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LSAVRAVRPFSIHVADDVLDDLRTRLSRTRWPEAECVPDWTQGIPLGYTRELAAYWADGYDWRSREAALN RFDQFVVEIHGVDIHFIHQRSPHQEAFPLVITHGWPGSIVEFHNVIEPLTNPTAHGGRAEDAFHVVCPAL PGYGFSGKPTNAGWGVGKIAQAWETLMLRLGYQRYGAQGGDWGAAITTQMGRNRGHCAAIHLNMPIAYPP AGGITDPTEEEQLALAALTTYQRWETGYSEQQSTRPQTVGYGLADSPVGQMAWIVEKFAAWMDCDGHPEN VLSRDELLDNVMMYWATNSGSSSARLYWESFKTLDATTRVELPTGIAAFPKEVLRAPRSWCEPIYNITHW TTMPRGGHFAALEQPRLFVDDIRAFFESVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0521 | - | - | 100% (380) | epocide hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4998 | - | e-160 | 68.45% (374) | epocide hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4764 | - | 9e-08 | 27.14% (140) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 3e-05 | 26.80% (97) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_0644 | - | 0.0 | 100.00% (377) | epocide hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1833c | - | 3e-05 | 26.80% (97) | haloalkane dehalogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3314 | - | 0.0 | 77.81% (374) | hydrolase |
| M. avium 104 | MAV_2202 | - | 0.0 | 77.54% (374) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_5658 | - | 1e-164 | 70.05% (374) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_2132 | - | 2e-74 | 77.42% (155) | epoxide hydrolase 1 |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0521|M.vanbaalenii_PYR-1 MSAVRAVRPFSIHVADDVLDDLRTRLSRTRWPEAECVPDWTQGIPLGYTR
Mflv_0644|M.gilvum_PYR-GCK ---MRAVRPFSIHVADDVLDDLRTRLSRTRWPEAECVPDWTQGIPLGYTR
MMAR_3314|M.marinum_M ------MRPFRIDVPDDVIDDLKARLTRTRWPEAECVDDWSQGIPLSYTR
MAV_2202|M.avium_104 ------MKPFRIDVPDDVLDDLRARLARTRWPEAECVDDWSQGMPLAYTR
TH_2132|M.thermoresistible__bu ---MPSVKPFRIAVPDDDLDDLRHRLARTRWPDRECVDDWGQGVPLDYVR
MSMEG_5658|M.smegmatis_MC2_155 -MTDSLIRPFRIAVPDADLDDLKSRLSRTRWPEPETVDDWGQGIPLDYTR
Mb1864c|M.bovis_AF2122/97 -------------------------------------------MSIDFT-
Rv1833c|M.tuberculosis_H37Rv -------------------------------------------MSIDFT-
:.: :.
Mvan_0521|M.vanbaalenii_PYR-1 ELAAYWADGYDWRSREAALNRFDQFVVEIHGVDIHFIHQRSPHQEAFPLV
Mflv_0644|M.gilvum_PYR-GCK ELAAYWADGYDWRSREAALNRFDQFVVEIHGVDIHFIHQRSPHQEAFPLV
MMAR_3314|M.marinum_M DLAAYWANEYDWRAREAALNRFDQFITEIDGLDLHFIHQRSPHQDAFPLL
MAV_2202|M.avium_104 ELADYWANDYDWRAREAALNRFDQFVTEIDGLDIHFIHQRSPHADAFPLL
TH_2132|M.thermoresistible__bu DLAGYWADGYDWRAREAALNRFDQFITELDGLDIHFIHQRSPHPDAFPLL
MSMEG_5658|M.smegmatis_MC2_155 ELAEYWANGYDWRAREQALNRFDHYVTELDGLDIHFIHQRCARPDAFPLL
Mb1864c|M.bovis_AF2122/97 --------------PDPQLYPFESRWFDSSRGRIHYVDEG----TGPPIL
Rv1833c|M.tuberculosis_H37Rv --------------PDPQLYPFESRWFDSSRGRIHYVDEG----TGPPIL
: * *: : :*::.: . *::
Mvan_0521|M.vanbaalenii_PYR-1 ITHGWPGSIVEFHNVIEPLTNPTAHGGRAEDAFHVVCPALPGYGFSGKPT
Mflv_0644|M.gilvum_PYR-GCK ITHGWPGSIVEFHNVIEPLTNPTAHGGRAEDAFHVVCPALPGYGFSGKPT
MMAR_3314|M.marinum_M ITHGWPGSVVEFHKVIEPLTNPTAHGGRAEDAFHVVCPSLPGYGFSGKPS
MAV_2202|M.avium_104 ITHGWPGSIVEFHKVIEPLTNPAS--GRGEDAFHVVCPSLPGYGFSGKPT
TH_2132|M.thermoresistible__bu ITHGWPGSIVEFHKVIGPLTDPTAHGGTAADAFHVVCPSLPGYGFSGKPT
MSMEG_5658|M.smegmatis_MC2_155 LTHGWPGSIVEFHKVIEPLT---------EAGFDVVCPSLPGYGFSGKPT
Mb1864c|M.bovis_AF2122/97 LCHGNPTWSFLYRDIIVALR----------DRFRCVAPDYLGFGLSERPS
