For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SAAPPSVFDAGLPTLDYDITDTPQQIRPQFCAAQQVAPIALGPIGPEVLSYPLARTVLGDPRFGIPPGIH LAAHGITSGELWDRVTRSILCMEGDEHRRLRSLVSRAFTPRATAKMDQTISEVITDLIDAVSDSGACEFV DQVARPYPIPVICALFGAPREDWELFSTWAQDIFKIVSFDIDLAAEEPTVLRAWDEFDAYIDDMIARRRT HLTTDLLSELIRAEDGGDRLDAGEVRMLAFSILIAGTDTTRTQLAASMQVLCDHHDQFALLRDRPELAMR AVEETMRHSPSMCSTVRTATEDVAIGEYTIPAGTFLVVNTFAANRDPVIYDEPDRFDITRDDPPPILTFG GGAHYCLGANLARRELSEALKILACRMPDARVSGPAPWRPLLGMSGPTRLPLEFGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1763 | - | - | 100% (407) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_0363 | - | e-149 | 60.49% (405) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4282 | - | e-143 | 61.39% (404) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 1e-38 | 30.17% (348) | cytochrome p450 140 CYP140 |
| M. tuberculosis H37Rv | Rv1256c | cyp130 | 2e-40 | 37.11% (291) | cytochrome P450 130 CYP130 |
| M. leprae Br4923 | MLBr_02088 | - | 9e-45 | 31.87% (320) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 2e-41 | 32.51% (323) | cytochrome P450 |
| M. marinum M | MMAR_0122 | cyp279A2 | 1e-135 | 58.50% (400) | cytochrome P450 279A2 Cyp279A2 |
| M. avium 104 | MAV_4569 | - | 1e-154 | 62.65% (407) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4213 | - | 1e-104 | 50.79% (378) | cytochrome P450 hydroxylase |
| M. thermoresistible (build 8) | TH_4132 | - | 1e-46 | 34.06% (323) | PUTATIVE putative cytochrome P450 |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 4e-41 | 33.64% (324) | cytochrome P450 124A1, Cyp124A1 |
| M. vanbaalenii PYR-1 | Mvan_4984 | - | 0.0 | 76.79% (405) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
TH_4132|M.thermoresistible__bu ------------------MTVQPVTDTTWDVKHVNVFDPQWWVDGPPHDL
MUL_1282|M.ulcerans_Agy99 ----MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGA
Mflv_1763|M.gilvum_PYR-GCK ---------------------MSAAP--PSVFDAGLPTLDYDITDTPQQI
Mvan_4984|M.vanbaalenii_PYR-1 ---------------------MTAAATKPSVFDAGLPTLSYDVTDTPQQI
MAV_4569|M.avium_104 ---------------------MTVGAAPPSVFDSDLPTLHYHSDETPAQV
MMAR_0122|M.marinum_M ------------------MTSTVDRQVAPNVFAAGLPNIDYQNAQSPDEA
MSMEG_4213|M.smegmatis_MC2_155 ------------------MTRMTVAELTP---------ISYHHATMPAEV
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0276|M.abscessus_ATCC_1997 ---------------------MPITTDPG------TLLLQVLDPANRANP
Mb1912c|M.bovis_AF2122/97 ----MKDKLHWLAMHGVIRGIAAIGIRRG-----DLQARLIADPAVATDP
Rv1256c|M.tuberculosis_H37Rv ------------------------------MTSVMSHEFQLATAETWPNP
TH_4132|M.thermoresistible__bu FKRMRAESPVHWYQFADGEGYGP--GYWSLFRHADIATVSHDTETFSSNR
MUL_1282|M.ulcerans_Agy99 FATLRREAPISFWPPIELAGLTAGKGHWALTKHDDIHFASRHPEIFHSSP
Mflv_1763|M.gilvum_PYR-GCK RPQFCAAQQV----APIALGPIGP----EVLSYPLARTVLGDPRFGIPP-
Mvan_4984|M.vanbaalenii_PYR-1 YPQFRAAQRI----APIALGPIGP----EVLSYEMARTVLRDPRFVIPP-
MAV_4569|M.avium_104 YPRLREAQRR----AAVAIGPHGP----EVLSYHLVRSVLRDPRFQIPP-
MMAR_0122|M.marinum_M HQILAEARCR----SPIALGPHGP----ELLTYDLVHTVLRDPRFRMPP-
MSMEG_4213|M.smegmatis_MC2_155 HDIIRQARAN----GPLALGPYGP----EILGYELVRAVLRDERFEVPR-
MLBr_02088|M.leprae_Br4923 FPVYRALIDY---GPMQLPGMPLT----VFSSFSDCDEALRHPLSASDRL
MAB_0276|M.abscessus_ATCC_1997 YPVYGQLVEQTQAGPVHPPGMDVS----VLATFADCNAVLRHPQASSDRR
Mb1912c|M.bovis_AF2122/97 VPFYDEVRSH---------GALVR----NRANYLTVDHRLAHDLLRSDDF
Rv1256c|M.tuberculosis_H37Rv WPMYRALRDHDP-VHHVVPPQRPEYDYYVLSRHADVWSAARDHQTFSSAQ
. .
