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PIATTNPATGETVKTFTAASNDEVDAAIARAYARFQDYRRNTTLAQRAEWAHATADLIEAEADQTAALMT LEMGKTIASAKAEVLKSAKGFRYYADNAAALLADEPADAGKVGASQAYTRYQPLGVVLAVMPWNFPLWQA VRFAAPALMAGNVGLLKHASNVPQSALYLADVIARGGFPDGCFQTLLVSASAVEGILRDPRVAAATLTGS EPAGQSVGAIAGDEIKPTVLELGGSDPFIVMPSADLDKAVSTAVTGRVQNNGQSCIAAKRFIAHADIYDA FVDKFVEQMSALTVGDPTDPQTQVGPLATEQSRDEIAQQVDDAAAAGAVIRCGGKPLAGPGWYYPPTVIT DITKDMNLYTEEVFGPVASVYRAADIDEAIEIANATTFGLGSNAWTQDEAEQRRFINDIEAGQVFINGMT VSYPELPFGGIKRSGYGRELAGHGIREFCNIKTVWVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0490 | gabD1 | - | 100% (458) | succinate-semialdehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | 2e-69 | 35.46% (454) | aldehyde dehydrogenase NAD dependent |
| M. marinum M | MMAR_3965 | - | 9e-67 | 34.79% (457) | NAD-dependent aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0239c | gabD1 | 0.0 | 86.65% (457) | succinic semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1858 | - | 3e-74 | 36.47% (447) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
| M. tuberculosis H37Rv | Rv0234c | gabD1 | 0.0 | 86.65% (457) | succinic semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 0.0 | 81.76% (455) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3471 | gabD1 | 0.0 | 80.74% (457) | succinic semialdehyde dehydrogenase |
| M. avium 104 | MAV_4936 | gabD1 | 0.0 | 86.24% (458) | succinic semialdehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6452 | - | 1e-103 | 44.93% (454) | [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium |
| M. thermoresistible (build 8) | TH_3419 | - | 2e-71 | 36.76% (457) | PUTATIVE putative aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1153 | gabD1 | 0.0 | 99.34% (458) | succinic semialdehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1844 | - | 1e-96 | 43.20% (456) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0239c|M.bovis_AF2122/97 MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
Rv0234c|M.tuberculosis_H37Rv MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
MMAR_0490|M.marinum_M --------------------------------------------------
MUL_1153|M.ulcerans_Agy99 --------------------------------------------------
MAV_4936|M.avium_104 --------------------------------------------------
MAB_3471|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6452|M.smegmatis_MC2_155 -------------------------------------------------M
Mvan_1844|M.vanbaalenii_PYR-1 -------------------------------------------------M
TH_3419|M.thermoresistible__bu ----------------------------VQRTLPDKLPAPRLVIGGGDVI
Mflv_1858|M.gilvum_PYR-GCK ---------------------------MDNSAVEALLASVPTGLWIGGEE
Mb0239c|M.bovis_AF2122/97 KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQ-TSFA
