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SFVSVTQEALAAAASDVGVIGSSLQAANMSVAAPTAGVLAAGADEVSVAMAALFSGHGQAYQTLSAQANA FHAQFLQALTNAGGAYAAAEVANLSPLQGVEQGVLGVVNAPAQALLGRPLIGDGAAGTAASPNGGAGGLL YGNGGAGYSYTSGATAEAGGNGGAAGLIGNGGAGGSGWAGGAGGAGGNGGWLYGNGGAGGLGGAAAGDYT AGGVGGAGGNAGLWGDGGAGGNGSATYDYDQNFSRLGALEGAGGNGGHGGLLFGNGGGGGDAGANNKFVT AQATPNGAAGGYGGNAGLWGNGGAGGDGGFGGTATVIGDGGTGGNGGLLSGDGGAGGVGGTGGIQIYSGG GIGGVGGIGGNGGAGGTSGLIGDGGAGGAGGTGGGNAGVGGVGGVGGTGGAARLFGSGGSGGIGGTGGHS LINSGGGIGGKGGGGGAAGLIGDGGAGGAGGNGGDGTGAGGLGGNGASADWIGNGGSGGAGGSGGLGAHA GAGGNGGSLYGNDGSGGAGGTGASGAGGNGGGGGAAGMMGDGGAGGDGGDGSAAGGLGGDGGNADWLGNG GGGTGGFGLPPATGGFGGRGGRLFGSPGAQGRRALMCLSAACRC*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_3507 | - | - | 100% (605) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_0572 | - | e-152 | 52.47% (648) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_0212 | - | e-152 | 51.60% (655) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1121 | PE_PGRS22 | 1e-172 | 53.17% (679) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-103 | 46.43% (532) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv1091 | PE_PGRS22 | 1e-171 | 53.08% (682) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 9e-12 | 34.78% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 4e-49 | 34.67% (450) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_3199 | - | 0.0 | 85.95% (605) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 2e-24 | 44.17% (163) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 6e-91 | 41.86% (602) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 6e-44 | 34.44% (360) | PUTATIVE - |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-104 | 45.34% (547) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3199|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3199|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3199|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3199|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 ---------------------MSFVSVTQEALAAAASDVGVIGSSLQAAN MMAR_3199|M.marinum_M ---------------------MSFVSVTQEALAAAASDVGVIGSSLQAAN Mb1121|M.bovis_AF2122/97 ---------------------MSFVIAAPEALVAVASDLAGIGSALAEAN Rv1091|M.tuberculosis_H37Rv ---------------------MSFVIAAPEALVAVASDLAGIGSALAEAN Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------MSIIDFILNLFRDPVEAASYVADPEAALA MAV_4827|M.avium_104 ------------------------------------------MNIVLGVS MUL_3507|M.ulcerans_Agy99 MSVAAPTAGVLAAGADEVSVAMAALFSGHGQAYQTLSAQANAFHAQFLQA MMAR_3199|M.marinum_M VVAAAPTAGVLAAGADEVSVAMAALFSGHGQAYQALSAQANAFHAQFLQA Mb1121|M.bovis_AF2122/97 AAALAPTTALLAAGADEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQA Rv1091|M.tuberculosis_H37Rv AAALAPTTALLAAGADEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQA Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MLBr_01183|M.leprae_Br4923 -------MPLFLNAEPQALTAAANTLEG----LSAATVASNAAAAQLTTE MAB_4284c|M.abscessus_ATCC_199 NAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNY MAV_4827|M.avium_104 MAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGT MUL_3507|M.ulcerans_Agy99 