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VMSLMVAPELVAAAAADLTGIGQAISAANAAAAGPTTQVLAAAGDEVSAAIAALFGTHAQEYQALSARVA TFHEQFVRSLTAAGSAYATAEAANASPLQALEQQVLGAINAPTQLWLGRPLIGDGVHGAPGTGQPGGAGG LLWGNGGNGGSGAAGQVGGPGGAAGLFGNGGSGGSGGAGAAGGVGGSGGWLNGNGGAGGAGGTGANGGAG GNAWLFGAGGSGGAGTNGGVGGSGGFVYGNGGAGGIGGIGGIGGNGGDAGLFGNGGAGGAGAAGLPGAAG LNGGDGSDGGNGGTGGNGGRGGLLVGNGGAGGAGGVGGDGGKGGAGDPSFAVNNGAGGNGGHGGNPGVGG AGGAGGLLAGAHGAAGATPTSGGNGGDGGIGATANSPLQAGGAGGNGGHGGLVGNGGTGGAGGAGHAGST GATGTALQPTGGNGTNGGAGGHGGNGGNGGAQHGDGGVGGKGGAGGSGGAGGNGFDAATLGSPGADGGMG GNGGKGGDGGKAGDGGAGAAGDVTLAVNQGAGGDGGNGGEVGVGGKGGAGGVSANPALNGSAGANGTAPT SGGNGGNGGAGATPTVAGENGGAGGNGGHGGSVGNGGAGGAGGNGVAGTGLALNGGNGGNGGIGGNGGSA AGTGGDGGKGGNGGAGANGQDFSASANGANGGQGGNGGNGGIGGKGGDAFATFAKAGNGGAGGNGGNVGV AGQGGAGGKGAIPAMKGATGADGTAPTSGGDGGNGGNGASPTVAGGNGGDGGKGGSGGNVGNGGNGGAGG NGAAGQAGTPGPTSGDSGTSGTDGGAGGNGGAGGAGGTLAGHGGNGGKGGNGGQGGIGGAGERGADGAGP NANGANGENGGSGGNGGDGGAGGNGGAGGKAQAAGYTDGATGTGGDGGNGGDGGKAGDGGAGENGLNSGA MLPGGGTVGNPGTGGNGGNGGNAGVGGTGGKAGTGSLTGLDGTDGITPNGGNGGNGGNGGKGGTAGNGSG AAGGNGGNGGSGLNGGDAGNGGNGGGALNQAGFFGTGGKGGNGGNGGAGMINGGLGGFGGAGGGGAVDVA ATTGGAGGNGGAGGFASTGLGGPGGAGGPGGAGDFASGVGGVGGAGGDGGAGGVGGFGGQGGIGGEGRTG GNGGSGGDGGGGISLGGNGGLGGNGGVSETGFGGAGGNGGYGGPGGPEGNGGLGGNGGAGGNGGVSTTGG DGGAGGKGGNGGDGGNVGLGGDAGSGGAGGNGGIGTDAGGAGGAGGAGGNGGSSKSTTTGNAGSGGAGGN GGTGLNGAGGAGGAGGNAGVAGVSFGNAVGGDGGNGGNGGHGGDGTTGGAGGKGGNGSSGAASGSGVVNV TAGHGGNGGNGGNGGNGSAGAGGQGGAGGSAGNGGHGGGATGGDGGNGGNGGNSGNSTGVAGLAGGAAGA GGNGGGTSSAAGHGGSGGSGGSGTTGGAGAAGGNGGAGAGGGSLSTGQSGGPRRQRWCRWQRRRWLGRQR RRRWCRWQRRCRRQRWRWRCRQRRLRRQWRQGRRRCRPWLHRRRGRQGRRWRQRRFQQRQRSRWQRR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv3345c | PE_PGRS50 | - | 100% (1538) | PE-PGRS FAMILY PROTEIN |
M. tuberculosis H37Rv | Rv2490c | PE_PGRS43 | 0.0 | 49.14% (1681) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 0.0 | 50.31% (1628) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3541 | PE_PGRS55 | 0.0 | 49.97% (1647) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 49.76% (826) | triple helix repeat-containing collagen |
M. leprae Br4923 | MLBr_01183 | - | 5e-14 | 40.40% (99) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 4e-58 | 34.21% (494) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_2656 | - | 0.0 | 47.33% (1857) | PE-PGRS family protein, PE_PGRS50 |
M. avium 104 | MAV_4827 | - | 2e-24 | 45.83% (168) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-170 | 41.09% (1078) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 8e-48 | 43.92% (296) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 46.96% (1201) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 0.0 | 49.22% (833) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_2656|M.marinum_M ----MSLVTVSPELVAGAASDLARIGSSLGAANAAAAGPTTTVLSAAADE MUL_4367|M.ulcerans_Agy99 ----MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDE Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ---MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALA TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 ----MSFVLISPEVVSAAAGDLANVGSTISAANKAAAAATTQVLAAGADE Rv3345c|M.tuberculosis_H37Rv ---MVMSLMVAPELVAAAAADLTGIGQAISAANAAAAGPTTQVLAAAGDE MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMP MAV_4827|M.avium_104 MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDR MMAR_2656|M.marinum_M VSVAIATLFGTHAAEYQSLSARMAAFHEQFVQTLTSGAGIYVSTEATNAS MUL_4367|M.ulcerans_Agy99 VSAAIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALN-- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PESPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNT-- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 VSARIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYMLAEATN-- Rv3345c|M.tuberculosis_H37Rv VSAAIAALFGTHAQEYQALSARVATFHEQFVRSLTAAGSAYATAEAAN-- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQP------------ MAV_4827|M.avium_104 VISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDN---- MMAR_2656|M.marinum_M FISALQLAEQNALNAINAPTQSWLGRPLIGNGVDATPGSGQAGGAGGLLW MUL_4367|M.ulcerans_Agy99 -MWPLQELEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILW Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------TDQPTSDSLGAQPTAQVARQVQ---APAT-DP----------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------VEQNLLNLINAPTQTLLGRPLIGDGANAT-TPGGAGGDGGLLF Rv3345c|M.tuberculosis_H37Rv -ASPLQALEQQVLGAINAPTQLWLGRPLIGDGVHGAPGTGQPGGAGGLLW MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M GNGGAGGSGAAGQSGGAGGSAGLFGNGGAGGAGGISAAGNGGSGGVGGRG MUL_4367|M.ulcerans_Agy99 