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TAVSLITGGAGGMGLATAKVVGQDRAVVLCDVRQDRLDGAAAALKDLGVAVTAVNCDVTDRRAVDALFET VSRLGTLVSVIHTAGVSPSMGDAEYVMRTNALGTLNVDEAFYGAATDGAAIVNVASMAAYLLPAELIPTS AFPLALQDTEAFMTEMLAACAIAPEEARSGISYAISKSFVRWYSSSQAERFNGRGLRIVSVSPGSVDTEM GRLEEQAGAGAMVADAAVPRWGKPEEMAELLAFCAGDKAGYLTGTDILNDGGVVASMTERARLAAASSS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5812 | - | - | 100% (280) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_2281 | - | 7e-18 | 30.83% (266) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4241 | - | 3e-17 | 32.41% (216) | 3-alpha-hydroxysteroid dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 5e-14 | 26.50% (283) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_1024 | - | 1e-122 | 78.62% (276) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 5e-14 | 26.50% (283) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 6e-12 | 27.20% (261) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0691 | - | 2e-28 | 33.46% (263) | short chain dehydrogenase |
| M. marinum M | MMAR_0243 | - | 6e-27 | 30.94% (265) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5240 | - | 1e-125 | 79.93% (274) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6662 | - | 1e-120 | 77.54% (276) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_0784 | - | 1e-108 | 74.14% (263) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4870 | - | 5e-26 | 30.83% (266) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5812|M.vanbaalenii_PYR-1 -------------------MTAVSLITGGAGGMGLATAKVVGQDRAVVLC
MAV_5240|M.avium_104 ----------------------MSVITGGAGGMGVATAKVVGRDHTLVLC
MSMEG_6662|M.smegmatis_MC2_155 -------------------MRTVSVITGGAGGMGVATAKIVGKEHAVVLC
TH_0784|M.thermoresistible__bu --------------------------------MGQATARVVGREHAVVLC
Mflv_1024|M.gilvum_PYR-GCK -------------------MSAVSLITGGAGGMGLATAKVVGRDHSVVLC
MMAR_0243|M.marinum_M -------------------MSRDVLTVIGVGGMGQAIARRLGSGKTVLLA
MUL_4870|M.ulcerans_Agy99 -------------------MSRNVLTVIGVGGMGQAIARRLGSGKTVVLA
MAB_0691|M.abscessus_ATCC_1997 -------------------MPDEVVVVIGVGGMGRVIARRQGIGKALLLA
Mb1976|M.bovis_AF2122/97 -------------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLC
Rv1941|M.tuberculosis_H37Rv -------------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLC
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
:* . *: :
Mvan_5812|M.vanbaalenii_PYR-1 DVRQDRLDGAAAALKDLGVAVTAVNCDVTDRRAVDALFETVSR-LGTLVS
