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MSAVSLITGGAGGMGLATAKVVGRDHSVVLCDVRQERLDAAAAELAGLGISATTVHCDVTDRDAVGRLFD GAAVAGTLASVIHTAGVSPSMGDAEYVMRTNALGTVNVGEQFFARAGEGAALVNVASMAAHILPAELIPT AVFPAALQDPDTFMAEMLTACEIAPEEARSGIAYALSKSFVRWYSVAQAERFNGKGLRILSVSPGSIDTE MGRLEEQAGAGAMVADAAVPRWGTAEEMADLLAFCASRKAGYLTGTDILNDGGVIASMTERTRLASQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1024 | - | - | 100% (277) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2405 | - | 1e-19 | 31.29% (278) | 3-alpha-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4062 | - | 4e-16 | 28.41% (271) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 4e-15 | 29.21% (267) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 4e-15 | 29.21% (267) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-12 | 26.62% (263) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0691 | - | 2e-29 | 33.84% (263) | short chain dehydrogenase |
| M. marinum M | MMAR_0243 | - | 6e-27 | 30.94% (265) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5240 | - | 1e-119 | 76.92% (273) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6662 | - | 1e-117 | 74.01% (277) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_0784 | - | 1e-110 | 76.14% (264) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4870 | - | 2e-26 | 30.94% (265) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5812 | - | 1e-122 | 78.62% (276) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5240|M.avium_104 ----------------------MSVITGGAGGMGVATAKVV-GRDHTLVL
Mvan_5812|M.vanbaalenii_PYR-1 -------------------MTAVSLITGGAGGMGLATAKVV-GQDRAVVL
MSMEG_6662|M.smegmatis_MC2_155 -------------------MRTVSVITGGAGGMGVATAKIV-GKEHAVVL
TH_0784|M.thermoresistible__bu --------------------------------MGQATARVV-GREHAVVL
Mflv_1024|M.gilvum_PYR-GCK -------------------MSAVSLITGGAGGMGLATAKVV-GRDHSVVL
MMAR_0243|M.marinum_M -------------------MSRDVLTVIGVGGMGQAIARRL-GSGKTVLL
MUL_4870|M.ulcerans_Agy99 -------------------MSRNVLTVIGVGGMGQAIARRL-GSGKTVVL
MAB_0691|M.abscessus_ATCC_1997 -------------------MPDEVVVVIGVGGMGRVIARRQ-GIGKALLL
Mb2882c|M.bovis_AF2122/97 MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMRAEGATIVV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
:* . .: . : :
MAV_5240|M.avium_104 CDVRQDRLTAATAALAELGMTPTAVNCDVTDRRAVAQLFDTAAG-LGTVV
Mvan_5812|M.vanbaalenii_PYR-1 CDVRQDRLDGAAAALKDLGVAVTAVNCDVTDRRAVDALFETVSR-LGTLV
