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TATQPPYRTLNPATGEVLATFDTATDDLIATAITAADDAYRAWREQPLEARVDVVRHVGRLLRERATELA ELAKLEMGKKLDEGTGEVEFSASIFEFYADHAAALLADQRIPSFSGGTAVVQRRPVGVLLGVMPWNFPVY QVARFAAPNLVLGNTILLKHAESVPQCALVIADVMRDAGVPEGVYTNLFASFDQVETIIGDPRVQGVSVT GSERAGAAVAATAGRSLKKCLLELGGSDPFIVLDGDSKQLARTAWEFRVYNMGQACNSNKRMIVTDDLYD DFVAELVTLAGDLAPAEIAPMSSRKAAETLAAQVADAVDKGATLHVGGELAEGPAAFYTPAVLTGVTPDM RAYSEELFGPVAVVYRVRDEEEAVALANASAYGLGASVFSTDTARAEKVAQRLEAGMVNVNTPAGEGPDI PFGGVKRSGFGRELGALGIDEFVNKQVYVVAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1844 | - | - | 100% (453) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4876 | - | 2e-68 | 34.82% (448) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 8e-60 | 35.45% (457) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0239c | gabD1 | 7e-97 | 42.86% (455) | succinic semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1858 | - | 2e-67 | 34.89% (450) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
| M. tuberculosis H37Rv | Rv0234c | gabD1 | 7e-97 | 42.86% (455) | succinic semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 5e-90 | 40.71% (452) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4322 | - | 1e-124 | 53.93% (445) | aldehyde dehydrogenase family protein |
| M. marinum M | MMAR_0490 | gabD1 | 1e-96 | 43.20% (456) | succinate-semialdehyde dehydrogenase |
| M. avium 104 | MAV_4936 | gabD1 | 2e-96 | 43.64% (456) | succinic semialdehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6702 | - | 0.0 | 77.75% (454) | [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium |
| M. thermoresistible (build 8) | TH_4137 | - | 7e-79 | 36.77% (465) | PUTATIVE putative [NADP+] succinate-semialdehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1153 | gabD1 | 5e-97 | 43.42% (456) | succinic semialdehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1844|M.vanbaalenii_PYR-1 ------------------------------------------------MT
MSMEG_6702|M.smegmatis_MC2_155 ------------------------------------------------MT
MAB_4322|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0490|M.marinum_M --------------------------------------------------
MUL_1153|M.ulcerans_Agy99 --------------------------------------------------
MAV_4936|M.avium_104 --------------------------------------------------
Mb0239c|M.bovis_AF2122/97 MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
Rv0234c|M.tuberculosis_H37Rv MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
Mflv_1858|M.gilvum_PYR-GCK -------------------------MDNSAVEALLASVPTGLWIGGEERE
TH_4137|M.thermoresistible__bu -----------------------------------------MYIDGEWQS
Mvan_1844|M.vanbaalenii_PYR-1 AT-QPPYRTLNPATGEVLATFDTATDDLIATAITAADDAYRAWR-EQPLE
MSMEG_6702|M.smegmatis_MC2_155 ATAQLPYRSTNPATGDVLAEFDTTTDDQVFAAIAAADEAFRSWR-STPLD
MAB_4322|M.abscessus_ATCC_1997 ---MTEYAVTDPATGDVVATYPTATDAELDAALTAAAENSRTWPTDTTVA
MMAR_0490|M.marinum_M ----MPIATTNPATGETVKTFTAASNDEVDAAIARAYARFQDYRRNTTLA
MUL_1153|M.ulcerans_Agy99 ----MPIATTNPATGETVKTFTAASNDEVDAAIARAYARFQDYRRNTTFA
MAV_4936|M.avium_104 ----MPIATINPATGETVKTFTPASDAEVDAAIARAYERFLDYRHSTTFA
Mb0239c|M.bovis_AF2122/97 KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQ-TSFA
Rv0234c|M.tuberculosis_H37Rv KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQ-TSFA
MLBr_02573|M.leprae_Br4923 ----MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRH-TTFT
Mflv_1858|M.gilvum_PYR-GCK GTS--TFDVLDPSDDTVLTSVADATADDARAALDAACAVQAEWAG-TAPR
TH_4137|M.thermoresistible__bu AASGKTFASINPANGAVLDSVPDGEREDARRAIDAAAAALPDWRS-RTAY
:*: . .: *: * : .
