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MTRMTVAELTPISYHHATMPAEVHDIIRQARANGPLALGPYGPEILGYELVRAVLRDERFEVPRGMFLAA QGITSGPLWERANNTLVGLGGPAHLRLRRLVARAFIPKAAERLRATCVDIVTELVARCVPAGRCDVVADL AVPYAVPVICALLGAPARDWARFSAWADEIFKMFSWDLGEHAEAVETAWKELDAYVDDMVVRRRHTLTDD LLSDLIRAEDDGDRLTHHELLMLAGGVLLAGTDTTRNQLAAAVETLCDHPREWDLLAEHPELAPTFVEEL MRFSPATLGTVRIAKEEVEIAGVTIPAGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGGLHY CLGVHLARVELAEALCVITAAMRHPHRDGPPPGNR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4213 | - | - | 100% (385) | cytochrome P450 hydroxylase |
| M. smegmatis MC2 155 | MSMEG_6695 | - | 1e-52 | 35.03% (354) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_0762 | - | 4e-43 | 36.13% (357) | cytochrome P450 FAS1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 3e-40 | 34.15% (284) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_4282 | - | 1e-117 | 55.29% (378) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 3e-40 | 34.15% (284) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-49 | 38.34% (313) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 4e-41 | 34.45% (299) | cytochrome P450 |
| M. marinum M | MMAR_0122 | cyp279A2 | 1e-128 | 58.51% (376) | cytochrome P450 279A2 Cyp279A2 |
| M. avium 104 | MAV_4569 | - | 1e-125 | 57.67% (378) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_4132 | - | 2e-43 | 33.14% (350) | PUTATIVE putative cytochrome P450 |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 5e-38 | 33.45% (284) | cytochrome P450 124A1, Cyp124A1 |
| M. vanbaalenii PYR-1 | Mvan_0373 | - | 1e-114 | 55.29% (378) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4569|M.avium_104 ------------------------MTVGAAPPSVFDSDLPTLHYHSDETP
Mvan_0373|M.vanbaalenii_PYR-1 ------------------------MVVSPTVANVFDAGLPTLTYDVFSTP
Mflv_4282|M.gilvum_PYR-GCK --------------------------MSTAAPSVFEADLPTFTYGFAATP
MMAR_0122|M.marinum_M ---------------------MTSTVDRQVAPNVFAAGLPNIDYQNAQSP
MSMEG_4213|M.smegmatis_MC2_155 ------------------------------MTRMTVAELTPISYHHATMP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0276|M.abscessus_ATCC_1997 ---------------------MPITTDPG------TLLLQVLDPANRANP
Mb2289|M.bovis_AF2122/97 -------------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDD
Rv2266|M.tuberculosis_H37Rv -------------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDD
MUL_1282|M.ulcerans_Agy99 ---------MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDD
TH_4132|M.thermoresistible__bu -----------------------MTVQPVTDTTWDVKHVNVFDPQWWVDG
: :
MAV_4569|M.avium_104 AQVYPRLREAQRRAAVAIGPHGPEVLS-YHLVRSVLRDPRFQIPPGINLL
