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YSLGEMQKPVPVGADYLASCLVARLRSTDVPTDLHRGCTVTLFLGDVEGLAELSETQPDEAADAIARLDC VVSEAVAAHGGVQQVVQGVRGNFLATFARASDATACALDLQLAPIVPVRFRIALHTGEVQISNDDVNNVV FMMVQAAGLLDLACGGQTVLSSITGDLVVDGLPADTWLVDLGSHLLRDLARPVRVMQLCHRNLRRNLHEL GIRTVPGGPSLPVPLTTFVGRAAQIKELQELLTEKRLLTLVGPGGVGKTRLALQVVARVADEFSGELSYF DLAPDTDHDIFPITVLDNLRRCIGDRRMLMVLDNCEYLLDVCANVMTTLLGACPSLTILATSREPIGVAG EVIWRVSMLSPADEAVELFTERAALVQPGFSVTDGNRQIVTEICQRLDGMPLAIELAAARIRTLSLTEIA DGLDDRFRLLTGGARTAVRRQQTLRASMDWSYALLTESERALFRRLSAISGTFDLKVAYAVGHDDLEEPD QVFDRLTMLIDKSLVIVEGRQGGSRYRLLETVRQYAMKKLEESNEVDLVLARHRDHYMALGALLDTPGDI DHEQLVEQVETELDNLRSAFAWSRETGDIAGALQLASSLQPIWFGRGHMYEGLAWFDSIFEHKNIEHLVA PKEVLARAVANKVMLHAILASSPPDGSDLVTQAQQALTMAREIGDSAVLARALTACGFSSGYDTEVARPY FAEAVELARTQGDKWTLSQIRLWGVVGFCVSGDPVALRAAAEAADDLAQEIGDRFVSLQCRLLLSIAQLW QGDMDGAIVRSGEVVAGAEAAHDTVTRTFGLYVQTRALVHRDVSAALVTAGLVVEAAAELSGVYQGIGYA AMVFAALAMGDVAAAVEASEACRPHLGADHGLVAIHLELMAAVALARGDVIVARRLADNSVSATTGWHQM AALTTRARIAMAQGEPELARADIHAALACGADIQASLGISDSMELLAELISQGDNHRQAGRLFGAASAQR EKTGEVRFKVWDAGYESAVAVLRGAMGCKDFDSAWAEGAAMPIDDAITYAQRGRGNRKRPTTGWESLTPA EHNVIRLVSEGLDTKDIAARLFVSVRTVHTHLTRIYSKLGLTSRVQLVQEAARHN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01753 | - | - | 100% (1106) | putative transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1393 | - | 0.0 | 58.12% (1084) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4504 | - | 8e-10 | 45.71% (70) | regulatory protein, LuxR |
| M. tuberculosis H37Rv | Rv1358 | - | 0.0 | 58.12% (1084) | transcriptional regulatory protein |
| M. abscessus ATCC 19977 | MAB_3907c | - | 3e-09 | 21.80% (899) | LuxR transcriptional regulator |
| M. marinum M | MMAR_0123 | - | 0.0 | 49.54% (1094) | LuxR family transcriptional regulator |
| M. avium 104 | MAV_2362 | - | 3e-13 | 22.68% (957) | TPR repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_4431 | - | 3e-16 | 23.62% (961) | putative regulatory protein |
| M. thermoresistible (build 8) | TH_3225 | - | 4e-09 | 43.08% (65) | PUTATIVE regulatory protein, LuxR |
| M. ulcerans Agy99 | MUL_2743 | - | 2e-85 | 34.76% (699) | LuxR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5928 | - | 0.0 | 51.39% (1082) | regulatory protein, LuxR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1393|M.bovis_AF2122/97 MFLSAPAFRVEPTRSRHSALRWARHRRFADVPRWQMLRSLQIADQIARTG
Rv1358|M.tuberculosis_H37Rv MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQIARTG
MLBr_01753|M.leprae_Br4923 MYSLGEMQKPVPVGADYLASCLVAR-----------LRSTDVPTDLHRG-
MMAR_0123|M.marinum_M --MLASMSEIDPRAEAPLVD----------------WSDVDMGELLPTG-
Mvan_5928|M.vanbaalenii_PYR-1 -----------------------------------------MSELVPTG-
MUL_2743|M.ulcerans_Agy99 --------------------------------------------------
MAB_3907c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2362|M.avium_104 --------------------------------------------------
Mflv_4504|M.gilvum_PYR-GCK --------------------------------------------------
TH_3225|M.thermoresistible__bu --------------------------------------------------
MSMEG_4431|M.smegmatis_MC2_155 --------------------------------------------------
Mb1393|M.bovis_AF2122/97 HMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTR
Rv1358|M.tuberculosis_H37Rv HMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTR
MLBr_01753|M.leprae_Br4923 ------------------------------CTVTLFLGDVEGLAELSETQ
MMAR_0123|M.marinum_M -------------------------------TVTLLLADVEGSTRLWQNQ
Mvan_5928|M.vanbaalenii_PYR-1 -------------------------------TVTLLLADVQGSTQLWETQ
MUL_2743|M.ulcerans_Agy99 --------------------------------MTFLFTDVEGSTRLWESD
MAB_3907c|M.abscessus_ATCC_199 --------------------------------MTTTTGTIDGRGQAPRLS
MAV_2362|M.avium_104 --------------------------------------------------
Mflv_4504|M.gilvum_PYR-GCK -----------------------------------MRAALPAAMMNAMSD
TH_3225|M.thermoresistible__bu -----------------------------------------MSSRDGDVV
MSMEG_4431|M.smegmatis_MC2_155 ------------------------MNRRQDTPVGPSTDFFDVGGERLITP
Mb1393|M.bovis_AF2122/97 LNELAADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIAC
Rv1358|M.tuberculosis_H37Rv LNELAADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIAC
MLBr_01753|M.leprae_Br4923 PDEAADAIARLDCVVSEAVAAHGGVQQVVQGVRGN-FLATFARASDATAC
MMAR_0123|M.marinum_M PEPMTAAVAHLDSVLATTVATHHGVR-PVEQGEGDSFVVAFASAREAIAC
Mvan_5928|M.vanbaalenii_PYR-1 PETMTAAVAQLDRTLTDLVSDHDGVR-PVEQGEGDSFVVAFTRASDAVAC
MUL_2743|M.ulcerans_Agy99 PDRMRAALAAHDAVLTRTIQTHRGWLFKHTG---DGVCAAFASPRSAVDA
MAB_3907c|M.abscessus_ATCC_199 PAKVHPDLHSYPMARSWQLLDR---------------QTEFGAVRSAMAD
MAV_2362|M.avium_104 -------------------MGR---------------EAELRRSLAALSN
Mflv_4504|M.gilvum_PYR-GCK ASPQAADDPQVAGFLCTATSAP----------------TGLIIEGDAGIG
TH_3225|M.thermoresistible__bu LHGRAAEIATLRDVMSTARAGS---------------SRVLVLHGEAGVG
MSMEG_4431|M.smegmatis_MC2_155 PIRGRADELKTAGALITAAARGRG--------------GVLVIEGPPGIG
: .
Mb1393|M.bovis_AF2122/97 ALELQLSTLAPMRPRVGVHTGDVRLRGDGT---ITGSAINESACLRDLAH
Rv1358|M.tuberculosis_H37Rv ALELQLSTLAPMRPRVGVHTGDVRLRGDGT---ITGSAINESACLRDLAH
MLBr_01753|M.leprae_Br4923 ALDLQLAPIVPVRFRIALHTGEVQISNDDVN--NVVFMMVQAAGLLDLAC
MMAR_0123|M.marinum_M ALDLQRSPLGPIRLRIGVHTGDIQLRDPNDPTNYIGPTINRTARIRELAH
Mvan_5928|M.vanbaalenii_PYR-1 ALALQRAPLAPIRLRIGVHTGEVRLRDEG---NYVGPTINRTARLRELAH
MUL_2743|M.ulcerans_Agy99 AVDAQRALELPVR--MGLATGEAEPHDAD----YFGAVLNRAARVMATGH
MAB_3907c|M.abscessus_ATCC_199 DSTCG-------------------------------------AVLVGAAG
MAV_2362|M.avium_104 AEFHG-------------------------------------VALVGDAG
Mflv_4504|M.gilvum_PYR-GCK KTTLWLSLLQTAR-------------------------MRGFQVLTARVG
TH_3225|M.thermoresistible__bu KTALLG-------------------------------------QLLGDAA
MSMEG_4431|M.smegmatis_MC2_155 KSRLLTEVLG-----------------------------------LADKC
Mb1393|M.bovis_AF2122/97 EGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRDLR
Rv1358|M.tuberculosis_H37Rv EGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRDLR
MLBr_01753|M.leprae_Br4923 GGQTVLSSITGDLVVDGLPADTWLVDLGSHLLRDLARPVRVMQLCHRNLR
MMAR_0123|M.marinum_M GGQTVISGATQLLVVDQLPDGAWLADLGLHPLRDLPRPERVMQLCHSGLQ
Mvan_5928|M.vanbaalenii_PYR-1 GGQTVLSGTTSDLVADLLPDGGWLSDLGTHRLRDLPRPERVVQLCHADLS
MUL_2743|M.ulcerans_Agy99 GGQILLTDSTANLIS-----GVDLLDLGSRRLRDLPAPVRVFQVRAPGLR
MAB_3907c|M.abscessus_ATCC_199 VGKTTLARAVTKSLDAD---VRWVACTESSRSIPLGVFAHWIQASGSRDP
MAV_2362|M.avium_104 VGKSTLARMLAKTVESAGRTVRFALGTQTGSAVPLGAFSHAVSLMAVNEP
Mflv_4504|M.gilvum_PYR-GCK QAESVMAFAALADLLGAVSDEHFAALPPLQRLALDRVLLRAGADGPATDQ
TH_3225|M.thermoresistible__bu GMRCVQVAGVESDMELAYAGLHQLCAPLLDRLDDLPSPQRDVLNVAFGRG
MSMEG_4431|M.smegmatis_MC2_155 GVRTLFGEAFEYQQTVPFFSLFMATLRADPPIGDVAALRELGGSADLRYW
. .
