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VTAAATKPSVFDAGLPTLSYDVTDTPQQIYPQFRAAQRIAPIALGPIGPEVLSYEMARTVLRDPRFVIPP GIHLSAHGITSGPLWDRVTRSILNMEGDEHRRLRSLVSRAFTPRATARMHDAIHLVVNELLDAIQDTGRC EFVAEVARPYPIPIICALLGAPREDWQLFSRWAEDIFKIVSFDCDLAEEEPVVLKAWAEFDDYIDGMIAD RRRHLSDDLLSDLIRIEDGGDRLDAAELRMLAFSVLVAGTDTTRSQLAASVQVLCEHPDQWALLRADSDL AMRTVEETMRHSPSMCSTVRSVTADVEVGEYTFPAGTFILVNTYAANRDHTVYDDPTRFDITREDPPPIL TFGGGVHHCLGANLARLELAEALKILSHRFRYARRTGPVPWKPLLGLSGPTSLPLEFGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4984 | - | - | 100% (409) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0373 | - | e-155 | 65.60% (407) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_1848 | - | 9e-55 | 34.91% (381) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 5e-40 | 34.84% (287) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_1763 | - | 0.0 | 76.79% (405) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 7e-43 | 32.40% (321) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-44 | 30.56% (409) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 1e-45 | 35.74% (319) | cytochrome P450 |
| M. marinum M | MMAR_0122 | cyp279A2 | 1e-129 | 56.00% (400) | cytochrome P450 279A2 Cyp279A2 |
| M. avium 104 | MAV_4569 | - | 1e-160 | 66.09% (407) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4213 | - | 1e-108 | 51.59% (378) | cytochrome P450 hydroxylase |
| M. thermoresistible (build 8) | TH_4410 | - | 1e-49 | 33.42% (398) | PUTATIVE putative cytochrome P450 107B1 |
| M. ulcerans Agy99 | MUL_4077 | cyp142A3 | 1e-43 | 33.02% (321) | cytochrome P450 142A3 Cyp142A3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4984|M.vanbaalenii_PYR-1 ---------------------MTAAAT---KPSVFDAGLPTLSYDVTDTP
Mflv_1763|M.gilvum_PYR-GCK ---------------------MSAAP-----PSVFDAGLPTLDYDITDTP
MAV_4569|M.avium_104 ---------------------MTVGAA---PPSVFDSDLPTLHYHSDETP
MMAR_0122|M.marinum_M ---------------------MTSTVDRQVAPNVFAAGLPNIDYQNAQSP
MSMEG_4213|M.smegmatis_MC2_155 ---------------------MTRMTV---------AELTPISYHHATMP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0276|M.abscessus_ATCC_1997 ---------------------MPITTDPG------TLLLQVLDPANRANP
Rv3518c|M.tuberculosis_H37Rv ----------------------------------MTE---APDVDLADGN
MUL_4077|M.ulcerans_Agy99 --------------------------------MAMTKPLIKPDVDLTDGN
Mb2289|M.bovis_AF2122/97 --------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGA
TH_4410|M.thermoresistible__bu ----------------------------------VTVLFDPLDEEQLADP
Mvan_4984|M.vanbaalenii_PYR-1 QQIYPQFRAAQRIAPIALGPIG----PEVLS-YEMARTVLRDPRFVIPPG
Mflv_1763|M.gilvum_PYR-GCK QQIRPQFCAAQQVAPIALGPIG----PEVLS-YPLARTVLGDPRFGIPPG