GNGGNGGLGAAGANGGAGGSAGLIGTGGVGGAGGVGAAGMTG-------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------APAAPSLRP-ISGLLSVVTLGTTLIPNAPTEPADMPGVWA---- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GSGGNGAPGAPGQAGGAGGSAGLLGNGGSGGAGGTGAPGGNGGNAG---- Rv3345c|M.tuberculosis_H37Rv GNGGNGGSGAAGQVGGPGGAAGLFGNGGSGGSGGAGAAGGVGGSGG---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----DGPSILSPSLLSPRDNDFLSHNDTDFASHN--------------- MAV_4827|M.avium_104 ---------VMLVSAFLAAAALAQNVGGAMG------------------- MMAR_2656|M.marinum_M GLVYGSGGAGGAGGQGALSGGAGGAGGGAWLWGAGGAG--GSGGEGLASA MUL_4367|M.ulcerans_Agy99 ----GSGGAG---------------GGGGWLWGAGGSG--GAAG-----A Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------------MVTF Mvan_1264|M.vanbaalenii_PYR-1 -------------MMFLAPPGGPGPISAAIQLTSTGSE--ATEPWYVVSF MSMEG_0868|M.smegmatis_MC2_155 ----VMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASA--VLDPTQIVNW TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 ----WLYGRGGVGGAGGIGGGTGGAGGHAWLFGHGGTG--GIGGGPGGNG Rv3345c|M.tuberculosis_H37Rv -----WLNGNGGAGGAGGTGANGGAGGNAWLFGAGGSGGAGTNGGVGGSG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------PIASGNQVMSPSGNVDSFNRGPLLDLSF MAV_4827|M.avium_104 ------------------------YERTAVLLVEPDTATLAVVETSDGSI MMAR_2656|M.marinum_M GGVGGAGGNAGLIGTGGLGGAGGVGGQNGGAGGDGGNAPLLGRGGTGGVG MUL_4367|M.ulcerans_Agy99 GGSGGSGG--WLWGN---------AGQTAGAG----------VGGAGGAG Mflv_5091|M.gilvum_PYR-GCK GGGATPTPTSLGAAAVDL-----SGTSCG----------LICNGQDGTGQ Mvan_1264|M.vanbaalenii_PYR-1 GGSGAPTPNNLAASLVDL-----SGTSCG----------LICNGQDGTGQ MSMEG_0868|M.smegmatis_MC2_155 LIYQPLHAAGQQFWVVSP-----IGSTLGGVINTISGQYLIGNGINGTAD TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GWLLGNGGHGGAGGIGGG-----SGGAGGNGGWLLGNGGIGGAGGTGGGA Rv3345c|M.tuberculosis_H37Rv GFVYGNGGAGGIGGIGGIGGNGGDAGLFGNGGAGGAGAAGLPGAAGLNGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GDLQFGNRDTTAIGDG-------------------------AVAVGGSNS MAV_4827|M.avium_104 PDVYKQQIRAESYGDAAG-----------------------QLSAMVAGL MMAR_2656|M.marinum_M GASDGGNGGAGGDGGVGGGLFGSGGAGGSGGAGGVLGTGGDGG------- MUL_4367|M.ulcerans_Agy99 GAGDAGDQGVSG--------VAPGEAGAVGFAG----------------- Mflv_5091|M.gilvum_PYR-GCK N-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNG------- Mvan_1264|M.vanbaalenii_PYR-1 N-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNG------- MSMEG_0868|M.smegmatis_MC2_155 NPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNG------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GGTGGNAAWLLGGGGTGGAGGIGGGNGGHGGNGGWLLGNGGNGGLGGDGD Rv3345c|M.tuberculosis_H37Rv DGSDGGNGGTGGNGGRGGLLVGNGGAGGAGGVGGDGGKGGAGD------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GPIASGQGSTAVNGDVRDSNIINADHGSNVGVDQ---------------- MAV_4827|M.avium_104 EKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPETA------- MMAR_2656|M.marinum_M ----------------------------SGGAAAGLWGAGGSGGAGGNGA MUL_4367|M.ulcerans_Agy99 -------------------------------------GAGGAGGAGGN-- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------GNGLGGGNGGNG- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------GNGLGSGDGGNG- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------GVGWAGLDGGNG- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GGTGGGHGGNGGNPGWLLGTAGGGGNGGAGSTGTAGGGSGGTGGDGGTG- Rv3345c|M.tuberculosis_H37Rv ------------------------------PSFAVNNGAGGNGGHGGNPG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------SQTRVGGDYTNVS MAV_4827|M.avium_104 -------------------------------------LARGAALAAANAP MMAR_2656|M.marinum_M DGISGGIGESGGDGGNAGNGGAGGRGGRLIGAGGAGGFGGVGGLGGAGGA MUL_4367|M.ulcerans_Agy99 --------------------GVGG------GVNGAGGAGGAGGVGGGGGA Mflv_5091|M.gilvum_PYR-GCK ------------------------------GNAGAFALFGNGGNGGNGGV Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------GDAGLFSLFGRGGNGGNGGV MSMEG_0868|M.smegmatis_MC2_155 ------------------------------GSGGLLMGIG--GAGGAGGV TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 ------------------------------GRGGLLMGAGAGGHGGTGGA Rv3345c|M.tuberculosis_H37Rv VG-----------------GAGGAGGLLAGAHGAAGATPTSGGNGGDGGI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------GHGSADIDKSVTVVDDHSQR MAV_4827|M.avium_104 ------------------------------LFASSTAALAYAQDPGTGAV MMAR_2656|M.marinum_M GANGIVAGSAGDGGGNGGS------------------------------- MUL_4367|M.ulcerans_Agy99 GASGVGAGVAGGDGGTGGA------------------------------- Mflv_5091|M.gilvum_PYR-GCK GVVGATGAVG--APGVAGAT------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 