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MTVGAAPPSVFDSDLPTLHYHSDETPAQVYPRLREAQRRAAVAIGPHGPEVLSYHLVRSVLRDPRFQIPP GINLLAQGIDSGPLWDKVANSLLCLEGDAHHRLRSLCSKAFTPRTVARLHDTMAAVMNELVDRVAAAGRC DVVTDIARPYPVPIICALLGAPREDWRRFSSWADDVFKAFSFTVDLREVEPVVMRAWRELDDYVDEMVAR RRHSLTDDLLSDLIRAGDEGDRLDAAELRMLAGGLLLAGTDTTRNQVAASVQVLCEHPHQWELLRQRPEL AMRAVEETMRHSPIACGTLRLVVEDAELDGHLFPAGTAVLVNTFAANRDPAVYDDPDRVDITREAAPPIL TFGGGVHYCLGANLARREIAEALNVLANRLRNPRLAGPAPWKPMVSLSGPTSLPIEFDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4569 | - | - | 100% (409) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_0358 | - | 2e-47 | 37.85% (317) | cytochrome P450 |
| M. avium 104 | MAV_2822 | - | 4e-43 | 33.16% (392) | P450 heme-thiolate protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 1e-41 | 33.06% (366) | cytochrome p450 140 CYP140 |
| M. gilvum PYR-GCK | Mflv_0363 | - | 1e-163 | 67.81% (407) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1880c | cyp140 | 1e-41 | 33.06% (366) | cytochrome p450 140 CYP140 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-52 | 33.18% (422) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 2e-45 | 35.80% (324) | cytochrome P450 |
| M. marinum M | MMAR_0122 | cyp279A2 | 1e-142 | 59.85% (401) | cytochrome P450 279A2 Cyp279A2 |
| M. smegmatis MC2 155 | MSMEG_4213 | - | 1e-125 | 57.67% (378) | cytochrome P450 hydroxylase |
| M. thermoresistible (build 8) | TH_4132 | - | 3e-48 | 34.57% (324) | PUTATIVE putative cytochrome P450 |
| M. ulcerans Agy99 | MUL_2979 | cyp140A5 | 2e-41 | 33.33% (366) | cytochrome P450 140A5 Cyp140A5 |
| M. vanbaalenii PYR-1 | Mvan_0373 | - | 1e-169 | 70.59% (408) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1912c|M.bovis_AF2122/97 ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
Rv1880c|M.tuberculosis_H37Rv ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
MUL_2979|M.ulcerans_Agy99 ---------MKDKLHWFAMHGVIRGMANIGLRRGELEARLIADPAVAANP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0276|M.abscessus_ATCC_1997 ---------------------MPITTDPG------TLLLQVLDPANRANP
Mflv_0363|M.gilvum_PYR-GCK ---------------------MTASTT---ARNVFDADLPALTYDLSSTP
Mvan_0373|M.vanbaalenii_PYR-1 ---------------------MVVSPT---VANVFDAGLPTLTYDVFSTP
MAV_4569|M.avium_104 ---------------------MTVGAA---PPSVFDSDLPTLHYHSDETP
MMAR_0122|M.marinum_M ---------------------MTSTVDRQVAPNVFAAGLPNIDYQNAQSP
MSMEG_4213|M.smegmatis_MC2_155 ---------------------MTRMTV---------AELTPISYHHATMP
TH_4132|M.thermoresistible__bu ---------------------MTVQPVTDTTWDVKHVNVFDPQWWVDGPP
*
Mb1912c|M.bovis_AF2122/97 VPFYDEVRSHGALVRNRANYLTVDHRLAHDLLR-SDDFRVVSFGENLPPP