Mvan_1844|M.vanbaalenii_PYR-1 ARVDVVRHVGRLLRERATELAELAKLEMGKKLDEGTGEVEFSASIFEFYA
MSMEG_6702|M.smegmatis_MC2_155 ERADVVRTVGKLLRERADDFAKLAQLEMGKKRGQGAGETRFSASIFEFYA
MAB_4322|M.abscessus_ATCC_1997 DRAAQMRRVAQLHTEKREMLADIIVREMGKPRDEALGEIDFCAAIYEYYA
MMAR_0490|M.marinum_M QRAEWAHATADLIEAEADQTAALMTLEMGKTIASAKAEVLKSAKGFRYYA
MUL_1153|M.ulcerans_Agy99 QRAEWAHATADLIEAEADQTAALMTLEMGKTIASAKAEVLKSAKGFRYYA
MAV_4936|M.avium_104 QRAQWANATADLLEAEADEVAAMMTLEMGKTLKSAKAEALKCAKGFRYYA
Mb0239c|M.bovis_AF2122/97 QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
Rv0234c|M.tuberculosis_H37Rv QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
MLBr_02573|M.leprae_Br4923 QRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYA
Mflv_1858|M.gilvum_PYR-GCK KRGEILRSVFETITARADDIAALMTLEMGKVLAESKGEVTYGAEFFRWFA
TH_4137|M.thermoresistible__bu ERAEVLVEAHRIMLERRDDLAELMTREQGKPLRMARTEVGYAADFLLWFA
* . . * : * ** . * * ::*
Mvan_1844|M.vanbaalenii_PYR-1 DHAAALLADQRIPS-FSG-GTAVVQRRPVGVLLGVMPWNFPVYQVARFAA
MSMEG_6702|M.smegmatis_MC2_155 DRGAGLLADEPIPT-FTG-GQAVIRRQPVGVLLGVMPWNFPVYQIARFAA
MAB_4322|M.abscessus_ATCC_1997 DNAEKFLADERIEL-LAGEGTAVIKRFPIGVLLGIMPWNFPYYQVARFAC
MMAR_0490|M.marinum_M DNAAALLADEPADAGKVGASQAYTRYQPLGVVLAVMPWNFPLWQAVRFAA
MUL_1153|M.ulcerans_Agy99 DNAAALLADEPADAGKVGASQAYTRYQPLGVVLAVMPWNFPLWQAGRFAA
MAV_4936|M.avium_104 QNAEQLLADEPADAGKVGAARAYIRYQPLGVVLAVMPWNFPLWQAVRFAA
Mb0239c|M.bovis_AF2122/97 ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
Rv0234c|M.tuberculosis_H37Rv ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
MLBr_02573|M.leprae_Br4923 EKAETLLADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAA
Mflv_1858|M.gilvum_PYR-GCK EEAVRIDG--RYTAAPAGTGRILVTKQAVGPCYAITPWNFPLAMGTRKMG
TH_4137|M.thermoresistible__bu EEAKRVYG--EVIPSARADQRFIVLAQPVGVCAAITPWNYPISMLTRKLA
:.. . . . .:* .: ***:* *
Mvan_1844|M.vanbaalenii_PYR-1 PNLVLGNTILLKHAESVPQCALVIADVMRDAGVPEGVYTNLFASFD--QV
MSMEG_6702|M.smegmatis_MC2_155 PNLVLGNTMLLKHAESVPQCALAFAELMRDAGVPEGVYTNLFATFD--QV
MAB_4322|M.abscessus_ATCC_1997 PNLLVGNTIVLKHAPQCPESAEALALLFAEAGLPAGAYLNIRAANE--QV
MMAR_0490|M.marinum_M PALMAGNVGLLKHASNVPQSALYLADVIARGGFPDGCFQTLLVSAS--AV
MUL_1153|M.ulcerans_Agy99 PALMAGNVGLLKHASNVPQSALYLADVIARAGFPDGCFQTLLVSAS--AV
MAV_4936|M.avium_104 PALMAGNVGILKHASNVPQSALYLADVITRGGFPEGCFQTLLVPSS--AV
Mb0239c|M.bovis_AF2122/97 PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSG--AV
Rv0234c|M.tuberculosis_H37Rv PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSG--AV
MLBr_02573|M.leprae_Br4923 PALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISAN--GV
Mflv_1858|M.gilvum_PYR-GCK PAFAAGCTMIVKPAQETPLTMLLLAKLMADAGLPKGVLSVLPTTSPGPVT
TH_4137|M.thermoresistible__bu PALAAGCTSVLKPAEQTPLCAVETFKVFADAGVPAGVVNLVTCSDPEPVA
* : * . ::* * . * :: .*.* . : . .
