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TDQPPPIDGVRRHFVTARGVNFHVTEAGPEDGRPVLALHGWPQHHWVYRSLLADPPTSAGASSRLPEPGL RIIAPDLPGYGWSGPAPHKWAKEDVVSDLVALMDAMGLDRVLLIGHDWGGYIGHLLAMRVPERIDGYLAL NIAHPWVPPKVMAPHLWRFLQYQPLVAFAGVPLQRHTSFLKRAYKLAAPKLDPQTVRVYSERFRDPVVAR TARDTYRTFLLREAPAAIRNGERRRSKVPTRALFGRDDAAIHPSLAAAETARADDYTIDVVDGGHFILDE QPELVRAKLIALAEEFPAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4764 | - | - | 100% (300) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_0326 | - | 3e-15 | 29.75% (158) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_5373 | - | 2e-13 | 32.03% (153) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 2e-12 | 23.21% (293) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_1960 | - | 1e-134 | 78.32% (286) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0134 | ephF | 3e-42 | 34.31% (306) | epoxide hydrolase EphF |
| M. leprae Br4923 | MLBr_02297 | - | 4e-10 | 25.48% (310) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4522c | - | 7e-43 | 37.85% (288) | epoxide hydrolase EphF |
| M. marinum M | MMAR_0342 | ephF | 3e-40 | 32.45% (302) | epoxide hydrolase EphF |
| M. avium 104 | MAV_5163 | - | 5e-38 | 31.62% (291) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_3287 | - | 6e-21 | 30.14% (282) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2421 | - | 1e-112 | 67.48% (286) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4778 | ephF | 7e-41 | 32.78% (302) | epoxide hydrolase EphF |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4764|M.vanbaalenii_PYR-1 ---MTDQPPPIDGVRRHFVTAR-GVNFHVTEAGPED------------GR
Mflv_1960|M.gilvum_PYR-GCK ------------------MTVR-GVDFHITEAGPED------------GR
TH_2421|M.thermoresistible__bu -------------VRRSFVEAR-GVRFHVTESGPAD------------GR
Rv0134|M.tuberculosis_H37Rv ----MIALPALEGVEHRHVDVAEGVRIHVADAGPAD------------GP
MAV_5163|M.avium_104 ----MVTMPELDGVEHRYVDLGDDVTIHVADAGPAS------------GP
MMAR_0342|M.marinum_M ----MSTLPALDGVEHRFVDLDGGITIHVADAGPAD------------GP
MUL_4778|M.ulcerans_Agy99 ----MSTLPALDGVEHRFVDLDGGITIHVADAGPAD------------GP
MAB_4522c|M.abscessus_ATCC_199 --MTQRSMPVLDGVEHQYVQAG-DVKIHVAVAGPQD------------GR
MSMEG_3287|M.smegmatis_MC2_155 ----------------MDSYRRGNLEFEVSEAGPSD------------GA
MLBr_02297|M.leprae_Br4923 MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPSATARP
Mb1864c|M.bovis_AF2122/97 MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEG---------------TGP
. : .
Mvan_4764|M.vanbaalenii_PYR-1 PVLALHGWPQHHWVYRSLLADPPTSAGASSRLPEPGLRIIAPDLPGYGWS
Mflv_1960|M.gilvum_PYR-GCK PVLALHGWPQHHWAYRDLLGDPP-----------PGLRIIAPDLPGYGWS
TH_2421|M.thermoresistible__bu PVLALHGWPQHHWAYRDLLADPP-----------AGLRIIAPDLPGYGWS
Rv0134|M.tuberculosis_H37Rv AVMLVHGFPQNWWEWRDLIGPLAAD----------GNRVLCPDLRGAGWS
MAV_5163|M.avium_104 AVMLVHGFPQNWWEWRALIGPLAAD----------GYRVLCPDLRGAGWS
MMAR_0342|M.marinum_M AVMLVHGFPENWWEWHELIGPLAAD----------GYRVLCPDLRGAGWS
MUL_4778|M.ulcerans_Agy99 AVMLVHGFPENWWEWHELIGPLAAD----------GYRVLCPDLRGAGWS
MAB_4522c|M.abscessus_ATCC_199 AVVLLHGWPENWWMWHKVIPALAAA----------GYRVHAMDLRGAGWS
MSMEG_3287|M.smegmatis_MC2_155 TVILLHGFPQRNSSWEPIVGRLTAH----------GFRCLAPNQRGYSPG
MLBr_02297|M.leprae_Br4923 LVMLLHGFGSFWWSWRHQLRGLTEA------------RLVAVDLRGYGGS
Mb1864c|M.bovis_AF2122/97 PILLCHGNPTWSFLYRDIIVALRDR-----------FRCVAPDYLGFGLS
:: ** :. : * . : * . .
