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QHRGCKNRGQAYDASVTDSLTEVPPAARRALLELANAPTVPVKVLITGGIGTGKTTVLAAARDTLRRSGL TVLACPPPDGEPPETALVIDDAQLLTDTELLRLTERVADSRLTVVAAAEAREHHRALRALTMALERDRPR ISLGPLPVAEHLRDCTAGLPFLIHAVSARAQAPAQAAKVALIERLRRLDEPTLDTLLMMSLTHELGVSDV AAALGISVTDARGLVDRAHASGLIESSHTAAFLQSVHDAIAQIVGNAHHHEVETSLLRSQLDISPVSAEL ALRLAEHGLRDERLADILTRYAADTRDASVRCARLYRAAVHAGAKGLTVRLADALARTGDCTAAATLADD LLSSPDATERAAAVRVAASVAVHDGNTGHAAELFGWLGPHPDTMVSSAATIVFAANGDLATARATLRLKD AGPPTMAARCARNLAEGLLLTMDQPYPVAMAKLGQAIATEQSLSQVIPDSPAALVTLAAIHAGDPVRARS VIGRAVRAGADPLFQRRHLLLSGWIKMQEGQLPSASADVAAASAGTHLHRRDALWAAALQTAISRRTGDI GALQQHWYAAMEALAEYSLDLFALLPLGELWVAAARMRQVDQLQHTLDQALTLLDSLGNPALWSNSLHWA GVHAGILANSPESVAPHGQALGAMVAHSTLAQALSDAGRTWLRVLAENVDADEVTAAARSLSHVGLTSDA TRLAGQAALQTSDARVSGAMLQLARDLKLGNDFGEPPSGAGDTEPASGTPPAPRQPPAGSPLSDREREVA ELLLLGMPYRDIGARLFISAKTVEHHVARIRQRLGAGSRSEMLSMLRAMLAPESLTADERR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0339c | - | - | 100% (832) | POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. tuberculosis H37Rv | Rv0890c | - | 5e-06 | 24.55% (501) | LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2488c | - | 6e-05 | 38.71% (62) | LuxR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0346c | - | 0.0 | 100.00% (832) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0277 | - | 0.0 | 55.89% (832) | response regulator receiver protein |
| M. leprae Br4923 | MLBr_01753 | - | 2e-05 | 37.70% (61) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4292 | - | 0.0 | 47.14% (804) | LuxR family transcriptional regulator |
| M. marinum M | MMAR_0612 | - | 0.0 | 73.76% (808) | transcriptional regulatory protein |
| M. avium 104 | MAV_0578 | - | 2e-16 | 27.89% (588) | transcriptional regulator, LuxR family protein |
| M. smegmatis MC2 155 | MSMEG_0691 | - | 0.0 | 59.40% (830) | putative transcriptional regulatory protein |
| M. thermoresistible (build 8) | TH_4413 | - | 1e-13 | 24.92% (662) | PUTATIVE putative response regulator receiver protein |
| M. ulcerans Agy99 | MUL_2555 | - | 3e-05 | 34.57% (81) | hypothetical protein MUL_2555 |
| M. vanbaalenii PYR-1 | Mvan_0620 | - | 0.0 | 58.67% (830) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0339c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0346c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0612|M.marinum_M --------------------------------------------------
Mflv_0277|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0620|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0691|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4292|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0578|M.avium_104 ----------------------------------MIGGELLIGRDSELAA
TH_4413|M.thermoresistible__bu --------------------------------------------------
MLBr_01753|M.leprae_Br4923 MYSLGEMQKPVPVGADYLASCLVARLRSTDVPTDLHRGCTVTLFLGDVEG
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
Rv0339c|M.tuberculosis_H37Rv -MQHRGCKNRGQAYDASVTDSLTEVPPAARRALLELANAPTVPVKVLITG
Mb0346c|M.bovis_AF2122/97 -MQHRGCKNRGQAYDASVTDSLTEVPPAARRALLELANAPTVPVKVLITG
