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TTHTRRTAAVAALVVALVAGMLTAPNAVAQRIITLTLVRHAQSEGNASGLIDTSTPGPPLTALGREQAET AAQKLAAGHTFDGIYASTMIRTQQTAQPLADLSREPVTVLPGLREIEAGIYEGQPEALAGFTYYEAPTRW LQGDRTARIPGSIDGDEFDARFDEAVREIYDSEDTDPVAFSHAGAIMTWVAMNVDNPDLGLLSRHPLGNT GHAVVKGNPTGGWTLVDWGGINTE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6545 | - | - | 100% (235) | phosphoglycerate mutase family protein |
| M. smegmatis MC2 155 | MSMEG_6416 | - | 1e-11 | 27.50% (200) | phosphoglycerate mutase family protein |
| M. smegmatis MC2 155 | MSMEG_4305 | - | 2e-06 | 29.17% (192) | bifunctional RNase H/acid phosphatase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3422 | lpqD | 2e-50 | 46.32% (231) | lipoprotein LpqD |
| M. gilvum PYR-GCK | Mflv_4577 | - | 7e-54 | 51.13% (221) | phosphoglycerate mutase |
| M. tuberculosis H37Rv | Rv3390 | lpqD | 2e-50 | 46.32% (231) | lipoprotein LpqD |
| M. leprae Br4923 | MLBr_00079 | - | 3e-15 | 28.71% (202) | putative phosphoglycerate mutase |
| M. abscessus ATCC 19977 | MAB_0133 | - | 1e-17 | 31.84% (201) | phosphoglycerate mutase |
| M. marinum M | MMAR_1154 | lpqD | 3e-50 | 43.97% (232) | lipoprotein, LpqD |
| M. avium 104 | MAV_4339 | - | 3e-58 | 52.68% (224) | phosphoglycerate mutase family protein |
| M. thermoresistible (build 8) | TH_2144 | - | 2e-75 | 62.39% (226) | phosphoglycerate mutase family protein |
| M. ulcerans Agy99 | MUL_0919 | lpqD | 5e-50 | 44.59% (222) | lipoprotein, LpqD |
| M. vanbaalenii PYR-1 | Mvan_5262 | - | 5e-59 | 54.08% (233) | phosphoglycerate mutase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3422|M.bovis_AF2122/97 MAKRTPVRKACTVLAVLAATLLLGACGG--PTQPRSITLTFIRNAQSQAN
Rv3390|M.tuberculosis_H37Rv MAKRTPVRKACTVLAVLAATLLLGACGG--PTQPRSITLTFIRNAQSQAN
MMAR_1154|M.marinum_M -----MIWNTSKVLALLATAMLLGACGGG-SPQARSITLTFIRNAQSQAD
MUL_0919|M.ulcerans_Agy99 MAKRSMIWNTSKVLALLATAMLPGACGGG-SPQARSITLTFIRNAQSQAD
MAV_4339|M.avium_104 -----------MALAALIATVTVAACGG--SPQARSITVTFVRHAQSEAN
MSMEG_6545|M.smegmatis_MC2_155 -MTTHTRRTA--AVAALVVALVAGMLTAPNAVAQRIITLTLVRHAQSEGN
TH_2144|M.thermoresistible__bu ------VLLL--ACALAAPAGIPGSVPTARAAGPAVMTLTLVRHAESMGN
Mflv_4577|M.gilvum_PYR-GCK --MPDPRTCR--VRRILIAALSAVLLVLVSAIPSWAMTLTFVRHAESLAN
Mvan_5262|M.vanbaalenii_PYR-1 --MRDVRRTARRLLTILAATLAAAVLFAASAFAAADIVLTFVRHGQSQAN
MLBr_00079|M.leprae_Br4923 ----------------------------------MSSRLVLLRHGQSYGN
MAB_0133|M.abscessus_ATCC_1997 -----------------------MARRDAGREAAMSGRLVLVRHGQSYGN
:.::*:.:* .:
Mb3422|M.bovis_AF2122/97 ADGIIDTDMPGSGLSADGKAEAQQVAHQVSRRD-VDSIYSSPMAADQQTA
Rv3390|M.tuberculosis_H37Rv ADGIIDTDMPGSGLSADGKAEAQQVAHQVSRRD-VDSIYSSPMAADQQTA
MMAR_1154|M.marinum_M AEGIIATELPGTGLSSDGKDQAQQLTHQFGRSE-FDSIYTSPMEAAQQTA
MUL_0919|M.ulcerans_Agy99 AEGIIATELPGTGLSSDGKDQAQQLTHQFGRSE-FDSIYTSPMEAAQQTA
MAV_4339|M.avium_104 ASGTIDTEVPGPGLSPEGKGQAEQVAHQLGRKD-YDSVYASTMTRAQQTA
