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MRDVRRTARRLLTILAATLAAAVLFAASAFAAADIVLTFVRHGQSQANADGIINTEVPGPHITALGQQQA ALVAGVLAAGGYQGIYASDMVRTQETAAPLADILGESVTVLPGLREIDAGIYEGSSETDGLGRLGYGLTP ALWTLGLRSAWIPDSTDTNGNVFSDRMSEAVQIIYEDGWARPVAFSHGATIMFWTMMNVDNPDLGLLLSH QLPNTGVVVLEGNPEDGWTLVSWDGVAVDPDPSFLTKTFVNVRELITTPQTAVYNVKKAFATGDLAAITD SFAQAVIDVVLAPVRFVGAVATDVLELVFPPAPSVQVEAPMSAESTTDESDVPADVPDDVVAVAPSEDVE SRTPEPASDEAETREESAAPESEATEPEISASQSEESEVETETTEETTTAGTTGDDDTDETDDGAAVKEA A
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5262 | - | - | 100% (421) | phosphoglycerate mutase |
| M. vanbaalenii PYR-1 | Mvan_2591 | - | 3e-07 | 32.56% (129) | hypothetical protein Mvan_2591 |
| M. vanbaalenii PYR-1 | Mvan_5661 | - | 4e-07 | 28.15% (238) | phosphoglycerate mutase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0776 | PE_PGRS11 | 4e-66 | 50.00% (290) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_4577 | - | 3e-91 | 45.74% (411) | phosphoglycerate mutase |
| M. tuberculosis H37Rv | Rv0754 | PE_PGRS11 | 5e-66 | 50.00% (290) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_00079 | - | 3e-10 | 25.65% (230) | putative phosphoglycerate mutase |
| M. abscessus ATCC 19977 | MAB_0133 | - | 4e-13 | 31.13% (212) | phosphoglycerate mutase |
| M. marinum M | MMAR_4953 | - | 5e-54 | 42.33% (300) | PE-PGRS family protein |
| M. avium 104 | MAV_4778 | - | 6e-51 | 48.45% (258) | pe_pgrs family protein |
| M. smegmatis MC2 155 | MSMEG_6545 | - | 1e-58 | 54.08% (233) | phosphoglycerate mutase family protein |
| M. thermoresistible (build 8) | TH_4040 | - | 7e-69 | 47.89% (284) | PUTATIVE Phosphoglycerate mutase |
| M. ulcerans Agy99 | MUL_0919 | lpqD | 6e-45 | 42.73% (227) | lipoprotein, LpqD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0776|M.bovis_AF2122/97 MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAA
Rv0754|M.tuberculosis_H37Rv MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAA
MMAR_4953|M.marinum_M MSFVLVAPDMLATAAADVVQIGSAVSAGNLAAAIPTTEVMAAAADEVSGA
MAV_4778|M.avium_104 --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK --------------------------------------------------
TH_4040|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 LAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRG
Rv0754|M.tuberculosis_H37Rv LAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRG
MMAR_4953|M.marinum_M IAALFGANAQEYQAAAAQAATFHEQFVRALSEAGASYASAEATIVTGLS-
MAV_4778|M.avium_104 --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK --------------------------------------------------
TH_4040|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 ALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLG
Rv0754|M.tuberculosis_H37Rv ALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLG
MMAR_4953|M.marinum_M ------SAVADGFQTAVYGPIRAAGQAWISSPAGEVVDPVINAPTEALFG
MAV_4778|M.avium_104 ---------------MLRTPLCRAG---------------------AVLA
Mflv_4577|M.gilvum_PYR-GCK -------------MPDPR--TCRVRR-----------------ILIAALS
TH_4040|M.thermoresistible__bu -------------------------------------------VVVAAIS
Mvan_5262|M.vanbaalenii_PYR-1 -------------MRDVRRTARRLLT-----------------ILAATLA
MSMEG_6545|M.smegmatis_MC2_155 --------------MTTHTRRTAAVA-----------------ALVVALV