MSMEG_6662|M.smegmatis_MC2_155 CDVRQDRLDTAATALAEVGITPTVVKCDVTDRHAVNRLFATTAG-LGTLA
TH_0784|M.thermoresistible__bu CDVRQDRLDTAAAVLRDDGITATPVHCDVTDPQAVDRLFKETAG-IGELA
Mflv_1024|M.gilvum_PYR-GCK CDVRQERLDAAAAELAGLGISATTVHCDVTDRDAVGRLFDGAAV-AGTLA
MMAR_0243|M.marinum_M ADNNADTLASVSETLAAEGHDVKSRGVDVCAAESVHDLAQYAAT-LGAVT
MUL_4870|M.ulcerans_Agy99 ADNNADTLASVAESLAAEGHDVRSRGVDVCAAESVHDLAQYAAT-LGAVT
MAB_0691|M.abscessus_ATCC_1997 ADHNEQALQAVVDELKADGHNVIGQRVDVSSRASVSGLAQAAAG-LGRVA
Mb2882c|M.bovis_AF2122/97 GDVDVEAGGAAADELSGL-----FVPTDVCDEDAVNGLFDGAAETYGRID
Rv2857c|M.tuberculosis_H37Rv GDVDVEAGGAAADELSGL-----FVPTDVCDEDAVNGLFDGAAETYGRID
MLBr_01807|M.leprae_Br4923 ----THRASVVPDWFFG-------VECDVTDNDAIGAAFKAVEEHQGPVE
. . : ** :: . * :
MAV_5240|M.avium_104 SVIHTAGVSPSMGPADYVMRTNAIGTLNVNEAFYAVAGDGSVIVNVASMA
Mvan_5812|M.vanbaalenii_PYR-1 SVIHTAGVSPSMGDAEYVMRTNALGTLNVDEAFYGAATDGAAIVNVASMA
MSMEG_6662|M.smegmatis_MC2_155 SVIHTAGVSPSMGDAEYVIRTNAIGTATINEAFYAAAPRGSAIVNVASMA
TH_0784|M.thermoresistible__bu SVIHTAGVSPSMGSAEYVMRTNAVGTVHVNEAFLRTAGAGAAIVNVASMA
Mflv_1024|M.gilvum_PYR-GCK SVIHTAGVSPSMGDAEYVMRTNALGTVNVGEQFFARAGEGAALVNVASMA
MMAR_0243|M.marinum_M QLAHTAGLSPAQASAQAILAVDLLGVALVLQEFGAVIAPGGAGVIIASMA
MUL_4870|M.ulcerans_Agy99 QLAHTAGLSPTQASAQAILAVDLVAVALVLQEFGAVIAPGGAGVIIASMA
MAB_0691|M.abscessus_ATCC_1997 QVAHTAGLSPAQSPTAAILAVDLVGVALVVEEFGKIVASGGAGVVIASMA
Mb2882c|M.bovis_AF2122/97 IAFNNAGISPPE---------DNLIENTELAAWQRVQDVNLKSVYLCCRA
Rv2857c|M.tuberculosis_H37Rv IAFNNAGISPPE---------DNLIENTELAAWQRVQDVNLKSVYLCCRA
MLBr_01807|M.leprae_Br4923 VLVANAGITS-----------DMLIMRMSEEQFQKVIDVNLTGVFRVAKL
.**::. : : : . * .
MAV_5240|M.avium_104 AHMLPAEIVPTAQFPLALSDADAFMDAMLAACEIAPEQARSGLAYAVSKS
Mvan_5812|M.vanbaalenii_PYR-1 AYLLPAELIPTSAFPLALQDTEAFMTEMLAACAIAPEEARSGISYAISKS
MSMEG_6662|M.smegmatis_MC2_155 AHLLPEEMIPTGLFPQAMQAPEVFLKDMLAACEIVPEEARSGIAYALSKS
TH_0784|M.thermoresistible__bu AHMLPAEMVRTNLFARALTDLDGFLSEMLATCDAFPEEGRSGIAYALSKS
Mflv_1024|M.gilvum_PYR-GCK AHILPAELIPTAVFPAALQDPDTFMAEMLTACEIAPEEARSGIAYALSKS
MMAR_0243|M.marinum_M GHLLPPPSAEQ------ERELAHRPPGQLLELDFVGSIVEPAFAYPFAKQ
MUL_4870|M.ulcerans_Agy99 GHLLPPPSAEQ------EHDLAHRPPGQLLELDFVGSIVEPAFAYPFAKQ
MAB_0691|M.abscessus_ATCC_1997 GHMPYELTAEQ------EQELGTTHAEDLLSLPYVRDIEHPAVAYQVSKR
Mb2882c|M.bovis_AF2122/97 ALRH-------------MVLAGKGSIVNTASFVAVMGSATSQISYTASKG