LTNAGGAYAAAEVANLSPLQGVEQGVLGVVNAPAQALLGRPLIGDGAAGT MMAR_3199|M.marinum_M LTNAGGAYAAAEVANVSPLQGVEQGVLGAVNAPTQALLGRPLIGDGTAGT Mb1121|M.bovis_AF2122/97 LTGGGGAYAAAEAANVSAAQSTDQRLLDLINGPTQALLGRPLIGDGANGG Rv1091|M.tuberculosis_H37Rv LTGGGGAYAAAEAANVSAAQSTDQRLLDLINGPTQALLGRPLIGDGANGG Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGGGTG MLBr_01183|M.leprae_Br4923 IAPPAADDVSILLAHFFSGHGRQYQAH-------------ASQGATNHQD MAB_4284c|M.abscessus_ATCC_199 YAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNV MAV_4827|M.avium_104 REGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAA MUL_3507|M.ulcerans_Agy99 AASPNGGAGGLLYGNGGAGYSYTSGATAEAGGNGGAAG-----------L MMAR_3199|M.marinum_M AASPNGGAGGLLYGNGGAGYSYTSGATAEAGGNGGAAG-----------L Mb1121|M.bovis_AF2122/97 PGQ-DGGPGGLLYGNGGNGG--TSTTAGVAGGNGGAAG-----------L Rv1091|M.tuberculosis_H37Rv PGQ-DGGPGGLLYGNGGNGG--TSTTAGVAGGNGGAAG-----------L Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT TH_3810|M.thermoresistible__bu IIS--------------------LLSLAGNGGNGG--------------- MLBr_01183|M.leprae_Br4923 LIQ---------------------SLLTSSSAYAG--------------- MAB_4284c|M.abscessus_ATCC_199 DSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGG--------------- MAV_4827|M.avium_104 LAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPD----------VY . .. MUL_3507|M.ulcerans_Agy99 IGNGGAGGSGWAGGAGGAGGNGGWLYGNGGAGGLG--------------- MMAR_3199|M.marinum_M IGNGGAGGSGWAGGAGGAGGNGGWLYGNGGAGGQG--------------- Mb1121|M.bovis_AF2122/97 IGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIPGVAGGNGGA Rv1091|M.tuberculosis_H37Rv IGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIPGVAGGNGGA Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG---------------- Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG---------------- MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGT---- TH_3810|M.thermoresistible__bu NGYRTTDNNALDGGHGG--------------------------------- MLBr_01183|M.leprae_Br4923 --TETANHDSL--------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SNSGPIASGQGSTAVNGDVRDSNIINADHGSNVG---------------- MAV_4827|M.avium_104 KQQIRAESYGDAAGQLSAMVAGLEKLESLPGGLLLVG------------- MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3199|M.marinum_M -------------------------------------------------- Mb1121|M.bovis_AF2122/97 GGSAGLWGTGGAGGDGGNGRSGPVNVAGSAGGNGGAGGAAGLFGDAGAGG Rv1091|M.tuberculosis_H37Rv GGSAGLWGTGGAGGDGGNGRSGPVNVAGSAGGNGGAGGAAGLFGDAGAGG Mflv_5091|M.gilvum_PYR-GCK ------------AVGAAGAAG------TVGTAGATGGTG----------- Mvan_1264|M.vanbaalenii_PYR-1 ------------AIGTAGVAG------AAGTAGATGGTG----------- MSMEG_0868|M.smegmatis_MC2_155 --------VDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 --------GAAAG-DYTAG-------------------GVGGAGGNAGLW MMAR_3199|M.marinum_M --------GAAAGTYYTAG-------------------GVGGAGGNAGLW Mb1121|M.bovis_AF2122/97 NGGKGGAGGAAFSINFTAGDGGAG--------------GAGGSGGHALLW Rv1091|M.tuberculosis_H37Rv NGGKGGAGGAAFSINFTAGDGGAG--------------GAGGSGGHALLW Mflv_5091|M.gilvum_PYR-GCK ----TGANGGAGGVGGVGGTGAAG--------------AAGGAGGLGETG Mvan_1264|M.vanbaalenii_PYR-1 ----VGGNGGAGQAGGIGGTGAAG--------------AAGQAGTAGETG MSMEG_0868|M.smegmatis_MC2_155 EGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDG TH_3810|M.thermoresistible__bu ----NGGNVGFFSLFNLGG--------------------AGGWGGSGVDG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------VDQSQTRVGGDYTN----------------VSGHGSADIDK MAV_4827|M.avium_104 ----SGVDVAPLKQVLQTTTFLDVS--------------VAEEPETALAR MUL_3507|M.ulcerans_Agy99 GDGGAGGNGSA---TYDYDQNFSRLGALEGAGGNGGHGG----------- MMAR_3199|M.marinum_M GDGGAGGNGGD---TWR--PGFFTVGSVEGAGGNGGHGG----------- Mb1121|M.bovis_AF2122/97 GAGGAGGNGGSG-GTGGAGGSTAGAGGNGGAGGGGGTGG----------- Rv1091|M.tuberculosis_H37Rv GAGGAGGNGGSG-GTGGAGGSTAGAGGNGGAGGGGGTGG----------- Mflv_5091|M.gilvum_PYR-GCK TTGGAGGVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQ Mvan_1264|M.vanbaalenii_PYR-1 VTGGVGGIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQ MSMEG_0868|M.smegmatis_MC2_155 GTGGAGGMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGY TH_3810|M.thermoresistible__bu ---------------------VDVVGGNP--------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SVTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTNTEIG----------- MAV_4827|M.avium_104 GAALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVP-------- MUL_3507|M.ulcerans_Agy99 --------------LLFGNGGGGGD-AGANNKFVTAQATPN--------- MMAR_3199|M.marinum_M --------------LLFGNGGGGGD-AGLNNQIFGAKGTPN--------- Mb1121|M.bovis_AF2122/97 --------------LLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGT Rv1091|M.tuberculosis_H37Rv --------------LLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGT Mflv_5091|M.gilvum_PYR-GCK G-------------LQGGKGGDGGAGGKGGDADSMGS------------- Mvan_1264|M.vanbaalenii_PYR-1 G-------------LQGGQGGDGGTGGTGGDATSMGE------------- MSMEG_0868|M.smegmatis_MC2_155 GPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIG TH_3810|M.thermoresistible__bu ---------------------DGGTPG----------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------SHNQANIGTSTSAGGSAAVGGNAG----------- MAV_4827|M.avium_104 --------------VDPEPGDDELAYSAVGEEDAESP------------- MUL_3507|M.ulcerans_Agy99 ------GAAGGYGGNAGLWGNGGAGG---------------DGGFG---- MMAR_3199|M.marinum_M ------GAAGGYGGNAGLWGNGGAGG---------------HGGFG---- Mb1121|M.bovis_AF2122/97 GGAGGDGGAGGAGGNARLWGVGGAGG---------------AGGDGGAGG Rv1091|M.tuberculosis_H37Rv GGAGGDGGAGGAGGNARLWGVGGAGG---------------AGGDGGAGG Mflv_5091|M.gilvum_PYR-GCK -----AGATGGKGGNGGNGGRGGLFG---------------KGGNAGNGA Mvan_1264|M.vanbaalenii_PYR-1 -----AGATGGKGGNGGNGGRGSLFG---------------RGGNAGNGG MSMEG_0868|M.smegmatis_MC2_155 GNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGG TH_3810|M.thermoresistible__bu -------AHGESHTPGVYTDRQ---------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----LAGNAGLAGNAGLAGNAGLAG------------------------ MAV_4827|M.avium_104 --TVVIEKLFLPEDSEPRRRPVLLVG------------------------ MUL_3507|M.ulcerans_Agy99 --------------GTAT-------VIGDGGTGGNGGLLSGDGGAGG--- MMAR_3199|M.marinum_M --------------GTATAPVGDGGVGGNGGAGGNGGLFYGDGGAGG--- Mb1121|M.bovis_AF2122/97 AGGKGGSGLSGNANGGAGGDSGRGGTGGAGGEGGAAGLLVGTGGHGG--- Rv1091|M.tuberculosis_H37Rv AGGKGGSGLSGNANGGAGGDSGRGGTGGAGGEGGAAGLLVGTGGHGG--- Mflv_5091|M.gilvum_PYR-GCK