MUL_0919|M.ulcerans_Agy99 ---------------MAKRSMIWNTS-----------------KVLALLA
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 RDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYT---------GGNGGSAGL
Rv0754|M.tuberculosis_H37Rv RDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYT---------GGNGGSAGL
MMAR_4953|M.marinum_M RGLISNGAAGTAAHPNGGAGGILFGDGGPGYTPTGGIGAVAGGIGGDAGL
MAV_4778|M.avium_104 SVVLLCSASATASAD-----------------------------------
Mflv_4577|M.gilvum_PYR-GCK AVLLVLVS---AIPSW----------------------------------
TH_4040|M.thermoresistible__bu AALLFIVS---AIPAW----------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 AAVLFAAS---AFAAA----------------------------------
MSMEG_6545|M.smegmatis_MC2_155 AGMLTAPN---AVAQR----------------------------------
MUL_0919|M.ulcerans_Agy99 TAMLPGACGGGSPQAR----------------------------------
MLBr_00079|M.leprae_Br4923 ------------MSSR----------------------------------
MAB_0133|M.abscessus_ATCC_1997 -MARRDAGREAAMSGR----------------------------------
Mb0776|M.bovis_AF2122/97 IGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLF
Rv0754|M.tuberculosis_H37Rv IGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLF
MMAR_4953|M.marinum_M IGNGGLGGNGFGGGTGGMGGTGGWLMGNGGGGGVGGVGG---VGGQALFF
MAV_4778|M.avium_104 --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK --------------------------------------------------
TH_4040|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 GNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHG
Rv0754|M.tuberculosis_H37Rv GNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHG
MMAR_4953|M.marinum_M GNGGAGGGSALG------GRAGLFIGEPGTGWVADPGNGQSIVIDFVRHG
MAV_4778|M.avium_104 ---------------------------------------ESIVIDLVRHG
Mflv_4577|M.gilvum_PYR-GCK ----------------------------------------AMTLTFVRHA
TH_4040|M.thermoresistible__bu ----------------------------------------SMTVTFVRHG
Mvan_5262|M.vanbaalenii_PYR-1 ----------------------------------------DIVLTFVRHG
MSMEG_6545|M.smegmatis_MC2_155 ----------------------------------------IITLTLVRHA
MUL_0919|M.ulcerans_Agy99 ----------------------------------------SITLTFIRNA
MLBr_00079|M.leprae_Br4923 -------------------------------------------LVLLRHG
MAB_0133|M.abscessus_ATCC_1997 -------------------------------------------LVLVRHG
: ::*:.
Mb0776|M.bovis_AF2122/97 QTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIR
Rv0754|M.tuberculosis_H37Rv QTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIR
MMAR_4953|M.marinum_M QTASNVAELIDTNVPGPPLTAEGHLQADIIAGQLFAKGPYAGIFDSELLR
MAV_4778|M.avium_104 QSVANAAGLIDTAVPGASLTQLGQQQAQTVAGVLAARGPVAAIFASQLIR
Mflv_4577|M.gilvum_PYR-GCK ESLANEAGIIDTRVPGPGLSEAGELQARAIAPVLAGMG-FDGIYVSSMLR
TH_4040|M.thermoresistible__bu ESQANAAHIIETDIPGRGLTERGHAEAAAVAEILARNG-HDKAYSSPLLR
Mvan_5262|M.vanbaalenii_PYR-1 QSQANADGIINTEVPGPHITALGQQQAALVAGVLAAGG-YQGIYASDMVR
MSMEG_6545|M.smegmatis_MC2_155 QSEGNASGLIDTSTPGPPLTALGREQAETAAQKLAAGHTFDGIYASTMIR
MUL_0919|M.ulcerans_Agy99 QSQADAEGIIATELPGTGLSSDGKDQAQQLTHQFGRSE-FDSIYTSPMEA
MLBr_00079|M.leprae_Br4923 QSYGNVEGRLDTRPPGASLTPFGRDQARVFAQ--AAGRPVLLVHS-VAIR
MAB_0133|M.abscessus_ATCC_1997 QSYGNVERRLDTKPPGAALTELGLQQARLFAKRYEEHAPAVLVHS-VAVR
:: .: : * ** :: * :* : .