GIAGATGAVG--APGVAGAT------------------------------ MSMEG_0868|M.smegmatis_MC2_155 GADGTSAHVDGGTGGTGGTG------------------------------ TH_3810|M.thermoresistible__bu --------VD----GDGGSG------------------------------ Mb3541|M.bovis_AF2122/97 GGAGVDGGGAGGAGGAGGNGGAGGQAALLFGRGGTGGAGGYGGDGGGGGD Rv3345c|M.tuberculosis_H37Rv GATANSPLQAGGAGGNGGHGG----------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NTTNINDSFNTDRSTNIGSG------------------------------ MAV_4827|M.avium_104 DQYSLPDYLYVPVDPEPGDD------------------------------ MMAR_2656|M.marinum_M ---------GGAGGVGGDGGKGGLIRFLGGRGAGGSGGEGGAGGAAGDGG MUL_4367|M.ulcerans_Agy99 ---------GGAAGVGG---------------AAGTGGTGGAAGVAGTGG Mflv_5091|M.gilvum_PYR-GCK ---------GATGVTSGVVGGN--------GEDAVGYGATGAAGAAGAAG Mvan_1264|M.vanbaalenii_PYR-1 ---------GATGVTSNVTGGN--------GADAVGYGATGAAGAAGAAG MSMEG_0868|M.smegmatis_MC2_155 ---------GGTGGTGGIGGTG--------GGLFGLLGHSGSTGAAGAAG TH_3810|M.thermoresistible__bu ---------GRTG-------------------LFSKLSR----------- Mb3541|M.bovis_AF2122/97 GFDGTMAGLGGTGGSGGTGGDGGAPGNGGAGGAGQLLSHSGVAGASGKGG Rv3345c|M.tuberculosis_H37Rv -----LVGNGGTGGAGGAGHAG------STGATGTALQPTGGNGTNGGAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------NTTNTEIGSHNQANIGT MAV_4827|M.avium_104 ---------------------------------ELAYSAVGEEDAESPTV MMAR_2656|M.marinum_M DGAAGSFLTGTGAGGAGGQGGDPGLGGAGGAGGRGSVPGSHGVTGQSPTS MUL_4367|M.ulcerans_Agy99 D------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK A------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 A------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 N------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 A------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv G------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 S------------------------------------------------- MAV_4827|M.avium_104 V------------------------------------------------- MMAR_2656|M.marinum_M GGDGGNGGRGADAIDPATTAGAGGVGGDGGRYGNGGVGGAGGDGYRGYDG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M MSVVGGDGTVGGDGGAGGAGGAGGMGGALAGHGGAGGAGGDGGTGGIGGD MUL_4367|M.ulcerans_Agy99 ----------GGDGGAGGAG------------------------------ Mflv_5091|M.gilvum_PYR-GCK ----------AGAAGAVGSAG----------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------AGKAGAVGSAG----------------------------- MSMEG_0868|M.smegmatis_MC2_155 ----------GGDGGNGGFGYVL--------------IAGPNVTVGSETR TH_3810|M.thermoresistible__bu ----------GGDGGDGGLG------------------------------ Mb3541|M.bovis_AF2122/97 ----------GGTGGNGGAGSAG--------------ADAPAGSGAMGST Rv3345c|M.tuberculosis_H37Rv ---------HGGNGGNGGAQHGDG------------GVGGKGGAGGSGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------TSAGGSAAVG------------------------------ MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M GGRGVDGTDLSLDGTDGGSGGMGGVGGAGGDGGAGGLAQA-AGFSDGIRG MUL_4367|M.ulcerans_Agy99 -------SDASLAGQAGFAGGSGGAGGVGGSAGAG--------------G Mflv_5091|M.gilvum_PYR-GCK -AAGEAGETGTWGNAGLP--GKAGDAGGAG-----------------AVG Mvan_1264|M.vanbaalenii_PYR-1 -TAGSAGAPGVWGNAGLP--GAAGAAGGAG-----------------AIG MSMEG_0868|M.smegmatis_MC2_155 GGTGGAGGTGGQSTAAGPGKGGGGGGGGGG-----------------AIL TH_3810|M.thermoresistible__bu --------------------GNGGHGGGTG-----------------IIS Mb3541|M.bovis_AF2122/97 GFAGGAGGDGGNGGGSGASQGNGGNGGNGGTGGKGGTGGA-GMNSLDPLL Rv3345c|M.tuberculosis_H37Rv GGNGFDAATLGSPGADGGMGGNGGKGGDGGKAGDGGAGAAGDVTLAVNQG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------GNAGLAGNAG-------------------- MAV_4827|M.avium_104 ------IEKLFLPEDSEPRRRPVLLVGSG--------------------- MMAR_2656|M.marinum_M VGGAGGDGGAGGGAGDGGDGANAP--------AASGLAGGSGGHGGDPGV MUL_4367|M.ulcerans_Agy99 VNGSGGDGGAGAAGGAGG---------------ASATVAGSGGVGGD--- Mflv_5091|M.gilvum_PYR-GCK AAGAAGTVGTAGATGGTGTG-------------ANGGAGGVGGVGGTGAA Mvan_1264|M.vanbaalenii_PYR-1 TAGVAGAAGTAGATGGTGVG-------------GNGGAGQAGGIGGTGAA MSMEG_0868|M.smegmatis_MC2_155 IGANGGTVDGHAIGGNGGNG-------------GNGSTTAAGGNGGTGGT TH_3810|M.thermoresistible__bu LLS---------LAGNGGNG-------------GNGYRTTDNN------- Mb3541|M.bovis_AF2122/97 AAQDGGQGGTGGTGGNAGAG-------------GTGFTQGADGNAGNGGD Rv3345c|M.tuberculosis_H37Rv AGGDGGNGGEVGVGGKGGAGGVSANPALNGSAGANGTAPTSGGNGGNGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAGLAG-------------NAGLAGNAGLAGN--- MAV_4827|M.avium_104 -LAVVGISAVLALEIALAIGIR-----------TTGTVALQPTPNQHLIV MMAR_2656|M.marinum_M GGAGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGDGANASTVGASGGAGGA MUL_4367|M.ulcerans_Agy99 --------------------------------------------GGAGGA Mflv_5091|M.gilvum_PYR-GCK