99 GGSGG--WLWGN---------AGQTAGAG----------VGGAGGAGGAG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------------PQAQLPVPTVA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv ANGATPGQDGAAGVAGSDDGAGGDGLAGSDGGDGGAGGVGGNGGRGGWLL Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M D-GGNGGAGGDGGVGGGLFGSGGAGGSGGAGGVLGTGGDGGSGGAAAGLW MUL_4367|M.ulcerans_Agy99 D-AGDQGVSG--------VAPGEAGAVGFAG------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 SAVLDPTQIVNWLIYQPLHAAGQQFWVVSPIG------------------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GNGGAGGVGGVG---------------------GAGG-------AGAAGG Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M GAGGSGGAGGNGADGISGGIGESGGDGGNAGNGGAGGRGGRLIGAGGAGG MUL_4367|M.ulcerans_Agy99 GAGGAGGAGGN----------------------GVGG------GVNGAGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------------STLGGVIN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv AGGAGATGINGPAGISAAGGDGGAGGNGGAGGNGGVGGAGGAGGSAGLLG Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M FGGVGGLGGAGGAGANG-IVAGSAGDGGGNGGSGGAGGVGGDGGKGGLIR MUL_4367|M.ulcerans_Agy99 AGGAGGVGGGGGAGASG-VGAGVAGGDGGTGGAGGAAGVGG--------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TISGQYLIGNGINGTADNPNGGTGGLLFGDGGHGYDGSAAG--------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv YVGRAGDGGAGGGGGLGGAPGDGGAGGNGGSWLAAGDGGAGGHGGDPGLG Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M FLGGRGAGGSGGEGGAGGAAGDGGDGAAGSFLTGTGAGGAGGQGGDPGLG MUL_4367|M.ulcerans_Agy99 ------AAGTGGTGGAAGVAGTGGD------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 --------LAGGNGGNAGLFGNGGN------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GAGGAGGASGGAGARAGANGLAAGNDGPVSGGNGGKGGNGAHAPVAGGHG Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2656|M.marinum_M GAGGAGGRGSVPGSHG------VTGQSPTSGGDGGNGGRGADAIDPATTA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GNGGAGGNGGLVGDGGAGGHGGDGAAGAGYADMTAIFLGSSGTPGEDGGN Mb2517c|M.bovis_AF2122/97 --------------------------------MTAIFLGSSGTPGEDGGN MMAR_2656|M.marinum_M GAGGVGGDGGRYGNGGVGGAGGDGYRGY----DGMSVVGGDGTVGGDGGA MUL_4367|M.ulcerans_Agy99 --------------------------------------------GGDGGA Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------------GNGGN Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------------GNGGN MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------GGVGWAGLDGGN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAHGFN-AVLVSDGGN Mb2517c|M.bovis_AF2122/97 GGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAHGFN-AVLVSDGGN MMAR_2656|M.marinum_M GGAGGAGGMGGALAGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGTD MUL_4367|M.ulcerans_Agy99 GGAG-------------------------------------SDASLAGQA Mflv_5091|M.gilvum_PYR-GCK GGNG--------------------------------------LGGGNGGN Mvan_1264|M.vanbaalenii_PYR-1 GGNG--------------------------------------LGSGDGGN MSMEG_0868|M.smegmatis_MC2_155 GGSGG------------------LLMGIGGAGGAGGVGADGTSAHVDGGT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------NVDSFNRGP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------------------------------DTATLAVVETSD Rv2490c|M.tuberculosis_H37Rv GGDGGAGG-RGGDGGAGGAGGDAPAG--RAGSQGVGGDGGAGGAGGAPGN Mb2517c|M.bovis_AF2122/97 GGDGGAGG-RGGDGGAGGAGGDAPAG--RAGSQGVGGDGGAGGAGGAPGN MMAR_2656|M.marinum_M