Rv0234c|M.tuberculosis_H37Rv KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQ-TSFA
MLBr_02573|M.leprae_Br4923 ----MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRH-TTFT
MMAR_0490|M.marinum_M ----MPIATTNPATGETVKTFTAASNDEVDAAIARAYARFQDYRRNTTLA
MUL_1153|M.ulcerans_Agy99 ----MPIATTNPATGETVKTFTAASNDEVDAAIARAYARFQDYRRNTTFA
MAV_4936|M.avium_104 ----MPIATINPATGETVKTFTPASDAEVDAAIARAYERFLDYRHSTTFA
MAB_3471|M.abscessus_ATCC_1997 ----MPIATINPATGETIKTFTAASDAEIDAAIGRAHDRFRQYRT-TSFS
MSMEG_6452|M.smegmatis_MC2_155 NMTQ--YAVTDPATAEVVATYPTATDAEVQAAIEAAHKTGRTWAKSTTVA
Mvan_1844|M.vanbaalenii_PYR-1 TATQPPYRTLNPATGEVLATFDTATDDLIATAITAADDAYRAWRE-QPLE
TH_3419|M.thermoresistible__bu STSGGVYEHHYAATGGVQAEVPLAGPAEVDAAVAAARAAFPAWRD-LDLN
Mflv_1858|M.gilvum_PYR-GCK REGTSTFDVLDPSDDTVLTSVADATADDARAALDAACAVQAEWAG-TAPR
.: . : *: * :
Mb0239c|M.bovis_AF2122/97 QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
Rv0234c|M.tuberculosis_H37Rv QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
MLBr_02573|M.leprae_Br4923 QRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYA
MMAR_0490|M.marinum_M QRAEWAHATADLIEAEADQTAALMTLEMGKTIASAKAEVLKSAKGFRYYA
MUL_1153|M.ulcerans_Agy99 QRAEWAHATADLIEAEADQTAALMTLEMGKTIASAKAEVLKSAKGFRYYA
MAV_4936|M.avium_104 QRAQWANATADLLEAEADEVAAMMTLEMGKTLKSAKAEALKCAKGFRYYA
MAB_3471|M.abscessus_ATCC_1997 DRAAWALSTADLLEAEADDVAALMTLEMGKTLASAKAEVLKCAKGFRFYA
MSMEG_6452|M.smegmatis_MC2_155 ERAALIRKVAELHEQRREQLADVIVREMGKPRDQSLGEVDFCAAIYQYYA
Mvan_1844|M.vanbaalenii_PYR-1 ARVDVVRHVGRLLRERATELAELAKLEMGKKLDEGTGEVEFSASIFEFYA
TH_3419|M.thermoresistible__bu RRRDILQELARRLVADGERLGAIATLEVGTPNLLASSSSAMAADWFTYYA
Mflv_1858|M.gilvum_PYR-GCK KRGEILRSVFETITARADDIAALMTLEMGKVLAESKGEVTYGAEFFRWFA
* . : *:*. . . * : ::*
Mb0239c|M.bovis_AF2122/97 ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
Rv0234c|M.tuberculosis_H37Rv ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
MLBr_02573|M.leprae_Br4923 EKAETLLADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAA
MMAR_0490|M.marinum_M DNAAALLADEPADAGKVGASQAYTRYQPLGVVLAVMPWNFPLWQAVRFAA
MUL_1153|M.ulcerans_Agy99 DNAAALLADEPADAGKVGASQAYTRYQPLGVVLAVMPWNFPLWQAGRFAA
MAV_4936|M.avium_104 QNAEQLLADEPADAGKVGAARAYIRYQPLGVVLAVMPWNFPLWQAVRFAA
MAB_3471|M.abscessus_ATCC_1997 ENAEAMLAPEPADASAVNASQAYAQYQPLGVVLAVMPWNFPLWQAVRFAA
MSMEG_6452|M.smegmatis_MC2_155 DNAEKFLADEPIEL-LDGEGSAVIKRSPIGVLLGIMPWNYPYYQVARFAG
Mvan_1844|M.vanbaalenii_PYR-1 DHAAALLADQRIPS-FSG-GTAVVQRRPVGVLLGVMPWNFPVYQVARFAA
TH_3419|M.thermoresistible__bu G-WIGRSAGEVVPVPAGG-ALDYVLDEPLGVIAAIIPWNGPLISIGMKVA
Mflv_1858|M.gilvum_PYR-GCK EEAVRIDG--RYTAAPAGTGRILVTKQAVGPCYAITPWNFPLAMGTRKMG
. . . .:* .: *** * .
Mb0239c|M.bovis_AF2122/97 PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSG--AV
