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LRTPLCRAGAVLASVVLLCSASATASADESIVIDLVRHGQSVANAAGLIDTAVPGASLTQLGQQQAQTVA GVLAARGPVAAIFASQLIRTQQTAAPLASALGMNVQVLPGLNEIDAGIFNGQPQFSLGGLAYLLAPIAWM LGLRIVPMLAPGSADANGYEFRRRFDGALQTVYGSAAASAGGFGDVLQAVYAGAVTNPVRAANGRITGVA FSSEFAIGVGTMMTVKNPDPLVLLFDPLPNTGIVVIQGSPRDGWTLISWNGKPVHPGWSATRNGRGANGL CLMLDPSTRTGVCAAKPPGPASAPVAARPGLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4778 | - | - | 100% (313) | pe_pgrs family protein |
| M. avium 104 | MAV_4339 | - | 2e-37 | 39.92% (253) | phosphoglycerate mutase family protein |
| M. avium 104 | MAV_4620 | - | 6e-10 | 38.05% (113) | phosphoglycerate mutase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0776 | PE_PGRS11 | 6e-78 | 63.03% (238) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_4577 | - | 2e-41 | 40.91% (264) | phosphoglycerate mutase |
| M. tuberculosis H37Rv | Rv0754 | PE_PGRS11 | 6e-78 | 63.03% (238) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_00079 | - | 5e-10 | 38.55% (83) | putative phosphoglycerate mutase |
| M. abscessus ATCC 19977 | MAB_0133 | - | 5e-12 | 44.58% (83) | phosphoglycerate mutase |
| M. marinum M | MMAR_4953 | - | 1e-68 | 55.51% (245) | PE-PGRS family protein |
| M. smegmatis MC2 155 | MSMEG_6545 | - | 2e-42 | 43.80% (258) | phosphoglycerate mutase family protein |
| M. thermoresistible (build 8) | TH_2144 | - | 1e-43 | 43.27% (245) | phosphoglycerate mutase family protein |
| M. ulcerans Agy99 | MUL_0919 | lpqD | 9e-34 | 35.32% (252) | lipoprotein, LpqD |
| M. vanbaalenii PYR-1 | Mvan_5262 | - | 5e-51 | 48.45% (258) | phosphoglycerate mutase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0776|M.bovis_AF2122/97 MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAA
Rv0754|M.tuberculosis_H37Rv MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAA
MMAR_4953|M.marinum_M MSFVLVAPDMLATAAADVVQIGSAVSAGNLAAAIPTTEVMAAAADEVSGA
MAV_4778|M.avium_104 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 LAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRG
Rv0754|M.tuberculosis_H37Rv LAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRG
MMAR_4953|M.marinum_M IAALFGANAQEYQAAAAQAATFHEQFVRALSEAGASYASAEATIVTGLS-
MAV_4778|M.avium_104 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 ALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLG
Rv0754|M.tuberculosis_H37Rv ALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLG
MMAR_4953|M.marinum_M ------SAVADGFQTAVYGPIRAAGQAWISSPAGEVVDPVINAPTEALFG
MAV_4778|M.avium_104 ---------------MLRTPLCRAG---------------------AVLA
MSMEG_6545|M.smegmatis_MC2_155 ---------------------------------------MTTHTRRTAAV
TH_2144|M.thermoresistible__bu --------------------------------------------VLLLAC
Mvan_5262|M.vanbaalenii_PYR-1 --------------------------------------MRDVRRTARRLL
Mflv_4577|M.gilvum_PYR-GCK ----------------------------------------MPDPRTCRVR
