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MSSATVGSVPAFAVTDPGFSITSAEVHAARERSWYATTEYGLAVLRYEQVNRLLKHPKLRQGSAAWPAHN GVTEGPFADWFAGWILNKEGEEHHRLRRLMNPAFSNKLIGGLVPRFQALAAELIDGFAEPGRCEFVGEFA EPYAARVIAIMLGLPESEWKVIATESATIGLALGVTILDDLPRIEAALAHLYEYCDELIADRRASPRDDF VTTLVNASRPEDGRLSDNELRDAMVLLIFGGFDTTRNQLGLAMQTFMAHPDQWRLLAERPELGGNAVEEV MRVNPTVRWVTREVLEDFEYEGVELAAGTTVHLYSESAGTDPRVFEPGFDITAERKPHFGFGGGVHHCLG HFVARSDMSEALPLLARRMLDPHELPGATWLPDSGNTGPITLPIGFTPAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1848 | - | - | 100% (400) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0373 | - | 1e-59 | 36.58% (380) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4984 | - | 8e-55 | 34.91% (381) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 4e-33 | 32.59% (316) | cytochrome P450 126 |
| M. gilvum PYR-GCK | Mflv_0363 | - | 7e-58 | 36.53% (386) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 2e-35 | 32.40% (321) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-30 | 25.97% (362) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3961c | - | 4e-33 | 30.83% (386) | cytochrome P450 |
| M. marinum M | MMAR_0122 | cyp279A2 | 2e-59 | 36.29% (372) | cytochrome P450 279A2 Cyp279A2 |
| M. avium 104 | MAV_4569 | - | 2e-58 | 37.33% (375) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6695 | - | 0.0 | 88.72% (399) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3500 | - | 1e-40 | 30.73% (410) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_4077 | cyp142A3 | 3e-32 | 30.84% (321) | cytochrome P450 142A3 Cyp142A3 |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_3961c|M.abscessus_ATCC_199 --------------------------------------------MPAAQQ
Mvan_1848|M.vanbaalenii_PYR-1 ------------------MSSATVG--SVPAFAVTDPGFSITSAEVH---
MSMEG_6695|M.smegmatis_MC2_155 ------------------MSSTTLD--SVPSFDVTDPAFSITSDEVH---
Mflv_0363|M.gilvum_PYR-GCK ------------------MTASTT---ARNVFDADLPALTYDLSSTPAEV
MAV_4569|M.avium_104 ------------------MTVGAA---PPSVFDSDLPTLHYHSDETPAQV
MMAR_0122|M.marinum_M ------------------MTSTVDRQVAPNVFAAGLPNIDYQNAQSPDEA
Rv3518c|M.tuberculosis_H37Rv -------------------MTE---APDVDLADGNFYAS-REARAAYRWM
MUL_4077|M.ulcerans_Agy99 -----------------MAMTKPLIKPDVDLTDGNFYAS-RQAREAYRWM
TH_3500|M.thermoresistible__bu -------------------MTS--TAPDIDLTDGRFYADSASARAAYRWM
Mb0801|M.bovis_AF2122/97 -------------------MTTAAGLSGIDLTDLDNFAD-GFPHHLFAIH
MLBr_02088|M.leprae_Br4923 FPVYRALIDYG-PMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
MAB_3961c|M.abscessus_ATCC_199 RELQRAGTVHR-VTTAVGDPAWLITGYATVRQLFDD-----ERVGRSHPE
Mvan_1848|M.vanbaalenii_PYR-1 -----AARERS--WYATTEYGLAVLRYEQVNRLLKHP----KLRQGSAAW
MSMEG_6695|M.smegmatis_MC2_155 -----EAREKS--WYATTPYGLAVLRYEQVNRLIKHP----KLRQGSAAW
Mflv_0363|M.gilvum_PYR-GCK WPSLREARSLA--PVAVGPLGPEVLSYDMARAILRDP----RFAIPPGIN
MAV_4569|M.avium_104 YPRLREAQRRA--AVAIGPHGPEVLSYHLVRSVLRDP----RFQIPPGIN
MMAR_0122|M.marinum_M HQILAEARCRS--PIALGPHGPELLTYDLVHTVLRDP----RFRMPPGMF
Rv3518c|M.tuberculosis_H37Rv RANQPVFRDR--------NGLAAASTYQAVIDAERQP----ELFSNAGG-
MUL_4077|M.ulcerans_Agy99 RANQPVFRDR--------NGLAAASTYQAVIDAERQP----ELFSNAGG-
TH_3500|M.thermoresistible__bu RQNQPVFRDR--------NGLAAAATYQAIIESERNP----ELFSNTGG-
Mb0801|M.bovis_AF2122/97 RREAPVYWHRPTEHTPDGEGFWSVATYAETLEVLRDP----VTYSSVTGG
: .
