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SRLSTFTNDGLTFDVIDEGALDGPVIVALHGFPERATMWEEVIPQLTGAGFRVLAPNQRGYSPGARPVGV RNYAVDKLEGDIIALVDQAGVRKFHVLAHDWGAAVAWQLAGNHADRVQTLSILSVPHPRAFQDAMLRGQL LHSWYMLLFQIPRLPEWLFGFNETEAFKKFGKSWMKVSDRLAERIRELFSEPGATTATVNWYRAMRYSLR SPARPSRVPTLFIWSDGDSAVTRAAADATPKYVEAPYRFEVFEGVSHWIAEERPLETAALVLEHIAEYSA *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0679c | - | - | 100% (281) | hydrolase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 4e-26 | 27.21% (305) | epoxide hydrolase EphA |
| M. abscessus ATCC 19977 | MAB_4573c | - | 1e-21 | 27.92% (283) | epoxide hydrolase EphC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1155 | ephC | 1e-24 | 28.67% (279) | epoxide hydrolase EphC |
| M. gilvum PYR-GCK | Mflv_1415 | - | 4e-30 | 29.13% (309) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3617 | ephA | 5e-34 | 31.15% (305) | epoxide hydrolase EphA |
| M. leprae Br4923 | MLBr_00862 | ephD | 3e-19 | 27.37% (285) | short chain dehydrogenase |
| M. marinum M | MMAR_5114 | ephA | 2e-32 | 30.49% (305) | epoxide hydrolase EphA |
| M. avium 104 | MAV_0539 | - | 5e-32 | 29.10% (299) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_3287 | - | 4e-68 | 47.72% (285) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_0992 | ephA | 4e-29 | 29.17% (312) | PROBABLE EPOXIDE HYDROLASE EPHA (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_4193 | ephA | 2e-32 | 29.51% (305) | epoxide hydrolase EphA |
| M. vanbaalenii PYR-1 | Mvan_5373 | - | 9e-31 | 29.70% (303) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_0679c|M.abscessus_ATCC_199 ---------------------MSRLSTFTNDGLTFDVIDEGALDGPVIVA
MSMEG_3287|M.smegmatis_MC2_155 ------------------------MDSYRRGNLEFEVSEAGPSDGATVIL
MMAR_5114|M.marinum_M ------------------MVATSTERLVDTNGVRLRVTEAGERGAPVVIL
MUL_4193|M.ulcerans_Agy99 ------------------MVATSTERLVDTNGVRLRVTEAGERGAPVVIL
Rv3617|M.tuberculosis_H37Rv -------------------MGAPTERLVDTNGVRLRVVEAGEPGAPVVIL
MAV_0539|M.avium_104 --------------------------------MRLRVTEAGDRGAPVVIL
TH_0992|M.thermoresistible__bu -------------------VITPSERSVETNGVRLRLVEAGERGDPLVVL
Mflv_1415|M.gilvum_PYR-GCK ----------------------MQSRMVHTNGITLRVFEAGERSAPVVVL
Mvan_5373|M.vanbaalenii_PYR-1 MNSRWCFRAVRDRGCPFGESGAMRSRMVQTNGVTLRVTEAGEPGAPVVVL
Mb1155|M.bovis_AF2122/97 ----MRAGRGERESTWRTTMAEPHWIDVKGPNGDLKALTWGPAGAPVALC
MLBr_00862|M.leprae_Br4923 ------------MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVL
: * . :
MAB_0679c|M.abscessus_ATCC_199 LHGFPERATMWEEVIPQLTGAGFRVLAPNQRGYSPGARPVGVRNYAVDKL
MSMEG_3287|M.smegmatis_MC2_155 LHGFPQRNSSWEPIVGRLTAHGFRCLAPNQRGYSPGARPPRRRDYRVGEL