Mvan_4764|M.vanbaalenii_PYR-1 GPAPHK--WAKEDVVSDLVALMDAMGLDRVLLIGHDWGGYIGHLLAMRVP
Mflv_1960|M.gilvum_PYR-GCK GPPPHR--WAKEDVVTDLVALVDALGLDRFLLVGHDWGGYIGHLLALRIP
TH_2421|M.thermoresistible__bu GPAPHR--WAKEDVASDLLALMDELGLGRTLLIGHDWGGYIGFLMILRAP
Rv0134|M.tuberculosis_H37Rv SAPRSR--YTKTEMADDLAAVLDGLGVAKVKLVAHDWGGPVAFIMMLRHP
MAV_5163|M.avium_104 SAPRSS--YRKDEMADDLAGVLDRLGVRSVDLVAHDWGGPVAFIMMLRHP
MMAR_0342|M.marinum_M SAPRSR--YTKKEMADDLAGVLDRLGIASVRLVAHDWGGPVAFIMMLRYP
MUL_4778|M.ulcerans_Agy99 SAPRSR--YTKKEMADDLAGVLDRLGIASVRLVAHDWGGPVAFIMMLRYP
MAB_4522c|M.abscessus_ATCC_199 EVAPAG--YEKEQFASDVLAAADALGLESFDLVGHDWGGWTAQLVALKAQ
MSMEG_3287|M.smegmatis_MC2_155 ARPPRRRDYRVGELVEDVVALIDASGADRVHLVGHDWGAAVAWGVASYVP
MLBr_02297|M.leprae_Br4923 DKPPRG--YDGWTLAGDTAGLIRALGHSSATLVGHAEGGLACWATALLHP
Mb1864c|M.bovis_AF2122/97 ERPSGFG-YQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERA
. : . * :.: *.
Mvan_4764|M.vanbaalenii_PYR-1 ERIDGYLALNIAHPWV-PPKVMAPHLW------RFLQYQPLVAFAGVPLQ
Mflv_1960|M.gilvum_PYR-GCK ERIDAYLALNIAHPWV-PPKVMAPHLW------RFLLYQPVVASAGVPLQ
TH_2421|M.thermoresistible__bu ERFDGYIPLNIAHPWV-STGTVLKHIW------RFS-YQPPMAAFGVPLQ
Rv0134|M.tuberculosis_H37Rv EKVTGFFGVNTVAPWV-KRDLGMLRNM------WRFWYQIPMSLPVIGPR
MAV_5163|M.avium_104 EKVTGFFGVNTSAPFV-KRSLSTIRNV------WRFWYQIPISLPVIGPR
MMAR_0342|M.marinum_M AKVTGFFGMNTAAPWF-PRDLGMVRDI------WRFWYQIPIMLPVIGPR
MUL_4778|M.ulcerans_Agy99 AKVTGFFGMNTAAPWF-PRDLGMVRDI------WRFWYQIPILLPVIGPR
MAB_4522c|M.abscessus_ATCC_199 SRIRRLVVLNIPPVWQ-QPGR-VARYA------HKLAYQLVVGAPVVGPL
MSMEG_3287|M.smegmatis_MC2_155 ARLATLSALSVPHPQAFLRAMTTSRQG------LASWYMYLNQLPRLPER
MLBr_02297|M.leprae_Br4923 RLVRAIALINSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERLLTR
Mb1864c|M.bovis_AF2122/97 DRVRGVVLG---NTWFWPADTLAMKAFS------RVMSSPPVQYAILRRN
. : :
Mvan_4764|M.vanbaalenii_PYR-1 RHTS-----FLKR-AYKLAAPKLDPQTVRVYSERFRDPVVARTARDTYRT
Mflv_1960|M.gilvum_PYR-GCK TRTR-----YLEKVVFRAAAPKLDAATVGTYAERFRDPVVARTARDTYRT
TH_2421|M.thermoresistible__bu QRTR-----VLERVVFGKGS-ALDAETAKVYADRFRDPVCARAGRDTYRT
Rv0134|M.tuberculosis_H37Rv VISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMREPGHAEAGSRWYRT
MAV_5163|M.avium_104 VISTPDSRFVRLLGSWVGGGYTLPEEDVRLYLECMRQPGHAEAGSRWYRS
MMAR_0342|M.marinum_M VIADPKARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAVAGSRWYRT
MUL_4778|M.ulcerans_Agy99 VIADPKARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAVAGSRWYRT
MAB_4522c|M.abscessus_ATCC_199 SHLSPTLWWFIRRS---G----MPKESVDFFRSCFRDRDRRVAGSKIYRS
MSMEG_3287|M.smegmatis_MC2_155 LMLGRDGGAARMVRTLQRSG--QTREIAERDARAMAEPGALTAALNWYRA
MLBr_02297|M.leprae_Br4923 NNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRW
Mb1864c|M.bovis_AF2122/97 ---------FFVERLIPAGTEHRPSSAVMAHYRAVQPNAAARRGVAEMPK
. .
