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TSTVDRQVAPNVFAAGLPNIDYQNAQSPDEAHQILAEARCRSPIALGPHGPELLTYDLVHTVLRDPRFRM PPGMFLAAQGITSGPLWDRLAANLISLDGPAHHRLRRLVSQAFTPRATGRLNTTITEVITDLVDRCADRG RCDVVADIARRYPIPIICALLGAPAGDWKLFSGWTDDILKAFSWDAAAQQPAILAAWDELDAYIDDMVAA RRGSLTEDLISALIRAEDDGDCLSSDELRMLVAGLLIGGTDTTRNQLAASAQALCDHPDQWVLLAQHPDL AANAAEETMRHSPITFSTLRIALDDVELAGVMIPTGTLVIANTGAANRDPALYRDPDRLDISRPIAGPIQ TFGAGMHYCLGANLARRELTEALRIITQRMPGARRTGAAPWKSLTGLSGPTTLPIEFDAGH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0122 | cyp279A2 | - | 100% (412) | cytochrome P450 279A2 Cyp279A2 |
| M. marinum M | MMAR_5268 | cyp164A3 | 6e-48 | 37.78% (315) | cytochrome P450 164A3 Cyp164A3 |
| M. marinum M | MMAR_5003 | cyp142A3 | 1e-42 | 33.04% (342) | cytochrome P450 142A3 Cyp142A3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 7e-45 | 34.12% (381) | cytochrome p450 140 CYP140 |
| M. gilvum PYR-GCK | Mflv_4282 | - | 1e-140 | 60.75% (400) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1880c | cyp140 | 7e-45 | 34.12% (381) | cytochrome p450 140 CYP140 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-47 | 33.53% (343) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 1e-45 | 35.51% (321) | cytochrome P450 |
| M. avium 104 | MAV_4569 | - | 1e-142 | 59.85% (401) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4213 | - | 1e-128 | 58.51% (376) | cytochrome P450 hydroxylase |
| M. thermoresistible (build 8) | TH_3500 | - | 6e-45 | 34.07% (317) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_4077 | cyp142A3 | 1e-41 | 32.75% (342) | cytochrome P450 142A3 Cyp142A3 |
| M. vanbaalenii PYR-1 | Mvan_0373 | - | 1e-138 | 60.60% (401) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1912c|M.bovis_AF2122/97 ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
Rv1880c|M.tuberculosis_H37Rv ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0276|M.abscessus_ATCC_1997 ---------------------MPITTDPG------TLLLQVLDPANRANP
MAV_4569|M.avium_104 ---------------------MTVGAAPPSVFDSDLPTLHYHSDETPAQV
Mvan_0373|M.vanbaalenii_PYR-1 ---------------------MVVSPTVANVFDAGLPTLTYDVFSTPAQV
Mflv_4282|M.gilvum_PYR-GCK -----------------------MSTAAPSVFEADLPTFTYGFAATPHDI
MMAR_0122|M.marinum_M ------------------MTSTVDRQVAPNVFAAGLPNIDYQNAQSPDEA
MSMEG_4213|M.smegmatis_MC2_155 ---------------------------MTRMTVAELTPISYHHATMPAEV
TH_3500|M.thermoresistible__bu --------------------------MTS--TAPDIDLTDGRFYADSASA
MUL_4077|M.ulcerans_Agy99 ------------------------MAMTKPLIKPDVDLTDGNFYAS-RQA
.
