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VDTSTANAAATRVRLVDAAVRLITRHGFAGTSLQMIADELGFTKAAIYYHFRTREQLLGAVVEPFLSELQ TVIDDAERLRGVHARADHMVRGYAGLAVRNRALVSVLAGDPSVNEALKTRPEWAALIDRQMRLLTDVAPG PAGRVKAMMVFSGMSAAAGPASDDIPVEELYAHLVDTSRRALGLRAPREKA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6537 | - | - | 100% (191) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0227 | - | 1e-29 | 39.34% (183) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5718 | - | 5e-17 | 31.43% (175) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1846 | - | 4e-07 | 30.69% (101) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0973 | - | 9e-48 | 50.26% (189) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1816 | - | 4e-07 | 30.69% (101) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00815 | - | 0.0001 | 27.38% (84) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2677c | - | 6e-11 | 28.10% (153) | putative trancscriptional regulator,TetR |
| M. marinum M | MMAR_4674 | - | 6e-17 | 31.61% (174) | transcriptional regulator |
| M. avium 104 | MAV_0959 | - | 5e-24 | 40.56% (180) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2336 | - | 3e-51 | 51.34% (187) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_0293 | - | 4e-17 | 31.61% (174) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0170 | - | 9e-50 | 53.07% (179) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1846|M.bovis_AF2122/97 -----------------------MCQTCRVGKRRDAREQIEAKIVELGRR
Rv1816|M.tuberculosis_H37Rv -----------------------MCQTCRVGKRRDAREQIEAKIVELGRR
Mflv_0973|M.gilvum_PYR-GCK --------------------------MSGDSTRAGGP--TRRRLIDVAIE
TH_2336|M.thermoresistible__bu ------------VSGVGKPISREAALLTSRASAGTGP--TRQRLIEVAIE
Mvan_0170|M.vanbaalenii_PYR-1 --------------------------MTTASSAQMPPQSARQRVLDVALA
MSMEG_6537|M.smegmatis_MC2_155 --------------------------MDTSTANAAAT---RVRLVDAAVR
MAV_0959|M.avium_104 -------------------MGTARQAVSDEQFWLVEHSPARTRVLDAALD
MMAR_4674|M.marinum_M ------------------------------MTKPRSD--TRRRIQEVARE
MUL_0293|M.ulcerans_Agy99 -----------------------------MVTKPRSD--TRRRIQEVARE
MAB_2677c|M.abscessus_ATCC_199 -----------------------------MLSDAAVAPGTRERIQTVARD
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
. :: .
Mb1846|M.bovis_AF2122/97 QLLDHGAAGLSLRAIARNLGMVSSAVYRYVSSRDELLTLLLVDAYSDLAD
Rv1816|M.tuberculosis_H37Rv QLLDHGAAGLSLRAIARNLGMVSSAVYRYVSSRDELLTLLLVDAYSDLAD
Mflv_0973|M.gilvum_PYR-GCK LFKRYSVAGTSLQMISDELGLTKSAIYHHFRTRDELLTAVMEPLIAEVAE
TH_2336|M.thermoresistible__bu LFKQHSVAGTSLQMISDALGLTKSAIYHHFRTRDELLTAVMEPLISEVAE
Mvan_0170|M.vanbaalenii_PYR-1 LFTRHGYAGTSLQMIADEMGVTKGSLYYHFRAREDLLRALVGPLIEQLRA
MSMEG_6537|M.smegmatis_MC2_155 LITRHGFAGTSLQMIADELGFTKAAIYYHFRTREQLLGAVVEPFLSELQT
MAV_0959|M.avium_104 LFAANGVSGTSLQMIADAVGITKAAVYHQFRTKEQIVIAVTERELGRLVP
MMAR_4674|M.marinum_M LFLRQGVRGTSLQDIADRLGITKPALYYHFASREDLVRSIVVPLIEEGER
MUL_0293|M.ulcerans_Agy99 LFLRQGVRGTSLQDIADRLGITKPALYYHFASREDLVRSIVVPLIEEGER
MAB_2677c|M.abscessus_ATCC_199 LFAERGLRNTSLQDIASRLKITKPALYYHFSSRDELVRSIVQPMVDDLQT
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
: . .: *: . . :* . :: :: :
Mb1846|M.bovis_AF2122/97 TVDRARDDTVADSWSDDVIAIARAVRGWAVTNPARWALLYGSPVPGYHAP
Rv1816|M.tuberculosis_H37Rv TVDRARDDTVADSWSDDVIAIARAVRGWAVTNPARWALLYGSPVPGYHAP
Mflv_0973|M.gilvum_PYR-GCK IVDAAEEQRTPHARAD---HMLVGYASIAARHRTLIPLLSGDPGVVALLR
TH_2336|M.thermoresistible__bu IVSAAEARRGARTRAD---HFLRGYAALAAAHREVISLLTGDPGVVALLR
Mvan_0170|M.vanbaalenii_PYR-1 IVEHAEAQRSPSVRAE---HVLTGYARLAAANRALVAVTSGDPSVVEVIH
MSMEG_6537|M.smegmatis_MC2_155 VIDDAERLRGVHARAD---HMVRGYAGLAVRNRALVSVLAGDPSVNEALK
MAV_0959|M.avium_104 ALEEAEAHDDGPQARD---ALLVRVIEMAVRDRRLVRTLQFDPVVVRLLA
MMAR_4674|M.marinum_M FVAERERLADGNVRG-----LLEGYFDFHYRHRQDLMLVVVELTLLSDLG
MUL_0293|M.ulcerans_Agy99 FVAERERLADGNVRG-----LLEGYFDFHYRHRQDLMLVVVELTLLSDLG
MAB_2677c|M.abscessus_ATCC_199 FLATNN---AGDRRQ-----LLEDYFDVLWTHRVVLGIIVRDLAALGQLE
MLBr_00815|M.leprae_Br4923 SVQQALRTTTNNRQRLH--AAVQAFFDFIEHDGQGYRLIFENDNITEPRV
: . .
