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AHQLGSLGARVTGLDLREPDAQSAIQDFVQLDLAEPRSVDAAAAAVDGRVDALFNVAGVSSGIKDPLLVM RINFLGMRQFTEALIARMPEGSSITNVSSLAASAYLENAATTAGLLETGSVAEGLQWCADHPEALADGGY RQSKEAIILYGMRRTADLGARGIRINCSAPGVTETPILDQLRSAYGQQYLDSFTAPLGRVSTAEEQAAML IFLGSRAAGYLTGQVVWTDGGILAQRISAQMTDIQAAQGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4241 | - | - | 100% (251) | 3-alpha-hydroxysteroid dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2008 | - | 2e-23 | 31.97% (244) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_5812 | - | 2e-17 | 32.41% (216) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 2e-10 | 26.79% (209) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2405 | - | 1e-107 | 77.60% (250) | 3-alpha-hydroxysteroid dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 2e-10 | 26.79% (209) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-12 | 28.50% (207) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_1219 | - | 4e-11 | 27.63% (257) | short chain dehydrogenase |
| M. marinum M | MMAR_4773 | - | 1e-72 | 56.33% (245) | dehydrogenase/reductase |
| M. avium 104 | MAV_0882 | - | 9e-76 | 59.02% (244) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4862 | - | 8e-98 | 70.92% (251) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3914 | - | 7e-37 | 37.50% (232) | PUTATIVE 3-alpha-hydroxysteroid dehydrogenase |
| M. ulcerans Agy99 | MUL_0344 | - | 5e-70 | 55.10% (245) | 3-alpha-hydroxysteroid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2882c|M.bovis_AF2122/97 --MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMRAEGATI
Rv2857c|M.tuberculosis_H37Rv --MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMRAEGATI
MLBr_01807|M.leprae_Br4923 --MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRV
Mvan_4241|M.vanbaalenii_PYR-1 --------------------------------------MAHQLGSLGARV
Mflv_2405|M.gilvum_PYR-GCK -------MRYDG-----------RHVVVTGCASGIGAQAARLLRDLGARV
MSMEG_4862|M.smegmatis_MC2_155 MAALDALVRYDG-----------RHVVVTGCSSGIGAKVTDQLRCLGARV
MMAR_4773|M.marinum_M MAQIEQLWRYDG-----------RRAVVTGCASGIGERAVHQLTGLGAQV
MUL_0344|M.ulcerans_Agy99 MAQIEQLWRYDG-----------RRAVVTGCASGIGERAVHRLTGLGAQV
MAV_0882|M.avium_104 MAEIDALWRYDG-----------RRAVVTGCASGIGEQVVRQLGQLGADV
TH_3914|M.thermoresistible__bu ------MSEFTN-----------RRYVVTGAASGIGDATARKLLAAGAEV
MAB_1219|M.abscessus_ATCC_1997 ------MGEFDN-----------KVAIVTGAAQGIGEAYAHALAREGAAV
: * :
Mb2882c|M.bovis_AF2122/97 VVGDVDVEA-----GGAAADELSGLFVPTDVCDEDAVNGLFDGAAETY--
Rv2857c|M.tuberculosis_H37Rv VVGDVDVEA-----GGAAADELSGLFVPTDVCDEDAVNGLFDGAAETY--
MLBr_01807|M.leprae_Br4923 AV----THR-----ASVVPDWFFG--VECDVTDNDAIGAAFKAVEEHQ--
Mvan_4241|M.vanbaalenii_PYR-1 TGLDLREPD-----AQSAIQDFVQLDLAEPRSVDAAAAAVDGRVDALFNV
Mflv_2405|M.gilvum_PYR-GCK TGLDVRAPE-----DVSALTDFISVDLADQDSVRAAAAAVDGAVDALFNV
MSMEG_4862|M.smegmatis_MC2_155 TGLDLRAPD-----SGAGPDAFREMDLADPDSVDAAAAAIDGPVHALFNV
MMAR_4773|M.marinum_M VGLDQRQP-------GYEISEFHQIDLADPGSIGRAVEAIGGPVDALFNI
MUL_0344|M.ulcerans_Agy99 VGLDQRQP-------GYEISEFHQIDLADPGSIDRAVEAIGGPVDALFNI
MAV_0882|M.avium_104 IGLDQRRP-------GCALGEFHEVDLADPESIDRAAAGIDGPVDALFNI
TH_3914|M.thermoresistible__bu TSMDRNPP-------SAPVSRHIEVDLANPRSIDAAVEQLEGSYDGLMNI
MAB_1219|M.abscessus_ATCC_1997 VVADINAEMGEGVAKQIVADGGRAIFAGVDVSDPDSAIAMADKAVSEFG-
:
Mb2882c|M.bovis_AF2122/97 ---------GRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYL
Rv2857c|M.tuberculosis_H37Rv ---------GRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYL
MLBr_01807|M.leprae_Br4923 ---------GPVEVLVANAGITS--DMLIMRMSEEQFQKVIDVNLTGVFR
Mvan_4241|M.vanbaalenii_PYR-1 AGVSSGIKDPLLVMRINFLGMRQFTEALIARMPEGSSITNVSSLAASAYL
Mflv_2405|M.gilvum_PYR-GCK AGVSSGIGDPLLVLRINFLGMRQFTESLLDRMPAGGAVTNVSSLAASAYR
MSMEG_4862|M.smegmatis_MC2_155 AGVSSGIGDPLLVVRINFLGTRQFTEALVDRIADGGSITSVSSLAASAYR
MMAR_4773|M.marinum_M AGVSSGIGDPLLVVTINFLGLRQLTEALLPMMGPGSAIVSVSSLAAAGYR
MUL_0344|M.ulcerans_Agy99 AGVSSGIGDPLLVVTINFLGLRHLTEALLPMMGPGSAIVSVSSLAAAGYR
MAV_0882|M.avium_104 AGVSSGIGNPPLVVTVNFLGTRQLTEALIPKMVAGSSIVSVSSLAAAGYR
TH_3914|M.thermoresistible__bu AGIP-GTAPGETVLAVNSLAVRHLTEAFLDRLNSGGTVTTVSSTAGFGWP
MAB_1219|M.abscessus_ATCC_1997 ---------GIDYLVNNAAIYGGMKLDLLLSVPWDYYKKFMSVNQDGALV
: :: .