G--------------------------------AAGGAGGLGETGTTGGA Mvan_1264|M.vanbaalenii_PYR-1 G--------------------------------AAGQAGTAGETGVTGGV MSMEG_0868|M.smegmatis_MC2_155 GRV------------------------------IAEGTGSTAEGTATGGD TH_3810|M.thermoresistible__bu --------------------------------------------ALDGGH Mb3541|M.bovis_AF2122/97 GGVGG-------------------------NGGNGADNTTTAAAGTTGGA Rv3345c|M.tuberculosis_H37Rv G----------------------------------ATPTVAGENGGAGGN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------AGLAGN MAV_4827|M.avium_104 P------------------------------------------TEQAPAP MMAR_2656|M.marinum_M GGDGGRYGNGGVGGAGGDGYRGYDGMSVVGGDGTVGGDGGAGGAGGAGGM MUL_4367|M.ulcerans_Agy99 AG-------GGVGAAS------------------LGGDG----------- Mflv_5091|M.gilvum_PYR-GCK GGVGGQGTAGGTGGVGG-----------------IGGAGSTG-------- Mvan_1264|M.vanbaalenii_PYR-1 GGIGGQGTEGGTGGVGG-----------------VGGVGATG-------- MSMEG_0868|M.smegmatis_MC2_155 GGHSTGTGIGGNGGIGS-----------------VYAYGNNGAV------ TH_3810|M.thermoresistible__bu GGN------GGNVGFFS-----------------LFNLG----------- Mb3541|M.bovis_AF2122/97 GGAGGAGGTGGTGGAAG-----------------TGTGGQQGNG------ Rv3345c|M.tuberculosis_H37Rv GGHGGSVGNGGAGGAGGNG---------------VAGTGLALNG------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAGLAG--------------------------------- MAV_4827|M.avium_104 PPVQASAPQPKISVPEP--------------------------------- MMAR_2656|M.marinum_M GGALAGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGTDGGSGGMGG- MUL_4367|M.ulcerans_Agy99 -----GHAGAGGAGGEGLSGGFN-----------------TGAAGGIGG- Mflv_5091|M.gilvum_PYR-GCK --------AVGGVGGKGIQGG----------------------------- Mvan_1264|M.vanbaalenii_PYR-1 --------GAGGVGGKGIQGG----------------------------- MSMEG_0868|M.smegmatis_MC2_155 -----SGTATGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGS TH_3810|M.thermoresistible__bu --------GAGGWGGSGVDG------------------------------ Mb3541|M.bovis_AF2122/97 -----GNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGNAGA Rv3345c|M.tuberculosis_H37Rv -----GNGGNGGIGGNGGSAAGTGGDGGKGGNGGAGANGQDFSASANGAN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------NAGLAGNAGLAG------------------------------ MAV_4827|M.avium_104 -------VAAPKPLSPPVAAPLP--------------------------- MMAR_2656|M.marinum_M -----------------VGGAGGDGGAGGLAQAAGFS------------- MUL_4367|M.ulcerans_Agy99 -----------------AGGAGGTGGDSG--------------------- Mflv_5091|M.gilvum_PYR-GCK -----------------QGLQGGKGG------------------------ Mvan_1264|M.vanbaalenii_PYR-1 -----------------QGLQGGQGG------------------------ MSMEG_0868|M.smegmatis_MC2_155 A--------------TGADSLGGRGGTSWVQAGYGPT-------TGGKAS TH_3810|M.thermoresistible__bu -----------------VDVVGGN-------------------------- Mb3541|M.bovis_AF2122/97 GGTGFTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAG Rv3345c|M.tuberculosis_H37Rv G---------------GQGGNGGNGGIGGKGGDAFAT------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M -DGIRGVGGAGGDGGAGGGAGDGGDGANAPAASGLAGGSGGHGGDPGVGG MUL_4367|M.ulcerans_Agy99 -----GVGGVNGDGGAGGGGGRGGDGGSSTSTS-------------GVGG Mflv_5091|M.gilvum_PYR-GCK ------------DGGAGGKGGDADSMG----------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------DGGTGGTGGDATSMG----------------------- MSMEG_0868|M.smegmatis_MC2_155 GTAKAGHGGKASDGGKGGNGGDALVMAA---------------------- TH_3810|M.thermoresistible__bu -----------PDGGTPG-------------------------------- Mb3541|M.bovis_AF2122/97 GTGGTGGAAGTGTGGQQGNGGNGGNGGT---------------------- Rv3345c|M.tuberculosis_H37Rv -------FAKAGNGGAGGNGGNVGVAGQ--------------------GG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------NAGLAGNAGLAGNAG----------------------- MAV_4827|M.avium_104 -------------AAPPPAAPPLPEAPP---------------------- MMAR_2656|M.marinum_M AGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGDGANASTVGASGGAGGAGG MUL_4367|M.ulcerans_Agy99 AGGAG-------------------GNGGNAGFGVSAGGTGGSAGDGGAGG Mflv_5091|M.gilvum_PYR-GCK -----------------------------------SAGATG--------- Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------EAGATG--------- MSMEG_0868|M.smegmatis_MC2_155 --GATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATS TH_3810|M.thermoresistible__bu --------------------------------------AHG--------- Mb3541|M.bovis_AF2122/97 --GGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGNAGAGGTGFTQGADG Rv3345c|M.tuberculosis_H37Rv AGGKGAIPAMKGATGADGTAPTSGGDGGNGGNGASPTVAGGNGGDGGKGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M DGGRYGNGGVGGAGGDGYRGYD--------GMSVVGGDGTVGGDGGAGGA MUL_4367|M.ulcerans_Agy99 -----GAGGVDGVGG-------------------------ASGNGGAAGA Mflv_5091|M.gilvum_PYR-GCK -----GKGGNGGNGGRG----------------------GLFGKGGNAGN Mvan_1264|M.vanbaalenii_PYR-1 -----GKGGNGGNGGRG----------------------SLFGRGGNAGN MSMEG_0868|M.smegmatis_MC2_155 GHGGAAQGGNGGNGGNGWV--------------------QAYDPNGPAGT TH_3810|M.thermoresistible__bu ---------------------------------------ESHTP----GV Mb3541|M.bovis_AF2122/97 NAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTGGAAGT Rv3345c|M.tuberculosis_H37Rv SGGNVGNGGNGGAGGNGAAG-------------------QAGTPGPTSGD MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------LAGNAGLAGN MAV_4827|M.avium_104 ----------------------------------------IPAAPPVVPV MMAR_2656|M.marinum_M GGAGGMGGALAGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGTDGGS MUL_4367|M.ulcerans_Agy99 GGAGGSG--------------------IG--------------------- Mflv_5091|M.gilvum_PYR-GCK GADGG--------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GGNGG--------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TIDKGKAA------------------------------------------ TH_3810|M.thermoresistible__bu YTDRQ--------------------------------------------- Mb3541|M.bovis_AF2122/97 GTGGQQGN------------------------------------------ Rv3345c|M.tuberculosis_H37Rv SGTSGTDG------------------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGLAG--------------------------------------------- MAV_4827|M.avium_104 PVVVPPVP------------------------------------------ MMAR_2656|M.marinum_M GGMGGVGGAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGDGGDG MUL_4367|M.ulcerans_Agy99 --------AGIDGGAG----------------GAGGTGGAAG-------- Mflv_5091|M.gilvum_PYR-GCK -----TGGAGGAGGTG----------------GTGGAGGTGGT------- Mvan_1264|M.vanbaalenii_PYR-1 -----TGGNGGNGGTG----------------GTGGNGGTGGT------- MSMEG_0868|M.smegmatis_MC2_155 ---GGNGGDGGFNGTGG---------------ATGGRGGDGAG------- TH_3810|M.thermoresistible__bu -------GEDGEDGTGT---------------GIGGRGGNGG-------- Mb3541|M.bovis_AF2122/97 ---GGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGGNGGDAGK------- Rv3345c|M.tuberculosis_H37Rv ----GAGGNGGAGGAGG------------TLAGHGGNGGKGGN------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------NAGLAGNAG-----------------LAGNAGLAGN------- MAV_4827|M.avium_104 -----VPVPVRIPVPDP----------------VSPPQLLAPP------- MMAR_2656|M.marinum_M ANAAAGSGAVGGKGGDGGDPGVGGAGGAGGTGSVTGAHGTEGLTQTTGGN MUL_4367|M.ulcerans_Agy99 ---------FPGGGGTTGAWGTGGAGGAG--------------------- Mflv_5091|M.gilvum_PYR-GCK ----------GGTGGIGGAGSTGG-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------GGTGGIGGAGSTGG-------------------------- MSMEG_0868|M.smegmatis_MC2_155 ----------ASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGG TH_3810|M.thermoresistible__bu --------------SSSGTHPMAE-------------------------- Mb3541|M.bovis_AF2122/97 ----------AGTGSAPGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGG Rv3345c|M.tuberculosis_H37Rv ----------GGQGGIGGAGERGADGAGPN-------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M GGDGGNGGSGTTGTTGSKGGAGGAGGDGGRYGNGGNGGTGGTGSTGTAGS MUL_4367|M.ulcerans_Agy99 -------------------GAGGAGDHGGVGVNPGDSGT----------- Mflv_5091|M.gilvum_PYR-GCK -----------------------TGGTGGTGGTGGTGGT----------- Mvan_1264|M.vanbaalenii_PYR-1 -----------------------TGGTGGTGGTGGTGGT----------- MSMEG_0868|M.smegmatis_MC2_155 AGGAGGV----------SEGEGGTGGHGGDGGRGGDGAL----------- TH_3810|M.thermoresistible__bu ---------------------------DGEHVKALDGRP----------- Mb3541|M.bovis_AF2122/97 TGGSGGAGGTGGDGGAANGGTAGAGGAGGNGGKGGDGGAGVTSST----- Rv3345c|M.tuberculosis_H37Rv -------------------ANGANGENGGSGGNGGDGGA----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------AAVAGNAAVAGNAAVAGN----------- MAV_4827|M.avium_104 ----------------------RLSVPQPVQPPVRVPQP----------- MMAR_2656|M.marinum_M SDVMGANGGAGGSGWAGGDGGAGGMGGTLAGHGGDGGDGGSGGTGGTGGR MUL_4367|M.ulcerans_Agy99 ------------AGWAGGAGGAGGAGGSAA-------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------GGTGGTGGTG------------------------ Mvan_1264|M.vanbaalenii_PYR-1 ----------------GGTGGTGGTG------------------------ MSMEG_0868|M.smegmatis_MC2_155 ----------------GGNGGTGGVGL----------------------- TH_3810|M.thermoresistible__bu ----------------GLDG------------------------------ Mb3541|M.bovis_AF2122/97 ------------AGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGGDG Rv3345c|M.tuberculosis_H37Rv ----------------GGNGGAGGKAQAAG-------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------AAVGGVLNTG------------------------ MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M GGNGFNGSTKAGLNGGDAGDGGAGGVGGAGGNGGAAGLAQAAGFSDGIQG MUL_4367|M.ulcerans_Agy99 ----FN----------------------------------------GVNG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------G Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------G MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------G TH_3810|M.thermoresistible__bu -------------------------------------------------G Mb3541|M.bovis_AF2122/97 GDGAAGAVGISGATGAGDG---------------------------GHGG Rv3345c|M.tuberculosis_H37Rv -------------------------------------------YTDGATG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------V MAV_4827|M.avium_104 ------------------------------------------------PS MMAR_2656|M.marinum_M AGGAGGDGGAGGGAGDGGDGANAAAGSGAVGGNGGDGGDPGLGGGGGAGG MUL_4367|M.ulcerans_Agy99 AGGAGGNGGAGG------------------------------GGGAGASG Mflv_5091|M.gilvum_PYR-GCK TGGKGGTGGTGG------------------------------AGGTGGD- Mvan_1264|M.vanbaalenii_PYR-1 TGGKGGTGGTGG------------------------------DGGTGGT- MSMEG_0868|M.smegmatis_MC2_155 NGGKGGNGGNGG------------------------------NGGTYVD- TH_3810|M.thermoresistible__bu NGSHGGNGGHGG------------------------------RGG----- Mb3541|M.bovis_AF2122/97 TGGAGGNGGTGG------------------------------AGGSGID- Rv3345c|M.tuberculosis_H37Rv TGGDGGNGGDGGKAG---------------------------DGGAGENG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SGAIGGSSHVGG-------------------------------------- MAV_4827|M.avium_104 PPQVGGTVPQSP-------------------------------------- MMAR_2656|M.marinum_M TGATTGAHGADGLSPTTGGNGGKGGNGGSGAIG----------------V MUL_4367|M.ulcerans_Agy99 IGAG-----------VAGGDGGTGGTGGAAGTG----------------G Mflv_5091|M.gilvum_PYR-GCK --------------GGTGGTGGTGGTGG---------------------- Mvan_1264|M.vanbaalenii_PYR-1 --------------GGTGGTGGTGGTGG---------------------- MSMEG_0868|M.smegmatis_MC2_155 --------------PSHTGAGGNGGNGGAGRIRVNNGTATGTA------- TH_3810|M.thermoresistible__bu ----------------FLGIGGSGGWG----------------------- Mb3541|M.bovis_AF2122/97 --------------GVGGGTGGTGGNGGNGAIGGAGGDAGGSGNSGGNGG Rv3345c|M.tuberculosis_H37Rv LNSG--AMLPGGGTVGNPGTGGNGGNGGNAGVG----------------G MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------AINESLGGSGSVGG---------------------- MAV_4827|M.avium_104 --------------PQHQTPPGEGTPPK---------------------- MMAR_2656|M.marinum_M AGGAGGAGGDGGLYGDG-------GDGGSGGNGGAGKA----GAAGVSAG MUL_4367|M.ulcerans_Agy99 AAGTGGTGGAAGAAGSA-------GDGGAGGAGGAGDD----GSAGVVSG Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGAGDGTG---------GTGGTGGTGG--------------QG Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGAGDGLG---------GTGGTGGTGG--------------FG MSMEG_0868|M.smegmatis_MC2_155 TGGNGGNGGNGDADG---------HRGGKGGDGGEA------LIRATVIG TH_3810|M.thermoresistible__bu --GHGGNGGDTDADG---------GNGGDGGNGG---------------- Mb3541|M.bovis_AF2122/97 TGGKGGNAGAGGAAGSNGGTVGANGTGGDGGNGGAAGAATAGSNGGAGTG Rv3345c|M.tuberculosis_H37Rv TGGKAGTGSLTGLDGTDG-ITPNGGNGGNGGNGGKGGTAGNGSGAAGGNG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --STAVGGGAHTGVG-----------GGVSTGVG--------------VG MAV_4827|M.avium_104 PDGPGNYGGGHVPTP---------GAGGSGGSGG---------------- MMAR_2656|M.marinum_M SNGEAGGQAGAGGVGGAGGNGGANAGNGGTGGNGGDGGVGGTGGAGKVGT MUL_4367|M.ulcerans_Agy99 DPGTAGKAGGAGGAGGVGGNG----------------------------- Mflv_5091|M.gilvum_PYR-GCK GQGGQGGTGGTGGQGGLGGGG----------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GQGGQGGTGGTGGQGGLGGVG----------------------------- MSMEG_0868|M.smegmatis_MC2_155 SNASGTATGGDGGNGGTLGATNGTGG-------AATIVAYNVVQANPQAS TH_3810|M.thermoresistible__bu -------SAGRGGTGGLRGVF----------------------------- Mb3541|M.bovis_AF2122/97 SAGGNGGTGGRGGSGGAGGDGIGGVG-------GGKGGNGADGEVGGAGG Rv3345c|M.tuberculosis_H37Rv GNGGSGLNGGDAGNGGNGGGALNQAG--------FFGTGGKGGNGGNGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SHVGGGISESLGGSGSVGGST----------------------------- MAV_4827|M.avium_104 ---GHVPTPGAGGSGGSGGGHVP--------------------------- MMAR_2656|M.marinum_M TGPAGGAGGEGGDGGKGGTGGRGGNGGAGGTAQAAGYSDGSQGVGGDGGA MUL_4367|M.ulcerans_Agy99 --VAGGVNGSGGAGGAGGAGGTGGAGASGVPASVD---------GGDGGA Mflv_5091|M.gilvum_PYR-GCK --GTGGQGGTGGTGGQGGTGGTGGTGGTG----------GTGGAGGDGGL Mvan_1264|M.vanbaalenii_PYR-1 --GTGGTGGTGGTGGQGGTGGTGGTGGTG----------GTGGAGGDGGL MSMEG_0868|M.smegmatis_MC2_155 GTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASG--IGAGGNGGDGID TH_3810|M.thermoresistible__bu ----------GINGGNGR-------------------------------- Mb3541|M.bovis_AF2122/97 AGGSGPNTSPGGNGGQGGQGGSGGAGGAAGAGGAGGGANGTAGNGGQGGA