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPP--DHTRLRKLVSKAFAPKVVQALEGDI
MAB_3961c|M.abscessus_ATCC_199 PDTAARSGDSAFFGGPIGSYETEREDHARGRRLMQPHFTPKQMRTLAGRV
Mvan_1848|M.vanbaalenii_PYR-1 PAHNGVTEGPFADWFAGWILNKEGEEHHRLRRLMNPAFSNKLIGGLVPRF
MSMEG_6695|M.smegmatis_MC2_155 PAHNGVTEGPFAEWFASWILNKEGEEHHRLRRLMNPAFSPKLIGSLVPRF
Mflv_0363|M.gilvum_PYR-GCK LAAQGVTSGPLFDKVMSSLLCLEGAEHQRLRKLVSKAFSPRATERLHDTI
MAV_4569|M.avium_104 LLAQGIDSGPLWDKVANSLLCLEGDAHHRLRSLCSKAFTPRTVARLHDTM
MMAR_0122|M.marinum_M LAAQGITSGPLWDRLAANLISLDGPAHHRLRRLVSQAFTPRATGRLNTTI
Rv3518c|M.tuberculosis_H37Rv --------IRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASI
MUL_4077|M.ulcerans_Agy99 --------IRPDQDALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDKEHSI
TH_3500|M.thermoresistible__bu --------IRPEHPGMPYMIDMDDPEHLVRRKLVNHGFTRKRVRDREDSI
Mb0801|M.bovis_AF2122/97 QRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDL
* * * . :: : .
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
MAB_3961c|M.abscessus_ATCC_199 HELADELITAMIDRGSPADFYTAVAVPLPMMVLCELLGVPYADRDEFREW
Mvan_1848|M.vanbaalenii_PYR-1 QALAAELIDGFAEPG-RCEFVGEFAEPYAARVIAIMLGLPESEWKVIA--
MSMEG_6695|M.smegmatis_MC2_155 QALANELIDNFAEPD-RCEFVSEFAEPYAARVIAIMLGLPEEEWKVIS--
Mflv_0363|M.gilvum_PYR-GCK VAVVDELIDQVVDAG-RCDVVADIARPYPIPIICALLGAPREDWRLFSQW
MAV_4569|M.avium_104 AAVMNELVDRVAAAG-RCDVVTDIARPYPVPIICALLGAPREDWRRFSSW
MMAR_0122|M.marinum_M TEVITDLVDRCADRG-RCDVVADIARRYPIPIICALLGAPAGDWKLFSGW
Rv3518c|M.tuberculosis_H37Rv AALCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRW
MUL_4077|M.ulcerans_Agy99 AQLCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVLPEQREMFLRW
TH_3500|M.thermoresistible__bu ARLCDTLIDNVCERG-ECDFVRDIAAPLPMAVIGDMLGVAPEDRGQLLKW
Mb0801|M.bovis_AF2122/97 RRRARGLLDGVEPGA-PFDFVVEIAAELPMQMICILLGVPETDRHWLFEA
*: :. .* . :: :** : :
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
MAB_3961c|M.abscessus_ATCC_199 TVAASNTRDRSRSEWGMG------------QLFVYGMQLVGRKRQQPGDD
Mvan_1848|M.vanbaalenii_PYR-1 TESATIGLALGVTILDDLPRIEA----ALAHLYEYCDELIADRRASPRDD
MSMEG_6695|M.smegmatis_MC2_155 TESATIGLALGVTLREDLPKIEA----AVQRLYEYSDELIADRRANPRDD
Mflv_0363|M.gilvum_PYR-GCK AEDVVRVFGFSVDVAARQDHVMR----AWNALDDYVDAMVEDRRTRLTDD