GGSGGMGG-VGGAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGD MUL_4367|M.ulcerans_Agy99 GFAGGSGG-AGGVGGSAGAG-------------GVNGSGGDGGAGAAGGA Mflv_5091|M.gilvum_PYR-GCK GGNAGAFA-LFGNGGNGGNGG-----------VGVVGATGAVGAPGVAGA Mvan_1264|M.vanbaalenii_PYR-1 GGDAGLFS-LFGRGGNGGNGG-----------VGIAGATGAVGAPGVAGA MSMEG_0868|M.smegmatis_MC2_155 GGTGGTGGGTGGTGGIGGTGG---------GLFGLLGHSGSTGAAGAAGN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LLDLSFGDLQFGNRDTTAIGD------------GAVAVGGSNSGPIASGQ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GSIPDVYKQQIRAESYGDAAG-----QLSAMVAGLEKLESLPGGLLLVGS Rv2490c|M.tuberculosis_H37Rv GGSGGRGDMAFKDGDGGAGGDGGDPGAGGKGGAGGAGATEGVTGATGATV Mb2517c|M.bovis_AF2122/97 GGSGGRGDMAFKDGDGGAGGDGGDPGAGGKGGAGGAGATEGVTGATGATV MMAR_2656|M.marinum_M GGDGANAPAASGLAGG-SGGHGGDPGVGGAGGAGGTGSVTGAHGTEGLTQ MUL_4367|M.ulcerans_Agy99 GG-------ASATVAG-SGGVGGD-------------------------- Mflv_5091|M.gilvum_PYR-GCK TG-------ATGVTSGVVGGNGED-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 TG-------ATGVTSNVTGGNGAD-------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGDGGNGGFGYVLIAGPNVTVGSETR------------------------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GSTAVNGDVRDSNIINADHGSNVG-------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GVDVAPLKQVLQTTTFLDVSVAEEPE------------------------ Rv2490c|M.tuberculosis_H37Rv HSGGNGGKGGNGADATVAGANGGKGGAGGNGGLVGDGGAGGDGGSGAAGA Mb2517c|M.bovis_AF2122/97 HSGGNGGKGGNGADATVAGANGGKGGAGGNGGLVGDGGAGGDGGSGAAGA MMAR_2656|M.marinum_M TTGGNGGDGGDGANASTVGASGGAGGAGGDGGRYGNGGVGGAGGDGYRGY MUL_4367|M.ulcerans_Agy99 ---------------------GGAGGAAG-------GGVGAAS------- Mflv_5091|M.gilvum_PYR-GCK ------------------AVGYGATGAAGAAGAAG--------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------AVGYGATGAAGAAGAAG--------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------GGTGGAGGTGGQSTAAGPGKGGGGGG------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------VDQSQTRVGGDYTNVS--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------TALARGAALAAANAPLFAS-------------- Rv2490c|M.tuberculosis_H37Rv NG-------ANVGEDGADGTLSGQPGEGSE--ANGGQGGVGG-GGAGGAG Mb2517c|M.bovis_AF2122/97 NG-------ANVGEDGADGTLSGQPGEGSE--ANGGQGGVGG-GGAGGAG MMAR_2656|M.marinum_M DGMSVVGGDGTVGGDGGAGGAGGAGGMGGALAGHGGAGGAGGDGGTGGIG MUL_4367|M.ulcerans_Agy99 -----------LGGDG----------------GHAGAGGAGGEGLSGGFN Mflv_5091|M.gilvum_PYR-GCK --------------------------------AAGAAGAVGSAGAAGEAG Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------AAGKAGAVGSAGTAGSAG MSMEG_0868|M.smegmatis_MC2_155 --------------------------------GGGGAILIGANGGTVDGH TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------GHGSADIDKSVTVVDDHS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------------------STAALAYAQDPGTGAVD Rv2490c|M.tuberculosis_H37Rv GDGGAGSSALGSGGNGGRGDAGQAGGAGGAGGAGGAGGSVSGDGGPGGKG Mb2517c|M.bovis_AF2122/97 GDGGAGSSALGSGGNGGRGDAGQAGGAGGAGGAGGAGGSVSGDGGPGGKG MMAR_2656|M.marinum_M GDGGRGVDGTDLSLDGTDGGSGGMGGVGGAGGDGGAGGLAQAAGFSDGIR MUL_4367|M.ulcerans_Agy99 -----------------TGAAGGIGGAGGAGGTGGDSG------------ Mflv_5091|M.gilvum_PYR-GCK ETG-------------TWGNAGLPGKAGDAGGAGAVGA-----------A Mvan_1264|M.vanbaalenii_PYR-1 APG-------------VWGNAGLPGAAGAAGGAGAIGT-----------A MSMEG_0868|M.smegmatis_MC2_155 AIG-------------GNGGNGGNGSTTAAGGNGGTGG-----------T TH_3810|M.thermoresistible__bu --------------------------VDGDGGSGGRTG------------ MAB_4284c|M.abscessus_ATCC_199 QRN------------TTNINDSFNTDRSTNIGSGNTTN------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 QYS---------------LPDYLYVPVDPEPGDDELAYS---------AV Rv2490c|M.tuberculosis_H37Rv GAGGAGGAGASGGGGGKGASGADSAEAVG---GAGGKGGDGGVGGVGGDG Mb2517c|M.bovis_AF2122/97 GAGGAGGAGASGGGGGKGASGADSAEAVG---GAGGKGGDGGVGGVGGDG MMAR_2656|M.marinum_M GVGGAGGDGGAGGGAGDGGDGANAPAASGLAGGSGGHGGDPGVGGAGGAG MUL_4367|M.ulcerans_Agy99 GVGGVNGDGGAGGGGGRGGDGGSSTSTS-------------GVGGAGGAG Mflv_5091|M.gilvum_PYR-GCK GAAGTVGTAGATGGTGTGANGGAG-----------------GVGGVGGTG Mvan_1264|M.vanbaalenii_PYR-1 GVAGAAGTAGATGGTGVGGNGGAG-----------------QAGGIGGTG MSMEG_0868|M.smegmatis_MC2_155 GRVIAEGTGSTAEGTATGGDGGHSTG--------------TGIGGNGGIG TH_3810|M.thermoresistible__bu ----------LFSKLSRGGDGGDG-----------------GLGGNGGHG MAB_4284c|M.abscessus_ATCC_199 TEIGSHNQANIGTSTSAGGSAAVG-------------------GNAGLAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GEEDAESPTVVIEKLFLPEDSEPR------------------RRPVLLVG Rv2490c|M.tuberculosis_H37Rv -------------------GPGGDGGAGGAAPAGQVGSHGVGGVGGDGGL Mb2517c|M.bovis_AF2122/97 -------------------GPGGDGGAGGAAPAGQVGSHGVGGVGGDGGL MMAR_2656|M.marinum_M GTGSVTGAHGTEGLTQTTGGNGGDGGDG-ANASTVGASGGAGGAGGDGGR MUL_4367|M.ulcerans_Agy99 -------------------GNGGNAGFG-VSAGGTGGSAGDGGAGG---- Mflv_5091|M.gilvum_PYR-GCK -------------------AAGAAGGAG--GLGETGTTGGAGGVGGQGTA Mvan_1264|M.vanbaalenii_PYR-1 -------------------AAGAAGQAG--TAGETGVTGGVGGIGGQGTE MSMEG_0868|M.smegmatis_MC2_155 -------------------SVYAYGNNGAVSGTATGGRGGDGIDGGTGGA TH_3810|M.thermoresistible__bu ------------------------GGTGIISLLSLAGN------------ MAB_4284c|M.abscessus_ATCC_199 -------------------NAGLAGNAGLAGNAGLAGNAGLAGN------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------SGLAVVGISAVLALEIALAIGIRTTG----- Rv2490c|M.tuberculosis_H37Rv GGAGGN-GGDGGHG--------------SDGGDGG-DGGDPGAGGLGG-- Mb2517c|M.bovis_AF2122/97 GGAGGN-GGDGGHG--------------SDGGDGG-DGGDPGAGGLGG-- MMAR_2656|M.marinum_M YGNGGV-GGAGGDGYRGYDGMSVVGGDGTVGGDGG-AGGAGGAGGMGGAL MUL_4367|M.ulcerans_Agy99 -GAGGV-DGVGG-----------------ASGNGG-AAGAGGAGGSG--- Mflv_5091|M.gilvum_PYR-GCK GGTGGV-GGIGG-----------------AGSTGA-VGGVGGKGIQGG-- Mvan_1264|M.vanbaalenii_PYR-1 GGTGGV-GGVGG-----------------VGATGG-AGGVGGKGIQGG-- MSMEG_0868|M.smegmatis_MC2_155 GGMGEIYSGADGEATG-----------ISAGGDGGSATGADSLGGRGG-- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv -----------------LGGDSGNGTR----AASGVDASDHG-------- Mb2517c|M.bovis_AF2122/97 -----------------LGGDSGNGTR----AASGVDASDHG-------- MMAR_2656|M.marinum_M AGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGTDGGSGGMGGVGGAG MUL_4367|M.ulcerans_Agy99 -----------------IG--------------AGIDGGAG--------- Mflv_5091|M.gilvum_PYR-GCK ---------------------------------QGLQ------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------QGLQ------------- MSMEG_0868|M.smegmatis_MC2_155 -----------------TSWVQAGYGPTTGGKASGTAKAGHG-------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv ---------------------PGSGGNGGNGGNG----------AQASVA Mb2517c|M.bovis_AF2122/97 ---------------------PGSGGNGGNGGNG----------AQASVA MMAR_2656|M.marinum_M GDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGDGGDGANAAAGSGAV MUL_4367|M.ulcerans_Agy99 ----------------------GAGGTGGAAG-----------------F