MUL_0919|M.ulcerans_Agy99 ----------------------------------------MAKRSMIWNT
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 RDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYT---------GGNGGSAGL
Rv0754|M.tuberculosis_H37Rv RDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYT---------GGNGGSAGL
MMAR_4953|M.marinum_M RGLISNGAAGTAAHPNGGAGGILFGDGGPGYTPTGGIGAVAGGIGGDAGL
MAV_4778|M.avium_104 SVVLLCSASATASAD-----------------------------------
MSMEG_6545|M.smegmatis_MC2_155 AALVVALVAGMLTAPN----------------------------------
TH_2144|M.thermoresistible__bu ALAAPAGIPGSVPTAR----------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 TILAATLAAAVLFAAS----------------------------------
Mflv_4577|M.gilvum_PYR-GCK RILIAALSAVLLVLVS----------------------------------
MUL_0919|M.ulcerans_Agy99 SKVLALLATAMLPGACGG--------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 IGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLF
Rv0754|M.tuberculosis_H37Rv IGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLF
MMAR_4953|M.marinum_M IGNGGLGGNGFGGGTGGMGGTGGWLMGNGGGGGVGGVGG---VGGQALFF
MAV_4778|M.avium_104 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 GNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHG
Rv0754|M.tuberculosis_H37Rv GNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHG
MMAR_4953|M.marinum_M GNGGAGGGSALG------GRAGLFIGEPGTGWVADPGNGQSIVIDFVRHG
MAV_4778|M.avium_104 ---------------------------------------ESIVIDLVRHG
MSMEG_6545|M.smegmatis_MC2_155 -----------------------------------AVAQRIITLTLVRHA
TH_2144|M.thermoresistible__bu -----------------------------------AAGPAVMTLTLVRHA
Mvan_5262|M.vanbaalenii_PYR-1 -----------------------------------AFAAADIVLTFVRHG
Mflv_4577|M.gilvum_PYR-GCK -----------------------------------AIPSWAMTLTFVRHA
MUL_0919|M.ulcerans_Agy99 ----------------------------------GSPQARSITLTFIRNA
MLBr_00079|M.leprae_Br4923 ---------------------------------------MSSRLVLLRHG
MAB_0133|M.abscessus_ATCC_1997 ----------------------------MARRDAGREAAMSGRLVLVRHG
: ::*:.
Mb0776|M.bovis_AF2122/97 QTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIR
Rv0754|M.tuberculosis_H37Rv QTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIR
MMAR_4953|M.marinum_M QTASNVAELIDTNVPGPPLTAEGHLQADIIAGQLFAKGPYAGIFDSELLR
MAV_4778|M.avium_104 QSVANAAGLIDTAVPGASLTQLGQQQAQTVAGVLAARGPVAAIFASQLIR
MSMEG_6545|M.smegmatis_MC2_155 QSEGNASGLIDTSTPGPPLTALGREQAETAAQKLAAGHTFDGIYASTMIR
TH_2144|M.thermoresistible__bu ESMGNASGVIDSSTPGPPLSPLGWVQAQVVAAELAGGG-HDGLYASTMIR
Mvan_5262|M.vanbaalenii_PYR-1 QSQANADGIINTEVPGPHITALGQQQAALVAGVLAAGG-YQGIYASDMVR
Mflv_4577|M.gilvum_PYR-GCK ESLANEAGIIDTRVPGPGLSEAGELQARAIAPVLAGMG-FDGIYVSSMLR
MUL_0919|M.ulcerans_Agy99 QSQADAEGIIATELPGTGLSSDGKDQAQQLTHQFGRSE-FDSIYTSPMEA
MLBr_00079|M.leprae_Br4923 QSYGNVEGRLDTRPPGASLTPFGRDQARVFAQ---AAGRPVLLVHSVAIR