D----------------------GGTGGAGGAGGTGG-TGGAGGTGG--- Mvan_1264|M.vanbaalenii_PYR-1 N----------------------GGTGGNGGNGGTGG-TGGNGGTGG--- MSMEG_0868|M.smegmatis_MC2_155 NGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGAS TH_3810|M.thermoresistible__bu ---------------------------GEDGEDGTGTGIGGRGGNGG--- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------NAGLAGNAGLAGNAGLAGNAGLAGN--- MAV_4827|M.avium_104 --------------------------SGLAVVGISAVLALEIALAIG--- MUL_3507|M.ulcerans_Agy99 --------------VGGTGGIQIYSG-------GGIGGVGGIGGNGGAGG MMAR_3199|M.marinum_M --------------AGGTGG-GLLQG-------SGIPGVG---GNGGAGG Mb1121|M.bovis_AF2122/97 --------------DGGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGGSGG Rv1091|M.tuberculosis_H37Rv --------------DGGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGGSGG Mflv_5091|M.gilvum_PYR-GCK --------------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTG Mvan_1264|M.vanbaalenii_PYR-1 --------------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTG MSMEG_0868|M.smegmatis_MC2_155 VWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEG TH_3810|M.thermoresistible__bu -------------SSSGTHPMAEDG--------EHVKALDGRPGLD---G MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------AGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG MAV_4827|M.avium_104 ------------IRTTGTVALQPTPNQHLIVPTEQAPAPPPVQASAPQPK MUL_3507|M.ulcerans_Agy99 TSG------------LIGDGGAGG-----AGGTGGGNAG----VGGVGGV MMAR_3199|M.marinum_M TSG------------LIGSGGAGG-----AGGTGGANHASTNSIGGVGGA Mb1121|M.bovis_AF2122/97 SGGDGGGGAAGPAGWLFGDGGAGGNGGAAAAGGAGGQAGGGGGNGGNGGN Rv1091|M.tuberculosis_H37Rv SGGDGGGGAAGPAGWLFGDGGAGGNGGAAAAGGAGGQAGGGGGNGGNGGN Mflv_5091|M.gilvum_PYR-GCK GTGG-----------TGGTGGKGGTGGTGGAGGTG----GDGGTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 GTGG-----------TGGTGGKGGTGGTGGDGGTG----GTGGTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GTGG-----------HGGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGN TH_3810|M.thermoresistible__bu GNGS-----------HGGNGGHGGRGGFLGIGGSG-------GWGGHGGN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAG---------LAGNAGLAGNAGLAGNAGLAG----NAGLAGNAGL MAV_4827|M.avium_104 ISVP------------EPVAAPKPLSPPVAAPLPAAPPPAAPPLPEAPPI MUL_3507|M.ulcerans_Agy99 GGTGG---------AARLFGSGGSGG---------------IGGTGGHSL MMAR_3199|M.marinum_M GGTGG---------AARLFGSGGSGG---------------TGGVGG--I Mb1121|M.bovis_AF2122/97 GGNGGN--GGNGATGGWLYGNGGAGGQ---------GATAGAGGAGANGV Rv1091|M.tuberculosis_H37Rv GGNGGN--GGNGATGGWLYGNGGAGGQ---------GATAGAGGAGANGV Mflv_5091|M.gilvum_PYR-GCK GGTG---------GTGGTGGTGGAG-----------DGTGGTGGTGG--- Mvan_1264|M.vanbaalenii_PYR-1 GGTG---------GTGGTGGTGGAG-----------DGLGGTGGTGG--- MSMEG_0868|M.smegmatis_MC2_155 GGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGD TH_3810|M.thermoresistible__bu GGD-----------TDADGGNGGDG---------------GNGGSAG--- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGNAAVAGNAAVAGNAAVAGNAAVGG-------------VLNTGVSG--- MAV_4827|M.avium_104 PAAPPVVPVPVVVPPVPVPVPVRIPVP---------------DPVSPPQL MUL_3507|M.ulcerans_Agy99 INSGGG------------------------IGGKGGGGGAAGLIGDGGAG