Mb1393|M.bovis_AF2122/97 NEFPP---LRMS-VGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLR
Rv1358|M.tuberculosis_H37Rv NEFPP---LRMS-VGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLR
MLBr_01753|M.leprae_Br4923 RNLHE---LGIRTVPGGPSLPVPLTTFVGRAAQIKELQELLTEKRLLTLV
MMAR_0123|M.marinum_M NDFPP---LRTTKSIAVHRMPARLTRFVGRIAQMADVRSLLADNRLVTLT
Mvan_5928|M.vanbaalenii_PYR-1 NEFPP---LRAREEIGVQRLPAQLTSFVGRVDDMAQVRGLMDANRLVTLT
MUL_2743|M.ulcerans_Agy99 TDFPA---LRAPDTSPG-NLRPALTSFVARAAEIGQVQTALQVHRLVTLT
MAB_3907c|M.abscessus_ATCC_199 TALIA---AARESIVSTANPIIGIDDAHLLDDLSATLLHQIAVDHVGHVV
MAV_2362|M.avium_104 AVMLA---AAHNTLSQDKNLVVVVDDAQLLDPLSATLVNQLAAWRSARLI
Mflv_4504|M.gilvum_PYR-GCK RVVAAGFVSLLHILAADAPVLIAIDDVQWLDASSRTAIEFAVRRLKGAFG
TH_3225|M.thermoresistible__bu AGPAP-------GRFLVGLAVLNLLAAAGADQPLLCVIDDAQWLDRVSLQ
MSMEG_4431|M.smegmatis_MC2_155 VVHDLHN--AIRAAAAQTPLMIVLEDIHWADNATLLALRSLTTEIDVPVL
. .
Mb1393|M.bovis_AF2122/97 GEGGVGKTRLAIQIAA--ASEFRDGLCFVDLAPIADPGMVSTTAAHALGL
Rv1358|M.tuberculosis_H37Rv GEGGVGKTRLAIQIAA--ASEFRDGLCFVDLAPIADPGMVSTTAAHALGL
MLBr_01753|M.leprae_Br4923 GPGGVGKTRLALQVVARVADEFSGELSYFDLAPDTDHDIFPIT-------
MMAR_0123|M.marinum_M GAGGAGKTRLAVEIAASAVDEFGDGLWYVDLAPVSHAEAVPVTVARALGL
Mvan_5928|M.vanbaalenii_PYR-1 GAGGVGKTRLATQVAVAVVEGYPGGVWYVDLAPITDPALVAITVARALGL
MUL_2743|M.ulcerans_Agy99 GVGGVGKTRLALEVATRVADEFPDGVWLFELAAVSDPAAVPDAVAAVLGI
MAB_3907c|M.abscessus_ATCC_199 ATVRSGEPVPDAVTALWKDNYLQR----FELDPLTQ--------------
MAV_2362|M.avium_104 VTIRSGEPVLDAVTALLKERLLLT----VHVDPFTR--------------
Mflv_4504|M.gilvum_PYR-GCK VVVTERCVPGDGTTAGWLTLERPDGLIRVSVPPMDAG-------------
TH_3225|M.thermoresistible__bu TLGFVARRLMAEPVAMVFALRDDIHEALVGVPALAVPG------------
MSMEG_4431|M.smegmatis_MC2_155 WVFTARTGAGGQAVQETLSVLQRTDATFLRLAAMTP--------------
. : .
Mb1393|M.bovis_AF2122/97 IDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELS
Rv1358|M.tuberculosis_H37Rv IDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELS
MLBr_01753|M.leprae_Br4923 -------VLDNLRRCIGDRRMLMVLDNCEYLLDVCANVMTTLLGACPSLT
MMAR_0123|M.marinum_M SDQPGRSTVDALARFIGEHQVLVVLDNCEHLLDATAALLLELTGRCPAVR
Mvan_5928|M.vanbaalenii_PYR-1 PDQPGRSTVDTIVRFIADRRMLVVLDNCEHLLDACATLIDALLGACPALA
MUL_2743|M.ulcerans_Agy99 TQQAGKTVTQSVATALERRVRLLVFDNCEHVRDAAADLIEAILAGSTTVR
MAB_3907c|M.abscessus_ATCC_199 -----RQSIALVEKVLGGPLEGLSADVMWRSSRGNPLFLRHLVEGSMQAG
MAV_2362|M.avium_104 -----EQTELLAGTVLGGPVDPWVVDELLQRSSGNPLLLRGFLTAGRDTG
Mflv_4504|M.gilvum_PYR-GCK ------RLHALISHRLGRTLTRPVVLRIAEMSGGNPFYALELAHTHVNSG
TH_3225|M.thermoresistible__bu --LADADARTLLEHMFPGAIDANVRDRLVAESRGNPLALLEVPRTYAVGE
MSMEG_4431|M.smegmatis_MC2_155 ------DAVADMVQDAVRARADTSLLSLAAKAHGNPFLISELVRGLGEEG
. .