Rv1880c|M.tuberculosis_H37Rv VPFYDEVRSHGALVRNRANYLTVDHRLAHDLLR-SDDFRVVSFGENLPPP
MUL_2979|M.ulcerans_Agy99 GPFHDELRRHGRMVRTRVNYLTVDYQLAHDVLR-SDDFHTISFGENLPGP
MLBr_02088|M.leprae_Br4923 FPVYRALIDY---GPMQLPGMPLTVFSSFSDCD-EALRHPLSASDRLKAT
MAB_0276|M.abscessus_ATCC_1997 YPVYGQLVEQTQAGPVHPPGMDVSVLATFADCN-AVLRHPQASSDRRKSN
Mflv_0363|M.gilvum_PYR-GCK AEVWPSLREARSLAPVAVGPLGPEVLS-YDMAR-AILRDPR---FAIPPG
Mvan_0373|M.vanbaalenii_PYR-1 AQVWPDLHDAQRTAPIAIGPMGPEVLS-YEMAR-AVLRDTR---FTIPPG
MAV_4569|M.avium_104 AQVYPRLREAQRRAAVAIGPHGPEVLS-YHLVR-SVLRDPR---FQIPPG
MMAR_0122|M.marinum_M DEAHQILAEARCRSPIALGPHGPELLT-YDLVH-TVLRDPR---FRMPPG
MSMEG_4213|M.smegmatis_MC2_155 AEVHDIIRQARANGPLALGPYGPEILG-YELVR-AVLRDER---FEVPRG
TH_4132|M.thermoresistible__bu HDLFKRMRAESPVHWYQFADGEGYGPGYWSLFRHADIATVSHDTETFSSN
:
Mb1912c|M.bovis_AF2122/97 LRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRD
Rv1880c|M.tuberculosis_H37Rv LRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRD
MUL_2979|M.ulcerans_Agy99 LRWLERRTRDEQLHPLRPPSLLAVEPPDHTRYRKTVSAVFTSRAVAALRD
MLBr_02088|M.leprae_Br4923 LAQQAIAAGA-EPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEG
MAB_0276|M.abscessus_ATCC_1997 IVQRQLAQ---NPNLIARPSFLGLDAPDHTRLRKLASKAFAPRVINAMAE
Mflv_0363|M.gilvum_PYR-GCK INLAAQGVTSGPLFDKVMSSLLCLEGAEHQRLRKLVSKAFSPRATERLHD
Mvan_0373|M.vanbaalenii_PYR-1 INLAAQGITSGPLFDKVMSTLLCLEGSEHQRLRKLVSKAFTPRATERLHD
MAV_4569|M.avium_104 INLLAQGIDSGPLWDKVANSLLCLEGDAHHRLRSLCSKAFTPRTVARLHD
MMAR_0122|M.marinum_M MFLAAQGITSGPLWDRLAANLISLDGPAHHRLRRLVSQAFTPRATGRLNT
MSMEG_4213|M.smegmatis_MC2_155 MFLAAQGITSGPLWERANNTLVGLGGPAHLRLRRLVARAFIPKAAERLRA
TH_4132|M.thermoresistible__bu RGGLFIHPDQMLSLDVLTNMLNFMDPPTHTRYRKILARVFTPAAVAKMED
: : * * * : .* . . :
Mb1912c|M.bovis_AF2122/97 LVEQTAINLLDRFAEQPGIVDVVGRYCSQLPIVVISEILGVPEHDRPRVL
Rv1880c|M.tuberculosis_H37Rv LVEQTAINLLDRFAEQPGIVDVVGRYCSQLPIVVISEILGVPEHDRPRVL
MUL_2979|M.ulcerans_Agy99 RVEQTANSLLDQLAQRPGVVDVVGQYCSQLPIMVISEILGVPEQDRGRVL
MLBr_02088|M.leprae_Br4923 DIAALVDSLLDKGAAA-GQFDVIADLAFPLAVAVICRLLGVPYEDAPEFG
MAB_0276|M.abscessus_ATCC_1997 DIQTFVDKMLDDIALR-GTFNLVTEFAYPLPVAVICRMLGVPIEDEPEFG
Mflv_0363|M.gilvum_PYR-GCK TIVAVVDELIDQVVDA-GRCDVVADIARPYPIPIICALLGAPREDWRLFS
Mvan_0373|M.vanbaalenii_PYR-1 TIVAVVDELVDNIAGA-RRCDVVADIARPYPIPIICALLGAPREDWRLFS
MAV_4569|M.avium_104 TMAAVMNELVDRVAAA-GRCDVVTDIARPYPVPIICALLGAPREDWRRFS
MMAR_0122|M.marinum_M TITEVITDLVDRCADR-GRCDVVADIARRYPIPIICALLGAPAGDWKLFS
MSMEG_4213|M.smegmatis_MC2_155 TCVDIVTELVARCVPA-GRCDVVADLAVPYAVPVICALLGAPARDWARFS
TH_4132|M.thermoresistible__bu GIRARVNRIIDKVIEA-GRCDFVEDIAVPIPLGILMELMGAPEEDMPKFY
:: :.: . .: :: ::*.* * .
