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VVSPTVANVFDAGLPTLTYDVFSTPAQVWPDLHDAQRTAPIAIGPMGPEVLSYEMARAVLRDTRFTIPPG INLAAQGITSGPLFDKVMSTLLCLEGSEHQRLRKLVSKAFTPRATERLHDTIVAVVDELVDNIAGARRCD VVADIARPYPIPIICALLGAPREDWRLFSDWTEDVFRAFSFSTDVATVQDDVMRAWNELDDYVDRMVAHR RRHLTDDLLSDLIRAEDDGDRLSTSELQMLAASLLMAGTDTTRNQLAASVQALSERPDQWALLADRPELA MRAVEETMRHSPVVCGAPRIVLDDVEFDGYLFPAGTFVFVNTFAANRDPAVYADADRLDLTREQAPAILT FGGGVHYCLGANLARRELAEALRILAGRLSNPRRSGSAPWKPMLGMTGPTVLELEFDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0373 | - | - | 100% (409) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4984 | - | e-155 | 65.60% (407) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_1848 | - | 1e-59 | 36.58% (380) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 4e-43 | 36.36% (297) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_0363 | - | 0.0 | 82.15% (409) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 4e-43 | 36.36% (297) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-49 | 34.90% (341) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 2e-44 | 34.50% (313) | cytochrome P450 |
| M. marinum M | MMAR_0122 | cyp279A2 | 1e-138 | 60.60% (401) | cytochrome P450 279A2 Cyp279A2 |
| M. avium 104 | MAV_4569 | - | 1e-169 | 70.59% (408) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4213 | - | 1e-114 | 55.29% (378) | cytochrome P450 hydroxylase |
| M. thermoresistible (build 8) | TH_4410 | - | 1e-46 | 31.97% (391) | PUTATIVE putative cytochrome P450 107B1 |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 2e-42 | 36.49% (296) | cytochrome P450 124A1, Cyp124A1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0373|M.vanbaalenii_PYR-1 ---------------------MVVSPT---VANVFDAGLPTLTYDVFSTP
Mflv_0363|M.gilvum_PYR-GCK ---------------------MTASTT---ARNVFDADLPALTYDLSSTP
MAV_4569|M.avium_104 ---------------------MTVGAA---PPSVFDSDLPTLHYHSDETP
MMAR_0122|M.marinum_M ---------------------MTSTVDRQVAPNVFAAGLPNIDYQNAQSP
MSMEG_4213|M.smegmatis_MC2_155 ---------------------MTRMTV---------AELTPISYHHATMP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0276|M.abscessus_ATCC_1997 ---------------------MPITTDPG------TLLLQVLDPANRANP
Mb2289|M.bovis_AF2122/97 -------------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDD
Rv2266|M.tuberculosis_H37Rv -------------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDD
MUL_1282|M.ulcerans_Agy99 ---------MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDD
TH_4410|M.thermoresistible__bu ----------------------------------VTVLFDPLDEEQLADP
: :