MAB_0133|M.abscessus_ATCC_1997 QSYGNVERRLDTKPPGAALTELGLQQARLFAKRY-EEHAPAVLVHSVAVR
:: .: : : **. :: * ** : : *
Mb0776|M.bovis_AF2122/97 TQQTAAPLANLLGMAPQ-VLPGLNEIHAGIFEDLPQ--ISPAGLLYLVGP
Rv0754|M.tuberculosis_H37Rv TQQTAAPLANLLGMAPQ-VLPGLNEIHAGIFEDLPQ--ISPAGLLYLVGP
MMAR_4953|M.marinum_M TQQTAAPLAALYGITDVPALSGLNEISAGIFDGLQQ--ITPAGLLYLIGP
MAV_4778|M.avium_104 TQQTAAPLASALGMNVQ-VLPGLNEIDAGIFNGQPQ--FSLGGLAYLLAP
MSMEG_6545|M.smegmatis_MC2_155 TQQTAQPLADLS-REPVTVLPGLREIEAGIYEGQPEALAG-FT--YYEAP
TH_2144|M.thermoresistible__bu TQQTAEPLANLT-GEPVVVLPGLREIEAGVFEGQPEASAGDYSGGYFTAP
Mvan_5262|M.vanbaalenii_PYR-1 TQETAAPLADIL-GESVTVLPGLREIDAGIYEGSSE-TDGLGRLGYGLTP
Mflv_4577|M.gilvum_PYR-GCK TQLTAQPMLDLLPGSSYQVLPGLREISAGIFEGSSE-NEGLGRLGYALAP
MUL_0919|M.ulcerans_Agy99 AQQTAAPLARQL-SKQAEIVPGLQSIDAGWYNGKPD---SMADRTYMVAP
MLBr_00079|M.leprae_Br4923 ALETAAVLGAEF-DVPIREIAGIHEVQVGELENRND---DDAIAEFNAIY
MAB_0133|M.abscessus_ATCC_1997 AVQTAAGIAEHL-GVQAEQIEGLHEVQAGELEDRTD---LEAFAVFDRTY
: ** : : *:..: .* :. : :
Mb0776|M.bovis_AF2122/97 IAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIY-------------
Rv0754|M.tuberculosis_H37Rv IAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIY-------------
MMAR_4953|M.marinum_M MAWTLGYPIVPMLTPGSLDFNGVVFNQDFTHAMDTMY-------------
MAV_4778|M.avium_104 IAWMLGLRIVPMLAPGSADANGYEFRRRFDGALQTVYGSAAASAGGFGDV
MSMEG_6545|M.smegmatis_MC2_155 TRWLQGD--RTARIPGSID--GDEFDARFDEAVREIY-------------
TH_2144|M.thermoresistible__bu ARWLRGD--RSARIPGSID--GNEFDARFDEAVQQIH-------------
Mvan_5262|M.vanbaalenii_PYR-1 ALWTLGL--RSAWIPDSTDTNGNVFSDRMSEAVQIIY-------------
Mflv_4577|M.gilvum_PYR-GCK VTWMLGA--RFVPVPGGED--GNAFDARVDGAIAEIA-------------
MUL_0919|M.ulcerans_Agy99 VSWIDGN--VEASIPGSTS--GSDFNSRFTGAIRKIY-------------
MLBr_00079|M.leprae_Br4923 DRWHHGE--LDVPLPGGET--ANDVLDRYLPVLVDLR-------------
MAB_0133|M.abscessus_ATCC_1997 ERWHFGD--LDARMPGGES--AQDVFDRYLPAVADLR-------------
* * *.. . . .: :
Mb0776|M.bovis_AF2122/97 -----DASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTH
Rv0754|M.tuberculosis_H37Rv -----DASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTH
MMAR_4953|M.marinum_M -----SAALANPVLAANGKITDVAYSSAFTIGVGTMMNVDNPDPLLLLTH
MAV_4778|M.avium_104 LQAVYAGAVTNPVRAANGRITGVAFSSEFAIGVGTMMTVKNPDPLVLLFD
MSMEG_6545|M.smegmatis_MC2_155 ---------------DSEDTDPVAFSHAGAIMTWVAMNVDNPDLGLLSRH
TH_2144|M.thermoresistible__bu ---------------ADGAVNPVAFAHAASIMVWVMMNVDNPDPDLLLQR
Mvan_5262|M.vanbaalenii_PYR-1 ---------------EDGWARPVAFSHGATIMFWTMMNVDNPDLGLLLSH
Mflv_4577|M.gilvum_PYR-GCK ---------------DNGDENAVAFAHGATIMFWVMMNVDNPDLLLMLRH
MUL_0919|M.ulcerans_Agy99 ---------------DGGHNRPVVFSQGTAIMVWTLMNVKNPKTNLLNTH
MLBr_00079|M.leprae_Br4923 ----------MRYLDDGDWTGDVVVVSHGAAIRLVSAVLAEVDGRFALEN
MAB_0133|M.abscessus_ATCC_1997 ----------LRHLENDASTGDVVIVSHGAAIRLVAAALAGVDPGFAVNR
. *. : . : . .