Mvan_4764|M.vanbaalenii_PYR-1 FLLREAPAAIR-NGERRR--SKVPTRALFGRDDAAIHPSLAAAETARAD-
Mflv_1960|M.gilvum_PYR-GCK FLTREIPKGVR-DGERRW--STVPTRVLFGRSDTAIHPDLAAAETARAD-
TH_2421|M.thermoresistible__bu FLVREMPAAAR-NPEKRR--ATVPIRALFGTRDLAIHPSLAAPETALAD-
Rv0134|M.tuberculosis_H37Rv FQTREMLRWLRGEYNDAR--VDVPVRWLHGTGDPVITPDLLDGYAERAS-
MAV_5163|M.avium_104 FQTREMLSWMRGEYDGAR--VHVPVRWLSGTEDPVLTPDLLDGYAERID-
MMAR_0342|M.marinum_M FQSSEALPWMRGEYADAR--VDVPVRWLHGTEDPVLTPQLLRGYEDHIS-
MUL_4778|M.ulcerans_Agy99 FQSSEALPWMRGEYADAR--VDVPVRWLHGTDDPVLTPQLLRGYEDHIS-
MAB_4522c|M.abscessus_ATCC_199 MVGKEFANLARGPYDDQK--LTMPVRVLFGLDDVAVHPSLLDGFKDHAD-
MSMEG_3287|M.smegmatis_MC2_155 MFLSTSDPRAKHKVAKRK--ITVPTLYVWSDRDIAITEKPARETANYVAG
MLBr_02297|M.leprae_Br4923 AVRSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRRYAP-
Mb1864c|M.bovis_AF2122/97 QILAARPLLARLAREVPATLGTKPTLLIWGMKDVAFRPKTIIPRLSATFP
: * : . * . .
Mvan_4764|M.vanbaalenii_PYR-1 DYTIDVVDGG-HFILDEQPELVRAKLIALAEEFPAR---
Mflv_1960|M.gilvum_PYR-GCK DYTIDVVDGG-HFILDEQPDLVRAKLIAVADEFPERPVR
TH_2421|M.thermoresistible__bu DYTLETVDCS-HFIVDERPDLVRARLVALAEETA-----
Rv0134|M.tuberculosis_H37Rv DFEVELVDGVGHWIVEQRPELVLDRVRAFLAAGTEQRD-
MAV_5163|M.avium_104 DFQLELVDGVGHWIVDQRPDLVLDRVRAFLRRET-----
MMAR_0342|M.marinum_M DFEVEFVDGVGHWIVEQRPDLVLDRLRAFLRIET-----
MUL_4778|M.ulcerans_Agy99 DFEVEFVDGVGHWIVEQRPDLVLDRLRAFLRIET-----
MAB_4522c|M.abscessus_ATCC_199 DLNITEVPNCGHFIVDEQPELVVKWLSEVLAEPAP----
MSMEG_3287|M.smegmatis_MC2_155 PYRFETLHGVSHWIPEERPDEVADLLLEWFAAHPV----
MLBr_02297|M.leprae_Br4923 HGRYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS
Mb1864c|M.bovis_AF2122/97 DHVLVELPNAKHFIQEDAPDRIAAAIIERFG--------
: *: :: *: : :