Rv3345c|M.tuberculosis_H37Rv GMINGGLGGFGGAGGGGAVDVAATTGGAGGNGGAGG--FASTGLGGPGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --AVGGGAHTGVGGGVSTGVGVGSHVGGG----------------ISESL MAV_4827|M.avium_104 ---TPGTGGPGGTGGSGGGHVPTPGAGTP--------------------- MMAR_2656|M.marinum_M GGTGGTAG-----NGGKGGAGTWAVNNGIGGKGGNGGNAGTGGTGGSFGT MUL_4367|M.ulcerans_Agy99 GGAGGAAG-----TGGSGGS---------------AGNTGAGGAGG---- Mflv_5091|M.gilvum_PYR-GCK GGLGGF--------GGSGGTGGQGGLGGPGGSTG-----GAGGAGG---- Mvan_1264|M.vanbaalenii_PYR-1 GGLGGF--------GGVGGTGGQGGQGGPGGSTG-----GAGGAGG---- MSMEG_0868|M.smegmatis_MC2_155 GGLGGN--------GGDGVVNTTANAANPGSATGTATGGDGGKATG---- TH_3810|M.thermoresistible__bu AGLGGR--------GXX----------------------XXGGGVG---- Mb3541|M.bovis_AF2122/97 GGTGGAGAASSATNGGSGGAGGTGGAGGTGGAGGDGVGGAGGGNGG---- Rv3345c|M.tuberculosis_H37Rv GGPGGAGDFASG-VGGVGGAGGDGGAGGVGGFGGQGGIGGEGRTGG---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGSGSVG--------------------------------GSTAVGG---- MAV_4827|M.avium_104 -----------------------------------------GGSGG---- MMAR_2656|M.marinum_M GSQIGNHGSTGHLGDGGDGGTGGAGVNATAPGQDGAAGGVGGNGGIVGDG MUL_4367|M.ulcerans_Agy99 ------------------------------------AGGAGG-------- Mflv_5091|M.gilvum_PYR-GCK ------------------------------------QAGTAGKGG----- Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------QAGVAGKGG----- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------TASQGGNGGP---- TH_3810|M.thermoresistible__bu ------------------------------------AAVRSGNG------ Mb3541|M.bovis_AF2122/97 ------------------------------------HGGDAGDGGNGANG Rv3345c|M.tuberculosis_H37Rv ------------------------------------NGGSGGDGG----- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M GVGGK------GGDGAAGTTGSSGTASGEAGKDGGDGGKGGAGGAGGNGG MUL_4367|M.ulcerans_Agy99 ---------------SAASTGVN-----------GDGGAGGAGGVGGLGG Mflv_5091|M.gilvum_PYR-GCK -------------LFGGSGSAGKAGATGAAGASGGKGAQGATGAQGATGA Mvan_1264|M.vanbaalenii_PYR-1 -------------LFGGSGSAGTAGVTGASGASGGKGAQGATGAQGATGA MSMEG_0868|M.smegmatis_MC2_155 -------------SWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGG TH_3810|M.thermoresistible__bu ---------------VFSGGG--------GTPSAGFGVPTT---IQFPAG Mb3541|M.bovis_AF2122/97 NNRSSGSFLAAGGTGGAAGDGGQGGQGGAGGGAGGQGGAGGAGGTGGNGG Rv3345c|M.tuberculosis_H37Rv --------------GGISLGGNGGLGGNGGVSETGFGGAGGNGGYGGPGG MLBr_01183|M.leprae_Br4923 --------------MPLFLNAEP-----QALTAAANTLEGLSAATVASNA MAB_4284c|M.abscessus_ATCC_199 --------------GAHTGVGGGVNTGVGVGSHVGGGISESLGGSGSVGG MAV_4827|M.avium_104 -------------------------------GHLPFPGAGSTPGGSGGGH MMAR_2656|M.marinum_M TSRGDGGAGGAGGTGGVGGSGGDGADGTSGLFGGADGTAGGAGGDGGDGG MUL_4367|M.ulcerans_Agy99 DSAATAGGGGAGGDGGKGGAGGAGVNGVG-------------GGDGGKGG Mflv_5091|M.gilvum_PYR-GCK -QGATGATGAAGKAGATGAAG---AAGAAG-----------SAGTTGAQG Mvan_1264|M.vanbaalenii_PYR-1 -QGATGATGASGAQGSAGSAG---SAGVAG-----------SAGTTGAQG MSMEG_0868|M.smegmatis_MC2_155 -NALVMAAGTTGVATGNTATGG--DGGAAT-----------TAGATGGAG TH_3810|M.thermoresistible__bu -SCTSRAVSREGIMPSSRAASA--RAGAAC-----------ASSTSRSRR Mb3541|M.bovis_AF2122/97 -NITGGTAGTAGAAGNGGAAGKGGAGGQGG-----------TGGGTGGQG Rv3345c|M.tuberculosis_H37Rv PEGNGGLGGNGGAGGNGGVSTTGGDGGAGG-----------KGGNGGDGG MLBr_01183|M.leprae_Br4923 AAAQLTTEIAPPAADDVSILLAHFFSGHGR-----------QYQAHASQG MAB_4284c|M.abscessus_ATCC_199 STAVGGGAHTSAINDALGGSGSVGGSTAVG------------GGAHTSAI MAV_4827|M.avium_104 LPTPGAGTPGGGLGGFGGGHAPAPGGGLGG------------GGGHAPAP MMAR_2656|M.marinum_M AGGAGGAGGKAVSGVGQNGSQGAGGNGGAAGDGGDGGNGGNGHDGNNGSV MUL_4367|M.ulcerans_Agy99 TGGAGGAG-------------GAGSDGIIPSNGGLGGNGGNGGNG----- Mflv_5091|M.gilvum_PYR-GCK SAGTNGAN------------------GANGSQGAAGKAGATGTTGATG-- Mvan_1264|M.vanbaalenii_PYR-1 SAGTNGAN------------------GANGSQGAAGKAGATGTTGATG-- MSMEG_0868|M.smegmatis_MC2_155 GFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSK TH_3810|M.thermoresistible__bu SFCCSRA------------------------------------------- Mb3541|M.bovis_AF2122/97 GAGGDGGAGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQGGADGGSGG Rv3345c|M.tuberculosis_H37Rv NVGLGGDAGSGGAGGNGGIGTDAGGAGGAGGAGGNGGSSKSTTTGNAG-- MLBr_01183|M.leprae_Br4923 ATNHQDLIQ-----------------SLLTSSSAYAGTETANHDSL---- MAB_4284c|M.abscessus_ATCC_199 NESMNSSIN-----------------ASHSSSMNESFGSSMGSHGAAG-- MAV_4827|M.avium_104 GGGLGGFG------------------GGHSGGGLGGLGGGHK-------- MMAR_2656|M.marinum_M PSGGTDRDGGDGQGGGDGGAGGAGGAGGNGGAAGAGGGGTRGAGGDGGDG MUL_4367|M.ulcerans_Agy99 -----------GQAFGDG-VGGAGGIGGKGGNAAIGTIVIN--GGVGGAG