TH_4132|M.thermoresistible__bu GGLFIHPDQMLSL-------------DVLTNMLNFMDPPTHTRYRKILAR
MUL_1282|M.ulcerans_Agy99 N--IVIHDQTPEL-------------AEYFGSMIVLDDPRHQRLRSIVSR
Mflv_1763|M.gilvum_PYR-GCK GIHLAAHGITSGE-----------LWDRVTRSILCMEGDEHRRLRSLVSR
Mvan_4984|M.vanbaalenii_PYR-1 GIHLSAHGITSGP-----------LWDRVTRSILNMEGDEHRRLRSLVSR
MAV_4569|M.avium_104 GINLLAQGIDSGP-----------LWDKVANSLLCLEGDAHHRLRSLCSK
MMAR_0122|M.marinum_M GMFLAAQGITSGP-----------LWDRLAANLISLDGPAHHRLRRLVSQ
MSMEG_4213|M.smegmatis_MC2_155 GMFLAAQGITSGP-----------LWERANNTLVGLGGPAHLRLRRLVAR
MLBr_02088|M.leprae_Br4923 KATLAQQAIAAGA----------EPRPFYASSFMFLDPPDHTRLRKLVSK
MAB_0276|M.abscessus_ATCC_1997 KSNIVQRQLAQ------------NPNLIARPSFLGLDAPDHTRLRKLASK
Mb1912c|M.bovis_AF2122/97 RVVSFGENLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSA
Rv1256c|M.tuberculosis_H37Rv GLTVNYGELEMIG-------------LHDTPPMVMQDPPVHTEFRKLVSR
: * . * :
TH_4132|M.thermoresistible__bu VFTPAAVAKMEDGIRARVNRIIDKVIEAG---RCDFVEDIAVPIPLGILM
MUL_1282|M.ulcerans_Agy99 AFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIIC
Mflv_1763|M.gilvum_PYR-GCK AFTPRATAKMDQTISEVITDLIDAVSDS---GACEFVDQVARPYPIPVIC
Mvan_4984|M.vanbaalenii_PYR-1 AFTPRATARMHDAIHLVVNELLDAIQDT---GRCEFVAEVARPYPIPIIC
MAV_4569|M.avium_104 AFTPRTVARLHDTMAAVMNELVDRVAAA---GRCDVVTDIARPYPVPIIC
MMAR_0122|M.marinum_M AFTPRATGRLNTTITEVITDLVDRCADR---GRCDVVADIARRYPIPIIC
MSMEG_4213|M.smegmatis_MC2_155 AFIPKAAERLRATCVDIVTELVARCVPA---GRCDVVADLAVPYAVPVIC
MLBr_02088|M.leprae_Br4923 AFAPKVVQALEGDIAALVDSLLDKGAAA---GQFDVIADLAFPLAVAVIC
MAB_0276|M.abscessus_ATCC_1997 AFAPRVINAMAEDIQTFVDKMLDDIALR---GTFNLVTEFAYPLPVAVIC
Mb1912c|M.bovis_AF2122/97 VFTSRAVSALRDLVEQTAINLLDRFAEQP--GIVDVVGRYCSQLPIVVIS
Rv1256c|M.tuberculosis_H37Rv GFTPRQVETVEPTVRKFVVERLEKLRAN---GGGDIVTELFKPLPSMVVA
* . : : :.: . ::
TH_4132|M.thermoresistible__bu ELMGAPEEDMPKFYYWTEAIEQAIRDPEPNTGVEV-----FDEMGAYLT-
MUL_1282|M.ulcerans_Agy99 DMMGIPEEDHEQIFHWTNVILG-FGDPDLTTDFDD-----FLQVSMAIGG
Mflv_1763|M.gilvum_PYR-GCK ALFGAPREDWELFSTWAQDIFKIVSFDIDLAAEEP----TVLRAWDEFDA
Mvan_4984|M.vanbaalenii_PYR-1 ALLGAPREDWQLFSRWAEDIFKIVSFDCDLAEEEP----VVLKAWAEFDD
MAV_4569|M.avium_104 ALLGAPREDWRRFSSWADDVFKAFSFTVDLREVEP----VVMRAWRELDD
MMAR_0122|M.marinum_M ALLGAPAGDWKLFSGWTDDILKAFSW--DAAAQQP----AILAAWDELDA