MMAR_5114|M.marinum_M AHGFPELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSRPEAIEDYDIHQL
MUL_4193|M.ulcerans_Agy99 AHGFPELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSRPEAIEDYDIHQL
Rv3617|M.tuberculosis_H37Rv AHGFPELAYSWRHQIPALADAGYHVLAPDQRGYGGSSRPEAIEAYDIHRL
MAV_0539|M.avium_104 AHGFPELAYSWRHQIDVLADAGYHVLAPDQRGYGGSDRPDAVEAYDIHQL
TH_0992|M.thermoresistible__bu AHGFPELAYSWRHQIPALVDAGYHVMAPDQRGYGGSSAPEAIEAYDITRL
Mflv_1415|M.gilvum_PYR-GCK CHGFPELAFTWRHQISALAAAGFHVLAPDQRGYGGSDKPGDAGVYNVAEL
Mvan_5373|M.vanbaalenii_PYR-1 CHGFPELAFTWRHQVRALADAGFHVLAPDQRGYGGSDKPDAVDSYNVAEL
Mb1155|M.bovis_AF2122/97 LHGFPDTAYGWRKVAPRLAESGWHVVAPFMRGYAPSSIPADG-SYHVGAL
MLBr_00862|M.leprae_Br4923 VHGFPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSSVPKPVSAYTMTRF
****: * *. :: : ** . . * * : :
MAB_0679c|M.abscessus_ATCC_199 EGDIIALVDQAG-VRKFHVLAHDWGAAVAWQLAGNH--ADRVQTLSILSV
MSMEG_3287|M.smegmatis_MC2_155 VEDVVALIDASG-ADRVHLVGHDWGAAVAWGVASYV--PARLATLSALSV
MMAR_5114|M.marinum_M TADLVGLLDDVG-AERAAWVGHDWGAVVVWNAPLLH--PDRVAAVAGLSV
MUL_4193|M.ulcerans_Agy99 TADLVGLLDDVG-AERAAWVGHDWGAVVVWNAPLLH--PDRVAAVAGLSV
Rv3617|M.tuberculosis_H37Rv TADLVGLLDDVG-AERAVWVGHDWGAVVVWNAPLLH--ADRVAAVAALSV
MAV_0539|M.avium_104 TADLVGLLDDVG-AQRAVWVGHDWGAAVVWNAPLLH--PDRVAAVAAMSV
TH_0992|M.thermoresistible__bu TADLMGLLDDIG-AEKAAFIGHDWGALVVWNAALLY--PDRVAAVAGLSV
Mflv_1415|M.gilvum_PYR-GCK TADVVGLLDDVG-AERAALVGHDFGAVVAWGAPLLE--PDRFSAVAGLSL
Mvan_5373|M.vanbaalenii_PYR-1 TADVVGLLDDLG-AERAALVGHDFGAVVAWAAPLLQ--PDRFSSVAGLSL
Mb1155|M.bovis_AF2122/97 MHDALRVRSAAGGTERDVIIGHDWGAIAATGLAAMP--DSPFAKAVIMSV
MLBr_00862|M.leprae_Br4923 ADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSG
* : . . :.**:*: . . :*
MAB_0679c|M.abscessus_ATCC_199 PHPRAFQ------DAMLRG-QLLHS--------WYMLLFQIPRLP-----
MSMEG_3287|M.smegmatis_MC2_155 PHPQAFL------RAMTTSRQGLAS--------WYMYLNQLPRLP-----
MMAR_5114|M.marinum_M PVLPRAQ------VPPIQAFRQRFG-----EHFFYILYFQQPGVA-----
MUL_4193|M.ulcerans_Agy99 PVLPRAQ------VPPIQAFRQRFG-----EHFFYILYFQQPGVA-----
Rv3617|M.tuberculosis_H37Rv PALPRAQ------VPPTQAFRSRFG-----ENFFYILYFQEPGIA-----
MAV_0539|M.avium_104 PVTPRPR------LAPTQAWRKMFG-----ENFFYILYFQEPGVA-----
TH_0992|M.thermoresistible__bu PPVPRSL------TRPTEAFRALVGE----DNFFYILYFQEPGVA-----
Mflv_1415|M.gilvum_PYR-GCK PPVPRPQ------VPTTQAFRRVFG-----DRFMYILYFQEPGPA-----
Mvan_5373|M.vanbaalenii_PYR-1 PPVPRPK------VPTTQAFRRIFA-----DRFFYILYFQDRGPA-----
Mb1155|M.bovis_AF2122/97 PPSAAFRP----LGRVPERGRLLRELPHQLLRSWYILYFQLPWLP-----
MLBr_00862|M.leprae_Br4923 PSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLW
* : *: .