Mb1912c|M.bovis_AF2122/97 VPFYDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPL
Rv1880c|M.tuberculosis_H37Rv VPFYDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPL
MLBr_02088|M.leprae_Br4923 FPVYRALIDY---GPMQLPGMPLTVFSSFSDCD-EALRHPLSASDRLKAT
MAB_0276|M.abscessus_ATCC_1997 YPVYGQLVEQTQAGPVHPPGMDVSVLATFADCN-AVLRHPQASSDRRKSN
MAV_4569|M.avium_104 YPRLREAQRRAAVAIGPHGPEVLSYHLVRSVLRDPRFQIPPG-------I
Mvan_0373|M.vanbaalenii_PYR-1 WPDLHDAQRTAPIAIGPMGPEVLSYEMARAVLRDTRFTIPPG-------I
Mflv_4282|M.gilvum_PYR-GCK FDDVREAQSRAPIALGPLGPEILSYELARDMLRDNRFRLPPG-------I
MMAR_0122|M.marinum_M HQILAEARCRSPIALGPHGPELLTYDLVHTVLRDPRFRMPPG-------M
MSMEG_4213|M.smegmatis_MC2_155 HDIIRQARANGPLALGPYGPEILGYELVRAVLRDERFEVPRG-------M
TH_3500|M.thermoresistible__bu RAAYRWMRQNQPVFRDRNGLAAAATYQAIIESERNPELFSNTG-------
MUL_4077|M.ulcerans_Agy99 REAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAG-------
Mb1912c|M.bovis_AF2122/97 RWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDL
Rv1880c|M.tuberculosis_H37Rv RWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDL
MLBr_02088|M.leprae_Br4923 LAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGD
MAB_0276|M.abscessus_ATCC_1997 IVQRQLAQ--NPNLIARPSFLGLDAPDHTRLRKLASKAFAPRVINAMAED
MAV_4569|M.avium_104 NLLAQGIDSGPLWDKVANSLLCLEGDAHHRLRSLCSKAFTPRTVARLHDT
Mvan_0373|M.vanbaalenii_PYR-1 NLAAQGITSGPLFDKVMSTLLCLEGSEHQRLRKLVSKAFTPRATERLHDT
Mflv_4282|M.gilvum_PYR-GCK TLAAQGITSGPLYDKITGSLLGLNGPPHVRLRKLVSKAFTPRATARLQDT
MMAR_0122|M.marinum_M FLAAQGITSGPLWDRLAANLISLDGPAHHRLRRLVSQAFTPRATGRLNTT
MSMEG_4213|M.smegmatis_MC2_155 FLAAQGITSGPLWERANNTLVGLGGPAHLRLRRLVARAFIPKAAERLRAT
TH_3500|M.thermoresistible__bu --------GIRPEHPGMPYMIDMDDPEHLVRRKLVNHGFTRKRVRDREDS
MUL_4077|M.ulcerans_Agy99 --------GIRPDQDALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDKEHS
:: : * * * :
Mb1912c|M.bovis_AF2122/97 VEQTAINLLDRFAEQPGIVDVVGRYCSQLPIVVISEILGVPEHDRPRVLE
Rv1880c|M.tuberculosis_H37Rv VEQTAINLLDRFAEQPGIVDVVGRYCSQLPIVVISEILGVPEHDRPRVLE
MLBr_02088|M.leprae_Br4923 IAALVDSLLDKGAAA-GQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
MAB_0276|M.abscessus_ATCC_1997 IQTFVDKMLDDIALR-GTFNLVTEFAYPLPVAVICRMLGVPIEDEPEFGR
MAV_4569|M.avium_104 MAAVMNELVDRVAAA-GRCDVVTDIARPYPVPIICALLGAPREDWRRFSS
Mvan_0373|M.vanbaalenii_PYR-1 IVAVVDELVDNIAGA-RRCDVVADIARPYPIPIICALLGAPREDWRLFSD
Mflv_4282|M.gilvum_PYR-GCK IHEVVNGLVDRVLDA-GRCDVVTDIARPYPTPIICALLGAPREDWPLFAD
MMAR_0122|M.marinum_M ITEVITDLVDRCADR-GRCDVVADIARRYPIPIICALLGAPAGDWKLFSG
MSMEG_4213|M.smegmatis_MC2_155 CVDIVTELVARCVPA-GRCDVVADLAVPYAVPVICALLGAPARDWARFSA
TH_3500|M.thermoresistible__bu IARLCDTLIDNVCER-GECDFVRDIAAPLPMAVIGDMLGVAPEDRGQLLK
MUL_4077|M.ulcerans_Agy99 IAQLCDTLIDAVCER-GECDFVRDLAAPLPMAVIGDMLGVLPEQREMFLR
:: :.: . . :* :**. : .