Mflv_5091|M.gilvum_PYR-GCK ------------------------GGKGGDGG-----------------A Mvan_1264|M.vanbaalenii_PYR-1 ------------------------GGQGGDGG-----------------T MSMEG_0868|M.smegmatis_MC2_155 -------------------GKASDGGKGGNGGD-----------ALVMAA TH_3810|M.thermoresistible__bu ------------------------GGNGGNGYR----------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------AGLAGNAG-----------------L MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------------------------------------TV Rv2490c|M.tuberculosis_H37Rv GGAGGNGGDGGNAGRVGDG------------------------------- Mb2517c|M.bovis_AF2122/97 GGAGGNGGDGGNAGRVGDG------------------------------- MMAR_2656|M.marinum_M GGKGGDGGDPGVGGAGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGNGGSG MUL_4367|M.ulcerans_Agy99 PGGGGTTGAWGTGGAGGAG------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGKGGDADSMGSAGATGGKG------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 GGTGGDATSMGEAGATGGKG------------------------------ MSMEG_0868|M.smegmatis_MC2_155 GATGVATGNTAIGGNGGAAS------------------------------ TH_3810|M.thermoresistible__bu -----TTDNNALDG------------------------------------ MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAG------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ALQPTPNQHLIVPTEQAPAPP----------------------------- Rv2490c|M.tuberculosis_H37Rv ---------GAGGNGGDGAAGANGANSGAPGSDALALGQP----GGNGGQ Mb2517c|M.bovis_AF2122/97 ---------GAGGNGGDGAAGANGANSGAPGSDALALGQP----GGNGGQ MMAR_2656|M.marinum_M TTGTTGSKGGAGGAGGDGGRYGNGGNGGTGGTGSTGTAGSSDVMGANGGA MUL_4367|M.ulcerans_Agy99 ---------GAGGAGDHGGVGVNPGDSGT--------------------- Mflv_5091|M.gilvum_PYR-GCK ---------GNGGNGGRGGLFGKGGNAGN--------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------GNGGNGGRGSLFGRGGNAGN--------------------- MSMEG_0868|M.smegmatis_MC2_155 ---------ANGAVGGNGGFTNIAAIHGSITDSSATSGHG---------- TH_3810|M.thermoresistible__bu ---------GHGGNGGNVGFFSLFN------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------NAGLAGNAGLAGNAG------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------PVQASAPQPKISVPEPVAAP--------------------- Rv2490c|M.tuberculosis_H37Rv GDAGQAGGAGGAGGAGGAGGSVSGDGGAGGNGGAGGNGGVGASGGAGARG Mb2517c|M.bovis_AF2122/97 GDAGQAGGAG---GAGGAGGSVSGDGGAGGNGGAGGNGGVGASGGAGARG MMAR_2656|M.marinum_M GGSGWAGGDG---GAGGMGGTLAGHGGDGGDGGSGGTGGTGGRGGNGFNG MUL_4367|M.ulcerans_Agy99 --AGWAGGAG---GAGGAGGSAA------------------------FN- Mflv_5091|M.gilvum_PYR-GCK ---GADGGTG---GAGGAG------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---GGNGGTG---GNGGNG------------------------------- MSMEG_0868|M.smegmatis_MC2_155 --GAAQGGNG---GNGGNGWVQAYDPNGPAGTTIDKGK------------ TH_3810|M.thermoresistible__bu -----LGGAG---GWGGSG------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----LAGNAG---LAGNAG------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv ANGIDSIG-------------------------------GTGGAGGGGGD Mb2517c|M.bovis_AF2122/97 ANGIDSIG-------------------------------GTGGAGGGGGD MMAR_2656|M.marinum_M STKAGLNGGDAGDGGAGGVGGAGGNGGAAGLAQAAGFSDGIQGAGGAGGD MUL_4367|M.ulcerans_Agy99 ---------------------------------------GVNGAGGAGGN Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------GTGGTGGAGGT Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------GTGGTGGNGGT MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------------AAGGNGGDGGF