MSMEG_6545|M.smegmatis_MC2_155 ASGLIDTSTPGPPLTALGREQAETAAQKLAAGHTFDGIYASTMIRTQQTA
TH_2144|M.thermoresistible__bu ASGVIDSSTPGPPLSPLGWVQAQVVAAELAGGG-HDGLYASTMIRTQQTA
Mflv_4577|M.gilvum_PYR-GCK EAGIIDTRVPGPGLSEAGELQARAIAPVLAGMG-FDGIYVSSMLRTQLTA
Mvan_5262|M.vanbaalenii_PYR-1 ADGIINTEVPGPHITALGQQQAALVAGVLAAGG-YQGIYASDMVRTQETA
MLBr_00079|M.leprae_Br4923 VEGRLDTRPPGASLTPFGRDQARVFAQ--AAGRPVLLVHS-VAIRALETA
MAB_0133|M.abscessus_ATCC_1997 VERRLDTKPPGAALTELGLQQARLFAKRYEEHAPAVLVHS-VAVRAVQTA
: : **. :: * :* : :: **
Mb3422|M.bovis_AF2122/97 GPLAGEL-GKQVEILPGLQAINAGWFNGKPE--SMANST--YMLAPADWL
Rv3390|M.tuberculosis_H37Rv GPLAGEL-GKQVEILPGLQAINAGWFNGKPE--SMANST--YMLAPADWL
MMAR_1154|M.marinum_M APLAGEL-SKQAEIVPGLQSIDAGWYNGKPD--SMADRT--YMVAPVSWI
MUL_0919|M.ulcerans_Agy99 APLARQL-SKQAEIVPGLQSIDAGWYNGKPD--SMADRT--YMVAPVSWI
MAV_4339|M.avium_104 APLAAEL-GKQVEVLPGIQEINAGWYNGKPE--SMAKST--YLVAPANWL
MSMEG_6545|M.smegmatis_MC2_155 QPLADLS-REPVTVLPGLREIEAGIYEGQPE-ALAG-FT--YYEAPTRWL
TH_2144|M.thermoresistible__bu EPLANLT-GEPVVVLPGLREIEAGVFEGQPE-ASAGDYSGGYFTAPARWL
Mflv_4577|M.gilvum_PYR-GCK QPMLDLLPGSSYQVLPGLREISAGIFEGSSENEGLGRLG--YALAPVTWM
Mvan_5262|M.vanbaalenii_PYR-1 APLADIL-GESVTVLPGLREIDAGIYEGSSETDGLGRLG--YGLTPALWT
MLBr_00079|M.leprae_Br4923 AVLGAEF-DVPIREIAGIHEVQVGELENRNDDDAIAEFN----AIYDRWH
MAB_0133|M.abscessus_ATCC_1997 AGIAEHL-GVQAEQIEGLHEVQAGELEDRTDLEAFAVFD----RTYERWH
: : *:: :..* :. : . *
Mb3422|M.bovis_AF2122/97 AGDVHNTIPGSIS-----GTEFNSQFSAAVRKIYDSGHNTPVVFSQGVAI
Rv3390|M.tuberculosis_H37Rv AGDVHNTIPGSIS-----GTEFNSQFSAAVRKIYDSGHNTPVVFSQGVAI
MMAR_1154|M.marinum_M DGNVEASIPGSTS-----GSDFNSRFTGAIRKIYDGGHNKPVVFSQGTAI
MUL_0919|M.ulcerans_Agy99 DGNVEASIPGSTS-----GSDFNSRFTGAIRKIYDGGHNRPVVFSQGTAI
MAV_4339|M.avium_104 KGDVSDSIPGSIS-----GKEFNDQFTAAVNKIYNSGHRNPVVFSHANSI
MSMEG_6545|M.smegmatis_MC2_155 QGDRTARIPGSID-----GDEFDARFDEAVREIYDSEDTDPVAFSHAGAI
TH_2144|M.thermoresistible__bu RGDRSARIPGSID-----GNEFDARFDEAVQQIHADGAVNPVAFAHAASI
Mflv_4577|M.gilvum_PYR-GCK LGARFVPVPGGED-----GNAFDARVDGAIAEIADNGDENAVAFAHGATI
Mvan_5262|M.vanbaalenii_PYR-1 LGLRSAWIPDSTDT---NGNVFSDRMSEAVQIIYEDGWARPVAFSHGATI
MLBr_00079|M.leprae_Br4923 HGELDVPLPGGETANDVLDRYLPVLVDLRMRYLDDGDWTGDVVVVSHGAA
MAB_0133|M.abscessus_ATCC_1997 FGDLDARMPGGESAQDVFDRYLPAVADLRLRHLENDASTGDVVIVSHGAA
* :*.. . : : : . *.. :
Mb3422|M.bovis_AF2122/97 MIWTLMNARNSRDSLLTTHPLPNIGRVVITGNPVTGWRLVEWDGIRNFT-
Rv3390|M.tuberculosis_H37Rv MIWTLMNARNSRDSLLTTHPLPNIGRVVITGNPVTGWRLVEWDGIRNFT-
MMAR_1154|M.marinum_M MVWTLMNVKNPKTNLLNTHPLPNIGRVVISGNPATGWKLVDWDGIRNFG-
MUL_0919|M.ulcerans_Agy99 MVWTLMNVKNPKTNLLNTHPLPNIGRVVISGNPATGWKLVDWDGIRNFG-
MAV_4339|M.avium_104 MVWTLMNTRNAKDSLMNTHPLPNTGRVVINGNPITGWTLVDWDGIRDFRS
MSMEG_6545|M.smegmatis_MC2_155 MTWVAMNVDNPDLGLLSRHPLGNTGHAVVKGNPTGGWTLVDWGGINTE--
TH_2144|M.thermoresistible__bu MVWVMMNVDNPDPDLLLQRPLRNTGRVVLTGSPGQGWTLVDWDGIPVRHR