Mvan_0373|M.vanbaalenii_PYR-1 AQVWPDLHDAQRTAPIAIGPMGPEVLS-YEMARAVLRDTRFTIPPGINLA
Mflv_4282|M.gilvum_PYR-GCK HDIFDDVREAQSRAPIALGPLGPEILS-YELARDMLRDNRFRLPPGITLA
MMAR_0122|M.marinum_M DEAHQILAEARCRSPIALGPHGPELLT-YDLVHTVLRDPRFRMPPGMFLA
MSMEG_4213|M.smegmatis_MC2_155 AEVHDIIRQARANGPLALGPYGPEILG-YELVRAVLRDERFEVPRGMFLA
MLBr_02088|M.leprae_Br4923 FPVYRALIDY---GPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATL
MAB_0276|M.abscessus_ATCC_1997 YPVYGQLVEQTQAGPVHPPGMDVSVLATFADCNAVLRHPQASSDRRKSNI
Mb2289|M.bovis_AF2122/97 VRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDI
Rv2266|M.tuberculosis_H37Rv VRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDI
MUL_1282|M.ulcerans_Agy99 FRDGAFATLRREAPISFWPPIELAGLTAGKGHWALTKHDDIHFASRHPEI
TH_4132|M.thermoresistible__bu PPHDLFKRMRAESPVHWYQFADGEGYGPG--YWSLFRHADIATVSHDTET
:
MAV_4569|M.avium_104 AQGIDSG---------PLWDKVANSLLCLEGDAHHRLRSLCSKAFTPRTV
Mvan_0373|M.vanbaalenii_PYR-1 AQGITSG---------PLFDKVMSTLLCLEGSEHQRLRKLVSKAFTPRAT
Mflv_4282|M.gilvum_PYR-GCK AQGITSG---------PLYDKITGSLLGLNGPPHVRLRKLVSKAFTPRAT
MMAR_0122|M.marinum_M AQGITSG---------PLWDRLAANLISLDGPAHHRLRRLVSQAFTPRAT
MSMEG_4213|M.smegmatis_MC2_155 AQGITSG---------PLWERANNTLVGLGGPAHLRLRRLVARAFIPKAA
MLBr_02088|M.leprae_Br4923 AQQAIAA-------GAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVV
MAB_0276|M.abscessus_ATCC_1997 VQRQLAQ---------NPNLIARPSFLGLDAPDHTRLRKLASKAFAPRVI
Mb2289|M.bovis_AF2122/97 FSSYPN--ITINDQ-TPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVV
Rv2266|M.tuberculosis_H37Rv FSSYPN--ITINDQ-TPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVV
MUL_1282|M.ulcerans_Agy99 FHSSPN--IVIHDQ-TPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVV
TH_4132|M.thermoresistible__bu FSSNRGGLFIHPDQ-MLSLDVLTNMLNFMDPPTHTRYRKILARVFTPAAV
: : * * * : ::.* * .
MAV_4569|M.avium_104 ARLHDTMAAVMNELVDRVAAAG---RCDVVTDIARPYPVPIICALLGAPR
Mvan_0373|M.vanbaalenii_PYR-1 ERLHDTIVAVVDELVDNIAGAR---RCDVVADIARPYPIPIICALLGAPR
Mflv_4282|M.gilvum_PYR-GCK ARLQDTIHEVVNGLVDRVLDAG---RCDVVTDIARPYPTPIICALLGAPR
MMAR_0122|M.marinum_M GRLNTTITEVITDLVDRCADRG---RCDVVADIARRYPIPIICALLGAPA
MSMEG_4213|M.smegmatis_MC2_155 ERLRATCVDIVTELVARCVPAG---RCDVVADLAVPYAVPVICALLGAPA
MLBr_02088|M.leprae_Br4923 QALEGDIAALVDSLLDKGAAAG---QFDVIADLAFPLAVAVICRLLGVPY
MAB_0276|M.abscessus_ATCC_1997 NAMAEDIQTFVDKMLDDIALRG---TFNLVTEFAYPLPVAVICRMLGVPI
Mb2289|M.bovis_AF2122/97 ARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPK
Rv2266|M.tuberculosis_H37Rv ARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPK
MUL_1282|M.ulcerans_Agy99 ARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPE
TH_4132|M.thermoresistible__bu AKMEDGIRARVNRIIDKVIEAG---RCDFVEDIAVPIPLGILMELMGAPE
: :: :.: ::* . :: ::* *
MAV_4569|M.avium_104 EDWRRFSSWADDVFK----AFSFTVDLREVEPVVMRAWRELDDYVDEMVA
Mvan_0373|M.vanbaalenii_PYR-1 EDWRLFSDWTEDVFR----AFSFSTDVATVQDDVMRAWNELDDYVDRMVA
Mflv_4282|M.gilvum_PYR-GCK EDWPLFADWTEEVFK----AFNFQPELTFDEAQIMRAWGELDAYVDDMVA
MMAR_0122|M.marinum_M GDWKLFSGWTDDILK----AFSW--DAAAQQPAILAAWDELDAYIDDMVA
MSMEG_4213|M.smegmatis_MC2_155 RDWARFSAWADEIFK----MFSW--DLGEHAEAVETAWKELDAYVDDMVV
MLBr_02088|M.leprae_Br4923 EDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVK
MAB_0276|M.abscessus_ATCC_1997 EDEPEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDLIA
Mb2289|M.bovis_AF2122/97 ADHQRIFHWTNVILG------FGDPDLATDFDEFMQVSADIGAYATALAE
Rv2266|M.tuberculosis_H37Rv ADHQRIFHWTNVILG------FGDPDLATDFDEFMQVSADIGAYATALAE
MUL_1282|M.ulcerans_Agy99 EDHEQIFHWTNVILG------FGDPDLTTDFDDFLQVSMAIGGYATALAD
TH_4132|M.thermoresistible__bu EDMPKFYYWTEAIEQ------AIR---DPEPNTGVEVFDEMGAYLTEQIE
* : : : . : *
MAV_4569|M.avium_104 RRRHSLTDD-LLSDLIRAGDEGDRLDAAELRMLAGGLLLAGTDTTRNQVA
Mvan_0373|M.vanbaalenii_PYR-1 HRRRHLTDD-LLSDLIRAEDDGDRLSTSELQMLAASLLMAGTDTTRNQLA
Mflv_4282|M.gilvum_PYR-GCK ARRSNLTDD-LLSELIRAESDGDRLNLDELRGLVAGFLMAGTDTTRNQLA
MMAR_0122|M.marinum_M ARRGSLTED-LISALIRAEDDGDCLSSDELRMLVAGLLIGGTDTTRNQLA
MSMEG_4213|M.smegmatis_MC2_155 RRRHTLTDD-LLSDLIRAEDDGDRLTHHELLMLAGGVLLAGTDTTRNQLA
MLBr_02088|M.leprae_Br4923 CRRGTPGED-LISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIA
MAB_0276|M.abscessus_ATCC_1997 SRRRNLGDD-LLSALIQVEEAGDQLTEEEIISTCTLLLIAGHETTVNLIA
Mb2289|M.bovis_AF2122/97 DRRVNHHDD-LTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAIT
Rv2266|M.tuberculosis_H37Rv DRRVNHHDD-LTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAIT
MUL_1282|M.ulcerans_Agy99 DRRVNHHGD-LTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTIS
TH_4132|M.thermoresistible__bu RQTTEAVEDSLVMRLRNAEVDGEKLTDVEIVMFFGLLTFAGNDTTRNTAS
: * * * . *: * *: . ..* :** * :
MAV_4569|M.avium_104 ASVQVLCEHPHQWELLRQRPE-LAMRAVEETMRHSPIACGTLRLVVEDAE
Mvan_0373|M.vanbaalenii_PYR-1 ASVQALSERPDQWALLADRPE-LAMRAVEETMRHSPVVCGAPRIVLDDVE
Mflv_4282|M.gilvum_PYR-GCK ASVQVLLEHPDQWTKLRDHPE-LAMQAVEESMRHSPAASIVPRAATEDAE
MMAR_0122|M.marinum_M ASAQALCDHPDQWVLLAQHPD-LAANAAEETMRHSPITFSTLRIALDDVE
MSMEG_4213|M.smegmatis_MC2_155 AAVETLCDHPREWDLLAEHPE-LAPTFVEELMRFSPATLGTVRIAKEEVE
MLBr_02088|M.leprae_Br4923 NAVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDMT
MAB_0276|M.abscessus_ATCC_1997 NASLAMLRHPEQWKLLGQNAD-RAPLVVEETLRYDPPVHMVARVADGEMA
Mb2289|M.bovis_AF2122/97 HGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIE
Rv2266|M.tuberculosis_H37Rv HGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIE
MUL_1282|M.ulcerans_Agy99 HGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDVD
TH_4132|M.thermoresistible__bu AGLRTLLEHPDALQQLYDDAA-LIPNAIEEILRYTSVVQWFARTATRDVE
. .: * . ** :* . * :
MAV_4569|M.avium_104 LDGHLFPAGTAVLVNTFAANRDPAVYDDPDRVDITREAAPPILTFGGGVH
Mvan_0373|M.vanbaalenii_PYR-1 FDGYLFPAGTFVFVNTFAANRDPAVYADADRLDLTREQAPAILTFGGGVH
Mflv_4282|M.gilvum_PYR-GCK FGGYMFPAGTFILVNTFVANRDPAIYHDADRFDITRTDLPPILTFGGGAH
MMAR_0122|M.marinum_M LAGVMIPTGTLVIANTGAANRDPALYRDPDRLDISRPIAGPIQTFGAGMH
MSMEG_4213|M.smegmatis_MC2_155 IAGVTIPAGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGGLH
MLBr_02088|M.leprae_Br4923 IGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVGSH
MAB_0276|M.abscessus_ATCC_1997 IRDFILPDGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEI-KHLAFGHGPH
Mb2289|M.bovis_AF2122/97 LRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAH
Rv2266|M.tuberculosis_H37Rv LRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAH
MUL_1282|M.ulcerans_Agy99 LRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAH
TH_4132|M.thermoresistible__bu LGGQKISEGDKVVMWYASGSRDEAVFDDSDTFDIHRPKPDHQAFGGGGRH
: :. * : ..** .: * . * *
MAV_4569|M.avium_104 YCLGANLARREIAEALNVLANRLRNPRLAGPAPWKPMVSLSGPTSLPIEF
Mvan_0373|M.vanbaalenii_PYR-1 YCLGANLARRELAEALRILAGRLSNPRRSGSAPWKPMLGMTGPTVLELEF
Mflv_4282|M.gilvum_PYR-GCK YCLGANLARRELAEALVVLTRRLAPPRRIGPAPWKSLLGMTGPTTLPIEV
MMAR_0122|M.marinum_M YCLGANLARRELTEALRIITQRMPGARRTGAAPWKSLTGLSGPTTLPIEF
MSMEG_4213|M.smegmatis_MC2_155 YCLGVHLARVELAEALCVITAAMRHPHRDGPPPGNR--------------
MLBr_02088|M.leprae_Br4923 FCLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV
MAB_0276|M.abscessus_ATCC_1997 FCLGAPLARLEARLALSSITARFPGARLMDEPTYKPNVTLRGLAELPVSI
Mb2289|M.bovis_AF2122/97 FCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTW
Rv2266|M.tuberculosis_H37Rv FCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTW
MUL_1282|M.ulcerans_Agy99 FCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPVAW
TH_4132|M.thermoresistible__bu FCLGASLARLELRIIFEEVLGRMKNLQLAGTTEILPSNWAYGLTKLPVTF
:***. *** * : : :
MAV_4569|M.avium_104 DR--------
Mvan_0373|M.vanbaalenii_PYR-1 DA--------
Mflv_4282|M.gilvum_PYR-GCK TSEQPVTANA
MMAR_0122|M.marinum_M DAGH------
MSMEG_4213|M.smegmatis_MC2_155 ----------
MLBr_02088|M.leprae_Br4923 ----------
MAB_0276|M.abscessus_ATCC_1997 A---------
Mb2289|M.bovis_AF2122/97 S---------
Rv2266|M.tuberculosis_H37Rv S---------
MUL_1282|M.ulcerans_Agy99 SR--------
TH_4132|M.thermoresistible__bu TAGRRLES--