MMAR_0612|M.marinum_M --MSEGHASRD---DTSAPPDSAAVPAPARGLIDELASGGATSVKALIGG
Mflv_0277|M.gilvum_PYR-GCK ------------------------MLPAAREAIAAVDADPRAATKSLVTG
Mvan_0620|M.vanbaalenii_PYR-1 -------------MTTPAAPRLSDLPPAAREAVAAMEADPHAPVKLVVVG
MSMEG_0691|M.smegmatis_MC2_155 -------------MANPAPEHAVDLPRAVQEMLAGVPSRP---AKLLVSG
MAB_4292|M.abscessus_ATCC_1997 -----------------MSGTFDGIASAITAITGPLSAGH--AVKVLVNG
MAV_0578|M.avium_104 IRRALNGADHHRGVVIAGAAGVGKTWLARAALRRAGASGEQIKWIVGTQS
TH_4413|M.thermoresistible__bu --------------------------------------------------
MLBr_01753|M.leprae_Br4923 LAELSETQPDEAADAIARLDCVVSEAVAAHGGVQQVVQGVRGNFLATFAR
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
Rv0339c|M.tuberculosis_H37Rv GIGTGKTTVLAAARDTLRRSGLTVLACPPPDGEPPE---TALVIDDAQLL
Mb0346c|M.bovis_AF2122/97 GIGTGKTTVLAAARDTLRRSGLTVLACPPPDGEPPE---TALVIDDAQLL
MMAR_0612|M.marinum_M GIGTGKTTVLGTVRDALRRAGVTVRAHPTKDCDPSE---VALVVDDAHLL
Mflv_0277|M.gilvum_PYR-GCK GIGTGKTTLLAAMRTTFRSAGRQVLSRPPDAGTPGDGAGYALVVDDAHLL
Mvan_0620|M.vanbaalenii_PYR-1 GAGSGKSTVLTAVRAVLRASDRPVRSRPRGGETAED---TVTVVDDAHLL
MSMEG_0691|M.smegmatis_MC2_155 GIGTGKSTVLAAVRATLREAGRTVLTRPP---RPDDDQGAVFVIDDAHHL
MAB_4292|M.abscessus_ATCC_1997 TAGSGKTFVLSRIREALGSAGTPAVNHVPEAAPGPN--TGPFVIDDADSL
MAV_0578|M.avium_104 AQALPLGAFIGLLGDAMSEPLTSVRRVIETFVARQRRGRVVVGVDDAHLL
TH_4413|M.thermoresistible__bu --------------------------------------------------
MLBr_01753|M.leprae_Br4923 ASDATACALDLQLAPIVPVRFRIALHTGEVQISNDDVNNVVFMMVQAAGL
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
Rv0339c|M.tuberculosis_H37Rv TDTELLRLTERVADSRLTVVAAAEAREHHR---------------ALRAL
Mb0346c|M.bovis_AF2122/97 TDTELLRLTERVADSRLTVVAAAEAREHHR---------------ALRAL
MMAR_0612|M.marinum_M AEDELLRLAEWVADPRATVVVGAQLHQQHH---------------ALRAL
Mflv_0277|M.gilvum_PYR-GCK GDDDLDRLTDLAGDPASTVVIATQALMHRS---------------RLQVL
Mvan_0620|M.vanbaalenii_PYR-1 DRAELDQLTELVTDPTAGVVIATEPLAHHG---------------PLREL
MSMEG_0691|M.smegmatis_MC2_155 ADDEIDCLTERSTDPSSTVVVAAEPLAHRP---------------VLRAL
MAB_4292|M.abscessus_ATCC_1997 TDRQLETLRAVVENDPAAIIVVAAAPRRNP---------------ALRSL
MAV_0578|M.avium_104 DGLSALVVHQLAQSGGVRLVVTVRTGSHQPDAVTALWKDDLLTRLDLEPL
TH_4413|M.thermoresistible__bu --------------------------------------------------
MLBr_01753|M.leprae_Br4923 LDLACGGQTVLSSITGDLVVDGLPADTWLVDLGSHLLRDLARPVRVMQLC
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
Rv0339c|M.tuberculosis_H37Rv TMALERDRPRISLGPLPVAEH-----------------------------
Mb0346c|M.bovis_AF2122/97 TMALERDRPRISLGPLPVAEH-----------------------------
MMAR_0612|M.marinum_M ATAIERERPQISLGPLPVADQ-----------------------------
Mflv_0277|M.gilvum_PYR-GCK MTVLARENPEVALRPLTAAQVQEAATSALG-----------ASVGPELTR
Mvan_0620|M.vanbaalenii_PYR-1 VTALEREHAAVALGPLPPVEVSRIAAAALG-----------LPAAPELVR
MSMEG_0691|M.smegmatis_MC2_155 ATALERENPIVALGPMSTAEVGRLLTATLG-----------SPPPPDTVR
MAB_4292|M.abscessus_ATCC_1997 FQALERESPAITLGPVNATDIGRMS-----------------PLAAPFAE
MAV_0578|M.avium_104 SAAATREVIESTLGGPVDARCAARFRRLTG-----------GNTLFLRQL