Rv1833c|M.tuberculosis_H37Rv LCHGNPTWSFLYRDIIVALR----------DRFRCVAPDYLGFGLSERPS
: ** * . ::.:* .* * *.* *:*:* :*:
Mvan_0521|M.vanbaalenii_PYR-1 NAGWGVGKIAQAWETLMLRLGYQRYGAQGGDWGAAITTQMGRNRGHCAAI
Mflv_0644|M.gilvum_PYR-GCK NAGWGVGKIAQAWETLMLRLGYQRYGAQGGDWGAAITTQMGRNRGHCAAI
MMAR_3314|M.marinum_M STGWGVDRIARAWETLMQNLGYQRYGAQGGDWGAAVTTQIGRNGGRCVAI
MAV_2202|M.avium_104 RAGWGVERIARAWETLMLRLGYQRYGAQGGDWGAAVTTQIGRNRGHCVAI
TH_2132|M.thermoresistible__bu TTGWGVGRIATXXX------------------------------------
MSMEG_5658|M.smegmatis_MC2_155 TTGWGIGRIAQAWDTLMTRLGYDRYGAQGGDWGAAVTTQIGRNVGNCVGI
Mb1864c|M.bovis_AF2122/97 GFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRVRG
Rv1833c|M.tuberculosis_H37Rv GFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRVRG
*: : . *
Mvan_0521|M.vanbaalenii_PYR-1 HLNMPIAYPPAGGITDPTEEEQLALAALTTYQRWETGYSEQQSTRPQTVG
Mflv_0644|M.gilvum_PYR-GCK HLNMPIAYPPAGGITDPTEEEQLALAALTTYQRWETGYSEQQSTRPQTVG
MMAR_3314|M.marinum_M HLNMPIAMPTRTALTNPTAAEQEVLAALAYHRKWGTGYFKQQSTRPQTVG
MAV_2202|M.avium_104 HLNMPIGRPGQEALTNPTEQERAALAALANHRKRGTGYSKQQSTRPQTLG
TH_2132|M.thermoresistible__bu ----------AARAPRPT--------SIRPWRRRCTG-----TTTP----
MSMEG_5658|M.smegmatis_MC2_155 HVNMPIARPPAEGVGEMTEEVRQALERMQYYRKWDSGYMKQQSTRPQTVG
Mb1864c|M.bovis_AF2122/97 VVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNFFVER--LIPAGTE
Rv1833c|M.tuberculosis_H37Rv VVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNFFVER--LIPAGTE
: : . *
Mvan_0521|M.vanbaalenii_PYR-1 YGLADSPVGQMAWIVEKFAAWMDCDGHPENVLSRDELLDNVMMYWATNSG
Mflv_0644|M.gilvum_PYR-GCK YGLADSPVGQMAWIVEKFAAWMDCDGHPENVLSRDELLDNVMMYWATNSG
MMAR_3314|M.marinum_M YGLTDSPVGQLAWIVEKFWAWMDCAGNPENVLTRDELLDNVMMYWVNAAA
MAV_2202|M.avium_104 YGLADSPVGQLAWIVEKFWDWADCDGHPENALSRDELLDNVMVYWVTNTA
TH_2132|M.thermoresistible__bu --------------------------------------------------
MSMEG_5658|M.smegmatis_MC2_155 YGLVDSPVGQLAWIVEKFWSWMDCDGHPENVLSRDELLDNVMLYWVTASA
Mb1864c|M.bovis_AF2122/97 HRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPATLG
Rv1833c|M.tuberculosis_H37Rv HRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPATLG
Mvan_0521|M.vanbaalenii_PYR-1 SSSARLYWESFKTLDATTRVELPTGIAAFPKEVLRAPRSWCEPIYNITHW
Mflv_0644|M.gilvum_PYR-GCK SSSARLYWESFKTLDATTRVELPTGIAAFPKEVLRAPRSWCEPIYNITHW
MMAR_3314|M.marinum_M ASSARLYWESFKVWGQTERVELPTGVASFPKEVLRAPRAWCEPNYNITHW
MAV_2202|M.avium_104 ASSARLYWESFSAWGGGDRVELPTGVAAFPGELLKAPRSWCEPAYNITHW
TH_2132|M.thermoresistible__bu --------------------------------------------------
MSMEG_5658|M.smegmatis_MC2_155 ASSARLYWESYDTFAGGDFVTLPTGVASFPKEILRAPRAWCEKAYNVTHF
Mb1864c|M.bovis_AF2122/97 TKPTLLIWG-MKDVAFRPKTIIPRLSATFPDHVL----------------
Rv1833c|M.tuberculosis_H37Rv TKPTLLIWG-MKDVAFRPKTIIPRLSATFPDHVL----------------
Mvan_0521|M.vanbaalenii_PYR-1 TTMPRGGHFAALEQPRLFVDDIRAFFESVR
Mflv_0644|M.gilvum_PYR-GCK TTMPRGGHFAALEQPRLFVDDIRAFFESVR
MMAR_3314|M.marinum_M TTMPRGGHFAAFEQPELFVGDVRAFFATVR
MAV_2202|M.avium_104 TDMPRGGHFAAFEQPELFVEDLRVFFATVR
TH_2132|M.thermoresistible__bu ------------------------------
MSMEG_5658|M.smegmatis_MC2_155 TMMPRGGHFAAFEQPELFVEDVAKFFDSVR
Mb1864c|M.bovis_AF2122/97 VELPNAKHFIQEDAPDRIAAAIIERFG---
Rv1833c|M.tuberculosis_H37Rv VELPNAKHFIQEDAPDRIAAAIIERFG---