Mb1393|M.bovis_AF2122/97 ILATSRESIGVTGEVTWVVPSLSPAN----EAIQLFTERARLVQPNFEIV
Rv1358|M.tuberculosis_H37Rv ILATSRESIGVTGEVTWVVPSLSPAN----EAIQLFTERARLVQPNFEIV
MLBr_01753|M.leprae_Br4923 ILATSREPIGVAGEVIWRVSMLSPAD----EAVELFTERAALVQPGFSVT
MMAR_0123|M.marinum_M LLATSREPLGVPGEVTFLVPSLSVT-----EATELFTDRARRVRPDFAVT
Mvan_5928|M.vanbaalenii_PYR-1 MLATSREPIAVAGEQTWRVPPLALDD----DAIELFTDRARRARPDFIIS
MUL_2743|M.ulcerans_Agy99 ILATSRERLEVPDEQLWSVPSLDVGGGVVSAAGTLFVERAQSVAPGFAPT
MAB_3907c|M.abscessus_ATCC_199 SLTEVNGVWQLRGDAVVPS-----------GLDTLIGDRLEHVD-----D
MAV_2362|M.avium_104 ALFRTAEGWQLRGPLRGDR-----------ELHDALEYRLQSLS-----S
Mflv_4504|M.gilvum_PYR-GCK DSPPAAEPPLPATLADVVR-----------RRVGLLDDATRTLLLGVACV
TH_3225|M.thermoresistible__bu LAGGFVSPGAGSAPSRIEEN--------YVHRIRALPAQTRRLLLIAAAE
MSMEG_4431|M.smegmatis_MC2_155 RLGLSDGRAVASGFALPRRLGASMHQ----RLDLLSEGASEVVRVAAVLP
Mb1393|M.bovis_AF2122/97 AD-NFAAVSEICRRLDGMPLAIELAAARLR-SLSPNEIANSLDDRFRLLT
Rv1358|M.tuberculosis_H37Rv AD-NFDAVSEICRRLDGMPLAIELAAARLR-SLSPNEIANSLDDRFRLLT
MLBr_01753|M.leprae_Br4923 DG-NRQIVTEICQRLDGMPLAIELAAARIR-TLSLTEIADGLDDRFRLLT
MMAR_0123|M.marinum_M DD-NTTAVTEICNRLDCMPLAIELAAARVR-ALSIDEIRTGLHDRFRLLT
Mvan_5928|M.vanbaalenii_PYR-1 AD-DAAAVSEICHRLDGMPLAIELAAARVR-ALSLTEIVDGLHDRFRLLT
MUL_2743|M.ulcerans_Agy99 DAQDAAAIGEICRRLDGIPLAIELAASRMA-SMTPIEVRDRLDHRFRLLV
MAB_3907c|M.abscessus_ATCC_199 TVFSALKVLSMCEPLDIDTLCEIASDEAVD-AAEIADLIRVERDGVRTVV
MAV_2362|M.avium_104 EEREVVEILATAGLLNWDILRDICDAEAVA-ALERRGLIRLVTDGSHAVA
Mflv_4504|M.gilvum_PYR-GCK ADPTVELLARAHGASTDEITAGLERAEAAG-IVVLE--GNRVRFTHPLLA
TH_3225|M.thermoresistible__bu PIGDSALFLRAAALMG-IAVDALAPAEAAR-VIQFGPRMRFFHPLMRSAA
MSMEG_4431|M.smegmatis_MC2_155 DRFTAGLLAAMLERSPTSLLSSLEEAVHADLFIEDGEQLRFRHDLLREAT
. .
Mb1393|M.bovis_AF2122/97 GGARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEV
Rv1358|M.tuberculosis_H37Rv GGARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEV
MLBr_01753|M.leprae_Br4923 GGARTAVRRQQTLRASMDWSYALLTESERALFRRLSAISGTFDLKVA---
MMAR_0123|M.marinum_M GGARTVVRRQQTLRASVDWSHALLTEPERVLFRRIAVFLGGFDLDAA---
Mvan_5928|M.vanbaalenii_PYR-1 GGSRTAVRRQQTLRASVDWSHGLLTDPERVLFRRLAVFAGGFDLDGA---
MUL_2743|M.ulcerans_Agy99 G-SRRGLGRHQTLRHAVAWSYDHLSDAEKVLLERCSVFAGGFDLQSAC--
MAB_3907c|M.abscessus_ATCC_199 RFSHPMFGEAVRRRVGTASGRRLRGKLVRVLRDRD--------LGTAS--
MAV_2362|M.avium_104 QLTHPMLGEAATRHAGMVRTRQLNGKLARALQKHERTGSRHLRLPHLQ--
Mflv_4504|M.gilvum_PYR-GCK GGVYTDAGPTARRAMHRAIASVESHPELRARHLALAASSGDDEIFAALDQ
TH_3225|M.thermoresistible__bu YRAADPRDRRAVHRALAEATDPGADPDRRAWHAANGVTGTDDAVAAELEK
MSMEG_4431|M.smegmatis_MC2_155 RQSLPKSLRRAMERQSASVMLGMGAAPAEVATQLARSAEPGDREAIDALR
.