Mb1912c|M.bovis_AF2122/97 EFGELAAPSLD-----IGIPWRQYLRVQQGIRGFDCWLEGHLQQLRHAPG
Rv1880c|M.tuberculosis_H37Rv EFGELAAPSLD-----IGIPWRQYLRVQQGIRGFDCWLEGHLQQLRHAPG
MUL_2979|M.ulcerans_Agy99 EYGELAAPSLD-----IGVTYRQYRRIQQGITGFNSWLTAHLEQLRRNPG
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
MAB_0276|M.abscessus_ATCC_1997 RASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDLIASRRRNLG
Mflv_0363|M.gilvum_PYR-GCK QWAEDVVRVFGFS----VDVAARQDHVMRAWNALDDYVDAMVEDRRTRLT
Mvan_0373|M.vanbaalenii_PYR-1 DWTEDVFRAFSFS----TDVATVQDDVMRAWNELDDYVDRMVAHRRRHLT
MAV_4569|M.avium_104 SWADDVFKAFSFT----VDLREVEPVVMRAWRELDDYVDEMVARRRHSLT
MMAR_0122|M.marinum_M GWTDDILKAFSW------DAAAQQPAILAAWDELDAYIDDMVAARRGSLT
MSMEG_4213|M.smegmatis_MC2_155 AWADEIFKMFSW------DLGEHAEAVETAWKELDAYVDDMVVRRRHTLT
TH_4132|M.thermoresistible__bu YWTEAIEQAIRDP---------EPNTGVEVFDEMGAYLTEQIERQTTEAV
. : :. :
Mb1912c|M.bovis_AF2122/97 DD-LMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGNGIR
Rv1880c|M.tuberculosis_H37Rv DD-LMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGNGIR
MUL_2979|M.ulcerans_Agy99 DD-LMSQLIRVAESGDAGTYLDKSELRAIAGLVLVAGFETTVNLLGNGIR
MLBr_02088|M.leprae_Br4923 ED-LISRLIELDESGD---QLTEEEIIATCGLLLVAGHETTVNLIANAVL
MAB_0276|M.abscessus_ATCC_1997 DD-LLSALIQVEEAGD---QLTEEEIISTCTLLLIAGHETTVNLIANASL
Mflv_0363|M.gilvum_PYR-GCK DD-LISELIRAEDDGD---RLSSAELQMLAVSLLMAGTDTTRNQLAASVQ
Mvan_0373|M.vanbaalenii_PYR-1 DD-LLSDLIRAEDDGD---RLSTSELQMLAASLLMAGTDTTRNQLAASVQ
MAV_4569|M.avium_104 DD-LLSDLIRAGDEGD---RLDAAELRMLAGGLLLAGTDTTRNQVAASVQ
MMAR_0122|M.marinum_M ED-LISALIRAEDDGD---CLSSDELRMLVAGLLIGGTDTTRNQLAASAQ
MSMEG_4213|M.smegmatis_MC2_155 DD-LLSDLIRAEDDGD---RLTHHELLMLAGGVLLAGTDTTRNQLAAAVE
TH_4132|M.thermoresistible__bu EDSLVMRLRNAEVDGE---KLTDVEIVMFFGLLTFAGNDTTRNTASAGLR
:* *: * . *: * *: : ..* :** * . .