Mvan_1844|M.vanbaalenii_PYR-1 ETIIGDPRVQGVSVTGSERAGAAVAATAGRSLKKCLLELGGSDPFIVLDG
MSMEG_6702|M.smegmatis_MC2_155 ATIIADPRVQGVSVTGSERAGAAIAGLAGQSLKKCVLELGGSDPFIVLDG
MAB_4322|M.abscessus_ATCC_1997 AGLIADPRVAGVSFTGSERAGAAVAEIAGRNLKKCVLELGGSDPFLVLSS
MMAR_0490|M.marinum_M EGILRDPRVAAATLTGSEPAGQSVGAIAGDEIKPTVLELGGSDPFIVMPS
MUL_1153|M.ulcerans_Agy99 EGILRDPRVAAATLTGSEPAGQSVGAIAGDEIKPTVLELGGSDPFIVMPS
MAV_4936|M.avium_104 ERILRDPRVAAATLTGSEPAGQSVAAIAGDEIKPTVLELGGSDPFIVMPS
Mb0239c|M.bovis_AF2122/97 EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
Rv0234c|M.tuberculosis_H37Rv EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
MLBr_02573|M.leprae_Br4923 EAILRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS
Mflv_1858|M.gilvum_PYR-GCK ETLIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFVVFDD
TH_4137|M.thermoresistible__bu DELLGDPRVRKISFTGSTEVGRMIASRAGATMKRVSMELGGHAPFLVFPD
:: * *: :.*** .* : :. : :**** **:*: .
Mvan_1844|M.vanbaalenii_PYR-1 D-SKQLARTAWEFRVYNMGQACNSNKRMIVTDDLYDDFVAELVTLAGDLA
MSMEG_6702|M.smegmatis_MC2_155 D-PKELARTAWNFRMHNMGQACNSNKRIIVLDTIYDDFVTELVAAAEAFT
MAB_4322|M.abscessus_ATCC_1997 DDLDATVEAAAAARLDNTGQACNAAKRFIVVDELYDAFVEKFTATLLAAA
MMAR_0490|M.marinum_M ADLDKAVSTAVTGRVQNNGQSCIAAKRFIAHADIYDAFVDKFVEQMSALT
MUL_1153|M.ulcerans_Agy99 ADLDKAVSTAVTGRVQNNGQSCIAAKRFIAHADIYDAFVDKFVEQMSALT
MAV_4936|M.avium_104 ADLDEAVKTAVTARVQNNGQSCIAAKRFIVHTDIYDTFVDKFVEQMKALK
Mb0239c|M.bovis_AF2122/97 ADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALR
Rv0234c|M.tuberculosis_H37Rv ADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALR
MLBr_02573|M.leprae_Br4923 ADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLR
Mflv_1858|M.gilvum_PYR-GCK ADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTDKFVKRMSEFT
TH_4137|M.thermoresistible__bu ADPEHAAKGGAAVKFLNTGQACICPNRFIVHRSIAEPFIATLRARIEKLV
. . . :. * *::* . :*: . : : * :
Mvan_1844|M.vanbaalenii_PYR-1 P-------AEIAPMSSRKAAETLAAQVADAVDKGATLHVGGELAEGP---
MSMEG_6702|M.smegmatis_MC2_155 G-------EEIAPLSSRAAAENLAAQVADAVDKGATLHTGGVLAEAP---
MAB_4322|M.abscessus_ATCC_1997 --------DGIAPLSSVRAAQTLEAQVAAAKAGGATVISAG---ERR---
MMAR_0490|M.marinum_M VGDPTDPQTQVGPLATEQSRDEIAQQVDDAAAAGAVIRCGGKPLAGP---
MUL_1153|M.ulcerans_Agy99 VGDPTDPQTQVGPLATEQSRDEIAQQVDDAAAAGAVIRCGGKPLAGP---
MAV_4936|M.avium_104 VGDPTDPATDVGPLATESGRDEIAKQVDDAVAAGATLRCGGKPLDGP---
Mb0239c|M.bovis_AF2122/97 VGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRP---
Rv0234c|M.tuberculosis_H37Rv VGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRP---
MLBr_02573|M.leprae_Br4923 VGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRP---
Mflv_1858|M.gilvum_PYR-GCK LGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGGVAPGGP---