MAV_5240|M.avium_104 DVRQDRLTAATAALAELGMTPTAVNCDVTDRRAVAQLFDTAAG-LGTVVS
MSMEG_6662|M.smegmatis_MC2_155 DVRQDRLDTAATALAEVGITPTVVKCDVTDRHAVNRLFATTAG-LGTLAS
TH_0784|M.thermoresistible__bu DVRQDRLDTAAAVLRDDGITATPVHCDVTDPQAVDRLFKETAG-IGELAS
Mflv_1024|M.gilvum_PYR-GCK DVRQERLDAAAAELAGLGISATTVHCDVTDRDAVGRLFDGAAV-AGTLAS
MMAR_0243|M.marinum_M DNNADTLASVSETLAAEGHDVKSRGVDVCAAESVHDLAQYAAT-LGAVTQ
MUL_4870|M.ulcerans_Agy99 DNNADTLASVAESLAAEGHDVRSRGVDVCAAESVHDLAQYAAT-LGAVTQ
MAB_0691|M.abscessus_ATCC_1997 DHNEQALQAVVDELKADGHNVIGQRVDVSSRASVSGLAQAAAG-LGRVAQ
Mb1976|M.bovis_AF2122/97 ADIDGDAADAAATKIG--CGAAACRVDVSDEQQIIAMVDACVAAFGGVDK
Rv1941|M.tuberculosis_H37Rv ADIDGDAADAAATKIG--CGAAACRVDVSDEQQIIAMVDACVAAFGGVDK
MLBr_01807|M.leprae_Br4923 THR--------ASVVP--DWFFGVECDVTDNDAIGAAFKAVEEHQGPVEV
** : * :
Mvan_5812|M.vanbaalenii_PYR-1 VIHTAGVSPSMGDAEYVMRTNALGTLNVDEAFYGAATDGAAIVNVASMAA
MAV_5240|M.avium_104 VIHTAGVSPSMGPADYVMRTNAIGTLNVNEAFYAVAGDGSVIVNVASMAA
MSMEG_6662|M.smegmatis_MC2_155 VIHTAGVSPSMGDAEYVIRTNAIGTATINEAFYAAAPRGSAIVNVASMAA
TH_0784|M.thermoresistible__bu VIHTAGVSPSMGSAEYVMRTNAVGTVHVNEAFLRTAGAGAAIVNVASMAA
Mflv_1024|M.gilvum_PYR-GCK VIHTAGVSPSMGDAEYVMRTNALGTVNVGEQFFARAGEGAALVNVASMAA
MMAR_0243|M.marinum_M LAHTAGLSPAQASAQAILAVDLLGVALVLQEFGAVIAPGGAGVIIASMAG
MUL_4870|M.ulcerans_Agy99 LAHTAGLSPTQASAQAILAVDLVAVALVLQEFGAVIAPGGAGVIIASMAG
MAB_0691|M.abscessus_ATCC_1997 VAHTAGLSPAQSPTAAILAVDLVGVALVVEEFGKIVASGGAGVVIASMAG
Mb1976|M.bovis_AF2122/97 LVANAGVVHLASLIDTTV-----------EDFDRVIAIN---LRGAWLCT
Rv1941|M.tuberculosis_H37Rv LVANAGVVHLASLIDTTV-----------EDFDRVIAIN---LRGAWLCT
MLBr_01807|M.leprae_Br4923 LVANAGITSDMLIMRMSE-----------EQFQKVIDVN---LTGVFRVA
: .**: : * . : .
Mvan_5812|M.vanbaalenii_PYR-1 YLLPAELIPTSAFPLALQDTEAFMTEMLAACAIAPEEARSGISYAISKSF
MAV_5240|M.avium_104 HMLPAEIVPTAQFPLALSDADAFMDAMLAACEIAPEQARSGLAYAVSKSF
MSMEG_6662|M.smegmatis_MC2_155 HLLPEEMIPTGLFPQAMQAPEVFLKDMLAACEIVPEEARSGIAYALSKSF
TH_0784|M.thermoresistible__bu HMLPAEMVRTNLFARALTDLDGFLSEMLATCDAFPEEGRSGIAYALSKSF
Mflv_1024|M.gilvum_PYR-GCK HILPAELIPTAVFPAALQDPDTFMAEMLTACEIAPEEARSGIAYALSKSF
MMAR_0243|M.marinum_M HLLPPPSAEQ------ERELAHRPPGQLLELDFVGSIVEPAFAYPFAKQA
MUL_4870|M.ulcerans_Agy99 HLLPPPSAEQ------EHDLAHRPPGQLLELDFVGSIVEPAFAYPFAKQA
MAB_0691|M.abscessus_ATCC_1997 HMPYELTAEQ------EQELGTTHAEDLLSLPYVRDIEHPAVAYQVSKRA
Mb1976|M.bovis_AF2122/97 KHAAPRMIER-------GGGAIVNLSSLAGQVAVGGTG----AYGMSKAG
