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M. tuberculosis H37Rv Rv3345c (PE_PGRS50)

annotation: PE-PGRS FAMILY PROTEIN
coordinates: 3738158 - 3742774
length: 1538

VMSLMVAPELVAAAAADLTGIGQAISAANAAAAGPTTQVLAAAGDEVSAAIAALFGTHAQEYQALSARVA
TFHEQFVRSLTAAGSAYATAEAANASPLQALEQQVLGAINAPTQLWLGRPLIGDGVHGAPGTGQPGGAGG
LLWGNGGNGGSGAAGQVGGPGGAAGLFGNGGSGGSGGAGAAGGVGGSGGWLNGNGGAGGAGGTGANGGAG
GNAWLFGAGGSGGAGTNGGVGGSGGFVYGNGGAGGIGGIGGIGGNGGDAGLFGNGGAGGAGAAGLPGAAG
LNGGDGSDGGNGGTGGNGGRGGLLVGNGGAGGAGGVGGDGGKGGAGDPSFAVNNGAGGNGGHGGNPGVGG
AGGAGGLLAGAHGAAGATPTSGGNGGDGGIGATANSPLQAGGAGGNGGHGGLVGNGGTGGAGGAGHAGST
GATGTALQPTGGNGTNGGAGGHGGNGGNGGAQHGDGGVGGKGGAGGSGGAGGNGFDAATLGSPGADGGMG
GNGGKGGDGGKAGDGGAGAAGDVTLAVNQGAGGDGGNGGEVGVGGKGGAGGVSANPALNGSAGANGTAPT
SGGNGGNGGAGATPTVAGENGGAGGNGGHGGSVGNGGAGGAGGNGVAGTGLALNGGNGGNGGIGGNGGSA
AGTGGDGGKGGNGGAGANGQDFSASANGANGGQGGNGGNGGIGGKGGDAFATFAKAGNGGAGGNGGNVGV
AGQGGAGGKGAIPAMKGATGADGTAPTSGGDGGNGGNGASPTVAGGNGGDGGKGGSGGNVGNGGNGGAGG
NGAAGQAGTPGPTSGDSGTSGTDGGAGGNGGAGGAGGTLAGHGGNGGKGGNGGQGGIGGAGERGADGAGP
NANGANGENGGSGGNGGDGGAGGNGGAGGKAQAAGYTDGATGTGGDGGNGGDGGKAGDGGAGENGLNSGA
MLPGGGTVGNPGTGGNGGNGGNAGVGGTGGKAGTGSLTGLDGTDGITPNGGNGGNGGNGGKGGTAGNGSG
AAGGNGGNGGSGLNGGDAGNGGNGGGALNQAGFFGTGGKGGNGGNGGAGMINGGLGGFGGAGGGGAVDVA
ATTGGAGGNGGAGGFASTGLGGPGGAGGPGGAGDFASGVGGVGGAGGDGGAGGVGGFGGQGGIGGEGRTG
GNGGSGGDGGGGISLGGNGGLGGNGGVSETGFGGAGGNGGYGGPGGPEGNGGLGGNGGAGGNGGVSTTGG
DGGAGGKGGNGGDGGNVGLGGDAGSGGAGGNGGIGTDAGGAGGAGGAGGNGGSSKSTTTGNAGSGGAGGN
GGTGLNGAGGAGGAGGNAGVAGVSFGNAVGGDGGNGGNGGHGGDGTTGGAGGKGGNGSSGAASGSGVVNV
TAGHGGNGGNGGNGGNGSAGAGGQGGAGGSAGNGGHGGGATGGDGGNGGNGGNSGNSTGVAGLAGGAAGA
GGNGGGTSSAAGHGGSGGSGGSGTTGGAGAAGGNGGAGAGGGSLSTGQSGGPRRQRWCRWQRRRWLGRQR
RRRWCRWQRRCRRQRWRWRCRQRRLRRQWRQGRRRCRPWLHRRRGRQGRRWRQRRFQQRQRSRWQRR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv3345cPE_PGRS50-100% (1538)PE-PGRS FAMILY PROTEIN
M. tuberculosis H37RvRv2490cPE_PGRS430.049.14% (1681) PE-PGRS family protein
M. tuberculosis H37RvRv3508PE_PGRS540.050.31% (1628) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3541PE_PGRS550.049.97% (1647) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-0.049.76% (826) triple helix repeat-containing collagen
M. leprae Br4923MLBr_01183-5e-1440.40% (99) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-4e-5834.21% (494) hypothetical protein MAB_4284c
M. marinum MMMAR_2656-0.047.33% (1857) PE-PGRS family protein, PE_PGRS50
M. avium 104MAV_4827-2e-2445.83% (168) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-17041.09% (1078) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-8e-4843.92% (296) PUTATIVE -
M. ulcerans Agy99MUL_4367-0.046.96% (1201) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-0.049.22% (833) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_2656|M.marinum_M               ----MSLVTVSPELVAGAASDLARIGSSLGAANAAAAGPTTTVLSAAADE
MUL_4367|M.ulcerans_Agy99           ----MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDE
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      ---MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            ----MSFVLISPEVVSAAAGDLANVGSTISAANKAAAAATTQVLAAGADE
Rv3345c|M.tuberculosis_H37Rv        ---MVMSLMVAPELVAAAAADLTGIGQAISAANAAAAGPTTQVLAAAGDE
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMP
MAV_4827|M.avium_104                MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDR
                                                                                      

MMAR_2656|M.marinum_M               VSVAIATLFGTHAAEYQSLSARMAAFHEQFVQTLTSGAGIYVSTEATNAS
MUL_4367|M.ulcerans_Agy99           VSAAIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALN--
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      PESPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNT--
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            VSARIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYMLAEATN--
Rv3345c|M.tuberculosis_H37Rv        VSAAIAALFGTHAQEYQALSARVATFHEQFVRSLTAAGSAYATAEAAN--
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQP------------
MAV_4827|M.avium_104                VISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDN----
                                                                                      