Rv0234c|M.tuberculosis_H37Rv PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSG--AV
MLBr_02573|M.leprae_Br4923 PALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISAN--GV
MMAR_0490|M.marinum_M PALMAGNVGLLKHASNVPQSALYLADVIARGGFPDGCFQTLLVSAS--AV
MUL_1153|M.ulcerans_Agy99 PALMAGNVGLLKHASNVPQSALYLADVIARAGFPDGCFQTLLVSAS--AV
MAV_4936|M.avium_104 PALMAGNVGILKHASNVPQSALYLADVITRGGFPEGCFQTLLVPSS--AV
MAB_3471|M.abscessus_ATCC_1997 PALMAGNVGLLKHASNVPQSALYLADVIARGGFPEGCFQTLLVPSS--AV
MSMEG_6452|M.smegmatis_MC2_155 PNLVVGNTILLKHAPQCPESAELLQLLFLEAGFPQGAYVDIRATNE--QV
Mvan_1844|M.vanbaalenii_PYR-1 PNLVLGNTILLKHAESVPQCALVIADVMRDAGVPEGVYTNLFASFD--QV
TH_3419|M.thermoresistible__bu PALAAGNCVVLKPPENAPFSALRFAELAAEAGLPPGVLNVIPGGAE--AG
Mflv_1858|M.gilvum_PYR-GCK PAFAAGCTMIVKPAQETPLTMLLLAKLMADAGLPKGVLSVLPTTSPGPVT
* : * ::* . . * : : .*.* . :
Mb0239c|M.bovis_AF2122/97 EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
Rv0234c|M.tuberculosis_H37Rv EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
MLBr_02573|M.leprae_Br4923 EAILRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS
MMAR_0490|M.marinum_M EGILRDPRVAAATLTGSEPAGQSVGAIAGDEIKPTVLELGGSDPFIVMPS
MUL_1153|M.ulcerans_Agy99 EGILRDPRVAAATLTGSEPAGQSVGAIAGDEIKPTVLELGGSDPFIVMPS
MAV_4936|M.avium_104 ERILRDPRVAAATLTGSEPAGQSVAAIAGDEIKPTVLELGGSDPFIVMPS
MAB_3471|M.abscessus_ATCC_1997 ERILRDPRVAAATLTGSEPAGRSVAAIAGDEVKPTVLELGGSDPFIVMPS
MSMEG_6452|M.smegmatis_MC2_155 ANIIADPRVAAVSLTGSERAGAAVAEIAGRNLKKCVLELGGSDPFIVLST
Mvan_1844|M.vanbaalenii_PYR-1 ETIIGDPRVQGVSVTGSERAGAAVAATAGRSLKKCLLELGGSDPFIVLD-
TH_3419|M.thermoresistible__bu SALCSHPGVDKITFTGGGETARKVFAAAAQALTPVVLELGGKSANIVFPD
Mflv_1858|M.gilvum_PYR-GCK ETLIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFVVFDD
: . : :.**. .. : :. : :****. . :*:
Mb0239c|M.bovis_AF2122/97 ADLDAAVSTAVTG-RVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAAL
Rv0234c|M.tuberculosis_H37Rv ADLDAAVSTAVTG-RVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAAL
MLBr_02573|M.leprae_Br4923 ADLDAAVATAVTG-RVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETL
MMAR_0490|M.marinum_M ADLDKAVSTAVTG-RVQNNGQSCIAAKRFIAHADIYDAFVDKFVEQMSAL
MUL_1153|M.ulcerans_Agy99 ADLDKAVSTAVTG-RVQNNGQSCIAAKRFIAHADIYDAFVDKFVEQMSAL
MAV_4936|M.avium_104 ADLDEAVKTAVTA-RVQNNGQSCIAAKRFIVHTDIYDTFVDKFVEQMKAL
MAB_3471|M.abscessus_ATCC_1997 ADLEQAVSTAVTA-RVQNNGQSCIAAKRFIAHRDIYDDFLSRFVEKMAAL
MSMEG_6452|M.smegmatis_MC2_155 DDLDATVQAAVDG-RMENTGQACNAAKRFIVNESIYDDFLAKFTEKLLAA
Mvan_1844|M.vanbaalenii_PYR-1 GDSKQLARTAWEF-RVYNMGQACNSNKRMIVTDDLYDDFVAELVTLAGDL
TH_3419|M.thermoresistible__bu ADLDAAATMAVSAGLMMLSGQGCILPTRLLVHDDVYDEMVTRVVAGADAL
Mflv_1858|M.gilvum_PYR-GCK ADVDAAVDGAILA-KMRNGGEACTAANRIHVANAVREEFTDKFVKRMSEF
* . . * : *:.* .*: . : : : ...