Mb1912c|M.bovis_AF2122/97 MLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVR
Rv1880c|M.tuberculosis_H37Rv MLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVR
MUL_2979|M.ulcerans_Agy99 MLLDAPEQLETLRQRPELWPNAVEEILRLDSPVQLTARVARTDVEIASWP
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTT
MAB_0276|M.abscessus_ATCC_1997 AMLRHPEQWKLLGQNADRAPLVVEETLRYDPPVHMVARVADGEMAIRDFI
Mflv_0363|M.gilvum_PYR-GCK ALSEQPDQWALLAEQPDLAMRAVEETMRHSPVVCGTPRIVVADVEFAGYL
Mvan_0373|M.vanbaalenii_PYR-1 ALSERPDQWALLADRPELAMRAVEETMRHSPVVCGAPRIVLDDVEFDGYL
MAV_4569|M.avium_104 VLCEHPHQWELLRQRPELAMRAVEETMRHSPIACGTLRLVVEDAELDGHL
MMAR_0122|M.marinum_M ALCDHPDQWVLLAQHPDLAANAAEETMRHSPITFSTLRIALDDVELAGVM
MSMEG_4213|M.smegmatis_MC2_155 TLCDHPREWDLLAEHPELAPTFVEELMRFSPATLGTVRIAKEEVEIAGVT
TH_4132|M.thermoresistible__bu TLLEHPDALQQLYDDAALIPNAIEEILRYTSVVQWFARTATRDVELGGQK
: * * . . ** :* . * . : .
Mb1912c|M.bovis_AF2122/97 IKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGA
Rv1880c|M.tuberculosis_H37Rv IKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGA
MUL_2979|M.ulcerans_Agy99 INRGEMVVAYLAGANRDPAVFPNPHRFDVERANAGRHLAFSTGRHFCLGA
MLBr_02088|M.leprae_Br4923 LTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVGSHFCLGA
MAB_0276|M.abscessus_ATCC_1997 LPDGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEI-KHLAFGHGPHFCLGA
Mflv_0363|M.gilvum_PYR-GCK FPAGTFVFVNTFTANRDPALYDDAERLDLRREGAPAILTFGGGVHYCLGA
Mvan_0373|M.vanbaalenii_PYR-1 FPAGTFVFVNTFAANRDPAVYADADRLDLTREQAPAILTFGGGVHYCLGA
MAV_4569|M.avium_104 FPAGTAVLVNTFAANRDPAVYDDPDRVDITREAAPPILTFGGGVHYCLGA
MMAR_0122|M.marinum_M IPTGTLVIANTGAANRDPALYRDPDRLDISRPIAGPIQTFGAGMHYCLGA
MSMEG_4213|M.smegmatis_MC2_155 IPAGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGGLHYCLGV
TH_4132|M.thermoresistible__bu ISEGDKVVMWYASGSRDEAVFDDSDTFDIHRPKPDHQAFGGGGRHFCLGA
: * : ..** : . .: * . * *:***.
Mb1912c|M.bovis_AF2122/97 ALARAEGEVGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARS
Rv1880c|M.tuberculosis_H37Rv ALARAEGEVGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARS
MUL_2979|M.ulcerans_Agy99 ALARAEGEVGLRTFFERFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARA
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV-----
MAB_0276|M.abscessus_ATCC_1997 PLARLEARLALSSITARFPGARLMDEPTYKPNVTLRGLAELPVSIA----
Mflv_0363|M.gilvum_PYR-GCK NLARRELAEALRILAARLPNPRISGEAPWKPMLGMTGPTALELEFGA---
Mvan_0373|M.vanbaalenii_PYR-1 NLARRELAEALRILAGRLSNPRRSGSAPWKPMLGMTGPTVLELEFDA---
MAV_4569|M.avium_104 NLARREIAEALNVLANRLRNPRLAGPAPWKPMVSLSGPTSLPIEFDR---
MMAR_0122|M.marinum_M NLARRELTEALRIITQRMPGARRTGAAPWKSLTGLSGPTTLPIEFDAGH-
MSMEG_4213|M.smegmatis_MC2_155 HLARVELAEALCVITAAMRHPHRDGPPPGNR-------------------
TH_4132|M.thermoresistible__bu SLARLELRIIFEEVLGRMKNLQLAGTTEILPSNWAYGLTKLPVTFTAGRR
*** * : . : : .
Mb1912c|M.bovis_AF2122/97 MVSP
Rv1880c|M.tuberculosis_H37Rv MVSP
MUL_2979|M.ulcerans_Agy99 LAAS
MLBr_02088|M.leprae_Br4923 ----
MAB_0276|M.abscessus_ATCC_1997 ----
Mflv_0363|M.gilvum_PYR-GCK ----
Mvan_0373|M.vanbaalenii_PYR-1 ----
MAV_4569|M.avium_104 ----
MMAR_0122|M.marinum_M ----
MSMEG_4213|M.smegmatis_MC2_155 ----
TH_4132|M.thermoresistible__bu LES-