Mb0776|M.bovis_AF2122/97 TQQTAAPLANLLGMAPQ-VLPGLNEIHAGIFEDLPQ-ISPAGLLYLVGPI
Rv0754|M.tuberculosis_H37Rv TQQTAAPLANLLGMAPQ-VLPGLNEIHAGIFEDLPQ-ISPAGLLYLVGPI
MMAR_4953|M.marinum_M TQQTAAPLAALYGITDVPALSGLNEISAGIFDGLQQ-ITPAGLLYLIGPM
MAV_4778|M.avium_104 TQQTAAPLASALGMNVQ-VLPGLNEIDAGIFNGQPQ-FSLGGLAYLLAPI
Mflv_4577|M.gilvum_PYR-GCK TQLTAQPMLDLLPGSSYQVLPGLREISAGIFEGSSENEGLGRLGYALAPV
TH_4040|M.thermoresistible__bu TLETARHFAD--DDSEITRLEGMREIPGGWFEGARDDSGLERLLYGLPGI
Mvan_5262|M.vanbaalenii_PYR-1 TQETAAPLAD-ILGESVTVLPGLREIDAGIYEGSSETDGLGRLGYGLTPA
MSMEG_6545|M.smegmatis_MC2_155 TQQTAQPLAD-LSREPVTVLPGLREIEAGIYEGQPE--ALAGFTYYEAPT
MUL_0919|M.ulcerans_Agy99 AQQTAAPLAR-QLSKQAEIVPGLQSIDAGWYNGKPD--SMADRTYMVAPV
MLBr_00079|M.leprae_Br4923 ALETAAVLGAEFDVPIR-EIAGIHEVQVGELENRND--DDAIAEFNAIYD
MAB_0133|M.abscessus_ATCC_1997 AVQTAAGIAEHLGVQAE-QIEGLHEVQAGELEDRTD--LEAFAVFDRTYE
: ** : : *:..: * :. : :
Mb0776|M.bovis_AF2122/97 AWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIY--------------
Rv0754|M.tuberculosis_H37Rv AWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIY--------------
MMAR_4953|M.marinum_M AWTLGYPIVPMLTPGSLDFNGVVFNQDFTHAMDTMY--------------
MAV_4778|M.avium_104 AWMLGLRIVPMLAPGSADANGYEFRRRFDGALQTVYGSAAASAGGFGDVL
Mflv_4577|M.gilvum_PYR-GCK TWMLGAR--FVPVPGGEDGN--AFDARVDGAIAEIADN------------
TH_4040|M.thermoresistible__bu AWALGLR--FIPVLGSEDGN--AFDARVDAALRQIHADY-----------
Mvan_5262|M.vanbaalenii_PYR-1 LWTLGLRSAWIPDSTDTNGN--VFSDRMSEAVQIIYED------------
MSMEG_6545|M.smegmatis_MC2_155 RWLQGDR--TARIPGSIDGD--EFDARFDEAVREIYDS------------
MUL_0919|M.ulcerans_Agy99 SWIDGNV--EASIPGSTSGS--DFNSRFTGAIRKIYDG------------
MLBr_00079|M.leprae_Br4923 RWHHGELDVPLPGGETANDVLDRYLPVLVDLRMRYLDD------------
MAB_0133|M.abscessus_ATCC_1997 RWHFGDLDARMPGGESAQDVFDRYLPAVADLRLRHLEN------------
* * . : .
Mb0776|M.bovis_AF2122/97 ----DASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHP
Rv0754|M.tuberculosis_H37Rv ----DASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHP
MMAR_4953|M.marinum_M ----SAALANPVLAANGKITDVAYSSAFTIGVGTMMNVDNPDPLLLLTHP
MAV_4778|M.avium_104 QAVYAGAVTNPVRAANGRITGVAFSSEFAIGVGTMMTVKNPDPLVLLFDP
Mflv_4577|M.gilvum_PYR-GCK ----------------GDENAVAFAHGATIMFWVMMNVDNPDLLLMLRHQ
TH_4040|M.thermoresistible__bu -------------LAGETQNPVVFGHGGTIMFWTMMNVDNPDLLLMLTHT
Mvan_5262|M.vanbaalenii_PYR-1 ----------------GWARPVAFSHGATIMFWTMMNVDNPDLGLLLSHQ
MSMEG_6545|M.smegmatis_MC2_155 ----------------EDTDPVAFSHAGAIMTWVAMNVDNPDLGLLSRHP
MUL_0919|M.ulcerans_Agy99 ----------------GHNRPVVFSQGTAIMVWTLMNVKNPKTNLLNTHP
MLBr_00079|M.leprae_Br4923 ---------------GDWTGDVVVVSHGAAIRLVSAVLAEVDGRFALENR
MAB_0133|M.abscessus_ATCC_1997 ---------------DASTGDVVIVSHGAAIRLVAAALAGVDPGFAVNRH
*. : . : . .
