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TEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAGGIRPDQPA LPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDM LGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVD GERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMC RVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLARLELS LMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | - | 100% (398) | PROBABLE CYTOCHROME P450 MONOOXYGENASE 142 CYP142 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 7e-58 | 35.25% (400) | cytochrome P450 124 CYP124 |
| M. tuberculosis H37Rv | Rv0778 | cyp126 | 1e-48 | 33.07% (375) | cytochrome P450 126 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3548c | cyp142a | 1e-112 | 100.00% (197) | cytochrome P450 monooxygenase |
| M. gilvum PYR-GCK | Mflv_1541 | - | 1e-175 | 77.18% (390) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-47 | 33.63% (333) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 3e-56 | 33.33% (411) | cytochrome P450 |
| M. marinum M | MMAR_5003 | cyp142A3 | 0.0 | 92.11% (393) | cytochrome P450 142A3 Cyp142A3 |
| M. avium 104 | MAV_0641 | - | 0.0 | 80.51% (395) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_5918 | - | 1e-180 | 78.34% (397) | P450 heme-thiolate protein |
| M. thermoresistible (build 8) | TH_3500 | - | 1e-171 | 73.42% (395) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_4077 | cyp142A3 | 0.0 | 91.35% (393) | cytochrome P450 142A3 Cyp142A3 |
| M. vanbaalenii PYR-1 | Mvan_5217 | - | 1e-180 | 78.28% (396) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3518c|M.tuberculosis_H37Rv ------------------------MTE-----APDVDLADGNFYASR-EA
Mb3548c|M.bovis_AF2122/97 ------------------------MTE-----APDVDLADGNFYASR-EA
MMAR_5003|M.marinum_M ------------------------MTKPLI--KPDVDLTDGNFYASR-QA
MUL_4077|M.ulcerans_Agy99 ----------------------MAMTKPLI--KPDVDLTDGNFYASR-QA
Mflv_1541|M.gilvum_PYR-GCK ------------------------MTSTVET-GLDVDLADGNFYADGTAA
Mvan_5217|M.vanbaalenii_PYR-1 ------------------------MTSTLP--ALDVDLADGNFYADGRAA
MSMEG_5918|M.smegmatis_MC2_155 ------------------------MTQMLT--RPDVDLVNGMFYADG-GA
MAV_0641|M.avium_104 ------------------------MTSTIPEAIANIDLADGNFYADRRAS
TH_3500|M.thermoresistible__bu ------------------------MTST----APDIDLTDGRFYADSASA
MAB_3825|M.abscessus_ATCC_1997 -----------------------MATALSEIEEAGRVLADPAAYADELRL
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
* * .
Rv3518c|M.tuberculosis_H37Rv RAAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
Mb3548c|M.bovis_AF2122/97 RAAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
MMAR_5003|M.marinum_M REAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
MUL_4077|M.ulcerans_Agy99 REAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
Mflv_1541|M.gilvum_PYR-GCK RAAYAWMRANQPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
Mvan_5217|M.vanbaalenii_PYR-1 REAYKWMRANQPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
MSMEG_5918|M.smegmatis_MC2_155 REAYRWMRANEPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
MAV_0641|M.avium_104 REAYRWMRANQPVFR----DRNGLAGATTYQAIQDAERNPELFSSTGG--
TH_3500|M.thermoresistible__bu RAAYRWMRQNQPVFR----DRNGLAAAATYQAIIESERNPELFSNTGG--
MAB_3825|M.abscessus_ATCC_1997 HAAMTLLRREQPVTKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLP----GMPLTVFSSFSDCDEALRHPLSASDRLKAT
. : *: : :... *. .