MMAR_2656|M.marinum_M               FISALQLAEQNALNAINAPTQSWLGRPLIGNGVDATPGSGQAGGAGGLLW
MUL_4367|M.ulcerans_Agy99           -MWPLQELEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILW
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      -------TDQPTSDSLGAQPTAQVARQVQ---APAT-DP-----------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            -------VEQNLLNLINAPTQTLLGRPLIGDGANAT-TPGGAGGDGGLLF
Rv3345c|M.tuberculosis_H37Rv        -ASPLQALEQQVLGAINAPTQLWLGRPLIGDGVHGAPGTGQPGGAGGLLW
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GNGGAGGSGAAGQSGGAGGSAGLFGNGGAGGAGGISAAGNGGSGGVGGRG
MUL_4367|M.ulcerans_Agy99           GNGGNGGLGAAGANGGAGGSAGLIGTGGVGGAGGVGAAGMTG--------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      ------APAAPSLRP-ISGLLSVVTLGTTLIPNAPTEPADMPGVWA----
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GSGGNGAPGAPGQAGGAGGSAGLLGNGGSGGAGGTGAPGGNGGNAG----
Rv3345c|M.tuberculosis_H37Rv        GNGGNGGSGAAGQVGGPGGAAGLFGNGGSGGSGGAGAAGGVGGSGG----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -----DGPSILSPSLLSPRDNDFLSHNDTDFASHN---------------
MAV_4827|M.avium_104                ---------VMLVSAFLAAAALAQNVGGAMG-------------------
                                                                                      

MMAR_2656|M.marinum_M               GLVYGSGGAGGAGGQGALSGGAGGAGGGAWLWGAGGAG--GSGGEGLASA
MUL_4367|M.ulcerans_Agy99           ----GSGGAG---------------GGGGWLWGAGGSG--GAAG-----A
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------------MVTF
Mvan_1264|M.vanbaalenii_PYR-1       -------------MMFLAPPGGPGPISAAIQLTSTGSE--ATEPWYVVSF
MSMEG_0868|M.smegmatis_MC2_155      ----VMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASA--VLDPTQIVNW
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            ----WLYGRGGVGGAGGIGGGTGGAGGHAWLFGHGGTG--GIGGGPGGNG
Rv3345c|M.tuberculosis_H37Rv        -----WLNGNGGAGGAGGTGANGGAGGNAWLFGAGGSGGAGTNGGVGGSG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------------PIASGNQVMSPSGNVDSFNRGPLLDLSF
MAV_4827|M.avium_104                ------------------------YERTAVLLVEPDTATLAVVETSDGSI
                                                                                      

MMAR_2656|M.marinum_M               GGVGGAGGNAGLIGTGGLGGAGGVGGQNGGAGGDGGNAPLLGRGGTGGVG
MUL_4367|M.ulcerans_Agy99           GGSGGSGG--WLWGN---------AGQTAGAG----------VGGAGGAG
Mflv_5091|M.gilvum_PYR-GCK          GGGATPTPTSLGAAAVDL-----SGTSCG----------LICNGQDGTGQ
Mvan_1264|M.vanbaalenii_PYR-1       GGSGAPTPNNLAASLVDL-----SGTSCG----------LICNGQDGTGQ
MSMEG_0868|M.smegmatis_MC2_155      LIYQPLHAAGQQFWVVSP-----IGSTLGGVINTISGQYLIGNGINGTAD
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GWLLGNGGHGGAGGIGGG-----SGGAGGNGGWLLGNGGIGGAGGTGGGA
Rv3345c|M.tuberculosis_H37Rv        GFVYGNGGAGGIGGIGGIGGNGGDAGLFGNGGAGGAGAAGLPGAAGLNGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GDLQFGNRDTTAIGDG-------------------------AVAVGGSNS
MAV_4827|M.avium_104                PDVYKQQIRAESYGDAAG-----------------------QLSAMVAGL
                                                                                      

MMAR_2656|M.marinum_M               GASDGGNGGAGGDGGVGGGLFGSGGAGGSGGAGGVLGTGGDGG-------
MUL_4367|M.ulcerans_Agy99           GAGDAGDQGVSG--------VAPGEAGAVGFAG-----------------
Mflv_5091|M.gilvum_PYR-GCK          N-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNG-------
Mvan_1264|M.vanbaalenii_PYR-1       N-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNG-------
MSMEG_0868|M.smegmatis_MC2_155      NPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNG-------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GGTGGNAAWLLGGGGTGGAGGIGGGNGGHGGNGGWLLGNGGNGGLGGDGD
Rv3345c|M.tuberculosis_H37Rv        DGSDGGNGGTGGNGGRGGLLVGNGGAGGAGGVGGDGGKGGAGD-------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GPIASGQGSTAVNGDVRDSNIINADHGSNVGVDQ----------------
MAV_4827|M.avium_104                EKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPETA-------
                                                                                      

MMAR_2656|M.marinum_M               ----------------------------SGGAAAGLWGAGGSGGAGGNGA
MUL_4367|M.ulcerans_Agy99           -------------------------------------GAGGAGGAGGN--
Mflv_5091|M.gilvum_PYR-GCK          -------------------------------------GNGLGGGNGGNG-
Mvan_1264|M.vanbaalenii_PYR-1       -------------------------------------GNGLGSGDGGNG-
MSMEG_0868|M.smegmatis_MC2_155      -------------------------------------GVGWAGLDGGNG-
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GGTGGGHGGNGGNPGWLLGTAGGGGNGGAGSTGTAGGGSGGTGGDGGTG-
Rv3345c|M.tuberculosis_H37Rv        ------------------------------PSFAVNNGAGGNGGHGGNPG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------------------------SQTRVGGDYTNVS
MAV_4827|M.avium_104                -------------------------------------LARGAALAAANAP
                                                                                      

MMAR_2656|M.marinum_M               DGISGGIGESGGDGGNAGNGGAGGRGGRLIGAGGAGGFGGVGGLGGAGGA
MUL_4367|M.ulcerans_Agy99           --------------------GVGG------GVNGAGGAGGAGGVGGGGGA
Mflv_5091|M.gilvum_PYR-GCK          ------------------------------GNAGAFALFGNGGNGGNGGV
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------GDAGLFSLFGRGGNGGNGGV
MSMEG_0868|M.smegmatis_MC2_155      ------------------------------GSGGLLMGIG--GAGGAGGV
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            ------------------------------GRGGLLMGAGAGGHGGTGGA
Rv3345c|M.tuberculosis_H37Rv        VG-----------------GAGGAGGLLAGAHGAAGATPTSGGNGGDGGI
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------------------GHGSADIDKSVTVVDDHSQR
MAV_4827|M.avium_104                ------------------------------LFASSTAALAYAQDPGTGAV
                                                                                      