TH_4137|M.thermoresistible__bu PGDGLAAGTTVGPLIDEVALKKMQRQVDDAVDKGAKLELGGSRLQGPAFD
:.*: : * * ** : .*
Mvan_1844|M.vanbaalenii_PYR-1 -AAFYTPAVLTGVTPDMRAYSEELFGPVAVVYRVRDEEEAVALANASAYG
MSMEG_6702|M.smegmatis_MC2_155 -KAYFTPAVLTGVTPGMRAYTEELFGPVAVVYRVADAEEAVALANSTDFG
MAB_4322|M.abscessus_ATCC_1997 -GAFHPPAVITGLTADNPAYGQELFGPVASVYRASSEDQAVAIANDTPFG
MMAR_0490|M.marinum_M -GWYYPPTVITDITKDMNLYTEEVFGPVASVYRAADIDEAIEIANATTFG
MUL_1153|M.ulcerans_Agy99 -GWYYPPTVITDITKDMNLYTEEVFGPVASVYRAADIDEAIEIANATTFG
MAV_4936|M.avium_104 -GWFYPPTVVTDITKDMALYTEEVFGPVASMYRAADIDEAIEIANATTFG
Mb0239c|M.bovis_AF2122/97 -GWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFG
Rv0234c|M.tuberculosis_H37Rv -GWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFG
MLBr_02573|M.leprae_Br4923 -GWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFG
Mflv_1858|M.gilvum_PYR-GCK -GNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAANDTEYG
TH_4137|M.thermoresistible__bu NGHFYAPTILTGVTPDMLICSEETFGPIAPVMVFDDEDEAIAMANSTEYG
:...:::*.:. . :* ***:* : ::.: ** : :*
Mvan_1844|M.vanbaalenii_PYR-1 LGASVFSTDTARAEKVAQRLEAGMVNVNTPAGEGPDIPFGGVKRSGFGRE
MSMEG_6702|M.smegmatis_MC2_155 LGASVFSADTARAEAVARRLEAGMVNVNTPSGDGPDIPFGGIKRSGFGRE
MAB_4322|M.abscessus_ATCC_1997 LGSYVFTTDPEQAQRVANRIEAGMVFVNGVGADGAELPFGGIKRSGFGRE
MMAR_0490|M.marinum_M LGSNAWTQDEAEQRRFINDIEAGQVFINGMTVSYPELPFGGIKRSGYGRE
MUL_1153|M.ulcerans_Agy99 LGSNAWTQDEAEQRRFINDIEAGQVFINGMTVSYPELPFGGIKRSGYGRE
MAV_4936|M.avium_104 LGSNAWTNDAAEQQRFIDDIEAGQVFINGMTVSYPELGFGGVKRSGYGRE
Mb0239c|M.bovis_AF2122/97 LGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRE
Rv0234c|M.tuberculosis_H37Rv LGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRE
MLBr_02573|M.leprae_Br4923 LGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRE
Mflv_1858|M.gilvum_PYR-GCK LAAYVYTQSLDRALRVAEGIESGMVGVNRGVISDPAAPFGGIKESGFGRE
TH_4137|M.thermoresistible__bu LAGYIYTRDISRAIRVGEALDFGMIGINDINPTSAAVPFGGIKQSGLGRE
*.. :: . . . : * : :* . ***:*.** ***
Mvan_1844|M.vanbaalenii_PYR-1 LGALGIDEFVNKQVYVVAD-------------
MSMEG_6702|M.smegmatis_MC2_155 LGTLGIDEFVNKQVYVVAESSSSSD-------
MAB_4322|M.abscessus_ATCC_1997 LGRFGMEEFVNKKLIRTL--------------
MMAR_0490|M.marinum_M LAGHGIREFCNIKTVWVG--------------
MUL_1153|M.ulcerans_Agy99 LAGHGIREFCNIKTVWVG--------------
MAV_4936|M.avium_104 LAGLGIRAFCNAKTVWIGSSKSGDAGGGSKVE
Mb0239c|M.bovis_AF2122/97 LSAHGIREFCNIKTVWIA--------------
Rv0234c|M.tuberculosis_H37Rv LSAHGIREFCNIKTVWIA--------------
MLBr_02573|M.leprae_Br4923 LSTHGIREFCNIKTVWIA--------------
Mflv_1858|M.gilvum_PYR-GCK GGTEGIEEYLDTKYIALTK-------------
TH_4137|M.thermoresistible__bu GARAGIEEYLDTKVLGIAL-------------
. *: : : :