Rv2857c|M.tuberculosis_H37Rv ALRH-------------MVLAGKGSIVNTASFVAVMGSATSQISYTASKG
MLBr_01807|M.leprae_Br4923 ASRN-------------MIKQRFGRYIFMGSVVGLSG-VPGQANYAASKS
. * :*
MAV_5240|M.avium_104 FVKWYSQSQAERFNARGLRIVSVSPGSIDTEMGRLEENAGAG----AMVA
Mvan_5812|M.vanbaalenii_PYR-1 FVRWYSSSQAERFNGRGLRIVSVSPGSVDTEMGRLEEQAGAG----AMVA
MSMEG_6662|M.smegmatis_MC2_155 FVRWYSSSQAERFTGRGLRIVSVSPGSVDTEMGRLEEKAGAG----ALVA
TH_0784|M.thermoresistible__bu FVKWYSAAQAERFNARGLRIVSVSPGSIDTEMGRLEEQAGAG----AMVA
Mflv_1024|M.gilvum_PYR-GCK FVRWYSVAQAERFNGKGLRILSVSPGSIDTEMGRLEEQAGAG----AMVA
MMAR_0243|M.marinum_M ANSIRVRAASRQWGQREARVNSISPGIISTPMGQQELASPVGDGMRAMIA
MUL_4870|M.ulcerans_Agy99 ANSIRVRAASRQWGQREARVNSISPDIISTPMGQQELASPVGDGMRAMIA
MAB_0691|M.abscessus_ATCC_1997 ANHIRVRFAARQWGTRGARINSISPGVVSTPMGHQELASETGAITKAMVD
Mb2882c|M.bovis_AF2122/97 GVLAMSRELGVQFARQGIRVNALCPGPVNTPLLQELFAKNPER-AARRMV
Rv2857c|M.tuberculosis_H37Rv GVLAMSRELGVQFARQGIRVNALCPGPVNTPLLQELFAKNPER-AARRMV
MLBr_01807|M.leprae_Br4923 GLIGMARSLARELGSRSITANVVAPGFIDTEMTRAMDSKYQEA-ALQ---
. . : :.*. :.* : :
MAV_5240|M.avium_104 DAAVPRWGKPEEMAELLAFCASDKAGYLTGTDILNDGGVIASMTERARVT
Mvan_5812|M.vanbaalenii_PYR-1 DAAVPRWGKPEEMAELLAFCAGDKAGYLTGTDILNDGGVVASMTERARLA
MSMEG_6662|M.smegmatis_MC2_155 DAAVPRWGTPEEMAELFAFCASDRAGYLTGTDILNDGGVVASMRERARVA
TH_0784|M.thermoresistible__bu DAAVPRWGTPEEMAELLAFCASAKASYLTGTDILNDGGVIASMTERARAA
Mflv_1024|M.gilvum_PYR-GCK DAAVPRWGTAEEMADLLAFCASRKAGYLTGTDILNDGGVIASMTERTRLA
MMAR_0243|M.marinum_M MSGTGRIGTPDDIAAAAAFLLGPEATFITGADLLVDGGVVAAIRASR---
MUL_4870|M.ulcerans_Agy99 MSGTGRIGTPDDIAAAAAFLLGPEATFITGADLLVDGGVVAAIRANG---
MAB_0691|M.abscessus_ATCC_1997 GSASRRIGTSDDIAAAAAFLLGPESSYVTGTDLLVDGGVIAAVRSGQLFN
Mb2882c|M.bovis_AF2122/97 HVPLGRFAEPDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---
Rv2857c|M.tuberculosis_H37Rv HVPLGRFAEPDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---
MLBr_01807|M.leprae_Br4923 AIPLGRIGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-------
* . :::* :* . : :::.: : ***: .
MAV_5240|M.avium_104 AAG---
Mvan_5812|M.vanbaalenii_PYR-1 AASSS-
MSMEG_6662|M.smegmatis_MC2_155 AEQQQQ
TH_0784|M.thermoresistible__bu AETQ--
Mflv_1024|M.gilvum_PYR-GCK SQ----
MMAR_0243|M.marinum_M ------
MUL_4870|M.ulcerans_Agy99 ------
MAB_0691|M.abscessus_ATCC_1997 ------
Mb2882c|M.bovis_AF2122/97 ------
Rv2857c|M.tuberculosis_H37Rv ------
MLBr_01807|M.leprae_Br4923 ------