MMAR_2656|M.marinum_M               GANGIVAGSAGDGGGNGGS-------------------------------
MUL_4367|M.ulcerans_Agy99           GASGVGAGVAGGDGGTGGA-------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GVVGATGAVG--APGVAGAT------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       GIAGATGAVG--APGVAGAT------------------------------
MSMEG_0868|M.smegmatis_MC2_155      GADGTSAHVDGGTGGTGGTG------------------------------
TH_3810|M.thermoresistible__bu      --------VD----GDGGSG------------------------------
Mb3541|M.bovis_AF2122/97            GGAGVDGGGAGGAGGAGGNGGAGGQAALLFGRGGTGGAGGYGGDGGGGGD
Rv3345c|M.tuberculosis_H37Rv        GATANSPLQAGGAGGNGGHGG-----------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      NTTNINDSFNTDRSTNIGSG------------------------------
MAV_4827|M.avium_104                DQYSLPDYLYVPVDPEPGDD------------------------------
                                                                                      

MMAR_2656|M.marinum_M               ---------GGAGGVGGDGGKGGLIRFLGGRGAGGSGGEGGAGGAAGDGG
MUL_4367|M.ulcerans_Agy99           ---------GGAAGVGG---------------AAGTGGTGGAAGVAGTGG
Mflv_5091|M.gilvum_PYR-GCK          ---------GATGVTSGVVGGN--------GEDAVGYGATGAAGAAGAAG
Mvan_1264|M.vanbaalenii_PYR-1       ---------GATGVTSNVTGGN--------GADAVGYGATGAAGAAGAAG
MSMEG_0868|M.smegmatis_MC2_155      ---------GGTGGTGGIGGTG--------GGLFGLLGHSGSTGAAGAAG
TH_3810|M.thermoresistible__bu      ---------GRTG-------------------LFSKLSR-----------
Mb3541|M.bovis_AF2122/97            GFDGTMAGLGGTGGSGGTGGDGGAPGNGGAGGAGQLLSHSGVAGASGKGG
Rv3345c|M.tuberculosis_H37Rv        -----LVGNGGTGGAGGAGHAG------STGATGTALQPTGGNGTNGGAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------------------------NTTNTEIGSHNQANIGT
MAV_4827|M.avium_104                ---------------------------------ELAYSAVGEEDAESPTV
                                                                                      

MMAR_2656|M.marinum_M               DGAAGSFLTGTGAGGAGGQGGDPGLGGAGGAGGRGSVPGSHGVTGQSPTS
MUL_4367|M.ulcerans_Agy99           D-------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          A-------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       A-------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      N-------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            A-------------------------------------------------
Rv3345c|M.tuberculosis_H37Rv        G-------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      S-------------------------------------------------
MAV_4827|M.avium_104                V-------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GGDGGNGGRGADAIDPATTAGAGGVGGDGGRYGNGGVGGAGGDGYRGYDG
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            --------------------------------------------------
Rv3345c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               MSVVGGDGTVGGDGGAGGAGGAGGMGGALAGHGGAGGAGGDGGTGGIGGD
MUL_4367|M.ulcerans_Agy99           ----------GGDGGAGGAG------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------AGAAGAVGSAG-----------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----------AGKAGAVGSAG-----------------------------
MSMEG_0868|M.smegmatis_MC2_155      ----------GGDGGNGGFGYVL--------------IAGPNVTVGSETR
TH_3810|M.thermoresistible__bu      ----------GGDGGDGGLG------------------------------
Mb3541|M.bovis_AF2122/97            ----------GGTGGNGGAGSAG--------------ADAPAGSGAMGST
Rv3345c|M.tuberculosis_H37Rv        ---------HGGNGGNGGAQHGDG------------GVGGKGGAGGSGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------TSAGGSAAVG------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GGRGVDGTDLSLDGTDGGSGGMGGVGGAGGDGGAGGLAQA-AGFSDGIRG
MUL_4367|M.ulcerans_Agy99           -------SDASLAGQAGFAGGSGGAGGVGGSAGAG--------------G
Mflv_5091|M.gilvum_PYR-GCK          -AAGEAGETGTWGNAGLP--GKAGDAGGAG-----------------AVG
Mvan_1264|M.vanbaalenii_PYR-1       -TAGSAGAPGVWGNAGLP--GAAGAAGGAG-----------------AIG
MSMEG_0868|M.smegmatis_MC2_155      GGTGGAGGTGGQSTAAGPGKGGGGGGGGGG-----------------AIL
TH_3810|M.thermoresistible__bu      --------------------GNGGHGGGTG-----------------IIS
Mb3541|M.bovis_AF2122/97            GFAGGAGGDGGNGGGSGASQGNGGNGGNGGTGGKGGTGGA-GMNSLDPLL
Rv3345c|M.tuberculosis_H37Rv        GGNGFDAATLGSPGADGGMGGNGGKGGDGGKAGDGGAGAAGDVTLAVNQG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------GNAGLAGNAG--------------------
MAV_4827|M.avium_104                ------IEKLFLPEDSEPRRRPVLLVGSG---------------------
                                                                                      

MMAR_2656|M.marinum_M               VGGAGGDGGAGGGAGDGGDGANAP--------AASGLAGGSGGHGGDPGV
MUL_4367|M.ulcerans_Agy99           VNGSGGDGGAGAAGGAGG---------------ASATVAGSGGVGGD---
Mflv_5091|M.gilvum_PYR-GCK          AAGAAGTVGTAGATGGTGTG-------------ANGGAGGVGGVGGTGAA
Mvan_1264|M.vanbaalenii_PYR-1       TAGVAGAAGTAGATGGTGVG-------------GNGGAGQAGGIGGTGAA
MSMEG_0868|M.smegmatis_MC2_155      IGANGGTVDGHAIGGNGGNG-------------GNGSTTAAGGNGGTGGT
TH_3810|M.thermoresistible__bu      LLS---------LAGNGGNG-------------GNGYRTTDNN-------
Mb3541|M.bovis_AF2122/97            AAQDGGQGGTGGTGGNAGAG-------------GTGFTQGADGNAGNGGD
Rv3345c|M.tuberculosis_H37Rv        AGGDGGNGGEVGVGGKGGAGGVSANPALNGSAGANGTAPTSGGNGGNGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LAGNAGLAGNAGLAGNAGLAG-------------NAGLAGNAGLAGN---
MAV_4827|M.avium_104                -LAVVGISAVLALEIALAIGIR-----------TTGTVALQPTPNQHLIV
                                                                                      