MAV_4569|M.avium_104 ADDVFKAFSFTVDLREVEPVVMR----AWRELDDYVDEMVARRRHSLTDD
MMAR_0122|M.marinum_M TDDILKAFSW--DAAAQQPAILA----AWDELDAYIDDMVAARRGSLTED
Rv3518c|M.tuberculosis_H37Rv SDDLVTFLSSHVSQED-FQITMD----AFAAYNDFTRATIAARRADPTDD
MUL_4077|M.ulcerans_Agy99 SDDLVTFLSSQVSQED-FQVTID----AFAAYNDFTRATIAARRAEPTDD
TH_3500|M.thermoresistible__bu SDDLVTGLSTTADEAT-VQAVMD----AFAGYTAYTMEIIGKRRAEPTDD
Mb0801|M.bovis_AF2122/97 VEPGFDFRGSRRATMP-RLNVED----AGSRLYTYALELIAGKRAEPADD
: : :* :*
MLBr_02088|M.leprae_Br4923 LISRLIELDES---GDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAML
MAB_3961c|M.abscessus_ATCC_199 VISRLCTIDG-------VADHEIASQSMALLLGGHETTVVQLGLATLLLL
Mvan_1848|M.vanbaalenii_PYR-1 FVTTLVNASRP--EDGRLSDNELRDAMVLLIFGGFDTTRNQLGLAMQTFM
MSMEG_6695|M.smegmatis_MC2_155 FMTTLVNASRP--DDGRLSDKELRDAILLLIFGGFDTTRNQLGLAMQTFM
Mflv_0363|M.gilvum_PYR-GCK LISELIRAEDD--GD-RLSSAELQMLAVSLLMAGTDTTRNQLAASVQALS
MAV_4569|M.avium_104 LLSDLIRAGDE--GD-RLDAAELRMLAGGLLLAGTDTTRNQVAASVQVLC
MMAR_0122|M.marinum_M LISALIRAEDD--GD-CLSSDELRMLVAGLLIGGTDTTRNQLAASAQALC
Rv3518c|M.tuberculosis_H37Rv LVSVLVSSEVD---GERLSDDELVMETLLILIGGDETTRHTLSGGTEQLL
MUL_4077|M.ulcerans_Agy99 LVSVLVSSEVD---GERLSDDELVMETLLILIGGDETTRHTLSGGSEQLL
TH_3500|M.thermoresistible__bu LFSILINAEVE---GQRMSDEEIVFETLLILIGGDETTRHTLSGGVEQLL
Mb0801|M.bovis_AF2122/97 MLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALA
..: : : *: :: .* :** :. . :
MLBr_02088|M.leprae_Br4923 RNPSQWKALSSNPQRAPLVVEETLRYD-PAIHLIGRVAAKDMTIGQTTLT
MAB_3961c|M.abscessus_ATCC_199 ANPEQWALLVSQPDLVPNAVEETLRASRTGGGEIPRYAREDLEIDGVHIA
Mvan_1848|M.vanbaalenii_PYR-1 AHPDQWRLLAERPELGGNAVEEVMRVN-PTVRWVTREVLEDFEYEGVELA
MSMEG_6695|M.smegmatis_MC2_155 KHPDQWRLLGERPDLGGKAVEEVMRVN-PTVRWVTREVVEDFEYEGVTLK
Mflv_0363|M.gilvum_PYR-GCK EQPDQWALLAEQPDLAMRAVEETMRHS-PVVCGTPRIVVADVEFAGYLFP
MAV_4569|M.avium_104 EHPHQWELLRQRPELAMRAVEETMRHS-PIACGTLRLVVEDAELDGHLFP
MMAR_0122|M.marinum_M DHPDQWVLLAQHPDLAANAAEETMRHS-PITFSTLRIALDDVELAGVMIP
Rv3518c|M.tuberculosis_H37Rv RNRDQWDLLQRDPSLLPGAIEEMLRWT-APVKNMCRVLTADTEFHGTALC
MUL_4077|M.ulcerans_Agy99 RNRVQWDLLQSDRELLPGAIEEMLRWT-APVKNMCRMLTADTEFHGTALS
TH_3500|M.thermoresistible__bu RHPDQWQRLRNDPDLVPGAIEEMLRWT-SPVKNMCRTLTADTEFHGTQLR