TH_4413|M.thermoresistible__bu -------VVRRSGG------------------------------------
MLBr_01753|M.leprae_Br4923 HRNLRRNLHELGIRTVPGGPSLPVPLTTFVGRAAQIKELQELLTEKRLLT
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
Rv0339c|M.tuberculosis_H37Rv -LRDCTAGLPFLIHAVSARAQA----------------------------
Mb0346c|M.bovis_AF2122/97 -LRDCTAGLPFLIHAVSARAQA----------------------------
MMAR_0612|M.marinum_M -LRDSTAGVPFLVEAVSRGTGS----------------------------
Mflv_0277|M.gilvum_PYR-GCK LLVSVTGGFPFLVSAALSAIPDG---------------------------
Mvan_0620|M.vanbaalenii_PYR-1 ALLSATAGLPFLLRPALAAAGDG---------------------------
MSMEG_0691|M.smegmatis_MC2_155 AVLAVTAGLPFLVRAVATSAAE----------------------------
MAB_4292|M.abscessus_ATCC_1997 QIAAASGGVLALTAAAVERLGDPDP-------------------------
MAV_0578|M.avium_104 LSDQMAAGRMRRVAGVWMWDGDV---------------------------
TH_4413|M.thermoresistible__bu --------------------------------------------------
MLBr_01753|M.leprae_Br4923 LVGPGGVGKTRLALQVVARVADEFSGELSYFDLAPDTDHDIFPITVLDNL
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
Rv0339c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0346c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0612|M.marinum_M --------------------------------------------------
Mflv_0277|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0620|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0691|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4292|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0578|M.avium_104 --------------------------------------------------
TH_4413|M.thermoresistible__bu --------------------------------------------------
MLBr_01753|M.leprae_Br4923 RRCIGDRRMLMVLDNCEYLLDVCANVMTTLLGACPSLTILATSREPIGVA
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
Rv0339c|M.tuberculosis_H37Rv ------------------------PAQAAKVALIERLRRLDEPTLDTLLM
Mb0346c|M.bovis_AF2122/97 ------------------------PAQAAKVALIERLRRLDEPTLDTLLM
MMAR_0612|M.marinum_M ------------------------PVPAARFALIERLRRLDEPTLDALLI
Mflv_0277|M.gilvum_PYR-GCK ---------------------AQSARQAAHFALIERLARLDGHLLDTLLV
Mvan_0620|M.vanbaalenii_PYR-1 ---------------------VASMRQAARFGLIERLRGFDERLLDTLLV
MSMEG_0691|M.smegmatis_MC2_155 ------------------------PEEAARYALIERVRHLGEQTRDTLLL
MAB_4292|M.abscessus_ATCC_1997 ---------------------LQSALRAIDTRVDELLRRLSPMAQAAVLL
MAV_0578|M.avium_104 -----------------------AVSASLSDTVGRQLGRLTPPLALVVDT
TH_4413|M.thermoresistible__bu -------------------------APGLIALIEERIGLLAEPVGDVVDI
MLBr_01753|M.leprae_Br4923 GEVIWRVSMLSPADEAVELFTERAALVQPGFSVTDGNRQIVTEICQRLDG
MUL_2555|M.ulcerans_Agy99 ----------------------MPALSANLVASIDRHPERITLRCDDLQS
:
Rv0339c|M.tuberculosis_H37Rv MSLTHELGV------------SDVAAALGISVTDARGLVDRAHASGLIES
Mb0346c|M.bovis_AF2122/97 MSLTHELGV------------SDVAAALGISVTDARGLVDRAHASGLIES
MMAR_0612|M.marinum_M MSLTQESGT------------TDVAAALGVSTSDARQLVDRVHASGLVEP
Mflv_0277|M.gilvum_PYR-GCK MTLSPGLGP------------DDVAAALRIPADEAVAAVDSARATALIDP
Mvan_0620|M.vanbaalenii_PYR-1 SSLSFDLGP------------DDVAAALRLSSQEALTAVDRARASGLIEP
