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RRIPAQLVERYQREGYWTQETLGDMLARGLAGSPEAGFCVHSSIRPYRGTFGEVERDARRLAAGLRERGV GPGDVVAMQLPNWREAAVTFWASAFLGAVVVPIVHFYGRRELAHIMATAKPRVFVTAEEFGRMRYQPDLC GDVAVVGLVGAAHPAAGNEHAFEQLLADEPMAGTVAADPAAPTLIAFTSGTTRDPKGVIHSHQTLSCETR QLLENYPPDRGRQLTATPVGHFIGMLGAFLIPVLEGAPIDLCDVWDPGRVLKLIESDGLSIGGGPPYFVT SLLDHPDFRPEHLRRFKTVGLGGSTVPAAVTQRLTDLGLFVFRSYGSTEHPSITGSRPDAPEVKRLFTDG NVRPGVEIRLGEDGEIFSRGPDLCLGYTDDELTARAFDDDGWYRTGDVGVLDDDGYLTITDRKADVIIRG GENISALEVEEVLLAMPAVAEAVVVAAPDARLGEHTAAVLRIREGQSMPALGDVREHFKQAGVATQKWPE ELHRVPEGQDFPRTASGKVQKFVIRQQLAAGELSAIATGQE*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_4135 | - | - | 100% (532) | AMP-dependent synthetase and ligase |
M. vanbaalenii PYR-1 | Mvan_4966 | - | 2e-63 | 37.44% (454) | AMP-dependent synthetase and ligase |
M. vanbaalenii PYR-1 | Mvan_1563 | - | 5e-50 | 31.51% (530) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3591 | fadD3 | 4e-49 | 33.47% (478) | acyl-CoA synthetase |
M. gilvum PYR-GCK | Mflv_2523 | - | 0.0 | 81.46% (534) | AMP-dependent synthetase and ligase |
M. tuberculosis H37Rv | Rv3561 | fadD3 | 1e-49 | 33.68% (478) | acyl-CoA synthetase |
M. leprae Br4923 | MLBr_02546 | fadD2 | 9e-27 | 25.66% (491) | acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_4377c | - | 2e-54 | 32.95% (528) | AMP-binding domain protein |
M. marinum M | MMAR_0303 | - | 4e-59 | 32.82% (515) | acyl-CoA synthetase |
M. avium 104 | MAV_2638 | - | 3e-84 | 39.59% (533) | AMP-dependent synthetase and ligase |
M. smegmatis MC2 155 | MSMEG_4774 | - | 0.0 | 77.56% (517) | AMP-dependent synthetase and ligase |
M. thermoresistible (build 8) | TH_2816 | - | 0.0 | 77.12% (520) | PUTATIVE AMP-dependent synthetase and ligase |
M. ulcerans Agy99 | MUL_4126 | fadD3 | 7e-48 | 33.06% (490) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_4135|M.vanbaalenii_PYR-1 -------------------------MRRIPAQLVERYQREGYWTQETLGD Mflv_2523|M.gilvum_PYR-GCK -------------------------MRRIPEELVRRYEQEGYWTPETLGE MSMEG_4774|M.smegmatis_MC2_155 -------------------------MRDIPAELTKRYVEEGWWTPETLGQ TH_2816|M.thermoresistible__bu -------------------------MRSIPAELRRRYEENGWWTQESLGD MAV_2638|M.avium_104 -------------------------MPFDHRQLRDKWYSAGWYSDRTCLD MMAR_0303|M.marinum_M ----------MGGPKVPQRRLIDGRWVRWDADRAAGAYAHRWWVRRTLAD Mb3591|M.bovis_AF2122/97 ----------------------------------------MINDLRTVPA Rv3561|M.tuberculosis_H37Rv ----------------------------------------MINDLRTVPA MUL_4126|M.ulcerans_Agy99 ----------------------------------------MTSDPRTVPT MAB_4377c|M.abscessus_ATCC_199 ------------------------------MKAYDAGATLSPIIEETIGE MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM Mvan_4135|M.vanbaalenii_PYR-1 MLARGLAGSPEAGFCVHSSIRPYRGTFGEVERDARRLAAGLRERGVGPGD Mflv_2523|M.gilvum_PYR-GCK LLARGLDSAPGAGFHVHSAVRPYAGTFAEVERDARRLAAGLRERGVAAGD MSMEG_4774|M.smegmatis_MC2_155 MLAEGLAAGPDVVFCVHSEVRPYTGTFGEVETLARRLAAGLRARGVGPGD TH_2816|M.thermoresistible__bu LLAEGLRAAPDAGFRVHSDVRPYTGTFADVEERARRLAAGLRARGVGPGD MAV_2638|M.avium_104 AFEAGAVEHKDVPLTFVIGDSVSSPTVCEIHDRAVALAASLQRLGVRDGD MMAR_0303|M.marinum_M ALREAAQSTPQRVALVDADR---QLDCQELHRQAMALAQHLRSR-MPAGS Mb3591|M.bovis_AF2122/97 ALDRLVRQLPDHTALIAE---DRRFTSTELRDAVYGAAAALIALGVEPAD Rv3561|M.tuberculosis_H37Rv ALDRLVRQLPDHTALIAE---DRRFTSTELRDAVYGAAAALIALGVEPAD MUL_4126|M.ulcerans_Agy99 ALDRLVRRLPNHDALVTD---ERSFTVSELNDEVYRAAAALIELGVKPAA MAB_4377c|M.abscessus_ATCC_199 NFERIARAHPDVGALVDVSG-DRRWTYRELDAEINRVARGLMSLGVAAGD MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEG---TLTYKELDRAAHALANGLIAKGVRGGD . :: * * : . Mvan_4135|M.vanbaalenii_PYR-1 VVAMQLPNWREAAVTFWASAFLGAVVVPIVHFYGRRELAHIMATAKPRVF Mflv_2523|M.gilvum_PYR-GCK VVALQLPNWREAAVTFWASAFLGAVVVPVVHFYGRKELAHILTTAKPRVF MSMEG_4774|M.smegmatis_MC2_155 VIAFQLPNWMEAAAAFWATSFLGAVTVPIVHFYGRKELAHILSTAKPKVF TH_2816|M.thermoresistible__bu VIAFQLPNWVEAAMTFWASAFLGAVVVPVVHFYGRKELGHILRTARPKVF MAV_2638|M.avium_104 AVAVQLTNRVECAVAYQAVLLCGAVLVPIVHIYGMAEVAFVLDQSAAKVL MMAR_0303|M.marinum_M VVSFMLPNWHEAAVIYLASTLAAMVANPVLPSLREHELRFILEDAGSRMI Mb3591|M.bovis_AF2122/97 RVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVL Rv3561|M.tuberculosis_H37Rv RVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVL MUL_4126|M.ulcerans_Agy99 RVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVL MAB_4377c|M.abscessus_ATCC_199 RVGIWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTL MLBr_02546|M.leprae_Br4923 GIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVI :.. * . . . : : : Mvan_4135|M.vanbaalenii_PYR-1 VTAEEFGRMRYQPDLC-GDVAVV-GLVG--AAHPAAG-NEHAFEQLLADE Mflv_2523|M.gilvum_PYR-GCK VTTAQFGRLQFHPDVC-AGVPIV-ALVGDGPDSGADG-GWEPFEDLLAAE MSMEG_4774|M.smegmatis_MC2_155 LTTERFGRMSFQPDLC-AQVPIV-GLVG-----------ESSFTDLLAER TH_2816|M.thermoresistible__bu ITAAEFGRMRYQPDLC-ADVPIV-GVVG-----------QHGFDDLVADE MAV_2638|M.avium_104 IMPERHGSIVYSKRLQ-DLSRID-SLQHVVMLDAEPGEGYLAWSQLDTPA MMAR_0303|M.marinum_M FAPADFRGHDYTSMLRRVAAQLP-SRPEVIEVRGQCPDGVSTFQSLLVGR Mb3591|M.bovis_AF2122/97 FAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALD Rv3561|M.tuberculosis_H37Rv FAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALD MUL_4126|M.ulcerans_Agy99 FAMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGT-DTG MAB_4377c|M.abscessus_ATCC_199 ICAKAFKSSDYVA-MASQVMPDAPGLRDVVFIGTSDWTELVAGAERVTET MLBr_02546|M.leprae_Br4923 IYDDEYTKVVSKAEPALGKLRALGVNPD---EEEPPGSTDETLAELIARS . . Mvan_4135|M.vanbaalenii_PYR-1 PMAG-TVAADPAAPTLIAFTSGTTRDPKGVIHSHQTLSCETR---QLLEN Mflv_2523|M.gilvum_PYR-GCK PMAG-TVAADPAGPALIAFTSGTTRDPKGVIHSHQTLSFETR---QLLEN MSMEG_4774|M.smegmatis_MC2_155 PMSG-TLDTDPAAPALIAFTSGTTRDPKGVIHSHQTLSCETR---QLLAN TH_2816|M.thermoresistible__bu PMTG-TLATDPAGPALIAFTSGTTRDPKGVIHSHQTLTFETR---QLLAN MAV_2638|M.avium_104 ARYR-RPAVAADDVCLLLYTSGTTSAPKGVQHTNNTVLAEQRTMPALLAG MMAR_0303|M.marinum_M ETAAPLPTADPDAVRMVLYTSGTTGRPKGVLHTHNSIHALICQIRDHWMV Mb3591|M.bovis_AF2122/97 AVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKI Rv3561|M.tuberculosis_H37Rv AVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKI MUL_4126|M.ulcerans_Agy99 AVTARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKI MAB_4377c|M.abscessus_ATCC_199 ALRARMSQLSNTDPINIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQL MLBr_02546|M.leprae_Br4923 SSAP--APKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPF : ***** .**. Mvan_4135|M.vanbaalenii_PYR-1 YPPDRGRQLTATPVGHFIGMLGAFLIPVLEGAPIDLCDV-WDPGRVLKLI Mflv_2523|M.gilvum_PYR-GCK YPPDRGRQLTATPVGHFIGMLGAFLIPVLEGSPIDLCDV-WDPGRVLQLM MSMEG_4774|M.smegmatis_MC2_155 YPPNRGRQLTATPVGHFIGMVGAFLIPVLEGAPVDLCDV-WDPAKVLRLM TH_2816|M.thermoresistible__bu YPPDRGRQLTATPVGHFIGMVGAFLIPVLEGAPIDLADV-WDPGRVLRLM MAV_2638|M.avium_104 KPDD--VSLVTFPPGHIAG-VGSMLRPLLSGARTVFMDG-WDPARAVEVV MMAR_0303|M.marinum_M EPGD--GFLVASPIAHIGGSIYAFECPLLLGTTAVLLDR-WDADRAVQLM Mb3591|M.bovis_AF2122/97 TSDD--RYLCINPFFHNFGYKAGILACLQTGATLIPHVT-FDPLHALRAI Rv3561|M.tuberculosis_H37Rv TSDD--RYLCINPFFHNFGYKAGILACLQTGATLIPHVT-FDPLHALRAI MUL_4126|M.ulcerans_Agy99 TADD--RHLCINPFFHNFGYKAGILACLQTGATLFPHLT-FDPLRTLQAI MAB_4377c|M.abscessus_ATCC_199 QAGD--RLCIPVPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEAI MLBr_02546|M.leprae_Br4923 RAHE--VTLLPAPMFHALGYLHATLAMFL-GSTLVLRRR-FKPATVLEDI . : * * * . *: :.. .:. : Mvan_4135|M.vanbaalenii_PYR-1 ESDGLSIGGGPPYFVTSLLD--HPDFRPEHLRRFKTVGLGGSTVPAAVTQ Mflv_2523|M.gilvum_PYR-GCK ETEGLSIGGGPPYFVTSLLD--HPQCRPEHVRRFKTVGLGGSTVPAAVTR MSMEG_4774|M.smegmatis_MC2_155 ESDGLSIGGGPPYFVTSLLD--HPDFADRHLARIRTVGLGGSTVPAAVTR TH_2816|M.thermoresistible__bu EAEDISIGGGPPYFVTSLLD--HPDCTPEHLARFKTVGLGGSTVPTTVTR