MMAR_2656|M.marinum_M               GGAGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGDGANASTVGASGGAGGA
MUL_4367|M.ulcerans_Agy99           --------------------------------------------GGAGGA
Mflv_5091|M.gilvum_PYR-GCK          G--------------------------------AAGGAGGLGETGTTGGA
Mvan_1264|M.vanbaalenii_PYR-1       G--------------------------------AAGQAGTAGETGVTGGV
MSMEG_0868|M.smegmatis_MC2_155      GRV------------------------------IAEGTGSTAEGTATGGD
TH_3810|M.thermoresistible__bu      --------------------------------------------ALDGGH
Mb3541|M.bovis_AF2122/97            GGVGG-------------------------NGGNGADNTTTAAAGTTGGA
Rv3345c|M.tuberculosis_H37Rv        G----------------------------------ATPTVAGENGGAGGN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------AGLAGN
MAV_4827|M.avium_104                P------------------------------------------TEQAPAP
                                                                                      

MMAR_2656|M.marinum_M               GGDGGRYGNGGVGGAGGDGYRGYDGMSVVGGDGTVGGDGGAGGAGGAGGM
MUL_4367|M.ulcerans_Agy99           AG-------GGVGAAS------------------LGGDG-----------
Mflv_5091|M.gilvum_PYR-GCK          GGVGGQGTAGGTGGVGG-----------------IGGAGSTG--------
Mvan_1264|M.vanbaalenii_PYR-1       GGIGGQGTEGGTGGVGG-----------------VGGVGATG--------
MSMEG_0868|M.smegmatis_MC2_155      GGHSTGTGIGGNGGIGS-----------------VYAYGNNGAV------
TH_3810|M.thermoresistible__bu      GGN------GGNVGFFS-----------------LFNLG-----------
Mb3541|M.bovis_AF2122/97            GGAGGAGGTGGTGGAAG-----------------TGTGGQQGNG------
Rv3345c|M.tuberculosis_H37Rv        GGHGGSVGNGGAGGAGGNG---------------VAGTGLALNG------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGLAGNAGLAGNAGLAG---------------------------------
MAV_4827|M.avium_104                PPVQASAPQPKISVPEP---------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GGALAGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGTDGGSGGMGG-
MUL_4367|M.ulcerans_Agy99           -----GHAGAGGAGGEGLSGGFN-----------------TGAAGGIGG-
Mflv_5091|M.gilvum_PYR-GCK          --------AVGGVGGKGIQGG-----------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------GAGGVGGKGIQGG-----------------------------
MSMEG_0868|M.smegmatis_MC2_155      -----SGTATGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGS
TH_3810|M.thermoresistible__bu      --------GAGGWGGSGVDG------------------------------
Mb3541|M.bovis_AF2122/97            -----GNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGNAGA
Rv3345c|M.tuberculosis_H37Rv        -----GNGGNGGIGGNGGSAAGTGGDGGKGGNGGAGANGQDFSASANGAN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------NAGLAGNAGLAG------------------------------
MAV_4827|M.avium_104                -------VAAPKPLSPPVAAPLP---------------------------
                                                                                      

MMAR_2656|M.marinum_M               -----------------VGGAGGDGGAGGLAQAAGFS-------------
MUL_4367|M.ulcerans_Agy99           -----------------AGGAGGTGGDSG---------------------
Mflv_5091|M.gilvum_PYR-GCK          -----------------QGLQGGKGG------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -----------------QGLQGGQGG------------------------
MSMEG_0868|M.smegmatis_MC2_155      A--------------TGADSLGGRGGTSWVQAGYGPT-------TGGKAS
TH_3810|M.thermoresistible__bu      -----------------VDVVGGN--------------------------
Mb3541|M.bovis_AF2122/97            GGTGFTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAG
Rv3345c|M.tuberculosis_H37Rv        G---------------GQGGNGGNGGIGGKGGDAFAT-------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               -DGIRGVGGAGGDGGAGGGAGDGGDGANAPAASGLAGGSGGHGGDPGVGG
MUL_4367|M.ulcerans_Agy99           -----GVGGVNGDGGAGGGGGRGGDGGSSTSTS-------------GVGG
Mflv_5091|M.gilvum_PYR-GCK          ------------DGGAGGKGGDADSMG-----------------------
Mvan_1264|M.vanbaalenii_PYR-1       ------------DGGTGGTGGDATSMG-----------------------
MSMEG_0868|M.smegmatis_MC2_155      GTAKAGHGGKASDGGKGGNGGDALVMAA----------------------
TH_3810|M.thermoresistible__bu      -----------PDGGTPG--------------------------------
Mb3541|M.bovis_AF2122/97            GTGGTGGAAGTGTGGQQGNGGNGGNGGT----------------------
Rv3345c|M.tuberculosis_H37Rv        -------FAKAGNGGAGGNGGNVGVAGQ--------------------GG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------NAGLAGNAGLAGNAG-----------------------
MAV_4827|M.avium_104                -------------AAPPPAAPPLPEAPP----------------------
                                                                                      

MMAR_2656|M.marinum_M               AGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGDGANASTVGASGGAGGAGG
MUL_4367|M.ulcerans_Agy99           AGGAG-------------------GNGGNAGFGVSAGGTGGSAGDGGAGG
Mflv_5091|M.gilvum_PYR-GCK          -----------------------------------SAGATG---------
Mvan_1264|M.vanbaalenii_PYR-1       -----------------------------------EAGATG---------
MSMEG_0868|M.smegmatis_MC2_155      --GATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATS
TH_3810|M.thermoresistible__bu      --------------------------------------AHG---------
Mb3541|M.bovis_AF2122/97            --GGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGNAGAGGTGFTQGADG
Rv3345c|M.tuberculosis_H37Rv        AGGKGAIPAMKGATGADGTAPTSGGDGGNGGNGASPTVAGGNGGDGGKGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               DGGRYGNGGVGGAGGDGYRGYD--------GMSVVGGDGTVGGDGGAGGA
MUL_4367|M.ulcerans_Agy99           -----GAGGVDGVGG-------------------------ASGNGGAAGA
Mflv_5091|M.gilvum_PYR-GCK          -----GKGGNGGNGGRG----------------------GLFGKGGNAGN
Mvan_1264|M.vanbaalenii_PYR-1       -----GKGGNGGNGGRG----------------------SLFGRGGNAGN
MSMEG_0868|M.smegmatis_MC2_155      GHGGAAQGGNGGNGGNGWV--------------------QAYDPNGPAGT
TH_3810|M.thermoresistible__bu      ---------------------------------------ESHTP----GV
Mb3541|M.bovis_AF2122/97            NAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTGGAAGT
Rv3345c|M.tuberculosis_H37Rv        SGGNVGNGGNGGAGGNGAAG-------------------QAGTPGPTSGD
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------------------------------LAGNAGLAGN
MAV_4827|M.avium_104                ----------------------------------------IPAAPPVVPV
                                                                                      