Mb1393|M.bovis_AF2122/97 AAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALE
Rv1358|M.tuberculosis_H37Rv AAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALE
MLBr_01753|M.leprae_Br4923 YAVGHDDLEEPDQVFDRLTMLIDKSLVIVEGRQGGSRYRLLETVRQYAMK
MMAR_0123|M.marinum_M QAVAGDSQVQRYQVVDELALLVDKSLVIAESGGGPTRYRLLETVRQYAQE
Mvan_5928|M.vanbaalenii_PYR-1 QAITVDGEVHRYEVVDLLTLLVDKSLLIAENTAGRTRYRLLETVRQYAQE
MUL_2743|M.ulcerans_Agy99 AVAGSADTHDDYEVLDLLDALVGKSLLIVDRLSGRSRFSMLETIREFAEE
MAB_3907c|M.abscessus_ATCC_199 NRIRLARLSIDCDEPVDVDLLVTAAKDAVYLSNLPLGEELARAAVDGGGG
MAV_2362|M.avium_104 SRIRLAEFMLHSDMEPDLDVITEAARDALAMSNVQLGEELARFALDRGGG
Mflv_4504|M.gilvum_PYR-GCK AADSARARGAPAAAAELMDLALGLGAHDPMRRLKAAENHFLAGDTAKAAA
TH_3225|M.thermoresistible__bu SAARAQQRGGIAATATFLERAVVLTADPGLRGRRALAAAQAKRDAADSAA
MSMEG_4431|M.smegmatis_MC2_155 EAAQAVGRGDAGAAADLSRCALELSPADDAEHGSLIAETVGWLNRASRYG
Mb1393|M.bovis_AF2122/97 KLNESEEIDGVRARHRTHYATMAAGLNVPASTD-YEQRLLQAEAEIDNLR
Rv1358|M.tuberculosis_H37Rv KLNESEEIDGVRARHRTHYATMAAGLNVPASTD-YEQRLLQAEAEIDNLR
MLBr_01753|M.leprae_Br4923 KLEESNEVDLVLARHRDHYMALGALLDTPGDID-HEQLVEQVETELDNLR
MMAR_0123|M.marinum_M KLAESGEVEAVRSRHVTYYKSVAKLLDAPTGTD-HERRLAQAEDELDNLR
Mvan_5928|M.vanbaalenii_PYR-1 KLGESGEADTLRARHRDHYTARAAELDAPSVAG-HERRLNQTDIEMDNLR
MUL_2743|M.ulcerans_Agy99 QLVTRGQALAARTAHARHFAQRLPDVAAVWDSPRQPEAYTWLTAELANLR
MAB_3907c|M.abscessus_ATCC_199 LQAAAMLSRSLLWQGRPEQAEEILAAFDPDDLD-ELSLVLWGIPRISIAF
MAV_2362|M.avium_104 LPAALVLAEAVSWQGRGEEAGFVLAHAEPDGDD-DWLIARWGCLRAANLF
Mflv_4504|M.gilvum_PYR-GCK ALGEVGSIEPPILRAMATSLLATVRMYDNEHRQ-----------AVDLLR
TH_3225|M.thermoresistible__bu AHDLLAIAERAPLSALEWARAVHLRAQLEFARSRAGDAGGPPVGQTAAAL
MSMEG_4431|M.smegmatis_MC2_155 EAEELADMALADAASPEVEAEIRLRLPTQTKHS---SPQRVAESRRALRL
Mb1393|M.bovis_AF2122/97 AAFTWSRGNGDIAAALQLASALQPLWS-QGRMREGLAWLESILE------
Rv1358|M.tuberculosis_H37Rv AAFTWSRGNGDIAAALQLASALQPLWS-QGRMREGLAWLESILE------
MLBr_01753|M.leprae_Br4923 SAFAWSRETGDIAGALQLASSLQPIWFGRGHMYEGLAWFDSIFE------
MMAR_0123|M.marinum_M SAFGWSLETRDFDSALELATSLHPVWMTRGQGREGLAWLEAGLGNEAGLG
Mvan_5928|M.vanbaalenii_PYR-1 AAFAWSRENANTDHSLLLASSLHPLWRARGRLQEGQAWFDAALT-----D
MUL_2743|M.ulcerans_Agy99 LAFRWTADNNDLDDAASIATWVGFLGFLVNRFEP-LTWVEEAIE------
MAB_3907c|M.abscessus_ATCC_199 WSMGENERAHELLALLHERVRHHILKPVVDATDAAIALHENRFDEG----
MAV_2362|M.avium_104 WGCGDAEAARREADTVKKRVSSEAGLHLIDALELSMAFFRGDVET-----
Mflv_4504|M.gilvum_PYR-GCK SALDDAADN--VPVQVQVLLRLSFALNSIGELDDARRYARDAVK------
TH_3225|M.thermoresistible__bu LTAAQLLQDVDAPAARESYLEAFAALMYAGRLAPSGALLEAADA------
MSMEG_4431|M.smegmatis_MC2_155 RGISELTRARHLASLAYNLVLQDEDAQSRTAADEAAAAAASTGD------
Mb1393|M.bovis_AF2122/97 ---REGDNHLVP-AGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALA
Rv1358|M.tuberculosis_H37Rv ---REGDNHLVP-AGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALA
MLBr_01753|M.leprae_Br4923 ---HKNIEHLVAPKEVLARAVANKVMLHAILASSPPDGSDLVTQAQQALT
MMAR_0123|M.marinum_M NEAGLGNEDVQVSPSTLARALADKVTLLAWTGSMAG-----FDDAERALT
Mvan_5928|M.vanbaalenii_PYR-1 YEARPG----EADPAVYARALADRAFMDGHVGITDR-----LDQAQKALA
