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M. tuberculosis H37Rv Rv0234c (gabD1)

annotation: succinic semialdehyde dehydrogenase
coordinates: 279605 - 281140
length: 511

RSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPAKDVSVPIATINPATGETVKTF
TAATDDEVDAAIARAHRRFADYRQTSFAQRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKC
AKGFRYYAENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLK
HASNVPQCALYLADVIARGGFPDGCFQTLLVSSGAVEAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKP
TVLELGGSDPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALRVGDP
TDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRPGWFYPPTVITDISKDMALYTEEVFGPV
ASVFRAANIDEAVEIANATTFGLGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYG
RELSAHGIREFCNIKTVWIA*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv0234cgabD1-100% (511)succinic semialdehyde dehydrogenase
M. tuberculosis H37RvRv1731gabD22e-5932.11% (464) succinic semialdehyde dehydrogenase
M. tuberculosis H37RvRv0223c-4e-5933.04% (457) aldehyde dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0239cgabD10.0100.00% (511) succinic semialdehyde dehydrogenase
M. gilvum PYR-GCKMflv_1858-8e-7335.25% (451) succinate-semialdehyde dehydrogenase (NAD(P)(+))
M. leprae Br4923MLBr_02573gabD10.085.71% (455) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977MAB_3471gabD10.081.62% (457) succinic semialdehyde dehydrogenase
M. marinum MMMAR_0490gabD10.086.65% (457) succinate-semialdehyde dehydrogenase
M. avium 104MAV_4936gabD10.085.56% (457) succinic semialdehyde dehydrogenase
M. smegmatis MC2 155MSMEG_6452-1e-10546.02% (452) [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium
M. thermoresistible (build 8)TH_3419-3e-7138.24% (455) PUTATIVE putative aldehyde dehydrogenase
M. ulcerans Agy99MUL_1153gabD10.086.43% (457) succinic semialdehyde dehydrogenase
M. vanbaalenii PYR-1Mvan_1844-1e-9642.86% (455) aldehyde dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Rv0234c|M.tuberculosis_H37Rv        MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
Mb0239c|M.bovis_AF2122/97           MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
MLBr_02573|M.leprae_Br4923          --------------------------------------------------
MMAR_0490|M.marinum_M               --------------------------------------------------
MUL_1153|M.ulcerans_Agy99           --------------------------------------------------
MAV_4936|M.avium_104                --------------------------------------------------
MAB_3471|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_6452|M.smegmatis_MC2_155      -------------------------------------------------M
Mvan_1844|M.vanbaalenii_PYR-1       -------------------------------------------------M
TH_3419|M.thermoresistible__bu      ----------------------------VQRTLPDKLPAPRLVIGGGDVI
Mflv_1858|M.gilvum_PYR-GCK          ---------------------------MDNSAVEALLASVPTGLWIGGEE
                                                                                      

Rv0234c|M.tuberculosis_H37Rv        KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQ-TSFA
Mb0239c|M.bovis_AF2122/97           KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQ-TSFA
MLBr_02573|M.leprae_Br4923          ----MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRH-TTFT
MMAR_0490|M.marinum_M               ----MPIATTNPATGETVKTFTAASNDEVDAAIARAYARFQDYRRNTTLA
MUL_1153|M.ulcerans_Agy99           ----MPIATTNPATGETVKTFTAASNDEVDAAIARAYARFQDYRRNTTFA
MAV_4936|M.avium_104                ----MPIATINPATGETVKTFTPASDAEVDAAIARAYERFLDYRHSTTFA
MAB_3471|M.abscessus_ATCC_1997      ----MPIATINPATGETIKTFTAASDAEIDAAIGRAHDRFRQYRT-TSFS
MSMEG_6452|M.smegmatis_MC2_155      NMTQ--YAVTDPATAEVVATYPTATDAEVQAAIEAAHKTGRTWAKSTTVA
Mvan_1844|M.vanbaalenii_PYR-1       TATQPPYRTLNPATGEVLATFDTATDDLIATAITAADDAYRAWRE-QPLE
TH_3419|M.thermoresistible__bu      STSGGVYEHHYAATGGVQAEVPLAGPAEVDAAVAAARAAFPAWRD-LDLN
Mflv_1858|M.gilvum_PYR-GCK          REGTSTFDVLDPSDDTVLTSVADATADDARAALDAACAVQAEWAG-TAPR
                                               .:   .      :       *:  *      :       