MMAR_2656|M.marinum_M               GGAGGMGGALAGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGTDGGS
MUL_4367|M.ulcerans_Agy99           GGAGGSG--------------------IG---------------------
Mflv_5091|M.gilvum_PYR-GCK          GADGG---------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       GGNGG---------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      TIDKGKAA------------------------------------------
TH_3810|M.thermoresistible__bu      YTDRQ---------------------------------------------
Mb3541|M.bovis_AF2122/97            GTGGQQGN------------------------------------------
Rv3345c|M.tuberculosis_H37Rv        SGTSGTDG------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGLAG---------------------------------------------
MAV_4827|M.avium_104                PVVVPPVP------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GGMGGVGGAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGDGGDG
MUL_4367|M.ulcerans_Agy99           --------AGIDGGAG----------------GAGGTGGAAG--------
Mflv_5091|M.gilvum_PYR-GCK          -----TGGAGGAGGTG----------------GTGGAGGTGGT-------
Mvan_1264|M.vanbaalenii_PYR-1       -----TGGNGGNGGTG----------------GTGGNGGTGGT-------
MSMEG_0868|M.smegmatis_MC2_155      ---GGNGGDGGFNGTGG---------------ATGGRGGDGAG-------
TH_3810|M.thermoresistible__bu      -------GEDGEDGTGT---------------GIGGRGGNGG--------
Mb3541|M.bovis_AF2122/97            ---GGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGGNGGDAGK-------
Rv3345c|M.tuberculosis_H37Rv        ----GAGGNGGAGGAGG------------TLAGHGGNGGKGGN-------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------NAGLAGNAG-----------------LAGNAGLAGN-------
MAV_4827|M.avium_104                -----VPVPVRIPVPDP----------------VSPPQLLAPP-------
                                                                                      

MMAR_2656|M.marinum_M               ANAAAGSGAVGGKGGDGGDPGVGGAGGAGGTGSVTGAHGTEGLTQTTGGN
MUL_4367|M.ulcerans_Agy99           ---------FPGGGGTTGAWGTGGAGGAG---------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------GGTGGIGGAGSTGG--------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----------GGTGGIGGAGSTGG--------------------------
MSMEG_0868|M.smegmatis_MC2_155      ----------ASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGG
TH_3810|M.thermoresistible__bu      --------------SSSGTHPMAE--------------------------
Mb3541|M.bovis_AF2122/97            ----------AGTGSAPGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGG
Rv3345c|M.tuberculosis_H37Rv        ----------GGQGGIGGAGERGADGAGPN--------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GGDGGNGGSGTTGTTGSKGGAGGAGGDGGRYGNGGNGGTGGTGSTGTAGS
MUL_4367|M.ulcerans_Agy99           -------------------GAGGAGDHGGVGVNPGDSGT-----------
Mflv_5091|M.gilvum_PYR-GCK          -----------------------TGGTGGTGGTGGTGGT-----------
Mvan_1264|M.vanbaalenii_PYR-1       -----------------------TGGTGGTGGTGGTGGT-----------
MSMEG_0868|M.smegmatis_MC2_155      AGGAGGV----------SEGEGGTGGHGGDGGRGGDGAL-----------
TH_3810|M.thermoresistible__bu      ---------------------------DGEHVKALDGRP-----------
Mb3541|M.bovis_AF2122/97            TGGSGGAGGTGGDGGAANGGTAGAGGAGGNGGKGGDGGAGVTSST-----
Rv3345c|M.tuberculosis_H37Rv        -------------------ANGANGENGGSGGNGGDGGA-----------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------------AAVAGNAAVAGNAAVAGN-----------
MAV_4827|M.avium_104                ----------------------RLSVPQPVQPPVRVPQP-----------
                                                                                      

MMAR_2656|M.marinum_M               SDVMGANGGAGGSGWAGGDGGAGGMGGTLAGHGGDGGDGGSGGTGGTGGR
MUL_4367|M.ulcerans_Agy99           ------------AGWAGGAGGAGGAGGSAA--------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------GGTGGTGGTG------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----------------GGTGGTGGTG------------------------
MSMEG_0868|M.smegmatis_MC2_155      ----------------GGNGGTGGVGL-----------------------
TH_3810|M.thermoresistible__bu      ----------------GLDG------------------------------
Mb3541|M.bovis_AF2122/97            ------------AGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGGDG
Rv3345c|M.tuberculosis_H37Rv        ----------------GGNGGAGGKAQAAG--------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------AAVGGVLNTG------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GGNGFNGSTKAGLNGGDAGDGGAGGVGGAGGNGGAAGLAQAAGFSDGIQG
MUL_4367|M.ulcerans_Agy99           ----FN----------------------------------------GVNG
Mflv_5091|M.gilvum_PYR-GCK          -------------------------------------------------G
Mvan_1264|M.vanbaalenii_PYR-1       -------------------------------------------------G
MSMEG_0868|M.smegmatis_MC2_155      -------------------------------------------------G
TH_3810|M.thermoresistible__bu      -------------------------------------------------G
Mb3541|M.bovis_AF2122/97            GDGAAGAVGISGATGAGDG---------------------------GHGG
Rv3345c|M.tuberculosis_H37Rv        -------------------------------------------YTDGATG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------------------------------------V
MAV_4827|M.avium_104                ------------------------------------------------PS
                                                                                      