MAV_2638|M.avium_104 HRFGVTCTAGTPFHLAGILD--LGDTG-DKLASLREFLVGAAPVAEEIGR MMAR_0303|M.marinum_M TSKRCTHMAGATPFLEQLLA--AAQRAGTRLPDLKFFVCGGASVSPSLIR Mb3591|M.bovis_AF2122/97 ERHRITVLPGPPTIYQSLLD--HPARKDFDLSSLRFAVTGAATVPVVLVE Rv3561|M.tuberculosis_H37Rv ERHRITVLPGPPTIYQSLLD--HPARKDFDLSSLRFAVTGAATVPVVLVE MUL_4126|M.ulcerans_Agy99 ERHRITVLPGPPTIYQTLLD--HPARDDYDLSSLRFAVTGAATVPVVLVE MAB_4377c|M.abscessus_ATCC_199 ERERCVGVYGVPTMFIAMLA--DPGFAHRDLSTLRTGIMAGSVCPVEVMK MLBr_02546|M.leprae_Br4923 EKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELAT . :* : :: ..: : Mvan_4135|M.vanbaalenii_PYR-1 RLTDLG--LFVFRSYGSTEHPSITGSR-PDAPEVKRLFTDGNVRPGVEIR Mflv_2523|M.gilvum_PYR-GCK RLSDLG--MFVFRSYGSTEHPSITGSR-PSAPEDKRLFTDGDARPGVEIK MSMEG_4774|M.smegmatis_MC2_155 RLADLG--IFVFRSYGSTEHPSITGSS-PSAPEGKRLYTDGNPRPGVEIR TH_2816|M.thermoresistible__bu RLAELG--MFVFRSYGSTEHPSITGSG-PAAPEEKRLYTDGNPRPGVEIR MAV_2638|M.avium_104 RAAQAG--ISTFRSYGATEHPTVTGEH-EGQPQWARLGTDGKPLPGSEIR MMAR_0303|M.marinum_M CATDYFDKAVVTRVYGSTEVPVTTIGA-PDSS-AHAAATDGRVG-AADVK Mb3591|M.bovis_AF2122/97 RMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELR Rv3561|M.tuberculosis_H37Rv RMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELR MUL_4126|M.ulcerans_Agy99 RMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELR MAB_4377c|M.abscessus_ATCC_199 RCIDEMHMAGVAIAYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIEIK MLBr_02546|M.leprae_Br4923 RALEELG-PVIYNMYGSTEIAFATIAG--PKDLQINSATVGPVVKGVKVK . ** ** * * .:: Mvan_4135|M.vanbaalenii_PYR-1 LGED-----------GEIFSRGPD--LCLG---YTDD-ELTARAFDDDGW Mflv_2523|M.gilvum_PYR-GCK LGPD-----------GEIFSRGPD--LCLG---YVDD-DLTAQAFDEDGW MSMEG_4774|M.smegmatis_MC2_155 LGPD-----------GEIFSRGPD--LCLG---YTDD-ALTAKAFDDEGW TH_2816|M.thermoresistible__bu IAED-----------GEILSRGPD--LCLG---YTDD-ALTARAFDDDGW MAV_2638|M.avium_104 IVGSD-GTDCPIGIGGEVVVRGPD--QFIG---YQDS-ALNTEAFTDDGW MMAR_0303|M.marinum_M LVAG------------EIRVRGPQ--MLVG---YRHP-EDEAGSFDAQGY Mb3591|M.bovis_AF2122/97 IADD-----------GEVLLRGPN--VMVG---YLDDTEATAAAIDADGW Rv3561|M.tuberculosis_H37Rv IADD-----------GEVLLRGPN--VMVG---YLDDTEATAAAIDADGW MUL_4126|M.ulcerans_Agy99 IGPDT----------GEVLLRGPN--VMLG---YLDDPRATAAAIDADGW MAB_4377c|M.abscessus_ATCC_199 IVDPNSGETVQRGQSGELCTRGYS--VMLG---YWNDEAHTREVLDTDGW MLBr_02546|M.leprae_Br4923 ILDDS----------GKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIIDGL : : ** :* . :* Mvan_4135|M.vanbaalenii_PYR-1 YRTGDVGVLDDDGYLTITDRKADVIIRGGENISALEVEEVLLAMPAVAEA Mflv_2523|M.gilvum_PYR-GCK