MSMEG_0691|M.smegmatis_MC2_155 TSLSLDLGP------------DDVAGALRVSGTDASVLVDRARAGGLVEP
MAB_4292|M.abscessus_ATCC_1997 MSLNPGIGA------------SDVAAALALP--DAADLVDEALASGLIAG
MAV_0578|M.avium_104 LSQCEPLPVD---------LLCDLASREDLVAAEAMGLVTVERTPRALMA
TH_4413|M.thermoresistible__bu LAVGEPVDLG---------LLTRLTDPAAVEEADVRGLIAIEDGDRALVR
MLBr_01753|M.leprae_Br4923 MPLAIELAAARIRTLSLTEIADGLDDRFRLLTGGARTAVRRQQTLRASMD
MUL_2555|M.ulcerans_Agy99 VFAELGAGPG-----------DRVAALPGDRTRRRVCGPACELSGGRFRP
:
Rv0339c|M.tuberculosis_H37Rv SHTAAFLQSVHDAIAQIVGNAHHHEVETSLLRSQLDIS---------PVS
Mb0346c|M.bovis_AF2122/97 SHTAAFLQSVHDAIAQIVGNAHHHEVETSLLRSQLDIS---------PVS
MMAR_0612|M.marinum_M SHPPAFVQLVHEAVVHIVGNTHHHEVETSLLRSQLDIS---------PMS
Mflv_0277|M.gilvum_PYR-GCK AHTSQFLAAVHDGIAQIVGAARHHDVEMAVLDSQLALC---------TLT
Mvan_0620|M.vanbaalenii_PYR-1 AHPLAFQRTLHDAVAQVVGAARHHDIEVSVLLSQLELS---------TLT
MSMEG_0691|M.smegmatis_MC2_155 AYDKRFLRLVHTSVAQIAGTSRHHDIEIALLHSQLEKA---------TLS
MAB_4292|M.abscessus_ATCC_1997 PGHVAFAARVHGCAARLLGAARHLDLERSLLRTQLEMG---------SVS
MAV_0578|M.avium_104 RLAHPLFGELRRAGAGEMYLSTIRGRLATRLAQDQDAD--------MQAT
TH_4413|M.thermoresistible__bu -LAHPLYGEVRRRRAAVTRLRRLRGLVADELAQAADADD-------LAQV
MLBr_01753|M.leprae_Br4923 WSYALLTESERALFRRLSAISGTFDLKVAYAVGHDDLEEPDQVFDRLTML
MUL_2555|M.ulcerans_Agy99 SARPQSCPGLTEAASPGRSRGPLHLARCAAELTIRRGD--------ACQA
Rv0339c|M.tuberculosis_H37Rv AELALRLAEHGLRDERL--ADILTRYAADTRDASVRCARLYR-AAVHAGA
Mb0346c|M.bovis_AF2122/97 AELALRLAEHGLRDERL--ADILTRYAADTRDASVRCARLYR-AAVHAGA
MMAR_0612|M.marinum_M QDLALRLAEHGLHGERL--ATALAGYASAARGEPAQTARLYR-AAVAAGA
Mflv_0277|M.gilvum_PYR-GCK ADLALRIADHGVRDDRL--ATALTDFAARVPDRPARAARLYR-AATDAGT
Mvan_0620|M.vanbaalenii_PYR-1 ADLALRLAEHGLRDERL--ATALTDLAGRTRGHPARAARLYR-AAAEAGA
MSMEG_0691|M.smegmatis_MC2_155 PELAVRLAEHGVRDDRL--AAALTDHAVQVRGQPARAARLYR-AAARAGS
MAB_4292|M.abscessus_ATCC_1997 ADLALALVGHGLRDLEV--ARLLSNWATTESD-PLSAADLYR-AALTAGA
MAV_0578|M.avium_104 VRRALLTLESDLDPQPE--LYLESARHAMTLLDLDLADRLAN-AAARAGA
TH_4413|M.thermoresistible__bu VRRTTLLLDSDRRPDVD--LFVRAARGAARIGDLPLAERLSG-AAVRAGA
MLBr_01753|M.leprae_Br4923 IDKSLVIVEGRQGGSRYR-LLETVRQYAMKKLEESNEVDLVL-ARHRDHY
MUL_2555|M.ulcerans_Agy99 IELLRRAGELSDRPRRREQLLASAAFVALQAAQLDEAERLLADAGLGGGA
* *
Rv0339c|M.tuberculosis_H37Rv KG--LTVRLADALARTGDCTAAATLADDLLSS----PDATERAAAVRVAA
Mb0346c|M.bovis_AF2122/97 KG--LTVRLADALARTGDCTAAATLADDLLSS----PDATERAAAVRVAA
MMAR_0612|M.marinum_M TG--LKSQLADALARTGDCAGAAELADELLGS----ADSAQRAAAVRIAA
Mflv_0277|M.gilvum_PYR-GCK TA--VRPALADALVLTGDCVTAGRLADDLLTS----QDPDERAAAVRIAA
Mvan_0620|M.vanbaalenii_PYR-1 SA--PGVRLADALALTGDCGTAGRLADDLLTA----PDPAERAAAVRIAA
MSMEG_0691|M.smegmatis_MC2_155 AA--LNARLADALALSGDCATAGRMADDLLSS----DDPAERAAAVRIAA
MAB_4292|M.abscessus_ATCC_1997 EPDPIRVPLAESLARAGDLAAAAAQADEVLAS----TDPAQRTAGVRVAA
MAV_0578|M.avium_104 P--GAAGVRAMNLVLLGRGEQAEEALRAITDGADG-DASDRHYWATVRAA
TH_4413|M.thermoresistible__bu TV-EAAIVHARALTWLGRGDQAETVLAAI-------DVADHTRLAFMRAS
MLBr_01753|M.leprae_Br4923 MALGALLDTPGDIDHEQLVEQVETELDNLRSAFAWSRETGDIAGALQLAS
MUL_2555|M.ulcerans_Agy99 SASALLISSFISLYRYGDVTATHRRLVERLQS-----ADDLDGETLTRMV
: .