MSMEG_4213|M.smegmatis_MC2_155 ALLGAPARDWARFSAWADEIFKMFSW--DLGEHAE----AVETAWKELDA
MLBr_02088|M.leprae_Br4923 RLLGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRD
MAB_0276|M.abscessus_ATCC_1997 RMLGVPIEDEPEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWD
Mb1912c|M.bovis_AF2122/97 EILGVPEHDRPRVLEFGELAAPSLD-----IGIPWRQYLRVQQGIRGFDC
Rv1256c|M.tuberculosis_H37Rv HYLGVPEEDWTQFDGWTQAIVAANAVDGATTGALD--------AVGSMMA
:* * * . :
TH_4132|M.thermoresistible__bu --EQIERQTTEAVEDSLVMRLRNAEVDGE---KLTDVEIVMFFGLLTFAG
MUL_1282|M.ulcerans_Agy99 YATALADDRRVNHHGDLTTSLVEAEVDGE---RLSSSEIAMFFILLVVAG
Mflv_1763|M.gilvum_PYR-GCK YIDDMIARRRTHLTTDLLSELIRAEDGGD---RLDAGEVRMLAFSILIAG
Mvan_4984|M.vanbaalenii_PYR-1 YIDGMIADRRRHLSDDLLSDLIRIEDGGD---RLDAAELRMLAFSVLVAG
MAV_4569|M.avium_104 YVDEMVARRRHSLTDDLLSDLIRAGDEGD---RLDAAELRMLAGGLLLAG
MMAR_0122|M.marinum_M YIDDMVAARRGSLTEDLISALIRAEDDGD---CLSSDELRMLVAGLLIGG
MSMEG_4213|M.smegmatis_MC2_155 YVDDMVVRRRHTLTDDLLSDLIRAEDDGD---RLTHHELLMLAGGVLLAG
MLBr_02088|M.leprae_Br4923 YLEQLVKCRRGTPGEDLISRLIELDESGD---QLTEEEIIATCGLLLVAG
MAB_0276|M.abscessus_ATCC_1997 YFIDLIASRRRNLGDDLLSALIQVEEAGD---QLTEEEIISTCTLLLIAG
Mb1912c|M.bovis_AF2122/97 WLEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAG
Rv1256c|M.tuberculosis_H37Rv YFTGLIERRRTEPADDAISHLVAAGVGADG-DTAGTLSILAFTFTMVTGG
. * .: .: : .*
TH_4132|M.thermoresistible__bu NDTTRNTASAGLRTLLEHPDALQQLYDDAA-LIPNAIEEILRYTSVVQWF
MUL_1282|M.ulcerans_Agy99 NETTRNTISHGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYM
Mflv_1763|M.gilvum_PYR-GCK TDTTRTQLAASMQVLCDHHDQFALLRDRPE-LAMRAVEETMRHSPSMCST
Mvan_4984|M.vanbaalenii_PYR-1 TDTTRSQLAASVQVLCEHPDQWALLRADSD-LAMRTVEETMRHSPSMCST
MAV_4569|M.avium_104 TDTTRNQVAASVQVLCEHPHQWELLRQRPE-LAMRAVEETMRHSPIACGT
MMAR_0122|M.marinum_M TDTTRNQLAASAQALCDHPDQWVLLAQHPD-LAANAAEETMRHSPITFST
MSMEG_4213|M.smegmatis_MC2_155 TDTTRNQLAAAVETLCDHPREWDLLAEHPE-LAPTFVEELMRFSPATLGT
MLBr_02088|M.leprae_Br4923 HETTVNLIANAVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLI
MAB_0276|M.abscessus_ATCC_1997 HETTVNLIANASLAMLRHPEQWKLLGQNAD-RAPLVVEETLRYDPPVHMV
Mb1912c|M.bovis_AF2122/97 FETTVNLLGNGIRMLLDTPEHLATLRQHPE-LWPNTVEEILRLDSPVQLT
Rv1256c|M.tuberculosis_H37Rv NDTVTGMLGGSMPLLHRRPDQRRLLLDDPE-GIPDAVEELLRLTSPVQGL
:*. . . : ** :* .
