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TSPPTKPPTTRQQGAARTRNALIDAGFRLAASGGLVGLSVNRIVEDAAVSKGSFFHHFGDRASYLVALHR DFHDRILTEALAIIDGSAPGARRLAIASRAYLDSCLTNRAVRALLLEARAEPAINDAVRQRNSDTADLIE PDFTAMGWPHPRRAAQLWIGMTAEAALLEFDAGHKLTDLRASLARYIDADPALLGN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5881 | - | - | 100% (197) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1244 | - | 4e-10 | 29.41% (204) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5079 | - | 9e-07 | 28.49% (172) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0080 | - | 9e-06 | 26.95% (167) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_5109 | - | 1e-06 | 27.22% (180) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0078 | - | 1e-05 | 26.35% (167) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_02677 | - | 1e-06 | 27.06% (170) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2290 | - | 4e-10 | 32.11% (109) | transcriptional regulator TetR |
| M. marinum M | MMAR_1145 | - | 1e-06 | 27.22% (169) | transcriptional regulatory protein |
| M. avium 104 | MAV_1141 | - | 6e-07 | 23.93% (117) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6537 | - | 3e-07 | 28.66% (164) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3094 | - | 2e-07 | 28.70% (108) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0910 | - | 1e-06 | 27.65% (170) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0080|M.bovis_AF2122/97 -MEIKRRTQEER------SAATREALITGARKLWGLRGYAEVGTPEIATE
Rv0078|M.tuberculosis_H37Rv -MEIKRRTQEER------SAATREALITGARKLWGLRGYAEVGTPEIATE
MLBr_02677|M.leprae_Br4923 -MESQRRTQEER------STATRDALTLARHRLWRLRGYAEVGTPEIAKE
TH_3094|M.thermoresistible__bu -MSKRGGRVEDRR---ARGDQTRRDLIDAGRALFVDPGYFHTSVGDLVER
MMAR_1145|M.marinum_M -MAATRTTARAG-------GDRRAAIIEAALNRFLSQGIDATALRQIQRD
MUL_0910|M.ulcerans_Agy99 -MAATRTTARAG-------GDRRAAIIEAALNRFLSQGIDATALRQIQRD
MAB_2290|M.abscessus_ATCC_1997 -MSESKPGRRER-----YAALTRSAIVEAARMLFVERGFDDTSVDDIAEA
Mvan_5881|M.vanbaalenii_PYR-1 MTSPPTKPPTTRQ---QGAARTRNALIDAGFRLAASGGLVGLSVNRIVED
MSMEG_6537|M.smegmatis_MC2_155 -MDTSTAN----------AAATRVRLVDAAVRLITRHGFAGTSLQMIADE
Mflv_5109|M.gilvum_PYR-GCK MSGAPHATRWAGVPLTDRRAERRALLVDAAFRLFGDGGESAVSVRSVSRE
MAV_1141|M.avium_104 -MARQVRS-----------EATRQKILDSAIEVFGEVGYAAAGWSTIIER
* : . * . :
Mb0080|M.bovis_AF2122/97 AGV-TRGAMYHQFADKAALFRDV-VEVVEQDVMARMATLVAASGAATPAD
Rv0078|M.tuberculosis_H37Rv AGV-TRGAMYHQFADKAALFRDV-VEVVEQDVMARMATLVAASGAATPAD
MLBr_02677|M.leprae_Br4923 ADT-TRGAVYHQFTDKAALFRDV-VETVEQDAMAQIASVVASSGAKTPVD
TH_3094|M.thermoresistible__bu SGVGTRGAFYHHFPDKAALFRAV-FEDVEQDLTLR--SIASPPEGSDSWE
MMAR_1145|M.marinum_M AGV-SNGSFFHHFPSKEVLAAAVYVDCVTRYQQALLKDLARYPDAESAVR
MUL_0910|M.ulcerans_Agy99 AGV-SNGSFFHHFPSKEVLTAAVYVDCVTRYQQALLKDLVRYPDAESAVR
MAB_2290|M.abscessus_ATCC_1997 AQV-SKGAIYHHFKDKQEIFIDVYRDATKGVIENVVKVLIDVPAG--SWN
Mvan_5881|M.vanbaalenii_PYR-1 AAV-SKGSFFHHFGDRASYLVALHRDFHDRILTEALAIIDGSAPG---AR
MSMEG_6537|M.smegmatis_MC2_155 LGF-TKAAIYYHFRTREQLLGAV----VEPFLSELQTVIDDAERLRGVHA
Mflv_5109|M.gilvum_PYR-GCK CGL-NTRYFYESFGGTDDLLGAV-YDRVSAELSVAVADAMDHAEDSLRAR