Rv0234c|M.tuberculosis_H37Rv        QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
Mb0239c|M.bovis_AF2122/97           QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
MLBr_02573|M.leprae_Br4923          QRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYA
MMAR_0490|M.marinum_M               QRAEWAHATADLIEAEADQTAALMTLEMGKTIASAKAEVLKSAKGFRYYA
MUL_1153|M.ulcerans_Agy99           QRAEWAHATADLIEAEADQTAALMTLEMGKTIASAKAEVLKSAKGFRYYA
MAV_4936|M.avium_104                QRAQWANATADLLEAEADEVAAMMTLEMGKTLKSAKAEALKCAKGFRYYA
MAB_3471|M.abscessus_ATCC_1997      DRAAWALSTADLLEAEADDVAALMTLEMGKTLASAKAEVLKCAKGFRFYA
MSMEG_6452|M.smegmatis_MC2_155      ERAALIRKVAELHEQRREQLADVIVREMGKPRDQSLGEVDFCAAIYQYYA
Mvan_1844|M.vanbaalenii_PYR-1       ARVDVVRHVGRLLRERATELAELAKLEMGKKLDEGTGEVEFSASIFEFYA
TH_3419|M.thermoresistible__bu      RRRDILQELARRLVADGERLGAIATLEVGTPNLLASSSSAMAADWFTYYA
Mflv_1858|M.gilvum_PYR-GCK          KRGEILRSVFETITARADDIAALMTLEMGKVLAESKGEVTYGAEFFRWFA
                                     *                  . :   *:*.    .  .    *  : ::*

Rv0234c|M.tuberculosis_H37Rv        ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
Mb0239c|M.bovis_AF2122/97           ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
MLBr_02573|M.leprae_Br4923          EKAETLLADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAA
MMAR_0490|M.marinum_M               DNAAALLADEPADAGKVGASQAYTRYQPLGVVLAVMPWNFPLWQAVRFAA
MUL_1153|M.ulcerans_Agy99           DNAAALLADEPADAGKVGASQAYTRYQPLGVVLAVMPWNFPLWQAGRFAA
MAV_4936|M.avium_104                QNAEQLLADEPADAGKVGAARAYIRYQPLGVVLAVMPWNFPLWQAVRFAA
MAB_3471|M.abscessus_ATCC_1997      ENAEAMLAPEPADASAVNASQAYAQYQPLGVVLAVMPWNFPLWQAVRFAA
MSMEG_6452|M.smegmatis_MC2_155      DNAEKFLADEPIEL-LDGEGSAVIKRSPIGVLLGIMPWNYPYYQVARFAG
Mvan_1844|M.vanbaalenii_PYR-1       DHAAALLADQRIPS-FSG-GTAVVQRRPVGVLLGVMPWNFPVYQVARFAA
TH_3419|M.thermoresistible__bu      G-WIGRSAGEVVPVPAGG-ALDYVLDEPLGVIAAIIPWNGPLISIGMKVA
Mflv_1858|M.gilvum_PYR-GCK          EEAVRIDG--RYTAAPAGTGRILVTKQAVGPCYAITPWNFPLAMGTRKMG
                                           .         . .       .:*   .: *** *        .

Rv0234c|M.tuberculosis_H37Rv        PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSG--AV
Mb0239c|M.bovis_AF2122/97           PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSG--AV
MLBr_02573|M.leprae_Br4923          PALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISAN--GV
MMAR_0490|M.marinum_M               PALMAGNVGLLKHASNVPQSALYLADVIARGGFPDGCFQTLLVSAS--AV
MUL_1153|M.ulcerans_Agy99           PALMAGNVGLLKHASNVPQSALYLADVIARAGFPDGCFQTLLVSAS--AV
MAV_4936|M.avium_104                PALMAGNVGILKHASNVPQSALYLADVITRGGFPEGCFQTLLVPSS--AV
MAB_3471|M.abscessus_ATCC_1997      PALMAGNVGLLKHASNVPQSALYLADVIARGGFPEGCFQTLLVPSS--AV
MSMEG_6452|M.smegmatis_MC2_155      PNLVVGNTILLKHAPQCPESAELLQLLFLEAGFPQGAYVDIRATNE--QV
Mvan_1844|M.vanbaalenii_PYR-1       PNLVLGNTILLKHAESVPQCALVIADVMRDAGVPEGVYTNLFASFD--QV
TH_3419|M.thermoresistible__bu      PALAAGNCVVLKPPENAPFSALRFAELAAEAGLPPGVLNVIPGGAE--AG
Mflv_1858|M.gilvum_PYR-GCK          PAFAAGCTMIVKPAQETPLTMLLLAKLMADAGLPKGVLSVLPTTSPGPVT
                                    * :  *   ::* . . *     :  :   .*.* .    :         