Mb0776|M.bovis_AF2122/97 PVPNTGAVVVQGNPEGGWTLVSWDGIPVGPAS-LPTALFVDVRELITAPQ
Rv0754|M.tuberculosis_H37Rv PVPNTGAVVVQGNPEGGWTLVSWDGIPVGPAS-LPTALFVDVRELITAPQ
MMAR_4953|M.marinum_M PLPNTGVVEVQGSPANGWTMVSWDGIPVAPAT-LPTQLFVDVRNLITAPQ
MAV_4778|M.avium_104 PLPNTGIVVIQGSPRDGWTLISWNGKPVHPG-------------------
MSMEG_6545|M.smegmatis_MC2_155 PLGNTGHAVVKGNPTGGWTLVDWGGINTE---------------------
TH_2144|M.thermoresistible__bu PLRNTGRVVLTGSPGQGWTLVDWDGIPVRHRP------------------
Mvan_5262|M.vanbaalenii_PYR-1 QLPNTGVVVLEGNPEDGWTLVSWDGVAVDPDPSFLTKTFVNVRELITTPQ
Mflv_4577|M.gilvum_PYR-GCK QLDNVESVVVEGSPEEGWTLVSWAGQAVSADPSLATKLLVNVRDLVVAPQ
MUL_0919|M.ulcerans_Agy99 PLPNIGRVVISGNPATGWKLVDWDGIRNFG--------------------
MLBr_00079|M.leprae_Br4923 RVNNAESVVLVPVTDGRWSCVRWGALTPPFY-------------------
MAB_0133|M.abscessus_ATCC_1997 HLRNAEAVVLAPVTDGRWSCVHWGDAVAPF--------------------
: * . : . *. : *
Mb0776|M.bovis_AF2122/97 YAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDATGH
Rv0754|M.tuberculosis_H37Rv YAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDATGH
MMAR_4953|M.marinum_M YAGWDIFYSLFTGNPTTILTAVRDGIEEVGSAVINFPIEVTEDVVNAICG
MAV_4778|M.avium_104 ------WSATRNGRGANGLCLMLDPSTRTGVCAAKPPGPASAPVA-----
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 TAVYNVKKAFATGDLAAITDSFAQAVIDVVLAPVRFVGAVATDVLELVFP
Mflv_4577|M.gilvum_PYR-GCK TALYNVGTAFSSGDFETLVNAVRDGLIEVTRAVVRFIPDTVRDIVDEFRP
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 -------PHLHRPDSTLVTDVVMSGRDSLG--------------------
MAB_0133|M.abscessus_ATCC_1997 -------PHQEAAS----AEELAQSADPMG--------------------
Mb0776|M.bovis_AF2122/97 PYLSGLPIGLPSLIP-----------------------------------
Rv0754|M.tuberculosis_H37Rv PYLSGLPIGLPSLIP-----------------------------------
MMAR_4953|M.marinum_M -ATDGLTAGAPSLVG-----------------------------------
MAV_4778|M.avium_104 -ARPGLS-------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 PAPSVQVEAPMSAESTTDESDVPADVPD-DVVAVAPSEDVESRTPEPASD
Mflv_4577|M.gilvum_PYR-GCK SVTEDSLDVTELHRAVVTAAPQDDDEAEPQSVAVAEAETRNGSGVAPAGS
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 --------------------------------------------------
Rv0754|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4953|M.marinum_M --------------------------------------------------
MAV_4778|M.avium_104 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 EAETREESA--APESEATEPEISASQSEESEVETETTEETTT--------
Mflv_4577|M.gilvum_PYR-GCK TPPSGDEVTGSTDDDEATASDVVLEDTVDVDTIDVDTVEEDTGASDHAVG
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 ------------------------------------
Rv0754|M.tuberculosis_H37Rv ------------------------------------
MMAR_4953|M.marinum_M ------------------------------------
MAV_4778|M.avium_104 ------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 ------------------------------------
TH_2144|M.thermoresistible__bu ------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 --------------AGTTGDDDTDETDDGAAVKEAA
Mflv_4577|M.gilvum_PYR-GCK NHPDAEADDAAPANGSAKSSDDDGDSDDDASERAAA
MUL_0919|M.ulcerans_Agy99 ------------------------------------
MLBr_00079|M.leprae_Br4923 ------------------------------------
MAB_0133|M.abscessus_ATCC_1997 ------------------------------------