MAV_1141|M.avium_104 TGM-TKGALYHHFDSKESLASNIIEEGSDRLLSAFRNVCGSSSPG---LE
. .: * :
Mb0080|M.bovis_AF2122/97 AIRAAVDAWLEVSGDPEVRQLVLLDAPVVLGWAGFRDVAQRYSLGMTEQ-
Rv0078|M.tuberculosis_H37Rv AIRAAVDAWLEVSGDPEVRQLILLDAPVVLGWAGFRDVAQRYSLGMTEQ-
MLBr_02677|M.leprae_Br4923 AIRAKVDAWLEGLADPQVRQLILLYAPSVLGWAAFRDVAQHYSLGMTEQQ
TH_3094|M.thermoresistible__bu RLTRGLHGFLDAAAEPEVQRIILIDGPVVLGWQTLRSIEERSSLAMIQQ-
MMAR_1145|M.marinum_M GIVGMHLSWCTEHP-EMARFLITMTEPAVHRAAADELRSHNERFATAVQT
MUL_0910|M.ulcerans_Agy99 GIVGMHLSWCTEHP-EMARFLITMTEPAVHRAAADELRSHNERFATAVQT
MAB_2290|M.abscessus_ATCC_1997 RIEAAASAVIKGYTDNREPRVLVRQVMGVLGAERTQALEGELALPLIRT-
Mvan_5881|M.vanbaalenii_PYR-1 RLAIASRAYLDSCLTNRAVRALLLEARAEPAINDAVRQRNSDTADLIEP-
MSMEG_6537|M.smegmatis_MC2_155 RADHMVRGYAGLAVRNRALVSVLAGDPSVNEALKTRPEWAALIDRQMRLL
Mflv_5109|M.gilvum_PYR-GCK TRAGMAAVLHFSSADPRRGRVLFTDARSNPVLTARRAATQDLLREAVLT-
MAV_1141|M.avium_104 NLVHGTFTIVEVLRSDKMVRAAAQLATALSGFNGAASRFYANLVLETAQE
Mb0080|M.bovis_AF2122/97 LITEAIRAGQLARQPVRPLAQVLIGALDEAAMFIATAD-----DPKR---
Rv0078|M.tuberculosis_H37Rv LITEAIRAGQLARQPVRPLAQVLIGALDEAAMFIATAD-----DPKR---
MLBr_02677|M.leprae_Br4923 LLSEASRARQLA----QPLDHVLIGKLYESAMAIRRHHRLPEASPARNQT
TH_3094|M.thermoresistible__bu ILRRAIADGSIEEQPVTALTHMLVSAVEEASLLIAHST-----DPER---
MMAR_1145|M.marinum_M WWRPHAHYGALRPLSPAHSQALWLGPAQELVRAWLLGN---LAAPPN---
MUL_0910|M.ulcerans_Agy99 WWRPHAHYGALRPLSPAHSQALWLGPAQELVRAWLLGN---LAAPPN---
MAB_2290|M.abscessus_ATCC_1997 LLTEAEENGELRDLSIEKASQLIFRVLCESSLLIANSAD--YAEAAQ---
Mvan_5881|M.vanbaalenii_PYR-1 ------DFTAMGWPHPRRAAQLWIGMTAEAALLEFDAG------------
MSMEG_6537|M.smegmatis_MC2_155 TDVAPGPAGRVKAMMVFSGMSAAAGPASDDIPVEELYA------------
Mflv_5109|M.gilvum_PYR-GCK --EGWRLHPDTDPVAAATGAAMYTGAMAELAQQWLSGNLG----------
MAV_1141|M.avium_104 ARRAIKEGDLRDDIDPDVLSASLMGTIFGARLIASTISGHGRIGDIIG--
Mb0080|M.bovis_AF2122/97 ----------AR------------RETRQVLRRLIDGMLNG---------
Rv0078|M.tuberculosis_H37Rv ----------AR------------RETRQVLRRLIDGMLNG---------
MLBr_02677|M.leprae_Br4923 GAAPTHREHVARPSCEALTRHIRHRSTRTRSHRGKRGELLPRAATSSLL-
TH_3094|M.thermoresistible__bu -----AR-----------------SDAEAVLDTLLNALTRRRSRSR----
MMAR_1145|M.marinum_M ------------------------AADAAILADAAWLCLRAGPAG-----
MUL_0910|M.ulcerans_Agy99 ------------------------AADAAILADAAWLCLRAGPAG-----
MAB_2290|M.abscessus_ATCC_1997 -------------------------EVETVMLCMFAGLRKPPAATRGRRK
Mvan_5881|M.vanbaalenii_PYR-1 -------------------------HKLTDLRASLARYIDADPALLGN--
MSMEG_6537|M.smegmatis_MC2_155 -------------------------HLVDTSRRALGLRAPREKA------
Mflv_5109|M.gilvum_PYR-GCK ------------------------DDLDVVVDHALRLVLR----------
MAV_1141|M.avium_104 ---------DPTARLHQIWSLLLPGIVSQASLPYFEQFLRREGMRHATAN
Mb0080|M.bovis_AF2122/97 --------
Rv0078|M.tuberculosis_H37Rv --------
MLBr_02677|M.leprae_Br4923 --------
TH_3094|M.thermoresistible__bu --------
MMAR_1145|M.marinum_M --------
MUL_0910|M.ulcerans_Agy99 --------
MAB_2290|M.abscessus_ATCC_1997 S-------
Mvan_5881|M.vanbaalenii_PYR-1 --------
MSMEG_6537|M.smegmatis_MC2_155 --------
Mflv_5109|M.gilvum_PYR-GCK --------
MAV_1141|M.avium_104 PGAEPEGE