Rv0339c|M.tuberculosis_H37Rv SVAVHDGNTGHAAELFGWLGPHPDTMVSSAATIVFAANGDLATARATLRL
Mb0346c|M.bovis_AF2122/97 SVAVHDGNTGHAAELFGWLGPHPDTMVSSAATIVFAANGDLATARATLRL
MMAR_0612|M.marinum_M SVAAHEGNAGQAAELFGWLGPYPDAVVGSSAAIVLAAVGDLQTARAALDV
Mflv_0277|M.gilvum_PYR-GCK SIALHDGAARQAADLFAWLGPAPDAVVGAAETIAALAVGDAAAVRSTAQG
Mvan_0620|M.vanbaalenii_PYR-1 SVALHDGGAEQAHSLFEWLGPVPDTVVAAAATIAAVAAGDAAAARSTAQM
MSMEG_0691|M.smegmatis_MC2_155 SIAMHDGSAAQAADLFRWLGPYPDAAVGSAGTVALLAAGDAEAARAALNT
MAB_4292|M.abscessus_ATCC_1997 AIACHNGDSGQAAALYSWLGADMDGLTALSASPVFVGTGQLAKGRKSLED
MAV_0578|M.avium_104 NLVWMLGRPADAALVLDGLAARPETPAQAAARCAVQACLDAVAARCQLAA
TH_4413|M.thermoresistible__bu NMLWALSDPEGAKRLIGQAAAG--MPADQRAHLDAFCAVHAAAMGQPDEV
MLBr_01753|M.leprae_Br4923 SLQPIWFGRGHMYEGLAWFDSIFEHKNIEHLVAPKEVLARAVANKVMLHA
MUL_2555|M.ulcerans_Agy99 NLLLAVSMFAADPALWQITDGLVDSLADRLGELSVIYRDAWADAARRGRT
:
Rv0339c|M.tuberculosis_H37Rv KDAGPPTMAARCARNLAEGLLLTMDQPYPVAMAKLGQAIATEQSLSQVIP
Mb0346c|M.bovis_AF2122/97 KDAGPPTMAARCARNLAEGLLLTMDQPYPVAMAKLGQAIATEQSLSQVIP
MMAR_0612|M.marinum_M KDTGPPTMAARAARGLADGLLLTMGQPYPVAMAKLGQAIAAEQPITEATP
Mflv_0277|M.gilvum_PYR-GCK PPSGPPTAVARSARAITEGLVMTLDQPYPAAIARLSQAIAVDAVHG-VLP
Mvan_0620|M.vanbaalenii_PYR-1 PAPGPPTSTARAASGLAAGLVMTLDQPYPAAVARLSQALGTDLGQAMALP
MSMEG_0691|M.smegmatis_MC2_155 ELSGPPTSAARAARSLAEGLVASLDQPFTTTVARLGQAVTADPHTDSVGP
MAB_4292|M.abscessus_ATCC_1997 NVGAPPTTSATAQRNAALGVIASVEGRGQEALSLLGQAVTQQPSTSSFIP
MAV_0578|M.avium_104 ERARAALDSESLPD--FHAMMASLALIMAMGALGQVDDLTAVAEQALRRA
TH_4413|M.thermoresistible__bu FRHAGAVVVDELPG--IIGAETAWALTLAAGEAGRTAEAVAAADTGYRLT
MLBr_01753|M.leprae_Br4923 ILASSPPDGSDLVTQAQQALTMAREIGDSAVLARALTACGFSSGYDTEVA
MUL_2555|M.ulcerans_Agy99 VTQRLKEQLDRLAELEPWDVMRVALAGYYVDLIDDFRSVLVPLADREIEG
Rv0339c|M.tuberculosis_H37Rv DSPAALVTLAAIHAGD-----PVRARSVIGRAVRAG--------------
Mb0346c|M.bovis_AF2122/97 DSPAALVTLAAIHAGD-----PVRARSVIGRAVRAG--------------
MMAR_0612|M.marinum_M DSPAALVTLAAIHGGD-----PVRARSVIGRAVRSG--------------
Mflv_0277|M.gilvum_PYR-GCK DTPAALVTLAALHGGD-----PVRARSVIGRAVLADSRPD--------RA
Mvan_0620|M.vanbaalenii_PYR-1 DTPAALVTLAALHGGD-----PVRARSVVGRAVHTDGQRE--------SE
MSMEG_0691|M.smegmatis_MC2_155 DTPAALVALAALHGGD-----SVRARSVIGRAVRTGAPGA--------EN
MAB_4292|M.abscessus_ATCC_1997 DSTVALAALTMLHSGD-----TARARSILTGAIRADR-------------