Mb0801|M.bovis_AF2122/97 ENPDQLQTLRSDFELLPTAIEEIVRWT-SPSPSKRRTASRAVSLGGQPIE
: * * . . ** :* . * :
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRP-SSRHLAFAVGSHFCLGAAL
MAB_3961c|M.abscessus_ATCC_199 AGELLLLDVGAANHDPAVFGCPDQLDVARK-HLAHVIFGYGSRYCVGAPL
Mvan_1848|M.vanbaalenii_PYR-1 AGTTVHLYSESAGTDPRVFEPGFDITAERK---PHFGFGGGVHHCLGHFV
MSMEG_6695|M.smegmatis_MC2_155 AGTTVHLYSESAGTDPRVFEPGFDITAERK---PHFGFGGGVHHCLGHFV
Mflv_0363|M.gilvum_PYR-GCK AGTFVFVNTFTANRDPALYDDAERLDLRREGAPAILTFGGGVHYCLGANL
MAV_4569|M.avium_104 AGTAVLVNTFAANRDPAVYDDPDRVDITREAAPPILTFGGGVHYCLGANL
MMAR_0122|M.marinum_M TGTLVIANTGAANRDPALYRDPDRLDISRPIAGPIQTFGAGMHYCLGANL
Rv3518c|M.tuberculosis_H37Rv AGEKMMLLFESANFDEAVFCEPEKFDVQRN-PNSHLAFGFGTHFCLGNQL
MUL_4077|M.ulcerans_Agy99 KGEKIMLLFESANFDEAVFTDPEKFDIQRN-PNSHLAFGFGTHFCMGNQL
TH_3500|M.thermoresistible__bu KGEKMLLLFESANFDETVFENPDDFRIDRD-PNPHIAFGFGTHFCLGNQL
Mb0801|M.bovis_AF2122/97 AGQKVVVWEGSANRDPSVFDRADEFDITRK-PNPHLGFGQGVHYCLGANL
* : :*. * :: . * *. * :.*:* :
MLBr_02088|M.leprae_Br4923 ARLEATVTLSAISARFPQVQLAG---ELVYKPNVAMRGMSALPVQV----
MAB_3961c|M.abscessus_ATCC_199 ARMQLTEVLGQLVERLPGLHLRRDISELTMRGDLLTGGLREVPVGW----
Mvan_1848|M.vanbaalenii_PYR-1 ARSDMSEALPLLARRMLDPHELPGAT---WLPDSGNTGPITLPIGFTPAS
MSMEG_6695|M.smegmatis_MC2_155 ARSDMSEALPLLARRLRDPHELPGAT---WLPDSGNTGPNTLPIGFTPAP
Mflv_0363|M.gilvum_PYR-GCK ARRELAEALRILAARLPNPRISGEAP---WKPMLGMTGPTALELEFGA--
MAV_4569|M.avium_104 ARREIAEALNVLANRLRNPRLAGPAP---WKPMVSLSGPTSLPIEFDR--
MMAR_0122|M.marinum_M ARRELTEALRIITQRMPGARRTGAAP---WKSLTGLSGPTTLPIEFDAGH
Rv3518c|M.tuberculosis_H37Rv ARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSP
MUL_4077|M.ulcerans_Agy99 ARLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSR
TH_3500|M.thermoresistible__bu ARLELTLMLRRLLQRLPDLRLASDDP-LPLRPANFVSGPEAMPVVFTPTE
Mb0801|M.bovis_AF2122/97 ARLELRVLFEELLSRFGSVRVVEPAE---WTRSNRHTGIRHLVVELRGG-
** : : *: : * : :
MLBr_02088|M.leprae_Br4923 ----
MAB_3961c|M.abscessus_ATCC_199 ----
Mvan_1848|M.vanbaalenii_PYR-1 ----
MSMEG_6695|M.smegmatis_MC2_155 ----
Mflv_0363|M.gilvum_PYR-GCK ----
MAV_4569|M.avium_104 ----
MMAR_0122|M.marinum_M ----
Rv3518c|M.tuberculosis_H37Rv PLG-
MUL_4077|M.ulcerans_Agy99 PLR-
TH_3500|M.thermoresistible__bu PVSA
Mb0801|M.bovis_AF2122/97 ----