MMAR_3199|M.marinum_M GNTIGG------------------------TGGVGGGGGAAGLIGDGGAG Mb1121|M.bovis_AF2122/97 SSTNGG---GNGGIG--------------GTGGSGGAGGNAGLLGVGGAG Rv1091|M.tuberculosis_H37Rv SSTNGGGTGGNGGIG--------------GTGGSGGAGGNAGLLGVGGAG Mflv_5091|M.gilvum_PYR-GCK -TGGQGGQGGQGG-----------------TGGTGGQGG-LGGGGGTG-- Mvan_1264|M.vanbaalenii_PYR-1 -TGGFGGQGGQGG-----------------TGGTGGQGG-LGGVGGTG-- MSMEG_0868|M.smegmatis_MC2_155 ADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGA TH_3810|M.thermoresistible__bu ------------------------------RGGTGGLRGVFGINGGNG-- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------------AIGGSSHVGGAINESLGGSGS MAV_4827|M.avium_104 LAPPR-------------------------LSVPQPVQPPVRVPQPPSPP MUL_3507|M.ulcerans_Agy99 ------------------------GAGGNGGDG----------------- MMAR_3199|M.marinum_M ------------------------GAGGNGGDG----------------- Mb1121|M.bovis_AF2122/97 GHGASGGAGDRGGAGGTGFISSDGGAGGDGGDGGNGGAGGTGGLLFGA-- Rv1091|M.tuberculosis_H37Rv GHGASGGAGDRGGAGGTGFISSDGGAGGDGGDGGNGGAGGTGGLLFGA-- Mflv_5091|M.gilvum_PYR-GCK ---------------------GQGGTGGTGGQGGTGGTGGTGGTG----- Mvan_1264|M.vanbaalenii_PYR-1 ---------------------GTGGTGGTGGQGGTGGTGGTGGTG----- MSMEG_0868|M.smegmatis_MC2_155 ATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVA TH_3810|M.thermoresistible__bu ----------------------RAGLGGRGXXXXGGGVGAAVRSG----- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------VGGSTAVGGGAHTGVGGGVSTG----- MAV_4827|M.avium_104 ---------------------QVGGTVPQSPPQHQTPPGEGTPPK----- MUL_3507|M.ulcerans_Agy99 --TGAGGLGGNGASADWIGNGGSG------GAGGSGGLGAHAG------- MMAR_3199|M.marinum_M --TGAGGLGGNGASADWIGNGGSG------GAGGSGGLGAHAG------- Mb1121|M.bovis_AF2122/97 --GGNGGPGGSGGAADIGGNGGAGNGGGTDGNGGNGGSGGGAGSGGDG-- Rv1091|M.tuberculosis_H37Rv --GGNGGPGGSGGAADIGGNGGAGNGGGTDGNGGNGGSGGGAGSGGDG-- Mflv_5091|M.gilvum_PYR-GCK ---GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--Q Mvan_1264|M.vanbaalenii_PYR-1 ---GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--Q MSMEG_0868|M.smegmatis_MC2_155 SGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKA TH_3810|M.thermoresistible__bu ----------NGVFSGGGGTPSAGFGVPTTIQFPAGSCTSRAVSREG--- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --VGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVG-- MAV_4827|M.avium_104 --PDGPGNYGGGHVPTPGAGGSGGSGGGHVPTPGAGGSGGSGGGHVP--- MUL_3507|M.ulcerans_Agy99 ---------------AGGNGGSLYGNDGSGGAGGTGASGAGGNGGGG--- MMAR_3199|M.marinum_M ---------------AGGNGGSLYGNGGSGGVGGTGASGAGGNGGGG--- Mb1121|M.bovis_AF2122/97 -------------GGAGGNGAWLFGNGGAGGGGGKGGNGAGGGLGGGS-- Rv1091|M.tuberculosis_H37Rv -------------GGAGGNGAWLFGNGGAGGGGGKGGNGAGGGLGGGS-- Mflv_5091|M.gilvum_PYR-GCK AGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG-- Mvan_1264|M.vanbaalenii_PYR-1 AGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG-- MSMEG_0868|M.smegmatis_MC2_155 TGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGN TH_3810|M.thermoresistible__bu ---------------------IMPSSRAASARAG---------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------SHVGGGISESLGGSGSVGGSTAVGGGAHTGVGGGVN-- MAV_4827|M.avium_104 ---------------TPGTGGPGGTGGSGGGHVPTPGAGTPGGSGGGHLP MUL_3507|M.ulcerans_Agy99 -------------GAAGMMGDGGAGGDGGDGS------------------ MMAR_3199|M.marinum_M -------------GAAGLIGDGGAGGDGGDGS------------------ Mb1121|M.bovis_AF2122/97 ------------FGLPGLNGSGGDGGDGGNGAPGGVLYGNGGAGGQGSSG Rv1091|M.tuberculosis_H37Rv ------------FGLPGLNGSGGDGGDGGNGAPGGVLYGNGGAGGQGSSG Mflv_5091|M.gilvum_PYR-GCK ----AQGATG-ATGAAGKAGATGAAGAAGAAGSAG-----------TTGA Mvan_1264|M.vanbaalenii_PYR-1 ----AQGATG-ATGASGAQGSAGSAGSAGVAGSAG-----------TTGA MSMEG_0868|M.smegmatis_MC2_155 ALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDS TH_3810|M.thermoresistible__bu -----------AACASSTSRSRRSFCCSRA-------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------TGVGVGSHVGGGISESLGGSGSVGG------------STA MAV_4827|M.avium_104 -----------FPGAGSTPGGSGGGHLPTPGAGTP--------------- MUL_3507|M.ulcerans_Agy99 ---------AAGGLGGDGGN------------------------------ MMAR_3199|M.marinum_M ---------GAGGLGGDGGN------------------------------ Mb1121|M.bovis_AF2122/97 GIGGPGATGGAGGKGGDGGD------------------------------ Rv1091|M.tuberculosis_H37Rv GIGGPGATGGAGGKGGDGGD------------------------------ Mflv_5091|M.gilvum_PYR-GCK QGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAG Mvan_1264|M.vanbaalenii_PYR-1 QGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPG MSMEG_0868|M.smegmatis_MC2_155 TAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VGGGAHTSAINDALGGSGSVG----------------------------- MAV_4827|M.avium_104 ----------GGGLGGFGGG------------------------------ MUL_3507|M.ulcerans_Agy99 ------------------------------ADWLGNGG-GGTGGFG---- MMAR_3199|M.marinum_M ------------------------------ADWMGNGGAGGSGGAG---- Mb1121|M.bovis_AF2122/97 ------------------------------AQLIGDGGNGGNGGAGGTGG Rv1091|M.tuberculosis_H37Rv ------------------------------AQLIGDGGNGGNGGAGGTGG Mflv_5091|M.gilvum_PYR-GCK SGGSG-INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE---- Mvan_1264|M.vanbaalenii_PYR-1 SEAVD-INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE---- MSMEG_0868|M.smegmatis_MC2_155 VNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------GSTAVGGGAHTSAINESMNS MAV_4827|M.avium_104 ------------------------------HAPAPGGGLGGGGGHAP--- MUL_3507|M.ulcerans_Agy99 --LPPATGGFGGRGGRLFGSPGAQGRRALMCLSAACRC------------ MMAR_3199|M.marinum_M --VPPATGGFGGRGGRLFGSPGAQG------------------------- Mb1121|M.bovis_AF2122/97 TPGPGGPGGSGGLGGLLFGQTGTAGVSP---------------------- Rv1091|M.tuberculosis_H37Rv TPGPGGPGGSGGLGGLLFGQTGTAGVSP---------------------- Mflv_5091|M.gilvum_PYR-GCK ----GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 ----GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 GNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAE MAV_4827|M.avium_104 ---APGGGLGGFGGGHSGGGLGGLGGGHK--------------------- MUL_3507|M.ulcerans_Agy99 -- MMAR_3199|M.marinum_M -- Mb1121|M.bovis_AF2122/97 -- Rv1091|M.tuberculosis_H37Rv -- Mflv_5091|M.gilvum_PYR-GCK -- Mvan_1264|M.vanbaalenii_PYR-1 -- MSMEG_0868|M.smegmatis_MC2_155 -- TH_3810|M.thermoresistible__bu -- MLBr_01183|M.leprae_Br4923 -- MAB_4284c|M.abscessus_ATCC_199 HH MAV_4827|M.avium_104 --