MAV_0578|M.avium_104 TTSFEASHMRFWFGAV-----YGRACRLTGRIDEFVS-------------
TH_4413|M.thermoresistible__bu ARFSDAAYTRFTLTDA-----HVTALILAGRIAAAVD-------------
MLBr_01753|M.leprae_Br4923 RPYFAEAVELARTQGDKWTLSQIRLWGVVGFCVSGDPVALRAAAEAADDL
MUL_2555|M.ulcerans_Agy99 GAATIALATLALVAAY-----QLASGQWAEAVDTSQR-------------
Rv0339c|M.tuberculosis_H37Rv ----ADPLFQRRHLLLSGWIKMQEGQLPSASADVAAASAGTHLHRRDALW
Mb0346c|M.bovis_AF2122/97 ----ADPLFQRRHLLLSGWIKMQEGQLPSASADVAAASAGTHLHRRDALW
MMAR_0612|M.marinum_M ----TDQVFHQRHLLLSGWIKMQEGQLPSASADVAAACSGAPMHRRDALW
Mflv_0277|M.gilvum_PYR-GCK ----DATFVTSRHRLLQGWAYMQDGQLAAAAAAIPAD-GDPRLHRRDALW
Mvan_0620|M.vanbaalenii_PYR-1 ----DATFVTRRHRLLQGWAYMQDGQLHAASAAVRAA-GDPGPHRRDALW
MSMEG_0691|M.smegmatis_MC2_155 GTPPPAPFWAARHRLLLGWVKMLDGQLTAAGADVSAVESGPPLHRRDALW
MAB_4292|M.abscessus_ATCC_1997 ----RHDVFGVRHRLLAAWIAMLSGDLSGAVQWLPGA--QVELSRRDRLF
MAV_0578|M.avium_104 ----TARRLADSARDVPGLAYANLALLLGNAELARGAAAEAARLVQEALA
TH_4413|M.thermoresistible__bu ----TATVLDRQVGDLPGGTALLARGVAGRAALAAGRLDDAVAWLRDVVS
MLBr_01753|M.leprae_Br4923 AQEIGDRFVSLQCRLLLSIAQLWQGDMDGAIVRSGEVVAGAEAAHDTVTR
MUL_2555|M.ulcerans_Agy99 ----GVALCSQHHYELFGYQLR--GYLGVISACRGDVVRARELAAQVRVW
: . :
Rv0339c|M.tuberculosis_H37Rv AAALQTAISRRTGDIGALQQHWYAAMEALAEYSLDLFALLPLGELWVAAA
Mb0346c|M.bovis_AF2122/97 AAALQTAISRRTGDIGALQQHWYAAMEALAEYSLDLFALLPLGELWVAAA
MMAR_0612|M.marinum_M AAALETAIARRSGDAGALQKHWNAAMEVLGEYSLDLFALLPLGELWVAAA
Mflv_0277|M.gilvum_PYR-GCK AAALHTGIARRSGDTGAMQMHWRSAMDVLAESSADLFTVLPLGELWIAAS
Mvan_0620|M.vanbaalenii_PYR-1 AAALQTAVARRSGDSGAMQKHWYSAMEVLAEYSIDVFTVLPLGELWVAAA
MSMEG_0691|M.smegmatis_MC2_155 AAALRTAIARRSGDSGAIQRHWFAAMEVLAEYSIDLYSLLPLGELWVAAA
MAB_4292|M.abscessus_ATCC_1997 AESLRTGIARRHGDTGPLRQHWQASMDALSAYSIDLYTLLPVGELWVAAA
MAV_0578|M.avium_104 GAQIHEVTSGLRPASY---FALAEAHGRLGHPAQANEAIAGARSCVPPDF
TH_4413|M.thermoresistible__bu VLFSADTAGGFYGFGYRYQHPYATALAVLGHTAAAATALATLDEREFPSW
MLBr_01753|M.leprae_Br4923 TFGLYVQTRALVHRDVSAALVTAGLVVEAAAELSGVYQGIGYAAMVFAAL
MUL_2555|M.ulcerans_Agy99 AEPRR--VGFLTGAVAQIAILCSFAEGDYESAYLQATAITAPGEFPPLAL
Rv0339c|M.tuberculosis_H37Rv RMRQVDQLQHTLDQALTLLDSLGNPALWSNSLHWAGVHAG-------ILA
Mb0346c|M.bovis_AF2122/97 RMRQVDQLQHTLDQALTLLDSLGNPALWSNSLHWAGVHAG-------ILA
MMAR_0612|M.marinum_M RNRQVDQLQHTLDQAFSLLNSLGNPVLWSNSLHWAGVHAG-------ILA
Mflv_0277|M.gilvum_PYR-GCK RLRQVDQVRHSLDEVFGLLAALGDPLLWSIPLHWAGVHAG-------ILA