TH_3810|M.thermoresistible__bu ----------------------------------------VDGVDVVGGN MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------LAGNAGLAGN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------------------------KPLSPPVAAPL Rv2490c|M.tuberculosis_H37Rv GGAGG-----------------------------VGGHGGDGGVGGAAPS Mb2517c|M.bovis_AF2122/97 GGAGG-----------------------------VGGHGGDGGVGGAAPS MMAR_2656|M.marinum_M GGAGGGAGDGGDGANAAAGSGAVGGNGGDGGDPGLGGGGGAGGTGATTGA MUL_4367|M.ulcerans_Agy99 GGAGG------------------------------GGGAGASGIGAG--- Mflv_5091|M.gilvum_PYR-GCK GGTGG-----------------------------TGGIGGAG-------- Mvan_1264|M.vanbaalenii_PYR-1 GGTGG-----------------------------TGGIGGAG-------- MSMEG_0868|M.smegmatis_MC2_155 NGTGG----------------------------ATGGRGGDGAGASVWKA TH_3810|M.thermoresistible__bu PDG----------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGLAG--------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PAAPP--------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GTVG---SHGTGGVGGDGGLGGAGGVGGAGGNGGIGITVGGAGGAG-GNG Mb2517c|M.bovis_AF2122/97 GTVG---SHGTGGVGGDGGLGGAGGVGGAGGNGGIGITVGGAGGAG-GNG MMAR_2656|M.marinum_M HGADGL-SPTTGGNGGKGGNGGSGAIGVAGGAGGA----GGDGGLY-GDG MUL_4367|M.ulcerans_Agy99 ---------VAGGDGGTGGTGGAAGTGGAAGTGGT----GGAAGAA-GSA Mflv_5091|M.gilvum_PYR-GCK ---------STGGTGGTGGTGGTGGTGGTGGTGGT----GGTGGTG-GKG Mvan_1264|M.vanbaalenii_PYR-1 ---------STGGTGGTGGTGGTGGTGGTGGTGGT----GGTGGTG-GKG MSMEG_0868|M.smegmatis_MC2_155 NGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGA----GGAGGVSEGEG TH_3810|M.thermoresistible__bu --------------GTPGAHGESHTPGVYTDRQGE----DGEDGTG---T MAB_4284c|M.abscessus_ATCC_199 ----------NAGLAGNAGLAGNAGLAGNAGLAGNAAVAGNAAVAG--NA MLBr_01183|M.leprae_Br4923 -----------------MPLFLNAEPQALTAAANT------LEGLS--AA MAV_4827|M.avium_104 ----------------PAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPV Rv2490c|M.tuberculosis_H37Rv GDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGGVGGNG------ Mb2517c|M.bovis_AF2122/97 GDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGGVGGNG------ MMAR_2656|M.marinum_M GDGGSGGNGGAGKAGAAGVSAGSNGEAGGQAG-AGGVGGAGGNGGANAGN MUL_4367|M.ulcerans_Agy99 GDGGAGGAGGAGDDGSAGVVSGDPGTAGKAGG-AGGAGGVGGNG------ Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAGGTGGDGGTGGTGGTGGTGG-----TGGTGGTGGAG------ Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGDGGTGGTGGTGGTGGTGGTGG-----TGGTGGTGGAG------ MSMEG_0868|M.smegmatis_MC2_155 GTGGHGGDGGRGGDGALGGNGGTGGVGLGNGG-KGGNGGNGGNG------ TH_3810|M.thermoresistible__bu GIGGRGGNGGSSSGTHPMAEDGEHVKALD-----GRPGLDGGNG------ MAB_4284c|M.abscessus_ATCC_199 AVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLGGSGSVGGST------ MLBr_01183|M.leprae_Br4923 TVASNAAAAQLTTEIAPPAADDVSILLA---------HFFSGHG------ MAV_4827|M.avium_104 RIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVPQPPSPPQVGGTVP----- . .* Rv2490c|M.tuberculosis_H37Rv ---------------------AKAAAAGGDGGQGGDGGNAGLFGDGGAGG Mb2517c|M.bovis_AF2122/97 ---------------------AKAAAAGGDGGQGGDGGNAGLFGDGGAGG MMAR_2656|M.marinum_M GGTGGNGGDGGVGGTGGAGKVGTTGPAGGAGGEGGDGGKGGTGGRGGNGG MUL_4367|M.ulcerans_Agy99 -------------------------VAGGVNGSGGAGGAGGAGGTGGAGA Mflv_5091|M.gilvum_PYR-GCK ---------------------------DGTGGTGGTGGTGGQGGQGGQGG Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------DGLGGTGGTGGTGGFGGQGGQGG MSMEG_0868|M.smegmatis_MC2_155 ----------------------GTYVDPSHTGAGGNGGNGGAGRIRVNNG TH_3810|M.thermoresistible__bu ----------------------------SHGGNGGHGGRGGFLGIGGSGG MAB_4284c|M.abscessus_ATCC_199 -------------------------AVGGGAHTGVGGGVSTGVGVGSHVG MLBr_01183|M.leprae_Br4923 ---------------------------RQYQAHASQGATNHQDLIQSLLT MAV_4827|M.avium_104 ------------------------QSPPQHQTPPGEGTPPKPDGPGNYGG * Rv2490c|M.tuberculosis_H37Rv DGADGTAAEALGGDGGAGGAGGKGGDAGDIG-DGGDGGKGGD--GAHGAL Mb2517c|M.bovis_AF2122/97 DGADGTAAEALGGDGGAGGAGGKGGDAGDIG-DGGDGGKGGD--GAHGAL MMAR_2656|M.marinum_M AGGTAQAAGYSDGSQGVGGDGGAGGTGGTAG-NGGKGGAGTW--AVNNGI MUL_4367|M.ulcerans_Agy99 SGVPASVD---------GGDGGAGGAGGAAG-TGGSGGS----------- Mflv_5091|M.gilvum_PYR-GCK TGGT-------------GGQGGLGGGGGTGG-QGGTGGT----------- Mvan_1264|M.vanbaalenii_PYR-1 TGGT-------------GGQGGLGGVGGTGG-TGGTGGT----------- MSMEG_0868|M.smegmatis_MC2_155 TATGTATG-------GNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSN TH_3810|M.thermoresistible__bu ----------------WGGHGGNGGDTDADGGNGGDGGN----------- MAB_4284c|M.abscessus_ATCC_199 GGISES----------LGGSGSVGGSTAVGG--GAHTGVG---------- MLBr_01183|M.leprae_Br4923 SS---------------SAYAGTETANHDSL------------------- MAV_4827|M.avium_104 GHVPTPG---------AGGSGGSGGGHVPTPGAGGSGGSG---------- .. .. Rv2490c|M.tuberculosis_H37Rv GGLTVAGGNGGAGGAGG--------------------------------- Mb2517c|M.bovis_AF2122/97 GGLTVAGGNGGAGGAGG--------------------------------- MMAR_2656|M.marinum_M GGKGGNGGNAGTGGTGGSFGTGSQIGNHGSTGHLGDGGDGGTGGAGVNAT MUL_4367|M.ulcerans_Agy99 ------AGNTGAGGAGG--------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------GGQGGTGGTGG--------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------GGQGGTGGTGG--------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ASGTATGGDGGNGGTLG--------------------------------- TH_3810|M.thermoresistible__bu ------GGSAGRGGTGG--------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------GGVSTGVGVG---------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------GGHVPTPGTGG--------------------------------- Rv2490c|M.tuberculosis_H37Rv -------AGGAGG--AFLGDGGNGGAGGQGGAGRGGSP------------ Mb2517c|M.bovis_AF2122/97 -------AGGAGG--AFLGDGGNGGAGGQGGAGRGGSP------------ MMAR_2656|M.marinum_M APGQDGAAGGVGGNGGIVGDGGVGGKGGDGAAGTTGSSGTASGEAGKDGG MUL_4367|M.ulcerans_Agy99 -------AGGAGG-----------------SAASTGVN-----------G Mflv_5091|M.gilvum_PYR-GCK -------TGGTGG------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------TGGTGG------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------ATNGTGGAATIVAYNVVQANPQASGTATDG-------------- TH_3810|M.thermoresistible__bu -------LRGVFG------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -SHVGG-------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv -GGGGGVGGHGGAGG--------------DAGMNGGGGTGGQGGNGAAGG Mb2517c|M.bovis_AF2122/97 -GGGGGVGGHGGAGG--------------DAGMNGGGGTGGQGGNGAAGG MMAR_2656|M.marinum_M DGGKGGAGGAGGNGGT-------------SRGDGGAGGAGGTGGVGGSGG MUL_4367|M.ulcerans_Agy99 DGGAGGAGGVGGLGGD-------------SAATAGGGGAGGDGGKGGAGG Mflv_5091|M.gilvum_PYR-GCK TGGAGGDGGLGGLGG-----------------FGGSGGTGGQGGLGGPGG Mvan_1264|M.vanbaalenii_PYR-1 TGGAGGDGGLGGLGG-----------------FGGVGGTGGQGGQGGPGG MSMEG_0868|M.smegmatis_MC2_155 HGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGG TH_3810|M.thermoresistible__bu --------------------------------INGGNGRAGLGGRGX--- MAB_4284c|M.abscessus_ATCC_199 ------------------------------GISESLGGSGSVGGSTAVGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------------------PGGTGGSGGGHVPTP Rv2490c|M.tuberculosis_H37Rv AGWSPDSDLKG-----FDGFDGGSGG-AGGDGGAGGAGG---------TQ Mb2517c|M.bovis_AF2122/97 AGWSPDSDLKG-----FDGFDGGSGG-AGGDGGAGGAGG---------TQ MMAR_2656|M.marinum_M DGADGTSGLFGG-ADGTAGGAGGDGG-DGGAGGAGGAGGKAVSGVGQNGS MUL_4367|M.ulcerans_Agy99 AGVNGVG--------------GGDGG-KGGTGGAGGAG------------ Mflv_5091|M.gilvum_PYR-GCK S-------------------TGGAGG-AGGQAGTAGKGG---------LF Mvan_1264|M.vanbaalenii_PYR-1 S-------------------TGGAGG-AGGQAGVAGKGG---------LF MSMEG_0868|M.smegmatis_MC2_155 DGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPS------WVQ TH_3810|M.thermoresistible__bu ---------------------XXXGG---GVGAAVRSGN----------- MAB_4284c|M.abscessus_ATCC_199 G-----------------AHTGVGGGVNTGVGVGSHVGG----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 G-------------------AGTPGGSGGGHLPFPGAGS----------- Rv2490c|M.tuberculosis_H37Rv TGDGGDGGAGGLG-GAGGVGGNGVDGFDINETTG---RDGGDGGDGGYGG Mb2517c|M.bovis_AF2122/97 TGDGGDGGAGGLG-GAGGVGGNGVDGFDINETTG---RDG-DGGDGGYGG MMAR_2656|M.marinum_M QGAGGNGGAAGDG-GDGGNGGNGHDGNNGSVPSGGTDRDGGDGQGGGDGG MUL_4367|M.ulcerans_Agy99 -GAGSDGIIPSNG-GLGGNGGNGGNG----------------GQAFGDG- Mflv_5091|M.gilvum_PYR-GCK GGSGSAGKAGATG-AAGASGGKGAQG--------------ATGAQGATGA Mvan_1264|M.vanbaalenii_PYR-1 GGSGSAGTAGVTG-ASGASGGKGAQG--------------ATGAQGATGA MSMEG_0868|M.smegmatis_MC2_155 SGYGSTLGGNATGTATAGKGGEASNG--------------GVAGNGGNAL TH_3810|M.thermoresistible__bu ------------G-VFSGGGGTPSAG---------------FGVPTTIQF MAB_4284c|M.abscessus_ATCC_199 ------GISESLG-GSGSVGGSTAVG----------------GGAHTSAI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------TPGGSGGGHLPTP---------------GAGTPGGG Rv2490c|M.tuberculosis_H37Rv WGGAGGNGGAGGSAPAGE--VGNRGVGGDGGDGGSGGDAGNGGLGGDGFT Mb2517c|M.bovis_AF2122/97 WGGAGGNGGAGGSAPAGE--VGNRGVGGDGGDGGSGGDAGNGGLGGDGFT MMAR_2656|M.marinum_M AGGAGGAGGNGGAAGAGG--GGTRGAGGDGGDGGNGGFAGDGGLGMDGLD MUL_4367|M.ulcerans_Agy99 VGGAGGIGGKGGNAAIGT--IVIN--GGVGGAGGSGGLGG---------- Mflv_5091|M.gilvum_PYR-GCK QGATGATGAAGKAGATGA--AGAAGAAGSAGTTGAQGSAGTN-------- Mvan_1264|M.vanbaalenii_PYR-1 QGATGATGASGAQGSAGS--AGSAGVAGSAGTTGAQGSAGTN-------- MSMEG_0868|M.smegmatis_MC2_155 VMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTA TH_3810|M.thermoresistible__bu PAGSCTSRAVSREGIMPS---SRAASARAGAACASS-------------- MAB_4284c|M.abscessus_ATCC_199 NDALGGSGSVGGSTAVGG---GAHTSAINESMNSSIN------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 LGGFGGGHAPAPGGGLGG--GGGHAPAPGGGLGGFGG------------- Rv2490c|M.tuberculosis_H37Rv YLADFDGEPGGDGGDGGDGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGG Mb2517c|M.bovis_AF2122/97 YLADFDGEPGGDGGDGGDGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGG MMAR_2656|M.marinum_M ATLTNRAGDGGDGGGGGQAFAGGAGGAGGTGSTQGSAGTTGAWRAGGDGG MUL_4367|M.ulcerans_Agy99 ---------ATEDGVGGVGCAGGAGGNGGRG--------DMLFTVGGSGG Mflv_5091|M.gilvum_PYR-GCK ---------GANGANGSQGAAGKAGATGTTG-------------ATGAAG Mvan_1264|M.vanbaalenii_PYR-1 ---------GANGANGSQGAAGKAGATGTTG-------------ATGAAG MSMEG_0868|M.smegmatis_MC2_155 ISGHGGAGNGGNGGKGADGWVQAYDPAGPVG-----SKIANSSAVAGNGG