Mb0239c|M.bovis_AF2122/97 RVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGA-VIRCGGKRLDRP-
Rv0234c|M.tuberculosis_H37Rv RVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGA-VIRCGGKRLDRP-
MLBr_02573|M.leprae_Br4923 RVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGA-VIRCGGKRPDRP-
MMAR_0490|M.marinum_M TVGDPTDPQTQVGPLATEQSRDEIAQQVDDAAAAGA-VIRCGGKPLAGP-
MUL_1153|M.ulcerans_Agy99 TVGDPTDPQTQVGPLATEQSRDEIAQQVDDAAAAGA-VIRCGGKPLAGP-
MAV_4936|M.avium_104 KVGDPTDPATDVGPLATESGRDEIAKQVDDAVAAGA-TLRCGGKPLDGP-
MAB_3471|M.abscessus_ATCC_1997 RVGDPTDPATDVGPLATEQGRDEVDKQVQQAVAAGA-SIRCGGTRPDGP-
MSMEG_6452|M.smegmatis_MC2_155 G--------EGIAPLSSEQAAVRLEDQVKSAVEAGA-KLTAAGERKG---
Mvan_1844|M.vanbaalenii_PYR-1 AP-------AEIAPMSSRKAAETLAAQVADAVDKGA-TLHVGGELAEGP-
TH_3419|M.thermoresistible__bu TVGDPWQPTTMMGPLATAAQLERVTRAVDSALSDKAGKLLAGGRRPDGLD
Mflv_1858|M.gilvum_PYR-GCK TLGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGA-TVAVGGVAPGGP-
:.*: . : * * * : .*
Mb0239c|M.bovis_AF2122/97 -GWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFG
Rv0234c|M.tuberculosis_H37Rv -GWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFG
MLBr_02573|M.leprae_Br4923 -GWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFG
MMAR_0490|M.marinum_M -GWYYPPTVITDITKDMNLYTEEVFGPVASVYRAADIDEAIEIANATTFG
MUL_1153|M.ulcerans_Agy99 -GWYYPPTVITDITKDMNLYTEEVFGPVASVYRAADIDEAIEIANATTFG
MAV_4936|M.avium_104 -GWFYPPTVVTDITKDMALYTEEVFGPVASMYRAADIDEAIEIANATTFG
MAB_3471|M.abscessus_ATCC_1997 -GWYYPPTVITDITKNMPIFGEEVFGPVASVYRATDIEEAIEVANATSFG
MSMEG_6452|M.smegmatis_MC2_155 --AFFPPAVLTGVTEDNPVYRQELFGPVAVVYKAGSEEEAVQIANDTPFG
Mvan_1844|M.vanbaalenii_PYR-1 -AAFYTPAVLTGVTPDMRAYSEELFGPVAVVYRVRDEEEAVALANASAYG
TH_3419|M.thermoresistible__bu AGYFYRPTVFGDVDPASDLAQTEIFGPVLAILRFRSEEEAVELANNTQYG
Mflv_1858|M.gilvum_PYR-GCK -GNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAANDTEYG
:: .:*. .: *:**** : ::.: ** : :*
Mb0239c|M.bovis_AF2122/97 LGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRE
Rv0234c|M.tuberculosis_H37Rv LGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRE
MLBr_02573|M.leprae_Br4923 LGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRE
MMAR_0490|M.marinum_M LGSNAWTQDEAEQRRFINDIEAGQVFINGMTVSYPELPFGGIKRSGYGRE
MUL_1153|M.ulcerans_Agy99 LGSNAWTQDEAEQRRFINDIEAGQVFINGMTVSYPELPFGGIKRSGYGRE
MAV_4936|M.avium_104 LGSNAWTNDAAEQQRFIDDIEAGQVFINGMTVSYPELGFGGVKRSGYGRE
MAB_3471|M.abscessus_ATCC_1997 LGANAWTRETAEQQRFINELDAGQVFINGMTVSYPEVPFGGIKRSGYGRE
MSMEG_6452|M.smegmatis_MC2_155 LGSYVFTTDSEQAARVADKIEAGMVFVNAVGAEGAELPFGGVKRSGFGRE
Mvan_1844|M.vanbaalenii_PYR-1 LGASVFSTDTARAEKVAQRLEAGMVNVNTPAGEGPDIPFGGVKRSGFGRE
TH_3419|M.thermoresistible__bu LAAYIHTRDLRRAHVMAAALDAGGVAVNGFPIVPSAAPFGGVKQSGFGRE
Mflv_1858|M.gilvum_PYR-GCK LAAYVYTQSLDRALRVAEGIESGMVGVNRGVISDPAAPFGGIKESGFGRE
*.: : . . . : :* * :* . ***:*.**:***
Mb0239c|M.bovis_AF2122/97 LSAHGIREFCNIKTVWIA--------------
Rv0234c|M.tuberculosis_H37Rv LSAHGIREFCNIKTVWIA--------------
MLBr_02573|M.leprae_Br4923 LSTHGIREFCNIKTVWIA--------------
MMAR_0490|M.marinum_M LAGHGIREFCNIKTVWVG--------------
MUL_1153|M.ulcerans_Agy99 LAGHGIREFCNIKTVWVG--------------
MAV_4936|M.avium_104 LAGLGIRAFCNAKTVWIGSSKSGDAGGGSKVE
MAB_3471|M.abscessus_ATCC_1997 LSAHGIREFCNIKTVWIA--------------
MSMEG_6452|M.smegmatis_MC2_155 LGRYGIDEFVNKKLIRVVD-------------
Mvan_1844|M.vanbaalenii_PYR-1 LGALGIDEFVNKQVYVVAD-------------
TH_3419|M.thermoresistible__bu GGIWGLREFQRTKNVYIGLQ------------
Mflv_1858|M.gilvum_PYR-GCK GGTEGIEEYLDTKYIALTK-------------
. *: : : :