TH_4132|M.thermoresistible__bu ARTATRDVELGGQKISEGDKVVMWYASGSRDEAVFD-DSDTFDIHRPKPD
MUL_1282|M.ulcerans_Agy99 RRTLNQDVDLRGTKMAAGDKVTLWYCSANRDEEKFA-DPWTFDVTRNPNP
Mflv_1763|M.gilvum_PYR-GCK VRTATEDVAIGEYTIPAGTFLVVNTFAANRDPVIYD-EPDRFDITRDDPP
Mvan_4984|M.vanbaalenii_PYR-1 VRSVTADVEVGEYTFPAGTFILVNTYAANRDHTVYD-DPTRFDITREDPP
MAV_4569|M.avium_104 LRLVVEDAELDGHLFPAGTAVLVNTFAANRDPAVYD-DPDRVDITREAAP
MMAR_0122|M.marinum_M LRIALDDVELAGVMIPTGTLVIANTGAANRDPALYR-DPDRLDISRPIAG
MSMEG_4213|M.smegmatis_MC2_155 VRIAKEEVEIAGVTIPAGTLVTVNTAAANRDPQVFA-DPDRFDVHRRASP
MLBr_02088|M.leprae_Br4923 GRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSS-
MAB_0276|M.abscessus_ATCC_1997 ARVADGEMAIRDFILPDGEWVLLMLAAAQRDPDVGP-DLDVFNPDRSEI-
Mb1912c|M.bovis_AF2122/97 ARVACRDVEVAGVRIKRGEVVVIYLAAANRDPAVFP-DPHRFDIERPNAG
Rv1256c|M.tuberculosis_H37Rv ARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPR-
* : : : * : :..** .: *
TH_4132|M.thermoresistible__bu HQAFGGGGRHFCLGASLARLELRIIFEEVLGRMKNLQLAGT-TEILPSNW
MUL_1282|M.ulcerans_Agy99 QVGFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEE-PARLLSQF
Mflv_1763|M.gilvum_PYR-GCK PILTFGGGAHYCLGANLARRELSEALKILACRMPDARVSGP-APWRPLLG
Mvan_4984|M.vanbaalenii_PYR-1 PILTFGGGVHHCLGANLARLELAEALKILSHRFRYARRTGP-VPWKPLLG
MAV_4569|M.avium_104 PILTFGGGVHYCLGANLARREIAEALNVLANRLRNPRLAGP-APWKPMVS
MMAR_0122|M.marinum_M PIQTFGAGMHYCLGANLARRELTEALRIITQRMPGARRTGA-APWKSLTG
MSMEG_4213|M.smegmatis_MC2_155 PMLGFGGGLHYCLGVHLARVELAEALCVITAAMRHPHRDGP-PPGNR---
MLBr_02088|M.leprae_Br4923 RHLAFAVGSHFCLGAALARLEATVTLSAISARFPQVQLAGE-LVYKPNVA
MAB_0276|M.abscessus_ATCC_1997 KHLAFGHGPHFCLGAPLARLEARLALSSITARFPGARLMDE-PTYKPNVT
Mb1912c|M.bovis_AF2122/97 RHLAFSTGRHFCLGAALARAEGEVGLRTFFDRFPDVRAAGA-GSRRDTRV
Rv1256c|M.tuberculosis_H37Rv NILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSY
. * *.***. ** : : .
TH_4132|M.thermoresistible__bu AYGLTKLPVTFTAGRRLES-
MUL_1282|M.ulcerans_Agy99 IHGIKRLPVAWSR-------
Mflv_1763|M.gilvum_PYR-GCK MSGPTRLPLEFGR-------
Mvan_4984|M.vanbaalenii_PYR-1 LSGPTSLPLEFGP-------
MAV_4569|M.avium_104 LSGPTSLPIEFDR-------
MMAR_0122|M.marinum_M LSGPTTLPIEFDAGH-----
MSMEG_4213|M.smegmatis_MC2_155 --------------------
MLBr_02088|M.leprae_Br4923 MRGMSALPVQV---------
MAB_0276|M.abscessus_ATCC_1997 LRGLAELPVSIA--------
Mb1912c|M.bovis_AF2122/97 LRGWSTLPVTLGPARSMVSP
Rv1256c|M.tuberculosis_H37Rv VRRPLSVPFRVTS-------