MMAR_2656|M.marinum_M               AGGAGGDGGAGGGAGDGGDGANAAAGSGAVGGNGGDGGDPGLGGGGGAGG
MUL_4367|M.ulcerans_Agy99           AGGAGGNGGAGG------------------------------GGGAGASG
Mflv_5091|M.gilvum_PYR-GCK          TGGKGGTGGTGG------------------------------AGGTGGD-
Mvan_1264|M.vanbaalenii_PYR-1       TGGKGGTGGTGG------------------------------DGGTGGT-
MSMEG_0868|M.smegmatis_MC2_155      NGGKGGNGGNGG------------------------------NGGTYVD-
TH_3810|M.thermoresistible__bu      NGSHGGNGGHGG------------------------------RGG-----
Mb3541|M.bovis_AF2122/97            TGGAGGNGGTGG------------------------------AGGSGID-
Rv3345c|M.tuberculosis_H37Rv        TGGDGGNGGDGGKAG---------------------------DGGAGENG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SGAIGGSSHVGG--------------------------------------
MAV_4827|M.avium_104                PPQVGGTVPQSP--------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               TGATTGAHGADGLSPTTGGNGGKGGNGGSGAIG----------------V
MUL_4367|M.ulcerans_Agy99           IGAG-----------VAGGDGGTGGTGGAAGTG----------------G
Mflv_5091|M.gilvum_PYR-GCK          --------------GGTGGTGGTGGTGG----------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------GGTGGTGGTGGTGG----------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------PSHTGAGGNGGNGGAGRIRVNNGTATGTA-------
TH_3810|M.thermoresistible__bu      ----------------FLGIGGSGGWG-----------------------
Mb3541|M.bovis_AF2122/97            --------------GVGGGTGGTGGNGGNGAIGGAGGDAGGSGNSGGNGG
Rv3345c|M.tuberculosis_H37Rv        LNSG--AMLPGGGTVGNPGTGGNGGNGGNAGVG----------------G
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------AINESLGGSGSVGG----------------------
MAV_4827|M.avium_104                --------------PQHQTPPGEGTPPK----------------------
                                                                                      

MMAR_2656|M.marinum_M               AGGAGGAGGDGGLYGDG-------GDGGSGGNGGAGKA----GAAGVSAG
MUL_4367|M.ulcerans_Agy99           AAGTGGTGGAAGAAGSA-------GDGGAGGAGGAGDD----GSAGVVSG
Mflv_5091|M.gilvum_PYR-GCK          TGGTGGTGGAGDGTG---------GTGGTGGTGG--------------QG
Mvan_1264|M.vanbaalenii_PYR-1       TGGTGGTGGAGDGLG---------GTGGTGGTGG--------------FG
MSMEG_0868|M.smegmatis_MC2_155      TGGNGGNGGNGDADG---------HRGGKGGDGGEA------LIRATVIG
TH_3810|M.thermoresistible__bu      --GHGGNGGDTDADG---------GNGGDGGNGG----------------
Mb3541|M.bovis_AF2122/97            TGGKGGNAGAGGAAGSNGGTVGANGTGGDGGNGGAAGAATAGSNGGAGTG
Rv3345c|M.tuberculosis_H37Rv        TGGKAGTGSLTGLDGTDG-ITPNGGNGGNGGNGGKGGTAGNGSGAAGGNG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --STAVGGGAHTGVG-----------GGVSTGVG--------------VG
MAV_4827|M.avium_104                PDGPGNYGGGHVPTP---------GAGGSGGSGG----------------
                                                                                      

MMAR_2656|M.marinum_M               SNGEAGGQAGAGGVGGAGGNGGANAGNGGTGGNGGDGGVGGTGGAGKVGT
MUL_4367|M.ulcerans_Agy99           DPGTAGKAGGAGGAGGVGGNG-----------------------------
Mflv_5091|M.gilvum_PYR-GCK          GQGGQGGTGGTGGQGGLGGGG-----------------------------
Mvan_1264|M.vanbaalenii_PYR-1       GQGGQGGTGGTGGQGGLGGVG-----------------------------
MSMEG_0868|M.smegmatis_MC2_155      SNASGTATGGDGGNGGTLGATNGTGG-------AATIVAYNVVQANPQAS
TH_3810|M.thermoresistible__bu      -------SAGRGGTGGLRGVF-----------------------------
Mb3541|M.bovis_AF2122/97            SAGGNGGTGGRGGSGGAGGDGIGGVG-------GGKGGNGADGEVGGAGG
Rv3345c|M.tuberculosis_H37Rv        GNGGSGLNGGDAGNGGNGGGALNQAG--------FFGTGGKGGNGGNGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SHVGGGISESLGGSGSVGGST-----------------------------
MAV_4827|M.avium_104                ---GHVPTPGAGGSGGSGGGHVP---------------------------
                                                                                      

MMAR_2656|M.marinum_M               TGPAGGAGGEGGDGGKGGTGGRGGNGGAGGTAQAAGYSDGSQGVGGDGGA
MUL_4367|M.ulcerans_Agy99           --VAGGVNGSGGAGGAGGAGGTGGAGASGVPASVD---------GGDGGA
Mflv_5091|M.gilvum_PYR-GCK          --GTGGQGGTGGTGGQGGTGGTGGTGGTG----------GTGGAGGDGGL
Mvan_1264|M.vanbaalenii_PYR-1       --GTGGTGGTGGTGGQGGTGGTGGTGGTG----------GTGGAGGDGGL
MSMEG_0868|M.smegmatis_MC2_155      GTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASG--IGAGGNGGDGID
TH_3810|M.thermoresistible__bu      ----------GINGGNGR--------------------------------
Mb3541|M.bovis_AF2122/97            AGGSGPNTSPGGNGGQGGQGGSGGAGGAAGAGGAGGGANGTAGNGGQGGA
Rv3345c|M.tuberculosis_H37Rv        GMINGGLGGFGGAGGGGAVDVAATTGGAGGNGGAGG--FASTGLGGPGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --AVGGGAHTGVGGGVSTGVGVGSHVGGG----------------ISESL
MAV_4827|M.avium_104                ---TPGTGGPGGTGGSGGGHVPTPGAGTP---------------------
                                                                                      