MUL_2743|M.ulcerans_Agy99 --------------------------------------------------
MAB_3907c|M.abscessus_ATCC_199 -----------------------------------------LARAHAVLS
MAV_2362|M.avium_104 -----------------------------------------TTELGPGLC
Mflv_4504|M.gilvum_PYR-GCK -------------------------------------------------L
TH_3225|M.thermoresistible__bu ------------------------------------------VQAAFARA
MSMEG_4431|M.smegmatis_MC2_155 --------------------------------------------------
Mb1393|M.bovis_AF2122/97 LARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLS
Rv1358|M.tuberculosis_H37Rv LARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLS
MLBr_01753|M.leprae_Br4923 MAREIGDSAVLARALTACGFSSGYDTEVARPYFAEAVELARTQGDKWTLS
MMAR_0123|M.marinum_M IARELADPALLIRALVARGVITAYDADVARPYFDEAAQLARELGDSWRLS
Mvan_5928|M.vanbaalenii_PYR-1 MARDIDDPALLVRALTACGGLAAYNADVARPLLAEAVDLARSMGDKWMLA
MUL_2743|M.ulcerans_Agy99 --RAVDHPKLAFLHVLASQCYTTGRVQEAIRYADEAARLLATDRYEVPFG
MAB_3907c|M.abscessus_ATCC_199 DPVAPKQAVEFAAFGVGLTLPVAGRGHEFEPIAQRCRDDKKRTTDGLIAA
MAV_2362|M.avium_104 ESDAVPMATTWAAVPTCAALAATGRYSEVGRIADIGVRAAMSCGMGLHRF
Mflv_4504|M.gilvum_PYR-GCK AEELGFPGATSAALAWAVHVDFQCGRGLDETALARAMKLYDSTFDVPIIF
TH_3225|M.thermoresistible__bu PEGSRAVDAFCQGMTQRIVGGISAAAAPLRVALTAMCELARSRPAEVVHW
MSMEG_4431|M.smegmatis_MC2_155 -----PEAIIMAEVTHALLDSGEGYAVRALRRLEQLRGIAYTNETALAHA
Mb1393|M.bovis_AF2122/97 QIDYWQVVGIFISG---QPIPLRAAAEQARELADSIGNRFVSRQCRLFAC
Rv1358|M.tuberculosis_H37Rv QIDYWQVVGIFISG---QPIPLRAAAEQARELADSIGNRFVSRQCRLFAC
MLBr_01753|M.leprae_Br4923 QIRLWGVVGFCVSG---DPVALRAAAEAADDLAQEIGDRFVSLQCRLLLS
MMAR_0123|M.marinum_M QILSLQTRAAMAAG---DPIALEAAGEEGLRIAEAIGDRTTSRECRGALG
Mvan_5928|M.vanbaalenii_PYR-1 ETLAWQAYAALMGGG--DPVAARTAGEEARELADEMGDGFVSRICGWLLG
MUL_2743|M.ulcerans_Agy99 -IEGWPSGACTSSG-----HPEQSVELCRTQLALGHDTHTLTLGC---LV
MAB_3907c|M.abscessus_ATCC_199 MVRYCDVLALTYTGQ--LDLAEERVAEY--TKFSSAGQFLAWAIARIMAG
MAV_2362|M.avium_104 NIGISEIIAATDAGD---DRAAERIYKR--YAAMAEGLPGAEAMVDAMLG
Mflv_4504|M.gilvum_PYR-GCK RAPFVHALAMSWTG---RLEQAHQELTAVRGVCLERGAESDMMAIAGFLA
TH_3225|M.thermoresistible__bu LVPAFPVLQESAGHELWDENLVDALSEAVVRQARDAGALAGLPQALVYRA
MSMEG_4431|M.smegmatis_MC2_155 YAGMFHANMLAVVG---RLDDATNRAAEGIAQADRERSAMVLDNWAVYAG
Mb1393|M.bovis_AF2122/97 LAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIG-DS
Rv1358|M.tuberculosis_H37Rv LAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIG-DS
MLBr_01753|M.leprae_Br4923 IAQLWQGDMDGAIVRSGEVVAGAEAAHDTVTRTFGLYVQTRALVHRD-VS
MMAR_0123|M.marinum_M WVRAWRGDPIGALHQLGEAIAEASAAHDLLLLMISQVVQGFTYAYVGDAD
Mvan_5928|M.vanbaalenii_PYR-1 IAHHFQGDLDAALALADGVVSESDVAHDTLNGCCGELVLAHSLAQRGDTD
MUL_2743|M.ulcerans_Agy99 LALTIKGQCDEAEQLADALIESAEATRNPAALCYALLAYGFTFRDTN---
MAB_3907c|M.abscessus_ATCC_199 VVATQRGLFREAIEAFEQALAAQRADRPLPWQLPARLLLARAYAALGRAV
MAV_2362|M.avium_104 VVRLARGEFPAACAAFTRSISLFAKGFPSPWLVVVGAFQAQAEGARGDST
Mflv_4504|M.gilvum_PYR-GCK INHLWRGQITDAEAEAAEAVERAEQLGGDDVLIIPMTVRGAIAAYAGRVD