Mvan_0373|M.vanbaalenii_PYR-1 AQVWPDLHDAQRTAPIAIG---------PMGPEVLS-YEMARAVLRDTRF
Mflv_0363|M.gilvum_PYR-GCK AEVWPSLREARSLAPVAVG---------PLGPEVLS-YDMARAILRDPRF
MAV_4569|M.avium_104 AQVYPRLREAQRRAAVAIG---------PHGPEVLS-YHLVRSVLRDPRF
MMAR_0122|M.marinum_M DEAHQILAEARCRSPIALG---------PHGPELLT-YDLVHTVLRDPRF
MSMEG_4213|M.smegmatis_MC2_155 AEVHDIIRQARANGPLALG---------PYGPEILG-YELVRAVLRDERF
MLBr_02088|M.leprae_Br4923 FPVYRALIDY---GPMQLP---------GMPLTVFSSFSDCDEALRHPLS
MAB_0276|M.abscessus_ATCC_1997 YPVYGQLVEQTQAGPVHPP---------GMDVSVLATFADCNAVLRHPQA
Mb2289|M.bovis_AF2122/97 VRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDI
Rv2266|M.tuberculosis_H37Rv VRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDI
MUL_1282|M.ulcerans_Agy99 FRDGAFATLRREAPISFWPPIELAGLTAGKGHWALTKHDDIHFASRHPEI
TH_4410|M.thermoresistible__bu IPT--YRALREQDPVQRIP--------VGGGTWVVSRYEDVRRLLRTTAG
. . *
Mvan_0373|M.vanbaalenii_PYR-1 TIPPGINLAAQGITSG--PLFDKVMSTLLCLEGSEHQRLRKLVSKAFTPR
Mflv_0363|M.gilvum_PYR-GCK AIPPGINLAAQGVTSG--PLFDKVMSSLLCLEGAEHQRLRKLVSKAFSPR
MAV_4569|M.avium_104 QIPPGINLLAQGIDSG--PLWDKVANSLLCLEGDAHHRLRSLCSKAFTPR
MMAR_0122|M.marinum_M RMPPGMFLAAQGITSG--PLWDRLAANLISLDGPAHHRLRRLVSQAFTPR
MSMEG_4213|M.smegmatis_MC2_155 EVPRGMFLAAQGITSG--PLWERANNTLVGLGGPAHLRLRRLVARAFIPK
MLBr_02088|M.leprae_Br4923 ASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPK
MAB_0276|M.abscessus_ATCC_1997 SSDRRKSNIVQRQLAQ--NPNLIARPSFLGLDAPDHTRLRKLASKAFAPR
Mb2289|M.bovis_AF2122/97 FSSYPNITINDQTP-----ELAEYFGSMIVLDDPRHQRLRSIVSRAFTPK
Rv2266|M.tuberculosis_H37Rv FSSYPNITINDQTP-----ELAEYFGSMIVLDDPRHQRLRSIVSRAFTPK
MUL_1282|M.ulcerans_Agy99 FHSSPNIVIHDQTP-----ELAEYFGSMIVLDDPRHQRLRSIVSRAFTPK
TH_4410|M.thermoresistible__bu LMQPPGATVPVELAGG--PAERIYRGLMVLNDPPVHTRLRKLTEKAMTRG
:: * *** : :*:
Mvan_0373|M.vanbaalenii_PYR-1 ATERLHDTIVAVVDELVDNIAGA---RRCDVVADIARPYPIPIICALLGA
Mflv_0363|M.gilvum_PYR-GCK ATERLHDTIVAVVDELIDQVVDA---GRCDVVADIARPYPIPIICALLGA
MAV_4569|M.avium_104 TVARLHDTMAAVMNELVDRVAAA---GRCDVVTDIARPYPVPIICALLGA
MMAR_0122|M.marinum_M ATGRLNTTITEVITDLVDRCADR---GRCDVVADIARRYPIPIICALLGA
MSMEG_4213|M.smegmatis_MC2_155 AAERLRATCVDIVTELVARCVPA---GRCDVVADLAVPYAVPVICALLGA
MLBr_02088|M.leprae_Br4923 VVQALEGDIAALVDSLLDKGAAA---GQFDVIADLAFPLAVAVICRLLGV
MAB_0276|M.abscessus_ATCC_1997 VINAMAEDIQTFVDKMLDDIALR---GTFNLVTEFAYPLPVAVICRMLGV
Mb2289|M.bovis_AF2122/97 VVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGI
Rv2266|M.tuberculosis_H37Rv VVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGI
MUL_1282|M.ulcerans_Agy99 VVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGI
TH_4410|M.thermoresistible__bu AVEKLRADVERVASEALDAMLEQ---GEADAMTELAFTVPLRVICGMLGI
. : : : ::::* .: :** ::*
Mvan_0373|M.vanbaalenii_PYR-1 PREDWRLFSDWTEDVFR----AFSFSTDVATVQDDVMRAWNELDDYVDRM
Mflv_0363|M.gilvum_PYR-GCK PREDWRLFSQWAEDVVR----VFGFSVDVAARQDHVMRAWNALDDYVDAM
MAV_4569|M.avium_104 PREDWRRFSSWADDVFK----AFSFTVDLREVEPVVMRAWRELDDYVDEM
MMAR_0122|M.marinum_M PAGDWKLFSGWTDDILK----AFSW--DAAAQQPAILAAWDELDAYIDDM
MSMEG_4213|M.smegmatis_MC2_155 PARDWARFSAWADEIFK----MFSW--DLGEHAEAVETAWKELDAYVDDM
MLBr_02088|M.leprae_Br4923 PYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQL
MAB_0276|M.abscessus_ATCC_1997 PIEDEPEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDL
Mb2289|M.bovis_AF2122/97 PKADHQRIFHWTN--VILG----FGDPDLATDFDEFMQVSADIGAYATAL
Rv2266|M.tuberculosis_H37Rv PKADHQRIFHWTN--VILG----FGDPDLATDFDEFMQVSADIGAYATAL
MUL_1282|M.ulcerans_Agy99 PEEDHEQIFHWTN--VILG----FGDPDLTTDFDDFLQVSMAIGGYATAL
TH_4410|M.thermoresistible__bu PEADRAQMLDWTPDFFRIF----LPQANDADGIAACHRACQNFIDYLSEQ
* * : : : . : *
Mvan_0373|M.vanbaalenii_PYR-1 VAHRRRHLTDDLLSDLIRAEDDGDRLSTSELQMLAASLLMAGTDTTRNQL
Mflv_0363|M.gilvum_PYR-GCK VEDRRTRLTDDLISELIRAEDDGDRLSSAELQMLAVSLLMAGTDTTRNQL
MAV_4569|M.avium_104 VARRRHSLTDDLLSDLIRAGDEGDRLDAAELRMLAGGLLLAGTDTTRNQV
MMAR_0122|M.marinum_M VAARRGSLTEDLISALIRAEDDGDCLSSDELRMLVAGLLIGGTDTTRNQL
MSMEG_4213|M.smegmatis_MC2_155 VVRRRHTLTDDLLSDLIRAEDDGDRLTHHELLMLAGGVLLAGTDTTRNQL
MLBr_02088|M.leprae_Br4923 VKCRRGTPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLI
MAB_0276|M.abscessus_ATCC_1997 IASRRRNLGDDLLSALIQVEEAGDQLTEEEIISTCTLLLIAGHETTVNLI
Mb2289|M.bovis_AF2122/97 AEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI
Rv2266|M.tuberculosis_H37Rv AEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI
MUL_1282|M.ulcerans_Agy99 ADDRRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTI
TH_4410|M.thermoresistible__bu IEYRRRTPADDIFSALVSAEDEGDRLSRDELVATVLSLLTGGFDTTMGMI
** *: : *: *: * *: :: .* :** . :
Mvan_0373|M.vanbaalenii_PYR-1 AASVQALSERPDQWALLADRPE-LAMRAVEETMRHSPVVCGAPRIVLDDV
Mflv_0363|M.gilvum_PYR-GCK AASVQALSEQPDQWALLAEQPD-LAMRAVEETMRHSPVVCGTPRIVVADV
MAV_4569|M.avium_104 AASVQVLCEHPHQWELLRQRPE-LAMRAVEETMRHSPIACGTLRLVVEDA
MMAR_0122|M.marinum_M AASAQALCDHPDQWVLLAQHPD-LAANAAEETMRHSPITFSTLRIALDDV
MSMEG_4213|M.smegmatis_MC2_155 AAAVETLCDHPREWDLLAEHPE-LAPTFVEELMRFSPATLGTVRIAKEEV
MLBr_02088|M.leprae_Br4923 ANAVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDM
MAB_0276|M.abscessus_ATCC_1997 ANASLAMLRHPEQWKLLGQNAD-RAPLVVEETLRYDPPVHMVARVADGEM
Mb2289|M.bovis_AF2122/97 THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDI
Rv2266|M.tuberculosis_H37Rv THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDI
MUL_1282|M.ulcerans_Agy99 SHGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDV
TH_4410|M.thermoresistible__bu GAGVFGLARQPEQLAALREDPAGLARTAVEEFIRWESPVAVTYRHFVEDV
. : * : . * .** :* . * :
Mvan_0373|M.vanbaalenii_PYR-1 EFDGYLFPAGTFVFVNTFAANRDPAVYADADRLDLTREQAPAILTFGGGV
Mflv_0363|M.gilvum_PYR-GCK EFAGYLFPAGTFVFVNTFTANRDPALYDDAERLDLRREGAPAILTFGGGV
MAV_4569|M.avium_104 ELDGHLFPAGTAVLVNTFAANRDPAVYDDPDRVDITREAAPPILTFGGGV
MMAR_0122|M.marinum_M ELAGVMIPTGTLVIANTGAANRDPALYRDPDRLDISRPIAGPIQTFGAGM
MSMEG_4213|M.smegmatis_MC2_155 EIAGVTIPAGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGGL
MLBr_02088|M.leprae_Br4923 TIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVGS
MAB_0276|M.abscessus_ATCC_1997 AIRDFILPDGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEI-KHLAFGHGP
Mb2289|M.bovis_AF2122/97 ELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGA
Rv2266|M.tuberculosis_H37Rv ELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGA
MUL_1282|M.ulcerans_Agy99 DLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGA
TH_4410|M.thermoresistible__bu TIADTTIPAGEPIWLLLLSANRDDTRFHDPDGFDVRRKPNQHVAFGGG-R
: :. * : :*:** .: * .
Mvan_0373|M.vanbaalenii_PYR-1 HYCLGANLARRELAEALRILAGRLSNPRRSGSAPWKPMLGMTGPTVLELE
Mflv_0363|M.gilvum_PYR-GCK HYCLGANLARRELAEALRILAARLPNPRISGEAPWKPMLGMTGPTALELE
MAV_4569|M.avium_104 HYCLGANLARREIAEALNVLANRLRNPRLAGPAPWKPMVSLSGPTSLPIE
MMAR_0122|M.marinum_M HYCLGANLARRELTEALRIITQRMPGARRTGAAPWKSLTGLSGPTTLPIE
MSMEG_4213|M.smegmatis_MC2_155 HYCLGVHLARVELAEALCVITAAMRHPHRDGPPPGNR-------------
MLBr_02088|M.leprae_Br4923 HFCLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQ
MAB_0276|M.abscessus_ATCC_1997 HFCLGAPLARLEARLALSSITARFPGARLMDEPTYKPNVTLRGLAELPVS
Mb2289|M.bovis_AF2122/97 HFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVT
Rv2266|M.tuberculosis_H37Rv HFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVT
MUL_1282|M.ulcerans_Agy99 HFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPVA
TH_4410|M.thermoresistible__bu HHCIGSHLARLEGEVVFAEIARRIETIEITGDSPRRPNFQFRSFTTLPVK
*.*:* *** * .: : :
Mvan_0373|M.vanbaalenii_PYR-1 FDA---
Mflv_0363|M.gilvum_PYR-GCK FGA---
MAV_4569|M.avium_104 FDR---
MMAR_0122|M.marinum_M FDAGH-
MSMEG_4213|M.smegmatis_MC2_155 ------
MLBr_02088|M.leprae_Br4923 V-----
MAB_0276|M.abscessus_ATCC_1997 IA----
Mb2289|M.bovis_AF2122/97 WS----
Rv2266|M.tuberculosis_H37Rv WS----
MUL_1282|M.ulcerans_Agy99 WSR---
TH_4410|M.thermoresistible__bu MTGRSR