Mflv_4577|M.gilvum_PYR-GCK MFWVMMNVDNPDLLLMLRHQLDNVESVVVEGSPEEGWTLVSWAGQAVSAD
Mvan_5262|M.vanbaalenii_PYR-1 MFWTMMNVDNPDLGLLLSHQLPNTGVVVLEGNPEDGWTLVSWDGVAVDPD
MLBr_00079|M.leprae_Br4923 IRLVSAVLAEVDGRFALENRVNNAESVVLVPVTDGRWSCVRWGALTPPFY
MAB_0133|M.abscessus_ATCC_1997 IRLVAAALAGVDPGFAVNRHLRNAEAVVLAPVTDGRWSCVHWGDAVAPF-
: . : . : * .*: . * * *
Mb3422|M.bovis_AF2122/97 --------------------------------------------------
Rv3390|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1154|M.marinum_M --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MAV_4339|M.avium_104 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu P-------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK PSLATKLLVNVRDLVVAPQTALYNVGTAFSSGDFETLVNAVRDGLIEVTR
Mvan_5262|M.vanbaalenii_PYR-1 PSFLTKTFVNVRELITTPQTAVYNVKKAFATGDLAAITDSFAQAVIDVVL
MLBr_00079|M.leprae_Br4923 PHLHRPDSTLVTDVVMSGRDSLG---------------------------
MAB_0133|M.abscessus_ATCC_1997 PHQEAAS----AEELAQSADPMG---------------------------
Mb3422|M.bovis_AF2122/97 --------------------------------------------------
Rv3390|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1154|M.marinum_M --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MAV_4339|M.avium_104 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK AVVRFIPDTVRDIVDEFRPSVTEDSLDVTELHRAVVTAAPQDDDEAEPQS
Mvan_5262|M.vanbaalenii_PYR-1 APVRFVGAVATDVLELVFPPAPSVQVEAP---MSAESTTDESDVPADVPD
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3422|M.bovis_AF2122/97 --------------------------------------------------
Rv3390|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1154|M.marinum_M --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MAV_4339|M.avium_104 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK VAVAEAETRNGSGVAPAGSTPPSGDEVTGSTDDDEATASDVVLEDTVDVD
Mvan_5262|M.vanbaalenii_PYR-1 DVVAVAPSEDVESRTPEPASDEAETREESAAPESEATEPEISASQSEESE
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3422|M.bovis_AF2122/97 --------------------------------------------------
Rv3390|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1154|M.marinum_M --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MAV_4339|M.avium_104 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
TH_2144|M.thermoresistible__bu --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK TIDVDTVEEDTGASDHAVGNHPDAEADDAAPANGSAKSSDDDGDSDDDAS
Mvan_5262|M.vanbaalenii_PYR-1 -VETETTEETTTAG---------------------TTGDDDTDETDDGAA
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3422|M.bovis_AF2122/97 -----
Rv3390|M.tuberculosis_H37Rv -----
MMAR_1154|M.marinum_M -----
MUL_0919|M.ulcerans_Agy99 -----
MAV_4339|M.avium_104 -----
MSMEG_6545|M.smegmatis_MC2_155 -----
TH_2144|M.thermoresistible__bu -----
Mflv_4577|M.gilvum_PYR-GCK ERAAA
Mvan_5262|M.vanbaalenii_PYR-1 VKEAA
MLBr_00079|M.leprae_Br4923 -----
MAB_0133|M.abscessus_ATCC_1997 -----