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SGAPHATRWAGVPLTDRRAERRALLVDAAFRLFGDGGESAVSVRSVSRECGLNTRYFYESFGGTDDLLGA VYDRVSAELSVAVADAMDHAEDSLRARTRAGMAAVLHFSSADPRRGRVLFTDARSNPVLTARRAATQDLL REAVLTEGWRLHPDTDPVAAATGAAMYTGAMAELAQQWLSGNLGDDLDVVVDHALRLVLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5109 | - | - | 100% (201) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4631 | - | 4e-21 | 32.81% (192) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1669 | - | 3e-20 | 33.33% (192) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0281c | - | 6e-21 | 36.36% (198) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0275c | - | 3e-20 | 35.86% (198) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02568 | - | 6e-06 | 23.24% (185) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1638 | - | 5e-24 | 31.58% (190) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3144 | - | 8e-23 | 31.91% (188) | AcrR family transcriptional regulator |
| M. avium 104 | MAV_3986 | - | 2e-82 | 77.84% (194) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_1355 | - | 1e-86 | 83.42% (193) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_4000 | - | 2e-82 | 77.11% (201) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0446 | - | 2e-19 | 33.33% (192) | hypothetical protein MUL_0446 |
| M. vanbaalenii PYR-1 | Mvan_1244 | - | 4e-90 | 86.08% (194) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5109|M.gilvum_PYR-GCK -----MSGAP-----HATRWAGVPLTDRRAERRALLVDAAFRLFGDG--G
Mvan_1244|M.vanbaalenii_PYR-1 -----MSSAASRPAATPTRWAGVPLTDRRAERRALLVDAAFRLFGDG--G
MSMEG_1355|M.smegmatis_MC2_155 -----MT--------TPTRWAGVPLTDRRAERRALLVDAAFRLFGDG--G
TH_4000|M.thermoresistible__bu -----MT--------SPTRWAGVPLTDRRAERRALLIAAAYRLFGEG--G
MAV_3986|M.avium_104 -----MS--------SPSRWAGVPLKDRRAERRALLVEAAYRLFGSE--G
MUL_0446|M.ulcerans_Agy99 -----MQAGQ-----RRGRWTGVPLEDRHAVRRDTLIAAGVQLLGEE--A
Mb0281c|M.bovis_AF2122/97 -----MTR-------SDRPYRGVEAAERLATRRRQLLSAGLDLLGSDQHD
Rv0275c|M.tuberculosis_H37Rv -----MTR-------SDRPYRGVEAAERLATRRRQSLSAGLDLLGSDQHD
MAB_1638|M.abscessus_ATCC_1997 ---MVTKQ-------ATGLYGGRTADERRAERRRRLLEAGLEVMASS--G
MMAR_3144|M.marinum_M MSP-------------ARVYGGLSATQRDAQRRALLIDAAVALMGKQ--G
MLBr_02568|M.leprae_Br4923 -------------------MAGGAKRIPRAVREQQMLDAAVQMFSVN--G
* * *. : *. ::.
Mflv_5109|M.gilvum_PYR-GCK ESAVSVRSVSRECGLNTRYFYESFGGTDDLLGAVYDRVSAELSVAVADAM
Mvan_1244|M.vanbaalenii_PYR-1 EQALSVRSVSREAGLNTRYFYESFTDTDDLLGAVYDRVSAELAEVVEAAM
MSMEG_1355|M.smegmatis_MC2_155 ETALSVRSVCRECGLNTRYFYESFADTDDLIGAVYDEVSALLAADVEAAM
TH_4000|M.thermoresistible__bu EAALSVRSVCRESELNSRYFYESFADVDELLGAVYDEVSAQLAAEVETAM
MAV_3986|M.avium_104 EAAVSVRSVCRECGLNTRYFYESFRDTDDLLGAVYDRVSEQLEEVIAAAI
MUL_0446|M.ulcerans_Agy99 GPALTVRAVCRQAALTERYFYESFSDRDHFVRAVYDDVCTRAMATLMSAN
Mb0281c|M.bovis_AF2122/97 IAELTIRTICRRAGLSVRYFYESFTDKDEFVGRVFDWVVAELVATTQAAV
Rv0275c|M.tuberculosis_H37Rv IAELTIRTICRRAGLSVRYFYESFTDKDEFVGRVFDWVVAELVATTQAAV
MAB_1638|M.abscessus_ATCC_1997 WAATTVREICKTAGLNTRYFYECFDGLDELLVAVFDWIIEDSIATAGSAM
MMAR_3144|M.marinum_M AAACTVTAVCTESGVTSRYFYQQFRDRDALLRAMFTKISTTFQAVITKAI
MLBr_02568|M.leprae_Br4923 YHKTSMDAIAAEAQISKPMLYLYYGSKEDLFGACLNREMSRFIAMVRADI
:: :. . :. :* : . : :.