MAV_4569|M.avium_104 AQVYPRLREAQRRAAVAIGPHG----PEVLS-YHLVRSVLRDPRFQIPPG
MMAR_0122|M.marinum_M DEAHQILAEARCRSPIALGPHG----PELLT-YDLVHTVLRDPRFRMPPG
MSMEG_4213|M.smegmatis_MC2_155 AEVHDIIRQARANGPLALGPYG----PEILG-YELVRAVLRDERFEVPRG
MLBr_02088|M.leprae_Br4923 FPVYRALIDY---GPMQLPGMP----LTVFSSFSDCDEALRHPLSASDRL
MAB_0276|M.abscessus_ATCC_1997 YPVYGQLVEQTQAGPVHPPGMD----VSVLATFADCNAVLRHPQASSDRR
Rv3518c|M.tuberculosis_H37Rv FYASREARAAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAG
MUL_4077|M.ulcerans_Agy99 FYASRQAREAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAG
Mb2289|M.bovis_AF2122/97 FATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYP
TH_4410|M.thermoresistible__bu IPTYRALREQD-----PVQRIPVGGGTWVVSRYEDVRRLLRTTAGLMQPP
:
Mvan_4984|M.vanbaalenii_PYR-1 IHLSAHGITSG--PLWDRVTRSILNMEGDEHRRLRSLVSRAFTPRATARM
Mflv_1763|M.gilvum_PYR-GCK IHLAAHGITSG--ELWDRVTRSILCMEGDEHRRLRSLVSRAFTPRATAKM
MAV_4569|M.avium_104 INLLAQGIDSG--PLWDKVANSLLCLEGDAHHRLRSLCSKAFTPRTVARL
MMAR_0122|M.marinum_M MFLAAQGITSG--PLWDRLAANLISLDGPAHHRLRRLVSQAFTPRATGRL
MSMEG_4213|M.smegmatis_MC2_155 MFLAAQGITSG--PLWERANNTLVGLGGPAHLRLRRLVARAFIPKAAERL
MLBr_02088|M.leprae_Br4923 KATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
MAB_0276|M.abscessus_ATCC_1997 KSNIVQRQLAQ--NPNLIARPSFLGLDAPDHTRLRKLASKAFAPRVINAM
Rv3518c|M.tuberculosis_H37Rv GIRPDQP-----------ALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
MUL_4077|M.ulcerans_Agy99 GIRPDQD-----------ALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDK
Mb2289|M.bovis_AF2122/97 NITINDQTP-----ELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARI
TH_4410|M.thermoresistible__bu GATVPVELAGG--PAERIYRGLMVLNDPPVHTRLRKLTEKAMTRGAVEKL
:: * * : .:
Mvan_4984|M.vanbaalenii_PYR-1 HDAIHLVVNELLDAIQDTG---RCEFVAEVARPYPIPIICALLGAPREDW
Mflv_1763|M.gilvum_PYR-GCK DQTISEVITDLIDAVSDSG---ACEFVDQVARPYPIPVICALFGAPREDW
MAV_4569|M.avium_104 HDTMAAVMNELVDRVAAAG---RCDVVTDIARPYPVPIICALLGAPREDW
MMAR_0122|M.marinum_M NTTITEVITDLVDRCADRG---RCDVVADIARRYPIPIICALLGAPAGDW
MSMEG_4213|M.smegmatis_MC2_155 RATCVDIVTELVARCVPAG---RCDVVADLAVPYAVPVICALLGAPARDW
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG---QFDVIADLAFPLAVAVICRLLGVPYEDA
MAB_0276|M.abscessus_ATCC_1997 AEDIQTFVDKMLDDIALRG---TFNLVTEFAYPLPVAVICRMLGVPIEDE
Rv3518c|M.tuberculosis_H37Rv EASIAALCDTLIDAVCERG---ECDFVRDLAAPLPMAVIGDMLGVRPEQR
MUL_4077|M.ulcerans_Agy99 EHSIAQLCDTLIDAVCERG---ECDFVRDLAAPLPMAVIGDMLGVLPEQR
Mb2289|M.bovis_AF2122/97 EAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADH
TH_4410|M.thermoresistible__bu RADVERVASEALDAMLEQG---EADAMTELAFTVPLRVICGMLGIPEADR
: . : : :.* .: :* ::* :
Mvan_4984|M.vanbaalenii_PYR-1 QLFSRWAEDIFKIVSFDCDLAEEEP----VVLKAWAEFDDYIDGMIADRR