Mb1912c|M.bovis_AF2122/97 FGELAAPSLD-----IGIPWRQYLRVQQGIRGFDCWLEGHLQQLRHAPGD
Rv1880c|M.tuberculosis_H37Rv FGELAAPSLD-----IGIPWRQYLRVQQGIRGFDCWLEGHLQQLRHAPGD
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE
MAB_0276|M.abscessus_ATCC_1997 ASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDLIASRRRNLGD
MAV_4569|M.avium_104 WADDVFKAFSFT----VDLREVEPVVMRAWRELDDYVDEMVARRRHSLTD
Mvan_0373|M.vanbaalenii_PYR-1 WTEDVFRAFSFS----TDVATVQDDVMRAWNELDDYVDRMVAHRRRHLTD
Mflv_4282|M.gilvum_PYR-GCK WTEEVFKAFNFQ----PELTFDEAQIMRAWGELDAYVDDMVAARRSNLTD
MMAR_0122|M.marinum_M WTDDILKAFSW------DAAAQQPAILAAWDELDAYIDDMVAARRGSLTE
MSMEG_4213|M.smegmatis_MC2_155 WADEIFKMFSW------DLGEHAEAVETAWKELDAYVDDMVVRRRHTLTD
TH_3500|M.thermoresistible__bu WSDDLVTGLSTT-----ADEATVQAVMDAFAGYTAYTMEIIGKRRAEPTD
MUL_4077|M.ulcerans_Agy99 WSDDLVTFLSSQ-----VSQEDFQVTIDAFAAYNDFTRATIAARRAEPTD
.. . : : * :
Mb1912c|M.bovis_AF2122/97 DLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGNGIRML
Rv1880c|M.tuberculosis_H37Rv DLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGNGIRML
MLBr_02088|M.leprae_Br4923 DLISRLIELDESGD---QLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
MAB_0276|M.abscessus_ATCC_1997 DLLSALIQVEEAGD---QLTEEEIISTCTLLLIAGHETTVNLIANASLAM
MAV_4569|M.avium_104 DLLSDLIRAGDEGD---RLDAAELRMLAGGLLLAGTDTTRNQVAASVQVL
Mvan_0373|M.vanbaalenii_PYR-1 DLLSDLIRAEDDGD---RLSTSELQMLAASLLMAGTDTTRNQLAASVQAL
Mflv_4282|M.gilvum_PYR-GCK DLLSELIRAESDGD---RLNLDELRGLVAGFLMAGTDTTRNQLAASVQVL
MMAR_0122|M.marinum_M DLISALIRAEDDGD---CLSSDELRMLVAGLLIGGTDTTRNQLAASAQAL
MSMEG_4213|M.smegmatis_MC2_155 DLLSDLIRAEDDGD---RLTHHELLMLAGGVLLAGTDTTRNQLAAAVETL
TH_3500|M.thermoresistible__bu DLFSILINAEVEGQ---RMSDEEIVFETLLILIGGDETTRHTLSGGVEQL
MUL_4077|M.ulcerans_Agy99 DLVSVLVSSEVDGE---RLSDDELVMETLLILIGGDETTRHTLSGGSEQL
**.* *: *: : *: .*:.* :** : :. . :
Mb1912c|M.bovis_AF2122/97 LDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVRIK
Rv1880c|M.tuberculosis_H37Rv LDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVRIK
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
MAB_0276|M.abscessus_ATCC_1997 LRHPEQWKLLGQNADRAPLVVEETLRYDPPVHMVARVADGEMAIRDFILP
MAV_4569|M.avium_104 CEHPHQWELLRQRPELAMRAVEETMRHSPIACGTLRLVVEDAELDGHLFP
Mvan_0373|M.vanbaalenii_PYR-1 SERPDQWALLADRPELAMRAVEETMRHSPVVCGAPRIVLDDVEFDGYLFP
Mflv_4282|M.gilvum_PYR-GCK LEHPDQWTKLRDHPELAMQAVEESMRHSPAASIVPRAATEDAEFGGYMFP
MMAR_0122|M.marinum_M CDHPDQWVLLAQHPDLAANAAEETMRHSPITFSTLRIALDDVELAGVMIP