Mflv_5091|M.gilvum_PYR-GCK ------AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEG Mvan_1264|M.vanbaalenii_PYR-1 ------AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEG MSMEG_0868|M.smegmatis_MC2_155 IANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTG TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 DGGDAGTGGNGGNGGNRNSGNGTGGAGGNGGGGANGGAGG-AGGSGGGTG Rv3345c|M.tuberculosis_H37Rv -------SGGAGGNGGTGLNGAGGAGGAGGNAGVAGVSFGNAVGGDGGNG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------TGFEAQGHAQGHASETAHTTLPGAEHH---------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M GNGGFAGDGGLGMDGLDATLTNRAGDGGDGGGGGQA-------------- MUL_4367|M.ulcerans_Agy99 GSGGLGG-------------------ATEDGVGGVG-------------- Mflv_5091|M.gilvum_PYR-GCK GDGGKGGA------------------GAEGGAGGGG-------------- Mvan_1264|M.vanbaalenii_PYR-1 GAGGAGGD------------------GSEGGAGGSG-------------- MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGD------------------GSEPGPGGNG-------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GNGGAGGD------------------AGDAGNGGNGNGTGNGGNGGNGGI Rv3345c|M.tuberculosis_H37Rv GNGGHGGD------------------GTTGGAGGKG-------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M -------------------FAGGAGGAGGTGSTQGSAGTTGAWRAGGDGG MUL_4367|M.ulcerans_Agy99 -------------------CAGGAGGNGGRG--------DMLFTVGGSGG Mflv_5091|M.gilvum_PYR-GCK --------------------GAGGSGAGGAG------------GAGGSGG Mvan_1264|M.vanbaalenii_PYR-1 --------------------GAGGSGTGGAG------------GAGGSGG MSMEG_0868|M.smegmatis_MC2_155 --------------------AGGAGGNGGTGGT-----TAGGSGNGGNGG TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 AGMGGNGGAGTGSGNGGNGGSGGNGGNAGMGGN-----SGTGSGDGGAGG Rv3345c|M.tuberculosis_H37Rv -------------------GNGSSGAASGSGVVN---VTAGHGGNGGNGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M SGGDGGDGFGLWNPGEGGRGGSGGDGGTGGDGGDGGNGRVEIWEGRGGNG MUL_4367|M.ulcerans_Agy99 TGGDGGG------------GGSASGSGTGGSGGTGG-------------- Mflv_5091|M.gilvum_PYR-GCK SGGSGGS------------GGSGGAAGDSDD------------------- Mvan_1264|M.vanbaalenii_PYR-1 SGGSGGA------------GGSGGAAGDSD-------------------- MSMEG_0868|M.smegmatis_MC2_155 NGGNGGA------------DGTPGTAGTTGANNP---------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 NGGAAGT------------GGTGGDGGLTGTGGTGGSGGTGGDGGNGGNG Rv3345c|M.tuberculosis_H37Rv NGGNGSAG----------AGGQGGAGGSAGNGGHGGG------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M GNGAI--------------------------------GPGGDGGDGGDAP MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GNGADNTANMTAQAGGDGGNGGDGGFGGGAGAGGGGLTAGANGTGGQGGA Rv3345c|M.tuberculosis_H37Rv -------------------------------------ATGGDGGNGGNGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M NQQRVSSSSPGYEGADGGNGGNGTIGGNGGNGGTGGPGYDASLGGEATAG MUL_4367|M.ulcerans_Agy99 ------------------------VGGIGGDGKLGG------------FG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GGDGGNGAIGGHGPLTDDPGGNGGTGGNGGTGGTGGAGIGSLGGGTGGDG Rv3345c|M.tuberculosis_H37Rv NSGNSTGVAGLAGGAAGAGGNGGGTSSAAGHGGSGGSGGSGTTGGAGAAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M GEGGDGGDGGKGFNGAGGAGGDGGAGGAGGSGAPAPFGSGGAYGGTGGQG MUL_4367|M.ulcerans_Agy99 GDGGDGGDGG--------------------------------FGVIGGQG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GNGGTGGNGGTGGEGGEVGGAGGTGGAAGNGGDGGTGGTGGGDGGAGGTG Rv3345c|M.tuberculosis_H37Rv GNGGAGAGGGSLSTGQSGGPRRQRWCRWQRRRWLGRQRRRRWCRWQRRCR MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M GTGGSGVIGGIGEGGKIGDAGFGGNPPNSQTGEGGSGGAGGAGGAGGDPS MUL_4367|M.ulcerans_Agy99 GGGGFGGLGGTGAGGAPSDKGINGEPGNPG-------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GTGGTGGLGDPRVGGSGGDGGTGGSGGAAGNGGNGGNAGAGGNGNGGTGG Rv3345c|M.tuberculosis_H37Rv RQRWRWRCRQRRLRRQWRQGRRRCRPWLHRRRGRQGRRWRQRRFQQRQRS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M N------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 AGGIGGTGGNGGDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTG Rv3345c|M.tuberculosis_H37Rv RWQRR--------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GDGGTGGGGGNGGTGWNGGKGDTGSGGGAGDGGKAPAGGTGGAGGDGGAG Rv3345c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_2656|M.marinum_M -------- MUL_4367|M.ulcerans_Agy99 -------- Mflv_5091|M.gilvum_PYR-GCK -------- Mvan_1264|M.vanbaalenii_PYR-1 -------- MSMEG_0868|M.smegmatis_MC2_155 -------- TH_3810|M.thermoresistible__bu -------- Mb3541|M.bovis_AF2122/97 GKGGSGGV Rv3345c|M.tuberculosis_H37Rv -------- MLBr_01183|M.leprae_Br4923 -------- MAB_4284c|M.abscessus_ATCC_199 -------- MAV_4827|M.avium_104 --------