Rv0234c|M.tuberculosis_H37Rv        EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
Mb0239c|M.bovis_AF2122/97           EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
MLBr_02573|M.leprae_Br4923          EAILRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS
MMAR_0490|M.marinum_M               EGILRDPRVAAATLTGSEPAGQSVGAIAGDEIKPTVLELGGSDPFIVMPS
MUL_1153|M.ulcerans_Agy99           EGILRDPRVAAATLTGSEPAGQSVGAIAGDEIKPTVLELGGSDPFIVMPS
MAV_4936|M.avium_104                ERILRDPRVAAATLTGSEPAGQSVAAIAGDEIKPTVLELGGSDPFIVMPS
MAB_3471|M.abscessus_ATCC_1997      ERILRDPRVAAATLTGSEPAGRSVAAIAGDEVKPTVLELGGSDPFIVMPS
MSMEG_6452|M.smegmatis_MC2_155      ANIIADPRVAAVSLTGSERAGAAVAEIAGRNLKKCVLELGGSDPFIVLST
Mvan_1844|M.vanbaalenii_PYR-1       ETIIGDPRVQGVSVTGSERAGAAVAATAGRSLKKCLLELGGSDPFIVLD-
TH_3419|M.thermoresistible__bu      SALCSHPGVDKITFTGGGETARKVFAAAAQALTPVVLELGGKSANIVFPD
Mflv_1858|M.gilvum_PYR-GCK          ETLIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFVVFDD
                                      :  .  :   :.**.  ..  :   :.  :    :****. . :*:  

Rv0234c|M.tuberculosis_H37Rv        ADLDAAVSTAVTG-RVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAAL
Mb0239c|M.bovis_AF2122/97           ADLDAAVSTAVTG-RVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAAL
MLBr_02573|M.leprae_Br4923          ADLDAAVATAVTG-RVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETL
MMAR_0490|M.marinum_M               ADLDKAVSTAVTG-RVQNNGQSCIAAKRFIAHADIYDAFVDKFVEQMSAL
MUL_1153|M.ulcerans_Agy99           ADLDKAVSTAVTG-RVQNNGQSCIAAKRFIAHADIYDAFVDKFVEQMSAL
MAV_4936|M.avium_104                ADLDEAVKTAVTA-RVQNNGQSCIAAKRFIVHTDIYDTFVDKFVEQMKAL
MAB_3471|M.abscessus_ATCC_1997      ADLEQAVSTAVTA-RVQNNGQSCIAAKRFIAHRDIYDDFLSRFVEKMAAL
MSMEG_6452|M.smegmatis_MC2_155      DDLDATVQAAVDG-RMENTGQACNAAKRFIVNESIYDDFLAKFTEKLLAA
Mvan_1844|M.vanbaalenii_PYR-1       GDSKQLARTAWEF-RVYNMGQACNSNKRMIVTDDLYDDFVAELVTLAGDL
TH_3419|M.thermoresistible__bu      ADLDAAATMAVSAGLMMLSGQGCILPTRLLVHDDVYDEMVTRVVAGADAL
Mflv_1858|M.gilvum_PYR-GCK          ADVDAAVDGAILA-KMRNGGEACTAANRIHVANAVREEFTDKFVKRMSEF
                                     * .  .  *     :   *:.*   .*: .   : : :  ...      

Rv0234c|M.tuberculosis_H37Rv        RVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGA-VIRCGGKRLDRP-
Mb0239c|M.bovis_AF2122/97           RVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGA-VIRCGGKRLDRP-
MLBr_02573|M.leprae_Br4923          RVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGA-VIRCGGKRPDRP-
MMAR_0490|M.marinum_M               TVGDPTDPQTQVGPLATEQSRDEIAQQVDDAAAAGA-VIRCGGKPLAGP-
MUL_1153|M.ulcerans_Agy99           TVGDPTDPQTQVGPLATEQSRDEIAQQVDDAAAAGA-VIRCGGKPLAGP-
MAV_4936|M.avium_104                KVGDPTDPATDVGPLATESGRDEIAKQVDDAVAAGA-TLRCGGKPLDGP-
MAB_3471|M.abscessus_ATCC_1997      RVGDPTDPATDVGPLATEQGRDEVDKQVQQAVAAGA-SIRCGGTRPDGP-
MSMEG_6452|M.smegmatis_MC2_155      G--------EGIAPLSSEQAAVRLEDQVKSAVEAGA-KLTAAGERKG---
Mvan_1844|M.vanbaalenii_PYR-1       AP-------AEIAPMSSRKAAETLAAQVADAVDKGA-TLHVGGELAEGP-
TH_3419|M.thermoresistible__bu      TVGDPWQPTTMMGPLATAAQLERVTRAVDSALSDKAGKLLAGGRRPDGLD
Mflv_1858|M.gilvum_PYR-GCK          TLGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGA-TVAVGGVAPGGP-
                                               :.*: .      :   *  *    *  :  .*       