MSMEG_4213|M.smegmatis_MC2_155 CDHPREWDLLAEHPELAPTFVEELMRFSPATLGTVRIAKEEVEIAGVTIP
TH_3500|M.thermoresistible__bu LRHPDQWQRLRNDPDLVPGAIEEMLRWTSPVKNMCRTLTADTEFHGTQLR
MUL_4077|M.ulcerans_Agy99 LRNRVQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALS
. * . : ** :* . * : . :
Mb1912c|M.bovis_AF2122/97 RGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAAL
Rv1880c|M.tuberculosis_H37Rv RGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAAL
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVGSHFCLGAAL
MAB_0276|M.abscessus_ATCC_1997 DGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEI-KHLAFGHGPHFCLGAPL
MAV_4569|M.avium_104 AGTAVLVNTFAANRDPAVYDDPDRVDITREAAPPILTFGGGVHYCLGANL
Mvan_0373|M.vanbaalenii_PYR-1 AGTFVFVNTFAANRDPAVYADADRLDLTREQAPAILTFGGGVHYCLGANL
Mflv_4282|M.gilvum_PYR-GCK AGTFILVNTFVANRDPAIYHDADRFDITRTDLPPILTFGGGAHYCLGANL
MMAR_0122|M.marinum_M TGTLVIANTGAANRDPALYRDPDRLDISRPIAGPIQTFGAGMHYCLGANL
MSMEG_4213|M.smegmatis_MC2_155 AGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGGLHYCLGVHL
TH_3500|M.thermoresistible__bu KGEKMLLLFESANFDETVFENPDDFRIDRDPN-PHIAFGFGTHFCLGNQL
MUL_4077|M.ulcerans_Agy99 KGEKIMLLFESANFDEAVFTDPEKFDIQRNPN-SHLAFGFGTHFCMGNQL
* : *: * : . . * *. * *:*:* *
Mb1912c|M.bovis_AF2122/97 ARAEGEVGLRTFFDRFPDVRAAGAGS---RRDTRVLRGWSTLPVTLGPAR
Rv1880c|M.tuberculosis_H37Rv ARAEGEVGLRTFFDRFPDVRAAGAGS---RRDTRVLRGWSTLPVTLGPAR
MLBr_02088|M.leprae_Br4923 ARLEATVTLSAISARFPQVQLAGELV---YKPNVAMRGMSALPVQV----
MAB_0276|M.abscessus_ATCC_1997 ARLEARLALSSITARFPGARLMDEPT---YKPNVTLRGLAELPVSIA---
MAV_4569|M.avium_104 ARREIAEALNVLANRLRNPRLAGPAP---WKPMVSLSGPTSLPIEFDR--
Mvan_0373|M.vanbaalenii_PYR-1 ARRELAEALRILAGRLSNPRRSGSAP---WKPMLGMTGPTVLELEFDA--
Mflv_4282|M.gilvum_PYR-GCK ARRELAEALVVLTRRLAPPRRIGPAP---WKSLLGMTGPTTLPIEVTSEQ
MMAR_0122|M.marinum_M ARRELTEALRIITQRMPGARRTGAAP---WKSLTGLSGPTTLPIEFDAGH
MSMEG_4213|M.smegmatis_MC2_155 ARVELAEALCVITAAMRHPHRDGPPP---GNR------------------
TH_3500|M.thermoresistible__bu ARLELTLMLRRLLQRLPDLRLASDDP-LPLRPANFVSGPEAMPVVFTPTE
MUL_4077|M.ulcerans_Agy99 ARLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSR
** * . : : . .
Mb1912c|M.bovis_AF2122/97 SMVSP-
Rv1880c|M.tuberculosis_H37Rv SMVSP-
MLBr_02088|M.leprae_Br4923 ------
MAB_0276|M.abscessus_ATCC_1997 ------
MAV_4569|M.avium_104 ------
Mvan_0373|M.vanbaalenii_PYR-1 ------
Mflv_4282|M.gilvum_PYR-GCK PVTANA
MMAR_0122|M.marinum_M ------
MSMEG_4213|M.smegmatis_MC2_155 ------
TH_3500|M.thermoresistible__bu PVSA--
MUL_4077|M.ulcerans_Agy99 PLR---