MMAR_2656|M.marinum_M               GGTGGTAG-----NGGKGGAGTWAVNNGIGGKGGNGGNAGTGGTGGSFGT
MUL_4367|M.ulcerans_Agy99           GGAGGAAG-----TGGSGGS---------------AGNTGAGGAGG----
Mflv_5091|M.gilvum_PYR-GCK          GGLGGF--------GGSGGTGGQGGLGGPGGSTG-----GAGGAGG----
Mvan_1264|M.vanbaalenii_PYR-1       GGLGGF--------GGVGGTGGQGGQGGPGGSTG-----GAGGAGG----
MSMEG_0868|M.smegmatis_MC2_155      GGLGGN--------GGDGVVNTTANAANPGSATGTATGGDGGKATG----
TH_3810|M.thermoresistible__bu      AGLGGR--------GXX----------------------XXGGGVG----
Mb3541|M.bovis_AF2122/97            GGTGGAGAASSATNGGSGGAGGTGGAGGTGGAGGDGVGGAGGGNGG----
Rv3345c|M.tuberculosis_H37Rv        GGPGGAGDFASG-VGGVGGAGGDGGAGGVGGFGGQGGIGGEGRTGG----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GGSGSVG--------------------------------GSTAVGG----
MAV_4827|M.avium_104                -----------------------------------------GGSGG----
                                                                                      

MMAR_2656|M.marinum_M               GSQIGNHGSTGHLGDGGDGGTGGAGVNATAPGQDGAAGGVGGNGGIVGDG
MUL_4367|M.ulcerans_Agy99           ------------------------------------AGGAGG--------
Mflv_5091|M.gilvum_PYR-GCK          ------------------------------------QAGTAGKGG-----
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------QAGVAGKGG-----
MSMEG_0868|M.smegmatis_MC2_155      ------------------------------------TASQGGNGGP----
TH_3810|M.thermoresistible__bu      ------------------------------------AAVRSGNG------
Mb3541|M.bovis_AF2122/97            ------------------------------------HGGDAGDGGNGANG
Rv3345c|M.tuberculosis_H37Rv        ------------------------------------NGGSGGDGG-----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GVGGK------GGDGAAGTTGSSGTASGEAGKDGGDGGKGGAGGAGGNGG
MUL_4367|M.ulcerans_Agy99           ---------------SAASTGVN-----------GDGGAGGAGGVGGLGG
Mflv_5091|M.gilvum_PYR-GCK          -------------LFGGSGSAGKAGATGAAGASGGKGAQGATGAQGATGA
Mvan_1264|M.vanbaalenii_PYR-1       -------------LFGGSGSAGTAGVTGASGASGGKGAQGATGAQGATGA
MSMEG_0868|M.smegmatis_MC2_155      -------------SWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGG
TH_3810|M.thermoresistible__bu      ---------------VFSGGG--------GTPSAGFGVPTT---IQFPAG
Mb3541|M.bovis_AF2122/97            NNRSSGSFLAAGGTGGAAGDGGQGGQGGAGGGAGGQGGAGGAGGTGGNGG
Rv3345c|M.tuberculosis_H37Rv        --------------GGISLGGNGGLGGNGGVSETGFGGAGGNGGYGGPGG
MLBr_01183|M.leprae_Br4923          --------------MPLFLNAEP-----QALTAAANTLEGLSAATVASNA
MAB_4284c|M.abscessus_ATCC_199      --------------GAHTGVGGGVNTGVGVGSHVGGGISESLGGSGSVGG
MAV_4827|M.avium_104                -------------------------------GHLPFPGAGSTPGGSGGGH
                                                                                      

MMAR_2656|M.marinum_M               TSRGDGGAGGAGGTGGVGGSGGDGADGTSGLFGGADGTAGGAGGDGGDGG
MUL_4367|M.ulcerans_Agy99           DSAATAGGGGAGGDGGKGGAGGAGVNGVG-------------GGDGGKGG
Mflv_5091|M.gilvum_PYR-GCK          -QGATGATGAAGKAGATGAAG---AAGAAG-----------SAGTTGAQG
Mvan_1264|M.vanbaalenii_PYR-1       -QGATGATGASGAQGSAGSAG---SAGVAG-----------SAGTTGAQG
MSMEG_0868|M.smegmatis_MC2_155      -NALVMAAGTTGVATGNTATGG--DGGAAT-----------TAGATGGAG
TH_3810|M.thermoresistible__bu      -SCTSRAVSREGIMPSSRAASA--RAGAAC-----------ASSTSRSRR
Mb3541|M.bovis_AF2122/97            -NITGGTAGTAGAAGNGGAAGKGGAGGQGG-----------TGGGTGGQG
Rv3345c|M.tuberculosis_H37Rv        PEGNGGLGGNGGAGGNGGVSTTGGDGGAGG-----------KGGNGGDGG
MLBr_01183|M.leprae_Br4923          AAAQLTTEIAPPAADDVSILLAHFFSGHGR-----------QYQAHASQG
MAB_4284c|M.abscessus_ATCC_199      STAVGGGAHTSAINDALGGSGSVGGSTAVG------------GGAHTSAI
MAV_4827|M.avium_104                LPTPGAGTPGGGLGGFGGGHAPAPGGGLGG------------GGGHAPAP
                                                                                      

MMAR_2656|M.marinum_M               AGGAGGAGGKAVSGVGQNGSQGAGGNGGAAGDGGDGGNGGNGHDGNNGSV
MUL_4367|M.ulcerans_Agy99           TGGAGGAG-------------GAGSDGIIPSNGGLGGNGGNGGNG-----
Mflv_5091|M.gilvum_PYR-GCK          SAGTNGAN------------------GANGSQGAAGKAGATGTTGATG--
Mvan_1264|M.vanbaalenii_PYR-1       SAGTNGAN------------------GANGSQGAAGKAGATGTTGATG--
MSMEG_0868|M.smegmatis_MC2_155      GFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSK
TH_3810|M.thermoresistible__bu      SFCCSRA-------------------------------------------
Mb3541|M.bovis_AF2122/97            GAGGDGGAGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQGGADGGSGG
Rv3345c|M.tuberculosis_H37Rv        NVGLGGDAGSGGAGGNGGIGTDAGGAGGAGGAGGNGGSSKSTTTGNAG--
MLBr_01183|M.leprae_Br4923          ATNHQDLIQ-----------------SLLTSSSAYAGTETANHDSL----
MAB_4284c|M.abscessus_ATCC_199      NESMNSSIN-----------------ASHSSSMNESFGSSMGSHGAAG--
MAV_4827|M.avium_104                GGGLGGFG------------------GGHSGGGLGGLGGGHK--------
                                                                                      