Mvan_0620|M.vanbaalenii_PYR-1 RMRQVERLRHTLDEVFAMLVGLGDPVLWAVPLHWAGVHAG-------ILA
MSMEG_0691|M.smegmatis_MC2_155 RMRRIDRLEHPLAEAFGLLDALGKPVLWSMPLHWAGVHAG-------ILA
MAB_4292|M.abscessus_ATCC_1997 RLRTLDVMTHHLDRAFAVLAHLGDPIAWSAPLRWAGVHAA-------ILT
MAV_0578|M.avium_104 LF-----MHTGLALATGWALAAGGQLREAVATAQAAARLA-------RDR
TH_4413|M.thermoresistible__bu RY-----LDHERTIALAWLRAAQGAVSTSIQRLRAEAESA-------RTA
MLBr_01753|M.leprae_Br4923 AMGDVAAAVEASEACRPHLGADHGLVAIHLELMAAVALARGDVIVARRLA
MUL_2555|M.ulcerans_Agy99 HATRTLFDLVEAAVHTDRLNEARRHVRAAKRLQFADAPPR----------
* .
Rv0339c|M.tuberculosis_H37Rv NSPESVAPHGQALGAMVAHSTLAQALSDAGRTWLRVLAENVDADEVTAAA
Mb0346c|M.bovis_AF2122/97 NSPESVAPHGQALGAMVAHSTLAQALSDAGRTWLRVLAENVDADEVTAAA
MMAR_0612|M.marinum_M NSPGAVAPHGQALGAAAAGNALAHALSVAGRTWLRVLADQVDVDEVTVAA
Mflv_0277|M.gilvum_PYR-GCK NSPDAVAPHGAALTAAAPHAQFAKALAAAGRTWLRVLADRVDVAEVTAAA
Mvan_0620|M.vanbaalenii_PYR-1 NSPDSVAPHGQALTAAAPHSSFARALAAAGRTWLKVLANQVDADEVSSAA
MSMEG_0691|M.smegmatis_MC2_155 NSPGAVAPHGQALTAAAGHSPFARALAGAGRTWLRVLANHVDVDEVAAAA
MAB_4292|M.abscessus_ATCC_1997 NSPETLAPHGQALAAGAGSSTYARILATAGRTWLRVLANHVDGEEVDSAA
MAV_0578|M.avium_104 GQPTHELACIQAAAQWGDAAGAVRARALADALSLPLADAIACHAEALRAG
TH_4413|M.thermoresistible__bu GRFAVELLCLQTAVQFGDRTCGPRLHQLEDRVDGPRVAVAARFADALHTG
MLBr_01753|M.leprae_Br4923 DNSVSATTGWHQMAALTTRARIAMAQGEPELARADIHAALACGADIQASL
MUL_2555|M.ulcerans_Agy99 LAIATGAAEALCASDERAPALFEKVLGHPAVASFPFEHARIRLAYGMRLR
Rv0339c|M.tuberculosis_H37Rv --------------------RSLSHVGLTSDATRLAGQAALQTSDARVSG
Mb0346c|M.bovis_AF2122/97 --------------------RSLSHVGLTSDATRLAGQAALQTSDARVSG
MMAR_0612|M.marinum_M --------------------RSLSGVGLTSDATRLAGQAALQTADARVSG
Mflv_0277|M.gilvum_PYR-GCK --------------------RGLALHGHTWDATRLAGQAALQTTDSRAAQ
Mvan_0620|M.vanbaalenii_PYR-1 --------------------RGLAQYGHTWDATRLAGQAALQTTDPRVSQ
MSMEG_0691|M.smegmatis_MC2_155 --------------------RGLAQFGLTWDATRLASQAALQTSDARVSQ
MAB_4292|M.abscessus_ATCC_1997 --------------------RMLADTGLGWDATRLASQAALHANDPKVAA
MAV_0578|M.avium_104 --------------------NGEALLTVAAAYRAIG--DAAAAADAAAQA
TH_4413|M.thermoresistible__bu --------------------DGSGLRSIADEFEDMG--DMVAAADAAAHA
MLBr_01753|M.leprae_Br4923 GISDSMELLAELISQGDNHRQAGRLFGAASAQREKTGEVRFKVWDAGYES
MUL_2555|M.ulcerans_Agy99 --------------------RLRRYRNARVVLRAAAEIFAGLGAEPWTQR
:.