Mflv_5109|M.gilvum_PYR-GCK --------DHAEDSLRARTRAGMAAVLHFSSADPRRGRVLFTDARSNPVL
Mvan_1244|M.vanbaalenii_PYR-1 --------SGAGASLPARTRAGMTAVLHFSSADPRRGRVLFTDARANPVL
MSMEG_1355|M.smegmatis_MC2_155 --------EGAGNSLRARTRAGIAAVLGFSSADPRRGRVLFTDARANPVL
TH_4000|M.thermoresistible__bu AAAVEGAGEGAGDSLRARTRAGIVAVLGFSSADPRRGRILFTDARANPVL
MAV_3986|M.avium_104 --------EQAGDSLRARTRAGIAAVLGFSSADPRRGRVLFTDARTNPVL
MUL_0446|M.ulcerans_Agy99 -----------------TPRDAVERFVALMVDDPVRGRVLLLAPAVEPVL
Mb0281c|M.bovis_AF2122/97 T--------AVP--AREQTRAGMANIVRTITADARVGRLLFSTQLANAVI
Rv0275c|M.tuberculosis_H37Rv T--------AVP--AREQTRAGMANIVRTITADARVGRLLFSTQLANAVI
MAB_1638|M.abscessus_ATCC_1997 A--------AADKDSRSQVHAGVVGAVTALTADPRRARVIATEAMGSQRL
MMAR_3144|M.marinum_M P--------DDTVAPQELAYAPIKALVQMIENDPSMARILFVESGAEPLL
MLBr_02568|M.leprae_Br4923 D---------FTQSPKDLLRNTIVSFLRYIDANRASWIVMYIQAMSLPAF
: : : :: :
Mflv_5109|M.gilvum_PYR-GCK TARRAATQDLLREAVLTEGWRLH--PDTDPVAAATGAAMYTGAMAELAQQ
Mvan_1244|M.vanbaalenii_PYR-1 TQRRAATQDLLREAVLTEGWRLH--PDSDPTAAMVGAAMYTGAMAELAQQ
MSMEG_1355|M.smegmatis_MC2_155 AQRRAVTQDLLREAVLSEGGRLN--PGSDPVAAQVGAAMYTGAMAELAQQ
TH_4000|M.thermoresistible__bu AARRAATQDQLREAVLTEGWRLH--PKSDPVAAQVGAAMYTGAMAELAQQ
MAV_3986|M.avium_104 AARRRATQDMLRQGVLSEGWRLN--PRSDPVAAEVAAAMYTGAMAELAQQ
MUL_0446|M.ulcerans_Agy99 TR---SGADWMPNFIDLLQRKLS--QIADPVLQKLVATSLIGALTGLFTA
Mb0281c|M.bovis_AF2122/97 TRKRAESSALFAMLSGQHAVDTL--HAPANDHVKAVAHFAVGGVGQTISA
Rv0275c|M.tuberculosis_H37Rv TRKRAESSALFAMLSGQHAVDTL--HAPANDHVKAVAHFAVGGVGQTISA
MAB_1638|M.abscessus_ATCC_1997 TRRRMRLTHYMALMLGAARAEFD--PEADPNYTAVQAEALAAGVAGTVLA
MMAR_3144|M.marinum_M RQLRSELMSEFAELVLREARLHLDIPSEVIQVADLAATYGVGGLFEILRR
MLBr_02568|M.leprae_Br4923 AQTVREARDQITELVAGLMRVGTR-SSRPDHEYEIMAGALVGAGEAMATR
: * ..
Mflv_5109|M.gilvum_PYR-GCK WLSGNLGDDLDVVVDHALRLVLR---------------------------
Mvan_1244|M.vanbaalenii_PYR-1 WLAGHLGDDLDAVVGYALRLVLR---------------------------
MSMEG_1355|M.smegmatis_MC2_155 WLAGNLGDDLDAVVDHALRLVLGR--------------------------
TH_4000|M.thermoresistible__bu WLAGNLGDDLDRVVDYALRLVLGR--------------------------
MAV_3986|M.avium_104 WLAGHLGGDLDAVVDYASKLVLR---------------------------
MUL_0446|M.ulcerans_Agy99 YLNGQLGATRQQFIDYCVDLLLGTAAAYAPHRDRGEAEHPVAARQHD---
Mb0281c|M.bovis_AF2122/97 WLAGDVRLDPDQLVDQLAALLDELTDPNLSRPRVAATAAKSGANDPQPPE
Rv0275c|M.tuberculosis_H37Rv WLAGDVRLDPDQLVDQLAALLDELTDPNLSRPRVAATAAKSGANDPQPPE
MAB_1638|M.abscessus_ATCC_1997 WLDGRLRLEREELAEYTAQFVDQAMFTPLPVHNSVEH-------------
MMAR_3144|M.marinum_M WIDGQLNLSTEVLIEHCAGFLGSLGLYTLGQKPDPAASHIQVDINSPAGH
MLBr_02568|M.leprae_Br4923 LTTGDIAVD--EAAELMINLFWHGLKGAPADRDFGPSIVAG---------
* : :.
Mflv_5109|M.gilvum_PYR-GCK ---------------
Mvan_1244|M.vanbaalenii_PYR-1 ---------------
MSMEG_1355|M.smegmatis_MC2_155 ---------------
TH_4000|M.thermoresistible__bu ---------------
MAV_3986|M.avium_104 ---------------
MUL_0446|M.ulcerans_Agy99 ---------------
Mb0281c|M.bovis_AF2122/97 VAGQPPSSARPARRS
Rv0275c|M.tuberculosis_H37Rv VAGQPPSSARPARRS
MAB_1638|M.abscessus_ATCC_1997 ---------------
MMAR_3144|M.marinum_M NR-------------
MLBr_02568|M.leprae_Br4923 ---------------