TH_3225|M.thermoresistible__bu GVHLLFGEFGLADTLLTEAESITAATDHRGPVRYHRLIIAAWRGDAVEAA
MSMEG_4431|M.smegmatis_MC2_155 WVHLAAGRLSAARG-AAESLPPPQASGAQELDVHRMLILAEVAAHSDDRN
* *
Mb1393|M.bovis_AF2122/97 AARTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAA-IEASEAS-W
Rv1358|M.tuberculosis_H37Rv AARTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAA-IEASEAS-W
MLBr_01753|M.leprae_Br4923 AALVTAGLVVEAAAELSGVYQGIGYAAMVFAALAMGDVAAAVEASEACRP
MMAR_0123|M.marinum_M GACACADAVFTSSAELVGANEGLGYATAAIACQAAGDATAAWKAYQKARE
Mvan_5928|M.vanbaalenii_PYR-1 AARAAAQVSLNVAVEVSPVHAGLAHAALAVANLAAGDVTAAEAASDSATR
MUL_2743|M.ulcerans_Agy99 --------------------------------------------------
MAB_3907c|M.abscessus_ATCC_199 DGERVLDEAREHSG------------------------------------
MAV_2362|M.avium_104 AAAAALWRADRAYG------------------------------------
Mflv_4504|M.gilvum_PYR-GCK DARADARWVLAAVRN----------------------------------R
TH_3225|M.thermoresistible__bu RLIEAAAADGEARGE-----------------------------------
MSMEG_4431|M.smegmatis_MC2_155 LLLETANDAHDAHCTG----------------------------------
Mb1393|M.bovis_AF2122/97 DLRNQHNVVTAH-HELMAQAALVRGDVTTARRFADEAVLASTGWHLMMAL
Rv1358|M.tuberculosis_H37Rv DLRNQHNVVTAH-HELMAQAALVRGDVTTARRFADEAVLASTGWHLMMAL
MLBr_01753|M.leprae_Br4923 HLGADHGLVAIH-LELMAAVALARGDVIVARRLADNSVSATTGWHQMAAL
MMAR_0123|M.marinum_M LVGMDPQMAGVFPFGALAPLVS--GDLSAARRWADDVVSTSYGCYLSVAL
Mvan_5928|M.vanbaalenii_PYR-1 SFGPS-EVAGIQDPNVAAQIACTRGDLDTARSLVDGAVSITRGVHRASAL
MUL_2743|M.ulcerans_Agy99 -------------------PASALAAMRRGLRIAQDTGNRNSETHLAAVL
MAB_3907c|M.abscessus_ATCC_199 -----------------PHVAIHMPQMMLAKAWLVAARGSDRGAVDAARR
MAV_2362|M.avium_104 -----------------PHAAVFLPELELARAWERAAAGDTQAATTHATQ
Mflv_4504|M.gilvum_PYR-GCK KASHIADWPGMTLCFLEESLGNHREALAALDDSFIAAGPPTTELMYAWHL
TH_3225|M.thermoresistible__bu ----------GRLMGLTGYAAALLYNGIGRYREALAAARTTCEYEDLGFY
MSMEG_4431|M.smegmatis_MC2_155 -----PPGQRRACAYVLARAAWYRGDIHEAARWLGDINLLGTPLFPHALV
Mb1393|M.bovis_AF2122/97 IARARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEA
Rv1358|M.tuberculosis_H37Rv IARARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEA
MLBr_01753|M.leprae_Br4923 TTRARIAMAQGEPELARADIHAALACGADIQASLGISDSMELLAELISQG
MMAR_0123|M.marinum_M TARARVALAQGELGQADRDSHAALSCSAANGTTLGVADTLECLAELAATE
Mvan_5928|M.vanbaalenii_PYR-1 TTRARIAIAQGDPEQAERNAHDALSLAAGVGARLEVPDTLECLARVVGDG
MUL_2743|M.ulcerans_Agy99 CR---VEAKYGDPLSALDHFTLAIHNHHEAGNTTLISTPLAVLAAFFDRL
MAB_3907c|M.abscessus_ATCC_199 AADAAHSAGQYALEAEALHHAARFGDRTVGRRIESLCTRVHGPLTGLYAR
MAV_2362|M.avium_104 AAEIARAAGMHAAEMRTRHAAVRFGDRSQTARLERLARILDTPLAEAAAD
Mflv_4504|M.gilvum_PYR-GCK PDAIEAMVGVGRLDDAEILTAALERNGVEHDRRWMRAVGARCRAMLLAAH
TH_3225|M.thermoresistible__bu SWCLHELVEAAARVGETDTAHRALGDIEERAGASGTPWGLGALAGARALL
MSMEG_4431|M.smegmatis_MC2_155 RLILAAQVASAAGDAGLRARVLQAAEVLGRERPAVPLFRAVVGYSRGILE
Mb1393|M.bovis_AF2122/97 GNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDFTA
Rv1358|M.tuberculosis_H37Rv GNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDFTA
MLBr_01753|M.leprae_Br4923 DNHRQAGRLFGAASAQREKTGEVRFKVWDAGYESAVAVLRGAMGCKDFDS
MMAR_0123|M.marinum_M GDRREAARLLASAEAIRHRTGEVRLKILDAHCEVVLAELRNELGEQDFAA
Mvan_5928|M.vanbaalenii_PYR-1 GSHHEAARLCGAAEAIRGRTGAVRFRIYDADHETTVTTLRDALGDKAFEA
MUL_2743|M.ulcerans_Agy99 GRYEAAATIAGFAFHPITEASFP-------ELRTTISHLRDALGDHAYES
MAB_3907c|M.abscessus_ATCC_199 HALAVAHSDITGLEAVSADFEAAGLLLSAADAAAQAVALRMRAGDRGKGS
MAV_2362|M.avium_104 HARGLTQRDGDLLDAAAQQFADLGALACAADAAAQAAGEHARRGDRGKKF
Mflv_4504|M.gilvum_PYR-GCK GDVAAAEQMAHRAISEHDHLPMPFERARTRLLLGQLQRRLRQKATAAKNL
TH_3225|M.thermoresistible__bu ADGDEADRLFREALDHLSRSRVVVHRARVHLTYGEWLRREHRRGEARREL
MSMEG_4431|M.smegmatis_MC2_155 HDADALVRAAESLRAFPRPLLYAGAAADAGAELIRAQRGTEALDQLNTAF
Mb1393|M.bovis_AF2122/97 AWAEGAAAPLDEAIAYAQRGR-------GERKRPSNGWDALTPAEHKIVK
Rv1358|M.tuberculosis_H37Rv AWAEGAAAPLDEAIAYAQRGR-------GERKRPSNGWDALTPAEHKIVK
MLBr_01753|M.leprae_Br4923 AWAEGAAMPIDDAITYAQRGR-------GNRKRPTTGWESLTPAEHNVIR
MMAR_0123|M.marinum_M VWGQGAVISTDEVISYVRRGR-------GTRRRPSSGWGSLTPTEHDVVR
Mvan_5928|M.vanbaalenii_PYR-1 AWTEGSATSITEAIAYAQRGR-------GERKRPSSGWASLTPTELDVVG
MUL_2743|M.ulcerans_Agy99 FSQSGAAMTTAAMATYAYHQI-------DHARTEFQAR------------
MAB_3907c|M.abscessus_ATCC_199 DAAARVLRMADRCGGVVTPAI-------LAAAKPLP----ISSREREIAV
MAV_2362|M.avium_104 ESSAWAHALASRY-ELHTPAV-------EAAARPLP----FSGRERQIVN
Mflv_4504|M.gilvum_PYR-GCK TDALHTFEQLGTPLWAQRARS-------ELARAVVAPAEGLTPSEQKVAE
TH_3225|M.thermoresistible__bu NEAHGMFTRMGAQGFAERSRRELIAVGEKVRRQPLTSGDELTAQEAQIAG
MSMEG_4431|M.smegmatis_MC2_155 DAYSECGATADARRVGRALRRLGAERRVVATQRAKTGWDSLTDSELTVVQ
Mb1393|M.bovis_AF2122/97 LVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST
Rv1358|M.tuberculosis_H37Rv LVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST
MLBr_01753|M.leprae_Br4923 LVSEGLDTKDIAARLFVSVRTVHTHLTRIYSKLGLTSRVQLVQEAARHN-
MMAR_0123|M.marinum_M LVQEGLSNKDIAARMFISPRTVQTHLTHVYTKLGLTSRIQLVHEVARHA-
Mvan_5928|M.vanbaalenii_PYR-1 LVSEGLSNKDIAARLFVSPRTVQTHLTHVYTKLCLASRVQLAQEAARHT-
MUL_2743|M.ulcerans_Agy99 --------------------------------------------------
MAB_3907c|M.abscessus_ATCC_199 LIGEGLSDKDIATRLQLSVRTVEGHIYRARMKLDADDREEFAKIVGSDLK
MAV_2362|M.avium_104 LVAAGLSNREIADRLVISVRTVEGHLYRLFTKLGINSREQLTLLVAREPR
Mflv_4504|M.gilvum_PYR-GCK MAAAGATNKDIAAAMFISSKTVEHNLTRIYRKLGISSRAELGRRMDQPGL
TH_3225|M.thermoresistible__bu LAADGLTNQEIGAQLFLSVHTVEWHLRKVFVKLGITSRRQLRAAPRVTAT
MSMEG_4431|M.smegmatis_MC2_155 LIAEGATNRAVAEHLQLSPHTVKTHVRNAFAKLGVTSRAQLAQFIHRAD-
Mb1393|M.bovis_AF2122/97 ------------------------
Rv1358|M.tuberculosis_H37Rv ------------------------
MLBr_01753|M.leprae_Br4923 ------------------------
MMAR_0123|M.marinum_M ------------------------
Mvan_5928|M.vanbaalenii_PYR-1 ------------------------
MUL_2743|M.ulcerans_Agy99 ------------------------
MAB_3907c|M.abscessus_ATCC_199 PPEAS-------------------
MAV_2362|M.avium_104 GRRELLGHSNPSLGDQDDVHPHAG
Mflv_4504|M.gilvum_PYR-GCK ------------------------
TH_3225|M.thermoresistible__bu W-----------------------
MSMEG_4431|M.smegmatis_MC2_155 ------------------------