TH_3810|M.thermoresistible__bu -----------TSRSRRSFCCSRA-------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------ASHSSSMNESFGSSMGSHGAAG-----------TGFEAQGH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------GHSGGGLGGLGGGHK------------------------- Rv2490c|M.tuberculosis_H37Rv DGGNGGHG--------GDGNGSFADAGDGG------PGGNGGNG------ Mb2517c|M.bovis_AF2122/97 DGGNGGHG--------GDGNGSFADAGDGG------PGGNGGNG------ MMAR_2656|M.marinum_M SGGDGGDGFGLWNPGEGGRGGSGGDGGTGG------DGGDGGNGRVEIWE MUL_4367|M.ulcerans_Agy99 TGGDGGG------------GGSASGSGTGG------SGGTGG-------- Mflv_5091|M.gilvum_PYR-GCK EDGDAGSG------------GSGINGGAGG------AGGAGG-------- Mvan_1264|M.vanbaalenii_PYR-1 DAGDPGSE------------AVDINGGAGG------AGGAGG-------- MSMEG_0868|M.smegmatis_MC2_155 DGGVNGTG-----------GASGGDGGNGGNTSVWKSGGQTADG------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AQG----------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv -------------------------------------GLGGAGRDGGAPG Mb2517c|M.bovis_AF2122/97 -------------------------------------GLGGAGRDGGAPG MMAR_2656|M.marinum_M GRGGNGGNGAIGPGGDGGDGGDAPNQQRVSSSSPGYEGADGGNGGNGTIG MUL_4367|M.ulcerans_Agy99 ------------------------------------------------VG Mflv_5091|M.gilvum_PYR-GCK ------------------------------------------------EG Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------------------EG MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------------EHNTGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------------HA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GDGGDGGTGGSGGFGAPPPRSIGGGDGGDGGRGGDGGRGAGG-------- Mb2517c|M.bovis_AF2122/97 GDGGDGGTGGSGGFGAPPPRSIGGGDGGDGGRGGDGGRGAGG-------- MMAR_2656|M.marinum_M GNGGNGGTGGPGYDASLGGEATAGGEGGDGGDGGKGFNGAGGAGGDGGAG MUL_4367|M.ulcerans_Agy99 GIGGDGKLGG------------FGGDGGDGGDGG---------------- Mflv_5091|M.gilvum_PYR-GCK GEGGDGGKGGAG---------AEGGAGGGGGAGG---------------- Mvan_1264|M.vanbaalenii_PYR-1 GEGGAGGAGGDG---------SEGGAGGSGGAGG---------------- MSMEG_0868|M.smegmatis_MC2_155 GNGGDGSEPGPGG-------NGAGGAGGNGGTGG---------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SETAHTTLPGAEHH------------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv --------------LTSGGVGSSGESGGSGNGRGDPGSGGSGGEGGEGGP Mb2517c|M.bovis_AF2122/97 --------------LTSGGVGSSGESGGSGNGRGDPGSGGSGGEGGEGGP MMAR_2656|M.marinum_M GAGGSGAPAPFGSGGAYGGTGGQGGTGGSG-VIGGIGEGGKIGDAGFGGN MUL_4367|M.ulcerans_Agy99 ----------------FGVIGGQGGGGGFG-GLGGTGAGGAPSDKGINGE Mflv_5091|M.gilvum_PYR-GCK -----------------SGAGGAGGAGGSG------GSGGSGGSGGSGGA Mvan_1264|M.vanbaalenii_PYR-1 -----------------SGTGGAGGAGGSG------GSGGSGGAGGSGGA MSMEG_0868|M.smegmatis_MC2_155 ---------------TTAGGSGNGGNGGNG------GNGGADGTPGTAGT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv SISVNVT------------------- Mb2517c|M.bovis_AF2122/97 SISVNVT------------------- MMAR_2656|M.marinum_M PPNSQTGEGGSGGAGGAGGAGGDPSN MUL_4367|M.ulcerans_Agy99 PGNPG--------------------- Mflv_5091|M.gilvum_PYR-GCK AGDSDD-------------------- Mvan_1264|M.vanbaalenii_PYR-1 AGDSD--------------------- MSMEG_0868|M.smegmatis_MC2_155 TGANNP-------------------- TH_3810|M.thermoresistible__bu -------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------- MLBr_01183|M.leprae_Br4923 -------------------------- MAV_4827|M.avium_104 --------------------------