Rv0339c|M.tuberculosis_H37Rv AMLQLA-----RDLKLGNDFGEPPSGAGDTEPASGTPPAPRQPPAGSP-L
Mb0346c|M.bovis_AF2122/97 AMLQLA-----RDLKLGNDFGEPPSGAGDTEPASGTPPAPRQPPAGSP-L
MMAR_0612|M.marinum_M AMLQLA-----RDLKLASGFDEPT----DAEPVAGAAPAPRQPPAGSP-L
Mflv_0277|M.gilvum_PYR-GCK AMLQLA-----RDLKATVA-ASDASVPSSATDTVAPPPAVPQRVSSTQ-L
Mvan_0620|M.vanbaalenii_PYR-1 AMLQLA-----RDLKDAVAGEAPVDLPDGAPPSAAASAGPSGRPAAAH-L
MSMEG_0691|M.smegmatis_MC2_155 AMLQLA-----RDLKQSGA-ADDVSAPETPRAPVATQAGAP--AGSAR-L
MAB_4292|M.abscessus_ATCC_1997 SMLALA-----RDLR----------SPSAAADGESTPSSAVHSPTSTR-L
MAV_0578|M.avium_104 SAAFVE-----GQQHQRGRYAAALAGELAEECGGLCTPALR-TPAGLK-L
TH_4413|M.thermoresistible__bu AIAHRR-----RGLRGSALACSAHAQGLAERCGGAHTPALRRAAEDLP-L
MLBr_01753|M.leprae_Br4923 AVAVLRGAMGCKDFDSAWAEGAAMPIDDAITYAQRGRGNRKRPTTGWESL
MUL_2555|M.ulcerans_Agy99 ARNELR---------------------------AAGTAVRHSAAVGPAPL
: *
Rv0339c|M.tuberculosis_H37Rv SDREREVAELLLLGMPYRDIGARLFISAKTVEHHVARIRQRLGAGSRSEM
Mb0346c|M.bovis_AF2122/97 SDREREVAELLLLGMPYRDIGARLFISAKTVEHHVARIRQRLGAGSRSEM
MMAR_0612|M.marinum_M SDREREVAELLLLGMPYRDIGAQLFISAKTVEHHVARIRRRLGAGSRSEM
Mflv_0277|M.gilvum_PYR-GCK SEREREVAELLLQGLPYREIGSQLFISAKTVEHHVARIRRRLGAESRSEM
Mvan_0620|M.vanbaalenii_PYR-1 SDREREVAELLLQGLPYRDIGAQLFISAKTVEHHVARIRRRLGAESRSEL
MSMEG_0691|M.smegmatis_MC2_155 SDREREVAELLLLGMPYRDIGNQLFISAKTVEHHVARIRRRLGAESRSEM
MAB_4292|M.abscessus_ATCC_1997 SEREREVAELLLRGLPYRDIGAQLFISAKTVEHHVARIRRRLGAESRSDM
MAV_0578|M.avium_104 SGRQRDVIELAVAGLSNRQIAERLVMSVRTVEGHIYRACQRVGAQSRDEL
TH_4413|M.thermoresistible__bu TDREREIVLLLGAGLTNREIADTLTLSVRTVENHIYKSMLKTGTSSRDEL
MLBr_01753|M.leprae_Br4923 TPAEHNVIRLVSEGLDTKDIAARLFVSVRTVHTHLTRIYSKLGLTSRVQL
MUL_2555|M.ulcerans_Agy99 TAQERLVAELAAKGLSNKEIAARLCLSPRTVGAHLYRLFPKLGVTNRAGL
: :: : * *: ::*. * :* :** *: : : * .* :
Rv0339c|M.tuberculosis_H37Rv LSMLRAMLAPESLTADERR-----
Mb0346c|M.bovis_AF2122/97 LSMLRAMLAPESLTADERR-----
MMAR_0612|M.marinum_M LSMLRAMLTAPG------------
Mflv_0277|M.gilvum_PYR-GCK LSMLRAALDTPASR----------
Mvan_0620|M.vanbaalenii_PYR-1 LSMLRALTDSPTRS----------
MSMEG_0691|M.smegmatis_MC2_155 LSMLRAMFSPQG------------
MAB_4292|M.abscessus_ATCC_1997 FSMLRAILTP--------------
MAV_0578|M.avium_104 ATIIRSRPAGRES-----------
TH_4413|M.thermoresistible__bu AALLPRSPRPSDPRRAPRSPRRID
MLBr_01753|M.leprae_Br4923 VQEAARHN----------------
MUL_2555|M.ulcerans_Agy99 HDALDAIHAAPDQI----------