Mb0776|M.bovis_AF2122/97 VPNTGAVVVQGNPEGGWTLVSWDGIPVGPAS-LPTALFVDVRELITAPQY
Rv0754|M.tuberculosis_H37Rv VPNTGAVVVQGNPEGGWTLVSWDGIPVGPAS-LPTALFVDVRELITAPQY
MMAR_4953|M.marinum_M LPNTGVVEVQGSPANGWTMVSWDGIPVAPAT-LPTQLFVDVRNLITAPQY
MAV_4778|M.avium_104 LPNTGIVVIQGSPRDGWTLISWNGKPVHPG--------------------
Mflv_4577|M.gilvum_PYR-GCK LDNVESVVVEGSPEEGWTLVSWAGQAVSADPSLATKLLVNVRDLVVAPQT
TH_4040|M.thermoresistible__bu LGNTETVVIEGSPDEGWTLVSWAGVEVSRTPSLPTTLFVRTRDLLVAPQT
Mvan_5262|M.vanbaalenii_PYR-1 LPNTGVVVLEGNPEDGWTLVSWDGVAVDPDPSFLTKTFVNVRELITTPQT
MSMEG_6545|M.smegmatis_MC2_155 LGNTGHAVVKGNPTGGWTLVDWGGINTE----------------------
MUL_0919|M.ulcerans_Agy99 LPNIGRVVISGNPATGWKLVDWDGIRNFG---------------------
MLBr_00079|M.leprae_Br4923 VNNAESVVLVPVTDGRWSCVRWGALTPPFY--------------------
MAB_0133|M.abscessus_ATCC_1997 LRNAEAVVLAPVTDGRWSCVHWGDAVAPF---------------------
: * . : . *. : *
Mb0776|M.bovis_AF2122/97 AAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQ------------FPHA
Rv0754|M.tuberculosis_H37Rv AAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQ------------FPHA
MMAR_4953|M.marinum_M AGWDIFYSLFTGNPTTILTAVRDGIEEVGSAVIN------------FPIE
MAV_4778|M.avium_104 -----WSATRNGRGANGLCLMLDPSTRTGVCAAK------------PPGP
Mflv_4577|M.gilvum_PYR-GCK ALYNVGTAFSSGDFETLVNAVRDGLIEVTRAVVRFIPDTVRDIVDEFRPS
TH_4040|M.thermoresistible__bu ALYNLGQALRTGDVVTVVEALRDGILDVVX-----------------XPG
Mvan_5262|M.vanbaalenii_PYR-1 AVYNVKKAFATGDLAAITDSFAQAVIDVVLAPVR------------FVGA
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 ------PHLHRPDSTLVTDVVMSGRDSLG---------------------
MAB_0133|M.abscessus_ATCC_1997 ------PHQEAAS----AEELAQSADPMG---------------------
Mb0776|M.bovis_AF2122/97 VADDVIDATGHPYLSGLPIGLPSLIP------------------------
Rv0754|M.tuberculosis_H37Rv VADDVIDATGHPYLSGLPIGLPSLIP------------------------
MMAR_4953|M.marinum_M VTEDVVNAICG-ATDGLTAGAPSLVG------------------------
MAV_4778|M.avium_104 ASAPVA------ARPGLS--------------------------------
Mflv_4577|M.gilvum_PYR-GCK VTEDSLDVTELHRAVVTAAPQDDDEAEPQSVAVAEAETRNGSGVAPAGST
TH_4040|M.thermoresistible__bu TSPTMMRAATHRR-------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 VATDVLELVFPPAPSVQVEAPMSAESTTDESDVPADVPDDVVAVAPS---
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 --------------------------------------------------
Rv0754|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4953|M.marinum_M --------------------------------------------------
MAV_4778|M.avium_104 --------------------------------------------------
Mflv_4577|M.gilvum_PYR-GCK PPSGDEVTGSTDDDEATASDVVLEDTVDVDTIDVDTVEEDTGASDHAVGN
TH_4040|M.thermoresistible__bu --------------------------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 -----EDVESRTPEPASDEAETREESAAPESEATEPEISASQSEESEVET
MSMEG_6545|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0919|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00079|M.leprae_Br4923 --------------------------------------------------
MAB_0133|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0776|M.bovis_AF2122/97 -----------------------------------
Rv0754|M.tuberculosis_H37Rv -----------------------------------
MMAR_4953|M.marinum_M -----------------------------------
MAV_4778|M.avium_104 -----------------------------------
Mflv_4577|M.gilvum_PYR-GCK HPDAEADDAAPANGSAKSSDDDGDSDDDASERAAA
TH_4040|M.thermoresistible__bu -----------------------------------
Mvan_5262|M.vanbaalenii_PYR-1 ETTEETTTAG-----TTGDDDTDETDDGAAVKEAA
MSMEG_6545|M.smegmatis_MC2_155 -----------------------------------
MUL_0919|M.ulcerans_Agy99 -----------------------------------
MLBr_00079|M.leprae_Br4923 -----------------------------------
MAB_0133|M.abscessus_ATCC_1997 -----------------------------------