MMAR_2656|M.marinum_M               PSGGTDRDGGDGQGGGDGGAGGAGGAGGNGGAAGAGGGGTRGAGGDGGDG
MUL_4367|M.ulcerans_Agy99           -----------GQAFGDG-VGGAGGIGGKGGNAAIGTIVIN--GGVGGAG
Mflv_5091|M.gilvum_PYR-GCK          ------AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEG
Mvan_1264|M.vanbaalenii_PYR-1       ------AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEG
MSMEG_0868|M.smegmatis_MC2_155      IANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            DGGDAGTGGNGGNGGNRNSGNGTGGAGGNGGGGANGGAGG-AGGSGGGTG
Rv3345c|M.tuberculosis_H37Rv        -------SGGAGGNGGTGLNGAGGAGGAGGNAGVAGVSFGNAVGGDGGNG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------TGFEAQGHAQGHASETAHTTLPGAEHH----------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GNGGFAGDGGLGMDGLDATLTNRAGDGGDGGGGGQA--------------
MUL_4367|M.ulcerans_Agy99           GSGGLGG-------------------ATEDGVGGVG--------------
Mflv_5091|M.gilvum_PYR-GCK          GDGGKGGA------------------GAEGGAGGGG--------------
Mvan_1264|M.vanbaalenii_PYR-1       GAGGAGGD------------------GSEGGAGGSG--------------
MSMEG_0868|M.smegmatis_MC2_155      GNGGNGGD------------------GSEPGPGGNG--------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GNGGAGGD------------------AGDAGNGGNGNGTGNGGNGGNGGI
Rv3345c|M.tuberculosis_H37Rv        GNGGHGGD------------------GTTGGAGGKG--------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               -------------------FAGGAGGAGGTGSTQGSAGTTGAWRAGGDGG
MUL_4367|M.ulcerans_Agy99           -------------------CAGGAGGNGGRG--------DMLFTVGGSGG
Mflv_5091|M.gilvum_PYR-GCK          --------------------GAGGSGAGGAG------------GAGGSGG
Mvan_1264|M.vanbaalenii_PYR-1       --------------------GAGGSGTGGAG------------GAGGSGG
MSMEG_0868|M.smegmatis_MC2_155      --------------------AGGAGGNGGTGGT-----TAGGSGNGGNGG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            AGMGGNGGAGTGSGNGGNGGSGGNGGNAGMGGN-----SGTGSGDGGAGG
Rv3345c|M.tuberculosis_H37Rv        -------------------GNGSSGAASGSGVVN---VTAGHGGNGGNGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               SGGDGGDGFGLWNPGEGGRGGSGGDGGTGGDGGDGGNGRVEIWEGRGGNG
MUL_4367|M.ulcerans_Agy99           TGGDGGG------------GGSASGSGTGGSGGTGG--------------
Mflv_5091|M.gilvum_PYR-GCK          SGGSGGS------------GGSGGAAGDSDD-------------------
Mvan_1264|M.vanbaalenii_PYR-1       SGGSGGA------------GGSGGAAGDSD--------------------
MSMEG_0868|M.smegmatis_MC2_155      NGGNGGA------------DGTPGTAGTTGANNP----------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            NGGAAGT------------GGTGGDGGLTGTGGTGGSGGTGGDGGNGGNG
Rv3345c|M.tuberculosis_H37Rv        NGGNGSAG----------AGGQGGAGGSAGNGGHGGG-------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GNGAI--------------------------------GPGGDGGDGGDAP
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GNGADNTANMTAQAGGDGGNGGDGGFGGGAGAGGGGLTAGANGTGGQGGA
Rv3345c|M.tuberculosis_H37Rv        -------------------------------------ATGGDGGNGGNGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               NQQRVSSSSPGYEGADGGNGGNGTIGGNGGNGGTGGPGYDASLGGEATAG
MUL_4367|M.ulcerans_Agy99           ------------------------VGGIGGDGKLGG------------FG
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GGDGGNGAIGGHGPLTDDPGGNGGTGGNGGTGGTGGAGIGSLGGGTGGDG
Rv3345c|M.tuberculosis_H37Rv        NSGNSTGVAGLAGGAAGAGGNGGGTSSAAGHGGSGGSGGSGTTGGAGAAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GEGGDGGDGGKGFNGAGGAGGDGGAGGAGGSGAPAPFGSGGAYGGTGGQG
MUL_4367|M.ulcerans_Agy99           GDGGDGGDGG--------------------------------FGVIGGQG
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GNGGTGGNGGTGGEGGEVGGAGGTGGAAGNGGDGGTGGTGGGDGGAGGTG
Rv3345c|M.tuberculosis_H37Rv        GNGGAGAGGGSLSTGQSGGPRRQRWCRWQRRRWLGRQRRRRWCRWQRRCR
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               GTGGSGVIGGIGEGGKIGDAGFGGNPPNSQTGEGGSGGAGGAGGAGGDPS
MUL_4367|M.ulcerans_Agy99           GGGGFGGLGGTGAGGAPSDKGINGEPGNPG--------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GTGGTGGLGDPRVGGSGGDGGTGGSGGAAGNGGNGGNAGAGGNGNGGTGG
Rv3345c|M.tuberculosis_H37Rv        RQRWRWRCRQRRLRRQWRQGRRRCRPWLHRRRGRQGRRWRQRRFQQRQRS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               N-------------------------------------------------
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            AGGIGGTGGNGGDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTG
Rv3345c|M.tuberculosis_H37Rv        RWQRR---------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               --------------------------------------------------
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GDGGTGGGGGNGGTGWNGGKGDTGSGGGAGDGGKAPAGGTGGAGGDGGAG
Rv3345c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_2656|M.marinum_M               --------
MUL_4367|M.ulcerans_Agy99           --------
Mflv_5091|M.gilvum_PYR-GCK          --------
Mvan_1264|M.vanbaalenii_PYR-1       --------
MSMEG_0868|M.smegmatis_MC2_155      --------
TH_3810|M.thermoresistible__bu      --------
Mb3541|M.bovis_AF2122/97            GKGGSGGV
Rv3345c|M.tuberculosis_H37Rv        --------
MLBr_01183|M.leprae_Br4923          --------
MAB_4284c|M.abscessus_ATCC_199      --------
MAV_4827|M.avium_104                --------