YHTGDIGVLDEDGYLTITDRKADVIIRGGENISALEVEEILLGMPAVAEA MSMEG_4774|M.smegmatis_MC2_155 YRTGDVGFLDDDGYLTITDRTADLIIRGGENISALEVEEVLLGIPGVIEA TH_2816|M.thermoresistible__bu YHTGDIGVLDDDGYLTITDRKADLIIRGGENISALEVEEVLLGMPAVAEA MAV_2638|M.avium_104 FRTGDLGHLDAHGRLTITDRIKDVIIRGGETISSGQVEEVLNAHPAVADG MMAR_0303|M.marinum_M FRTGDLGHWVDDEYLVVTGRAKDIIIRNGENISPKEIEDILITHPGIADV Mb3591|M.bovis_AF2122/97 LHTGDIGAVDQAGNLRINDRLKDMYICGGFNVYPAEVEQVLARMDGVADA Rv3561|M.tuberculosis_H37Rv LHTGDIGAVDQAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMDGVADA MUL_4126|M.ulcerans_Agy99 LHTGDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADV MAB_4377c|M.abscessus_ATCC_199 MHTGDLAVMRDDGYCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDV MLBr_02546|M.leprae_Br4923 LSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEA :**:. : .* :: : .* .: . ::*:.: : : Mvan_4135|M.vanbaalenii_PYR-1 VVVAAPDARLGEHTAAVLRIREGQSMPALGDVREHFKQAGVATQKWPEEL Mflv_2523|M.gilvum_PYR-GCK VVVAAPDERLGEHTAAVLRIRDGHVMPSLDDVRAHFRAAGAATQKWPEEL MSMEG_4774|M.smegmatis_MC2_155 IVVAAPDARLGERVAAVLRTRSGAPLPTLDDVRAHFERVGIARQKWPEEL TH_2816|M.thermoresistible__bu VVVAAPDPRLGERTAAVVRVKPGHAMPTLDEVRDHFERTGVARQKWPEEL MAV_2638|M.avium_104 VAVAAPDSRYGDVVAAVVVLKPGYALN-LDDLRAHFAASGLARQKTPERL MMAR_0303|M.marinum_M AIVGLPDDRTGERACAVIVAAAD-PPPGLPGVRAFLEGAGVARFKIPEQV Mb3591|M.bovis_AF2122/97 AVIGVPDQRLGEVGRAFVVARPG-TGLDEASVIAYTREH-LANFKTPRSV Rv3561|M.tuberculosis_H37Rv AVIGVPDQRLGEVGRAFVVARPG-TGLDEASVIAYTREH-LANFKTPRSV MUL_4126|M.ulcerans_Agy99 AVIGIPDHRLGEVGRAFIVARPG-FNLDEKSVIDYTREH-LANFKAPRSV MAB_4377c|M.abscessus_ATCC_199 HVVGVPDEKYGEELCAWVRMRPDRVVIDAVAIRAFASGR-LAHYKIPRYV MLBr_02546|M.leprae_Br4923 TAIGVDDKEWGARLRAFVVKKQD-ATIDEDAIKAYVRDH-LARYKVPREV :. * . * * : . : . * * *. : Mvan_4135|M.vanbaalenii_PYR-1 HRVPEGQDFPRTASGKVQKFVIRQQLAAGELSAIATGQE-- Mflv_2523|M.gilvum_PYR-GCK HRVPEGQDFPRTASGKVQKYVIRQQVAAGMHGVVAASQK-- MSMEG_4774|M.smegmatis_MC2_155 HHVPDGQDFPRTASGKVQKYRVRQAVRNPAAVMDIATSAN- TH_2816|M.thermoresistible__bu HEVS---DYPRTASGKVQKYRVRQSIAEIAAAQQ------- MAV_2638|M.avium_104 AIVD---ELPRTSLGKVRKAQLRSDHFGAARR--------- MMAR_0303|M.marinum_M VIWD---HLPKNHAGKIVKHRIKAALMKAEQ---------- Mb3591|M.bovis_AF2122/97 RFVD---VLPRNAAGKVSKPQLRELG--------------- Rv3561|M.tuberculosis_H37Rv RFVD---VLPRNAAGKVSKPQLRELG--------------- MUL_4126|M.ulcerans_Agy99 RFVD---TLPRNAGGKVVKPQLRELA--------------- MAB_4377c|M.abscessus_ATCC_199 HVVE---SFPMTVTGKVRKIEMRQQTIQIFGLPEPGRTDEQ MLBr_02546|M.leprae_Br4923 IFLE---ELPRNPTGKVLKRELRDFEVH------------- * . **: * ::