MAB_0679c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5114|M.marinum_M --------------------------------------------------
MUL_4193|M.ulcerans_Agy99 --------------------------------------------------
Rv3617|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0539|M.avium_104 --------------------------------------------------
TH_0992|M.thermoresistible__bu --------------------------------------------------
Mflv_1415|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5373|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1155|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 IALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRR
MAB_0679c|M.abscessus_ATCC_199 ----------------------------EWLFGFNETEAFKKFGKS-WMK
MSMEG_3287|M.smegmatis_MC2_155 ----------------------------ERLMLGRDGGAARMVRTLQRSG
MMAR_5114|M.marinum_M ----------------------------DAELNGDPARTMRRMIGGQRSP
MUL_4193|M.ulcerans_Agy99 ----------------------------DAELNGDPARTMRRMIGGQRSP
Rv3617|M.tuberculosis_H37Rv ----------------------------DAELNGDPARTMRRMIGGLRPP
MAV_0539|M.avium_104 ----------------------------DAELNADPAQVMRRMMGSLRTD
TH_0992|M.thermoresistible__bu ----------------------------DAELDGDPARTMRRMFGGLTSD
Mflv_1415|M.gilvum_PYR-GCK ----------------------------DAELARDPATTFRRLFA--LTT
Mvan_5373|M.vanbaalenii_PYR-1 ----------------------------DAELARDPAGTFRRLFA--MDV
Mb1155|M.bovis_AF2122/97 ----------------------------ERSASWVVPLLWRRWSPGYHAE
MLBr_00862|M.leprae_Br4923 RGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSP
: :
MAB_0679c|M.abscessus_ATCC_199 VSDRLAERIR--------E-LFSEPG---------------------ATT
MSMEG_3287|M.smegmatis_MC2_155 QTREIAERDA--------R-AMAEPG---------------------ALT
MMAR_5114|M.marinum_M TDQGAALRMVAPGPEGFID-RLPEPDTPPSWISRDELDHYISEFTRTGFT
MUL_4193|M.ulcerans_Agy99 TDQGAALRMVAPGPEGFID-RLPEPDAPPSWISRDELDHYISEFTRTGFT
Rv3617|M.tuberculosis_H37Rv GDQSAAMRMLAPGPDGFID-RLPEPAGLPAWISQEELDHYIGEFTRTGFT
MAV_0539|M.avium_104 GDKAAGLRMVAPGPEGFLE-RLPEPDGLPEWISQDELDHYIAEFSRTGFT
TH_0992|M.thermoresistible__bu PD--AAHRMLQPGPAGFID-RLPEPEALPDWLTAEELDHYIAEFTRTGFT
Mflv_1415|M.gilvum_PYR-GCK G---GAEMVGDAGPQGFLD-RIPEPGGLPDWISQADFDVYVDEFTRGGFT
Mvan_5373|M.vanbaalenii_PYR-1 ADEQSALRMTEPGPAGFLD-RIPDPGRLPDWISPPDFAVYVDEFRRGGFT
Mb1155|M.bovis_AF2122/97 EDLRHVDAAIG----------TPE-----------------------GRR
MLBr_00862|M.leprae_Br4923 MSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAG
.. .
MAB_0679c|M.abscessus_ATCC_199 ATVNWYRAMRYSLRSP----------ARPSRVPTLFIWS---------DG
MSMEG_3287|M.smegmatis_MC2_155 AALNWYRAMFLSTSDPR---AKHKVAKRKITVPTLYVWS---------DR
MMAR_5114|M.marinum_M GGLNWYRNFDRNWETT------ADLEGATITVPSLFMAG---------TK
MUL_4193|M.ulcerans_Agy99 GGLNWYRNFDRNWETT------ADLEGATITVPSLFMAG---------TK
Rv3617|M.tuberculosis_H37Rv GGLNWYRNFDRNWETT------ADLAGKTISVPSLFIAG---------TA
MAV_0539|M.avium_104 GGLNWYRNFDRNWETT------PELDGAKIAVPCLFIGG---------TA
TH_0992|M.thermoresistible__bu GGLNWYRNMDRNWELT------EHLAGATITAPALFLAG---------AA
Mflv_1415|M.gilvum_PYR-GCK GPLNWYRCFDRNWELT------AETPAPTIEVPALFVGG---------TE
Mvan_5373|M.vanbaalenii_PYR-1 APLNWYRCFDLNWELT------ADPPAPTIGVPALFVGG---------TA
Mb1155|M.bovis_AF2122/97 AALGPYRATMRNTRAPADYADLNRLWTEAPKLPVLYLHG---------HD
MLBr_00862|M.leprae_Br4923 SGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVS
. :. . . : .