Mflv_1763|M.gilvum_PYR-GCK ELFSTWAQDIFKIVSFDIDLAAEEP----TVLRAWDEFDAYIDDMIARRR
MAV_4569|M.avium_104 RRFSSWADDVFKAFSFTVDLREVEP----VVMRAWRELDDYVDEMVARRR
MMAR_0122|M.marinum_M KLFSGWTDDILKAFSW--DAAAQQP----AILAAWDELDAYIDDMVAARR
MSMEG_4213|M.smegmatis_MC2_155 ARFSAWADEIFKMFSW--DLGEHAE----AVETAWKELDAYVDDMVVRRR
MLBr_02088|M.leprae_Br4923 PEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRR
MAB_0276|M.abscessus_ATCC_1997 PEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDLIASRR
Rv3518c|M.tuberculosis_H37Rv DMFLRWS-DDLVTFLS----SHVSQEDFQITMDAFAAYNDFTRATIAARR
MUL_4077|M.ulcerans_Agy99 EMFLRWS-DDLVTFLS----SQVSQEDFQVTIDAFAAYNDFTRATIAARR
Mb2289|M.bovis_AF2122/97 QRIFHWT-NVILGFGD----PDLAT-DFDEFMQVSADIGAYATALAEDRR
TH_4410|M.thermoresistible__bu AQMLDWTPDFFRIFLP----QANDADGIAACHRACQNFIDYLSEQIEYRR
: : . . : **
Mvan_4984|M.vanbaalenii_PYR-1 RHLSDDLLSDLIRIEDGGDRLDAAELRMLAFSVLVAGTDTTRSQLAASVQ
Mflv_1763|M.gilvum_PYR-GCK THLTTDLLSELIRAEDGGDRLDAGEVRMLAFSILIAGTDTTRTQLAASMQ
MAV_4569|M.avium_104 HSLTDDLLSDLIRAGDEGDRLDAAELRMLAGGLLLAGTDTTRNQVAASVQ
MMAR_0122|M.marinum_M GSLTEDLISALIRAEDDGDCLSSDELRMLVAGLLIGGTDTTRNQLAASAQ
MSMEG_4213|M.smegmatis_MC2_155 HTLTDDLLSDLIRAEDDGDRLTHHELLMLAGGVLLAGTDTTRNQLAAAVE
MLBr_02088|M.leprae_Br4923 GTPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVL
MAB_0276|M.abscessus_ATCC_1997 RNLGDDLLSALIQVEEAGDQLTEEEIISTCTLLLIAGHETTVNLIANASL
Rv3518c|M.tuberculosis_H37Rv ADPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTE
MUL_4077|M.ulcerans_Agy99 AEPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGSE
Mb2289|M.bovis_AF2122/97 VNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVL
TH_4410|M.thermoresistible__bu RTPADDIFSALVSAEDEGDRLSRDELVATVLSLLTGGFDTTMGMIGAGVF
*: * *: *: * *: :: .* :** : .
Mvan_4984|M.vanbaalenii_PYR-1 VLCEHPDQWALLRADSD-LAMRTVEETMRHSPSMCSTVRSVTADVEVGEY
Mflv_1763|M.gilvum_PYR-GCK VLCDHHDQFALLRDRPE-LAMRAVEETMRHSPSMCSTVRTATEDVAIGEY
MAV_4569|M.avium_104 VLCEHPHQWELLRQRPE-LAMRAVEETMRHSPIACGTLRLVVEDAELDGH
MMAR_0122|M.marinum_M ALCDHPDQWVLLAQHPD-LAANAAEETMRHSPITFSTLRIALDDVELAGV
MSMEG_4213|M.smegmatis_MC2_155 TLCDHPREWDLLAEHPE-LAPTFVEELMRFSPATLGTVRIAKEEVEIAGV
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDMTIGQT
MAB_0276|M.abscessus_ATCC_1997 AMLRHPEQWKLLGQNAD-RAPLVVEETLRYDPPVHMVARVADGEMAIRDF
Rv3518c|M.tuberculosis_H37Rv QLLRNRDQWDLLQRDPS-LLPGAIEEMLRWTAPVKNMCRVLTADTEFHGT
MUL_4077|M.ulcerans_Agy99 QLLRNRVQWDLLQSDRE-LLPGAIEEMLRWTAPVKNMCRMLTADTEFHGT
Mb2289|M.bovis_AF2122/97 ALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGT
TH_4410|M.thermoresistible__bu GLARQPEQLAALREDPAGLARTAVEEFIRWESPVAVTYRHFVEDVTIADT
: : ** :* . * : .