Rv1941|M.tuberculosis_H37Rv KHAAPRMIER-------GGGAIVNLSSLAGQVAVGGTG----AYGMSKAG
MLBr_01807|M.leprae_Br4923 KLASRNMIKQ-------RFGRYIFMGSVVGLSGVPGQA----NYAASKSG
: * :*
Mvan_5812|M.vanbaalenii_PYR-1 VRWYSSSQAERFNGRGLRIVSVSPGSVDTEMGR---LEEQAGAG----AM
MAV_5240|M.avium_104 VKWYSQSQAERFNARGLRIVSVSPGSIDTEMGR---LEENAGAG----AM
MSMEG_6662|M.smegmatis_MC2_155 VRWYSSSQAERFTGRGLRIVSVSPGSVDTEMGR---LEEKAGAG----AL
TH_0784|M.thermoresistible__bu VKWYSAAQAERFNARGLRIVSVSPGSIDTEMGR---LEEQAGAG----AM
Mflv_1024|M.gilvum_PYR-GCK VRWYSVAQAERFNGKGLRILSVSPGSIDTEMGR---LEEQAGAG----AM
MMAR_0243|M.marinum_M NSIRVRAASRQWGQREARVNSISPGIISTPMGQ---QELASPVGDGMRAM
MUL_4870|M.ulcerans_Agy99 NSIRVRAASRQWGQREARVNSISPDIISTPMGQ---QELASPVGDGMRAM
MAB_0691|M.abscessus_ATCC_1997 NHIRVRFAARQWGTRGARINSISPGVVSTPMGH---QELASETGAITKAM
Mb1976|M.bovis_AF2122/97 IIQLSRITAAELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGARS
Rv1941|M.tuberculosis_H37Rv IIQLSRITAAELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGARS
MLBr_01807|M.leprae_Br4923 LIGMARSLARELGSRSITANVVAPGFIDTEMTRAMDSKYQEAA-------
: . : * :.* * :
Mvan_5812|M.vanbaalenii_PYR-1 VADAAVPRWGKPEEMAELLAFCAGDKAGYLTGTDILNDGGVVASMTERAR
MAV_5240|M.avium_104 VADAAVPRWGKPEEMAELLAFCASDKAGYLTGTDILNDGGVIASMTERAR
MSMEG_6662|M.smegmatis_MC2_155 VADAAVPRWGTPEEMAELFAFCASDRAGYLTGTDILNDGGVVASMRERAR
TH_0784|M.thermoresistible__bu VADAAVPRWGTPEEMAELLAFCASAKASYLTGTDILNDGGVIASMTERAR
Mflv_1024|M.gilvum_PYR-GCK VADAAVPRWGTAEEMADLLAFCASRKAGYLTGTDILNDGGVIASMTERTR
MMAR_0243|M.marinum_M IAMSGTGRIGTPDDIAAAAAFLLGPEATFITGADLLVDGGVVAAIRASR-
MUL_4870|M.ulcerans_Agy99 IAMSGTGRIGTPDDIAAAAAFLLGPEATFITGADLLVDGGVVAAIRANG-
MAB_0691|M.abscessus_ATCC_1997 VDGSASRRIGTSDDIAAAAAFLLGPESSYVTGTDLLVDGGVIAAVRSGQL
Mb1976|M.bovis_AF2122/97 MIARLQGRMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW----
Rv1941|M.tuberculosis_H37Rv MIARLQGRMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW----
MLBr_01807|M.leprae_Br4923 LQAIPLGRIGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-----
: * . :::* * . : ::*: *** .
Mvan_5812|M.vanbaalenii_PYR-1 LAAASSS-
MAV_5240|M.avium_104 VTAAG---
MSMEG_6662|M.smegmatis_MC2_155 VAAEQQQQ
TH_0784|M.thermoresistible__bu AAAETQ--
Mflv_1024|M.gilvum_PYR-GCK LASQ----
MMAR_0243|M.marinum_M --------
MUL_4870|M.ulcerans_Agy99 --------
MAB_0691|M.abscessus_ATCC_1997 FN------
Mb1976|M.bovis_AF2122/97 --------
Rv1941|M.tuberculosis_H37Rv --------
MLBr_01807|M.leprae_Br4923 --------