MAB_0679c|M.abscessus_ATCC_199 DSAVTRAAADATPKYVEAPYRFEVFEGVSHW--IAEERPLETAALVLEHI
MSMEG_3287|M.smegmatis_MC2_155 DIAITEKPARETANYVAGPYRFETLHGVSHW--IPEERPDEVADLLLEWF
MMAR_5114|M.marinum_M DPVLSFARSDRASEVITGPYREVMVEGAGHW--LQQERPDEVNATLLDFL
MUL_4193|M.ulcerans_Agy99 DPVLSFARSDRASEVITGPYREVMVEGAGHW--LQQERPDEVNATLLDFL
Rv3617|M.tuberculosis_H37Rv DPVLTFTRTDRAAEVISGPYREVLIDGAGHW--LQQERPGEVTAALLEFL
MAV_0539|M.avium_104 DPVLSFTRADRAAEVISGPYRHVMIDGAGHW--LQQERPAEVNAALLDFL
TH_0992|M.thermoresistible__bu DPVLGFMRPERATEVAVGPYRQVLLDGAGHW--VQQERPQEVNAALIDFL
Mflv_1415|M.gilvum_PYR-GCK DATLAYTPRDRVREVVTGDYREVMIDGAGHW--LTEERPDEVSRVLVDFL
Mvan_5373|M.vanbaalenii_PYR-1 DATLAYTPRHRVREVVTGDYREVMIDGAGHW--LTEERPDEVSRILLEFL
Mb1155|M.bovis_AF2122/97 DGCATSAFTHWTARVLPAGSEVAVVEHAGHF--LQLEQPDKIAELIVAFI
MLBr_00862|M.leprae_Br4923 DAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNL
* . .: . * : : :
MAB_0679c|M.abscessus_ATCC_199 AEYSA---------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 AAHPV---------------------------------------------
MMAR_5114|M.marinum_M KGVQW---------------------------------------------
MUL_4193|M.ulcerans_Agy99 KGVQW---------------------------------------------
Rv3617|M.tuberculosis_H37Rv TGLELR--------------------------------------------
MAV_0539|M.avium_104 NGLELR--------------------------------------------
TH_0992|M.thermoresistible__bu RGLELQ--------------------------------------------
Mflv_1415|M.gilvum_PYR-GCK TTVR----------------------------------------------
Mvan_5373|M.vanbaalenii_PYR-1 TAAR----------------------------------------------
Mb1155|M.bovis_AF2122/97 GSPG----------------------------------------------
MLBr_00862|M.leprae_Br4923 GGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
MAB_0679c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5114|M.marinum_M --------------------------------------------------
MUL_4193|M.ulcerans_Agy99 --------------------------------------------------
Rv3617|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0539|M.avium_104 --------------------------------------------------
TH_0992|M.thermoresistible__bu --------------------------------------------------
Mflv_1415|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5373|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1155|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 FSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQ
MAB_0679c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5114|M.marinum_M --------------------------------------------------
MUL_4193|M.ulcerans_Agy99 --------------------------------------------------
Rv3617|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0539|M.avium_104 --------------------------------------------------
TH_0992|M.thermoresistible__bu --------------------------------------------------
Mflv_1415|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5373|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1155|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVL
MAB_0679c|M.abscessus_ATCC_199 ---------
MSMEG_3287|M.smegmatis_MC2_155 ---------
MMAR_5114|M.marinum_M ---------
MUL_4193|M.ulcerans_Agy99 ---------
Rv3617|M.tuberculosis_H37Rv ---------
MAV_0539|M.avium_104 ---------
TH_0992|M.thermoresistible__bu ---------
Mflv_1415|M.gilvum_PYR-GCK ---------
Mvan_5373|M.vanbaalenii_PYR-1 ---------
Mb1155|M.bovis_AF2122/97 ---------
MLBr_00862|M.leprae_Br4923 RSTARIRVI