Mvan_4984|M.vanbaalenii_PYR-1 TFPAGTFILVNTYAANRDHTVYDDPTRFDITREDPPPILTFGGG-VHHCL
Mflv_1763|M.gilvum_PYR-GCK TIPAGTFLVVNTFAANRDPVIYDEPDRFDITRDDPPPILTFGGG-AHYCL
MAV_4569|M.avium_104 LFPAGTAVLVNTFAANRDPAVYDDPDRVDITREAAPPILTFGGG-VHYCL
MMAR_0122|M.marinum_M MIPTGTLVIANTGAANRDPALYRDPDRLDISRPIAGPIQTFGAG-MHYCL
MSMEG_4213|M.smegmatis_MC2_155 TIPAGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGG-LHYCL
MLBr_02088|M.leprae_Br4923 TLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVG-SHFCL
MAB_0276|M.abscessus_ATCC_1997 ILPDGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEI-KHLAFGHG-PHFCL
Rv3518c|M.tuberculosis_H37Rv ALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPN-SHLAFGFG-THFCL
MUL_4077|M.ulcerans_Agy99 ALSKGEKIMLLFESANFDEAVFTDPEKFDIQRNPN-SHLAFGFG-THFCM
Mb2289|M.bovis_AF2122/97 KMAAGDKVSLWYCSANRDESKFADPWTFDLARNPN-PHLGFGGGGAHFCL
TH_4410|M.thermoresistible__bu TIPAGEPIWLLLLSANRDDTRFHDPDGFDVRRKPN-QHVAFGGG-RHHCI
: * : :*: * .: * *. * *.*:
Mvan_4984|M.vanbaalenii_PYR-1 GANLARLELAEALKILSHRFRYARRTGPVPWKPL---LGLSGPTSLPLEF
Mflv_1763|M.gilvum_PYR-GCK GANLARRELSEALKILACRMPDARVSGPAPWRPL---LGMSGPTRLPLEF
MAV_4569|M.avium_104 GANLARREIAEALNVLANRLRNPRLAGPAPWKPM---VSLSGPTSLPIEF
MMAR_0122|M.marinum_M GANLARRELTEALRIITQRMPGARRTGAAPWKSL---TGLSGPTTLPIEF
MSMEG_4213|M.smegmatis_MC2_155 GVHLARVELAEALCVITAAMRHPHRDGPPPGNR-----------------
MLBr_02088|M.leprae_Br4923 GAALARLEATVTLSAISARFPQVQLAGELVYKPN---VAMRGMSALPVQV
MAB_0276|M.abscessus_ATCC_1997 GAPLARLEARLALSSITARFPGARLMDEPTYKPN---VTLRGLAELPVSI
Rv3518c|M.tuberculosis_H37Rv GNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVF
MUL_4077|M.ulcerans_Agy99 GNQLARLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVF
Mb2289|M.bovis_AF2122/97 GANLARREIRVAFDELRRQMPDVVATEEPARLLS---QFIHGIKTLPVTW
TH_4410|M.thermoresistible__bu GSHLARLEGEVVFAEIARRIETIEITGDSPRRPN---FQFRSFTTLPVKM
* *** * : :
Mvan_4984|M.vanbaalenii_PYR-1 GP-----
Mflv_1763|M.gilvum_PYR-GCK GR-----
MAV_4569|M.avium_104 DR-----
MMAR_0122|M.marinum_M DAGH---
MSMEG_4213|M.smegmatis_MC2_155 -------
MLBr_02088|M.leprae_Br4923 -------
MAB_0276|M.abscessus_ATCC_1997 A------
Rv3518c|M.tuberculosis_H37Rv TPSPPLG
MUL_4077|M.ulcerans_Agy99 TPSRPLR
Mb2289|M.bovis_AF2122/97 S------
TH_4410|M.thermoresistible__bu TGRSR--