Rv3518c|M.tuberculosis_H37Rv ------------IRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
Mb3548c|M.bovis_AF2122/97 ------------IRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
MMAR_5003|M.marinum_M ------------IRPDQDALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
MUL_4077|M.ulcerans_Agy99 ------------IRPDQDALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDK
Mflv_1541|M.gilvum_PYR-GCK ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDK
Mvan_5217|M.vanbaalenii_PYR-1 ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDK
MSMEG_5918|M.smegmatis_MC2_155 ------------IRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDK
MAV_0641|M.avium_104 ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNAGFTRKRVKEK
TH_3500|M.thermoresistible__bu ------------IRPEHPGMPYMIDMDDPEHLVRRKLVNHGFTRKRVRDR
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
MLBr_02088|M.leprae_Br4923 LAQQAIAAG---AEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
. :: :* * * * : * * :
Rv3518c|M.tuberculosis_H37Rv EASIAALCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVRPEQRDM
Mb3548c|M.bovis_AF2122/97 EASIAALCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVRPEQRDM
MMAR_5003|M.marinum_M ERSIAQLCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVLPEQREM
MUL_4077|M.ulcerans_Agy99 EHSIAQLCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVLPEQREM
Mflv_1541|M.gilvum_PYR-GCK VPSIEKLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPEERDM
Mvan_5217|M.vanbaalenii_PYR-1 VPSIENLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPDERDM
MSMEG_5918|M.smegmatis_MC2_155 VDSIGRLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPTERDM
MAV_0641|M.avium_104 EPSIGTLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPTERGM
TH_3500|M.thermoresistible__bu EDSIARLCDTLIDNVCERG-ECDFVRDIAAPLPMAVIGDMLGVAPEDRGQ
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDR
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPE
* : :: * . *. *:* :.: ** :**: :
Rv3518c|M.tuberculosis_H37Rv FLRWSDDLVTFLSSHVS-----QEDFQITMDAFAAYNDFTRATIAARRAD
Mb3548c|M.bovis_AF2122/97 FLRWSDDLVTFLSSHVS-----QEDFQITMDAFAAYNDFTRATIAARRAD
MMAR_5003|M.marinum_M FLRWSDDLVTFLSSHVS-----QEDFQVTIDAFAAYNDFTRATIAARRAE
MUL_4077|M.ulcerans_Agy99 FLRWSDDLVTFLSSQVS-----QEDFQVTIDAFAAYNDFTRATIAARRAE
Mflv_1541|M.gilvum_PYR-GCK LLTWSDDLVCGLSSTVD-----EQTIQKLMDTFAAYTAFTMEVIADRRAN
Mvan_5217|M.vanbaalenii_PYR-1 LLKWSDDLVCGLSSTVD-----EQTIQKLMDTFAAYTAFTTEVIADRRAN
MSMEG_5918|M.smegmatis_MC2_155 LLKWSDDLVCGLSSHVD-----EAAIQKLMDTFAAYTEFTKDVITKRRAE
MAV_0641|M.avium_104 LLKWSDDLVCGLSSHIDPT---SAEFQTVMDAFAAYTAFTMDIIAKRRAE
TH_3500|M.thermoresistible__bu LLKWSDDLVTGLSTTAD-----EATVQAVMDAFAGYTAYTMEIIGKRRAE
MAB_3825|M.abscessus_ATCC_1997 MLKLTQELFGGDDSEFQR----GTTPEEQLMALLDFFGYFSGLTASRRQH
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
: : *. .. : : : : **
Rv3518c|M.tuberculosis_H37Rv PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQL
Mb3548c|M.bovis_AF2122/97 PPTTWSACW-----------------------------------------
MMAR_5003|M.marinum_M PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGSEQL
MUL_4077|M.ulcerans_Agy99 PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGSEQL
Mflv_1541|M.gilvum_PYR-GCK PRDDLFSILVNAEVEGSRMSDDEIVFETLLILIGGDETTRHTLSGGTEQI
Mvan_5217|M.vanbaalenii_PYR-1 PRDDLFSVLVNAEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQL
MSMEG_5918|M.smegmatis_MC2_155 PTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQL
MAV_0641|M.avium_104 PTDDLFSILVNAEVEGQRMSDDEIVMETLLILIGGDETTRHTLSGGTEQL
TH_3500|M.thermoresistible__bu PTDDLFSILINAEVEGQRMSDEEIVFETLLILIGGDETTRHTLSGGVEQL
MAB_3825|M.abscessus_ATCC_1997 PTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
* :
Rv3518c|M.tuberculosis_H37Rv LRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALC
Mb3548c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5003|M.marinum_M LRNRDQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALS
MUL_4077|M.ulcerans_Agy99 LRNRVQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALS
Mflv_1541|M.gilvum_PYR-GCK LRHQDQWRQVVAQPDLLPSAIEEMLRWTSPVKNMCRTLTADTEFHGTALK
Mvan_5217|M.vanbaalenii_PYR-1 LRHQDQWRQAVADPELLPGAIEEMLRWTSPVKNMCRTLTADTEFHGTSLK
MSMEG_5918|M.smegmatis_MC2_155 LRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELR
MAV_0641|M.avium_104 LRHRDQWDALVRDPSLLPGAIEEMLRWTSPVKNMCRTLTADTEFHGTELR
TH_3500|M.thermoresistible__bu LRHPDQWQRLRNDPDLVPGAIEEMLRWTSPVKNMCRTLTADTEFHGTQLR
MAB_3825|M.abscessus_ATCC_1997 LEHPDQLARLRENPGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPIT
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
Rv3518c|M.tuberculosis_H37Rv AGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLA
Mb3548c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5003|M.marinum_M EGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLA
MUL_4077|M.ulcerans_Agy99 KGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLA
Mflv_1541|M.gilvum_PYR-GCK SGEKIMLMFESANFDESVFENPESFDIHRDPNSHVAFGFGTHFCLGNQLA
Mvan_5217|M.vanbaalenii_PYR-1 AGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLA
MSMEG_5918|M.smegmatis_MC2_155 AGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLA
MAV_0641|M.avium_104 AGEKIMLLFESGNFDESVFDDPDSFDIRRNPNSHMAFGFGTHFCLGNQLA
TH_3500|M.thermoresistible__bu KGEKMLLLFESANFDETVFENPDDFRIDRDPNPHIAFGFGTHFCLGNQLA
MAB_3825|M.abscessus_ATCC_1997 EGESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFGVHFCLGAALA
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVGSHFCLGAALA
Rv3518c|M.tuberculosis_H37Rv RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPP
Mb3548c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5003|M.marinum_M RLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRP
MUL_4077|M.ulcerans_Agy99 RLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRP
Mflv_1541|M.gilvum_PYR-GCK RLELKLMLGKILQRLPDMRLAD-ENMLPLRPANFVSGLESMPVVFTPTAK
Mvan_5217|M.vanbaalenii_PYR-1 RLELRLMLTKILQRLPDLRLAD-ESMLPLRPANFVSGLESMPVVFTPTAP
MSMEG_5918|M.smegmatis_MC2_155 RLELRLMTERVLRRLPDLRLAD-DAPVPLRPANFVSGPESMPVVFTPSAP
MAV_0641|M.avium_104 RLELSMMTERVLKRLPDLRLAD-DGDLPLRPANFVSGLEAMPVVFTPSAP
TH_3500|M.thermoresistible__bu RLELTLMLRRLLQRLPDLRLAS-DDPLPLRPANFVSGPEAMPVVFTPTEP
MAB_3825|M.abscessus_ATCC_1997 RMEVNSFFSALLPRLESIEVDG---NIERTSTIFVGGIKHLPIRYTLR--
MLBr_02088|M.leprae_Br4923 RLEATVTLSAISARFPQVQLAG---ELVYKPNVAMRGMSALPVQV-----
Rv3518c|M.tuberculosis_H37Rv LG-
Mb3548c|M.bovis_AF2122/97 ---
MMAR_5003|M.marinum_M LS-
MUL_4077|M.ulcerans_Agy99 LR-
Mflv_1541|M.gilvum_PYR-GCK VLS
Mvan_5217|M.vanbaalenii_PYR-1 VGA
MSMEG_5918|M.smegmatis_MC2_155 VLA
MAV_0641|M.avium_104 LLR
TH_3500|M.thermoresistible__bu VSA
MAB_3825|M.abscessus_ATCC_1997 ---
MLBr_02088|M.leprae_Br4923 ---