Rv0234c|M.tuberculosis_H37Rv        -GWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFG
Mb0239c|M.bovis_AF2122/97           -GWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFG
MLBr_02573|M.leprae_Br4923          -GWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFG
MMAR_0490|M.marinum_M               -GWYYPPTVITDITKDMNLYTEEVFGPVASVYRAADIDEAIEIANATTFG
MUL_1153|M.ulcerans_Agy99           -GWYYPPTVITDITKDMNLYTEEVFGPVASVYRAADIDEAIEIANATTFG
MAV_4936|M.avium_104                -GWFYPPTVVTDITKDMALYTEEVFGPVASMYRAADIDEAIEIANATTFG
MAB_3471|M.abscessus_ATCC_1997      -GWYYPPTVITDITKNMPIFGEEVFGPVASVYRATDIEEAIEVANATSFG
MSMEG_6452|M.smegmatis_MC2_155      --AFFPPAVLTGVTEDNPVYRQELFGPVAVVYKAGSEEEAVQIANDTPFG
Mvan_1844|M.vanbaalenii_PYR-1       -AAFYTPAVLTGVTPDMRAYSEELFGPVAVVYRVRDEEEAVALANASAYG
TH_3419|M.thermoresistible__bu      AGYFYRPTVFGDVDPASDLAQTEIFGPVLAILRFRSEEEAVELANNTQYG
Mflv_1858|M.gilvum_PYR-GCK          -GNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAANDTEYG
                                       :: .:*. .:         *:****  :      ::.:  ** : :*

Rv0234c|M.tuberculosis_H37Rv        LGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRE
Mb0239c|M.bovis_AF2122/97           LGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRE
MLBr_02573|M.leprae_Br4923          LGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRE
MMAR_0490|M.marinum_M               LGSNAWTQDEAEQRRFINDIEAGQVFINGMTVSYPELPFGGIKRSGYGRE
MUL_1153|M.ulcerans_Agy99           LGSNAWTQDEAEQRRFINDIEAGQVFINGMTVSYPELPFGGIKRSGYGRE
MAV_4936|M.avium_104                LGSNAWTNDAAEQQRFIDDIEAGQVFINGMTVSYPELGFGGVKRSGYGRE
MAB_3471|M.abscessus_ATCC_1997      LGANAWTRETAEQQRFINELDAGQVFINGMTVSYPEVPFGGIKRSGYGRE
MSMEG_6452|M.smegmatis_MC2_155      LGSYVFTTDSEQAARVADKIEAGMVFVNAVGAEGAELPFGGVKRSGFGRE
Mvan_1844|M.vanbaalenii_PYR-1       LGASVFSTDTARAEKVAQRLEAGMVNVNTPAGEGPDIPFGGVKRSGFGRE
TH_3419|M.thermoresistible__bu      LAAYIHTRDLRRAHVMAAALDAGGVAVNGFPIVPSAAPFGGVKQSGFGRE
Mflv_1858|M.gilvum_PYR-GCK          LAAYVYTQSLDRALRVAEGIESGMVGVNRGVISDPAAPFGGIKESGFGRE
                                    *.:   : .  .   .   : :* * :*      .   ***:*.**:***

Rv0234c|M.tuberculosis_H37Rv        LSAHGIREFCNIKTVWIA--------------
Mb0239c|M.bovis_AF2122/97           LSAHGIREFCNIKTVWIA--------------
MLBr_02573|M.leprae_Br4923          LSTHGIREFCNIKTVWIA--------------
MMAR_0490|M.marinum_M               LAGHGIREFCNIKTVWVG--------------
MUL_1153|M.ulcerans_Agy99           LAGHGIREFCNIKTVWVG--------------
MAV_4936|M.avium_104                LAGLGIRAFCNAKTVWIGSSKSGDAGGGSKVE
MAB_3471|M.abscessus_ATCC_1997      LSAHGIREFCNIKTVWIA--------------
MSMEG_6452|M.smegmatis_MC2_155      LGRYGIDEFVNKKLIRVVD-------------
Mvan_1844|M.vanbaalenii_PYR-1       LGALGIDEFVNKQVYVVAD-------------
TH_3419|M.thermoresistible__bu      GGIWGLREFQRTKNVYIGLQ------------
Mflv_1858|M.gilvum_PYR-GCK          GGTEGIEEYLDTKYIALTK-------------
                                     .  *:  :   :   :