Mb2882c|M.bovis_AF2122/97 CCRAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSREL
Rv2857c|M.tuberculosis_H37Rv CCRAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSREL
MLBr_01807|M.leprae_Br4923 VAKLASRNMIKQRFGRYIFMGSVVGLSG-VPGQANYAASKSGLIGMARSL
Mvan_4241|M.vanbaalenii_PYR-1 ENAATTAGLLET--GSVAEGLQWCADHPEALADGGYRQSKEAIILYGMRR
Mflv_2405|M.gilvum_PYR-GCK ENAHVTAGLLAT--RSVDEGLRWCADHPEALADGGYRQSKEAIILYGMQR
MSMEG_4862|M.smegmatis_MC2_155 ENRAVTAGLVST--GSVDEGLRWCAENPDALADGGYRLSKEAIILYGMSK
MMAR_4773|M.marinum_M EHHRAVAPLVNT--TTMVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRS
MUL_0344|M.ulcerans_Agy99 EHHRAVAPLLNT--TTMVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRS
MAV_0882|M.avium_104 EHLRQVAPLLDT--ATMREGIDWCTSHPEELGTG-YQLSKEALILYTMRS
TH_3914|M.thermoresistible__bu ERLEAIRDLLAT--ESFEDGARWFKEHP--QQGNAYNFSKEVTTVYTMTM
MAB_1219|M.abscessus_ATCC_1997 CTRAVYKHIAQRGGGAIVN----QSSTAAWLYSGFYGLAKVGINGLTQQL
: * :*
Mb2882c|M.bovis_AF2122/97 GVQFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEP
Rv2857c|M.tuberculosis_H37Rv GVQFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEP
MLBr_01807|M.leprae_Br4923 ARELGSRSITANVVAPGFIDTEMTRAMDSKYQEAALQ---AIPLGRIGAV
Mvan_4241|M.vanbaalenii_PYR-1 TADLGARGIRINCSAPGVTETPILDQLRSAYGQQYLDS-FTAPLGRVSTA
Mflv_2405|M.gilvum_PYR-GCK VTDLGARGIRVNCTAPGVTETPILDQLRSAYGQQYLDS-FTAPLGRVSTP
MSMEG_4862|M.smegmatis_MC2_155 AVELGARGIRVNCTGPGVTDTPILDQLRSAYGQQYLDS-FTTPLGRNSEP
MMAR_4773|M.marinum_M AVGLGARGIRINCTGPGVTETPILDQLTTAYGAEFLDD-IAKPLGRVATP
MUL_0344|M.ulcerans_Agy99 AVGLGARGIRINCTGPGVTETPILDQLTTAYGAEFPDD-IAKPLGRVATP
MAV_0882|M.avium_104 VTPLGARGIRINCTGPGVTETPILDQLRTAYGQGFLDD-IPKPLGRVSRP
TH_3914|M.thermoresistible__bu GLTAAQRGIRINAVLPGPVETPILADFEESMGKDTLDG-VKALLGRHASP
MAB_1219|M.abscessus_ATCC_1997 SRELGGQKIRINAIAPGPTDTEATRGTVPEQFRSELVK--NIPLSRMGTV
. : * * ** :* *.* .
Mb2882c|M.bovis_AF2122/97 DEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL----------
Rv2857c|M.tuberculosis_H37Rv DEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL----------
MLBr_01807|M.leprae_Br4923 EEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH--------------
Mvan_4241|M.vanbaalenii_PYR-1 EEQAAMLIFLGSRAAGYLTGQVVWTDGGILAQRISAQMTDIQAAQGS
Mflv_2405|M.gilvum_PYR-GCK EEQAAVLVFLGSRAAGYISGQVLWTDGGILGRRIASQMFDEPLTQGN
MSMEG_4862|M.smegmatis_MC2_155 DEQAALLVFLGSAAASYVTGQVIWADGGIIAQRETALIESTRATQES
MMAR_4773|M.marinum_M GEQASVLVFLNGHAASYISGQVVWVDGGNVAASIAGELGEGRA----
MUL_0344|M.ulcerans_Agy99 GEQASVLVFLNGHSASYISGQVVRVDGGNVAASIAGELGEGRA----
MAV_0882|M.avium_104 AEQAAVLLFLNSDAASYISGQVVWVDGGNVGAAIARELEEGRTPWPV
TH_3914|M.thermoresistible__bu DDIADVVVFLASDAARWINGQAVAVDGGITGAVASGVVPKPEF----
MAB_1219|M.abscessus_ATCC_1997 DDMVGMCLFLLSDKASWITGQVFNVDGGQIIRS--------------
: . ** . * ::.. .. .***