Mb1846|M.bovis_AF2122/97 PDRTAGVATRVVGAFFDAIAAGIATGDIRLTDDVAPQPMSSDFEKIRQEF
Rv1816|M.tuberculosis_H37Rv PDRTAGVATRVVGAFFDAIAAGIATGDIRLTDDVAPQPMSSDFEKIRQEF
Mflv_0973|M.gilvum_PYR-GCK TRSEWGDLVRRQLALFSEVEPGLGG-------------------QVKAAL
TH_2336|M.thermoresistible__bu TRPDWAEVVQRQMALLGDVQPGPGG-------------------RVKAAV
Mvan_0170|M.vanbaalenii_PYR-1 ADPDWADLIDRQIGLLAAVQPGLAG-------------------RVRATI
MSMEG_6537|M.smegmatis_MC2_155 TRPEWAALIDRQMRLLTDVAPGPAG-------------------RVKAMM
MAV_0959|M.avium_104 EHEPFQRFMDRLYRVLLSD-AGLDG-------------------RIEAAM
MMAR_4674|M.marinum_M LIDTVLAWRERLGRLVFGAAPTLGQ-------------------ATRAVL
MUL_0293|M.ulcerans_Agy99 LIDTVLARRERLGRLVFGAAPTLGQ-------------------ATRAVL
MAB_2677c|M.abscessus_ATCC_199 LGEWMMGWRRRLIVLLAGGKPSAAQ-------------------MIQATV
MLBr_00815|M.leprae_Br4923 AAQVRVATESCIDAVFALISADSRLD------------------PHRARM
.. . . .
Mb1846|M.bovis_AF2122/97 GFPGDDRVVTKCFLLWAGVVGAISLEVFGQYGADMLTDPGVVFDAQTRLL
Rv1816|M.tuberculosis_H37Rv GFPGDDRVVTKCFLLWAGVVGAISLEVFGQYGADMLTDPGVVFDAQTRLL
Mflv_0973|M.gilvum_PYR-GCK AMSG---------IASAAGVDYGGDVDDDTLRDQLIAAGRRALGLRNSRT
TH_2336|M.thermoresistible__bu VMAG---------IAAAAGVDYG-DLDEAALRDELLAAGRRTLGLR----
Mvan_0170|M.vanbaalenii_PYR-1 VMAG---------IAATAAPGVV-EADEAELCRQLIDAGRRTLGLR----
MSMEG_6537|M.smegmatis_MC2_155 VFSG---------MSAAAGPASD-DIPVEELYAHLVDTSRRALGLR----
MAV_0959|M.avium_104 FSGA---------LSTAVMHPLVVDIDDETLLDRVTDLSRRLLGLPR---
MMAR_4674|M.marinum_M AFGG---------LQDCCMQFPD--EPYAQLRQYSVEAALAALGV-----
MUL_0293|M.ulcerans_Agy99 AFGG---------LQDCCMQFPD--EPYAQLRQYSVEAALAALGV-----
MAB_2677c|M.abscessus_ATCC_199 ALGG---------LSDCTIEYAD--RPHRQVKKTAVAAAIAALES-----
MLBr_00815|M.leprae_Br4923 VAVG---------LVGISVDCARYWLDTNRPISKSDAVEGTVQFAWGGLS
. :
Mb1846|M.bovis_AF2122/97 VAVLAEH
Rv1816|M.tuberculosis_H37Rv VAVLAEH
Mflv_0973|M.gilvum_PYR-GCK GAVTARR
TH_2336|M.thermoresistible__bu -APHARG
Mvan_0170|M.vanbaalenii_PYR-1 -APRA--
MSMEG_6537|M.smegmatis_MC2_155 -APREKA
MAV_0959|M.avium_104 -KPVE--
MMAR_4674|M.marinum_M -------
MUL_0293|M.ulcerans_Agy99 -------
MAB_2677c|M.abscessus_ATCC_199 -------
MLBr_00815|M.leprae_Br4923 HVPLTRL