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M. vanbaalenii PYR-1 Mvan_4135 (-)

annotation: AMP-dependent synthetase and ligase
coordinates: 4445700 - 4447298
length: 532

RRIPAQLVERYQREGYWTQETLGDMLARGLAGSPEAGFCVHSSIRPYRGTFGEVERDARRLAAGLRERGV
GPGDVVAMQLPNWREAAVTFWASAFLGAVVVPIVHFYGRRELAHIMATAKPRVFVTAEEFGRMRYQPDLC
GDVAVVGLVGAAHPAAGNEHAFEQLLADEPMAGTVAADPAAPTLIAFTSGTTRDPKGVIHSHQTLSCETR
QLLENYPPDRGRQLTATPVGHFIGMLGAFLIPVLEGAPIDLCDVWDPGRVLKLIESDGLSIGGGPPYFVT
SLLDHPDFRPEHLRRFKTVGLGGSTVPAAVTQRLTDLGLFVFRSYGSTEHPSITGSRPDAPEVKRLFTDG
NVRPGVEIRLGEDGEIFSRGPDLCLGYTDDELTARAFDDDGWYRTGDVGVLDDDGYLTITDRKADVIIRG
GENISALEVEEVLLAMPAVAEAVVVAAPDARLGEHTAAVLRIREGQSMPALGDVREHFKQAGVATQKWPE
ELHRVPEGQDFPRTASGKVQKFVIRQQLAAGELSAIATGQE*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_4135--100% (532)AMP-dependent synthetase and ligase
M. vanbaalenii PYR-1Mvan_4966-2e-6337.44% (454) AMP-dependent synthetase and ligase
M. vanbaalenii PYR-1Mvan_1563-5e-5031.51% (530) acyl-CoA synthetase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3591fadD34e-4933.47% (478) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_2523-0.081.46% (534) AMP-dependent synthetase and ligase
M. tuberculosis H37RvRv3561fadD31e-4933.68% (478) acyl-CoA synthetase
M. leprae Br4923MLBr_02546fadD29e-2725.66% (491) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_4377c-2e-5432.95% (528) AMP-binding domain protein
M. marinum MMMAR_0303-4e-5932.82% (515) acyl-CoA synthetase
M. avium 104MAV_2638-3e-8439.59% (533) AMP-dependent synthetase and ligase
M. smegmatis MC2 155MSMEG_4774-0.077.56% (517) AMP-dependent synthetase and ligase
M. thermoresistible (build 8)TH_2816-0.077.12% (520) PUTATIVE AMP-dependent synthetase and ligase
M. ulcerans Agy99MUL_4126fadD37e-4833.06% (490) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mvan_4135|M.vanbaalenii_PYR-1       -------------------------MRRIPAQLVERYQREGYWTQETLGD
Mflv_2523|M.gilvum_PYR-GCK          -------------------------MRRIPEELVRRYEQEGYWTPETLGE
MSMEG_4774|M.smegmatis_MC2_155      -------------------------MRDIPAELTKRYVEEGWWTPETLGQ
TH_2816|M.thermoresistible__bu      -------------------------MRSIPAELRRRYEENGWWTQESLGD
MAV_2638|M.avium_104                -------------------------MPFDHRQLRDKWYSAGWYSDRTCLD
MMAR_0303|M.marinum_M               ----------MGGPKVPQRRLIDGRWVRWDADRAAGAYAHRWWVRRTLAD
Mb3591|M.bovis_AF2122/97            ----------------------------------------MINDLRTVPA
Rv3561|M.tuberculosis_H37Rv         ----------------------------------------MINDLRTVPA
MUL_4126|M.ulcerans_Agy99           ----------------------------------------MTSDPRTVPT
MAB_4377c|M.abscessus_ATCC_199      ------------------------------MKAYDAGATLSPIIEETIGE
MLBr_02546|M.leprae_Br4923          MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
                                                                                      

Mvan_4135|M.vanbaalenii_PYR-1       MLARGLAGSPEAGFCVHSSIRPYRGTFGEVERDARRLAAGLRERGVGPGD
Mflv_2523|M.gilvum_PYR-GCK          LLARGLDSAPGAGFHVHSAVRPYAGTFAEVERDARRLAAGLRERGVAAGD
MSMEG_4774|M.smegmatis_MC2_155      MLAEGLAAGPDVVFCVHSEVRPYTGTFGEVETLARRLAAGLRARGVGPGD
TH_2816|M.thermoresistible__bu      LLAEGLRAAPDAGFRVHSDVRPYTGTFADVEERARRLAAGLRARGVGPGD
MAV_2638|M.avium_104                AFEAGAVEHKDVPLTFVIGDSVSSPTVCEIHDRAVALAASLQRLGVRDGD
MMAR_0303|M.marinum_M               ALREAAQSTPQRVALVDADR---QLDCQELHRQAMALAQHLRSR-MPAGS
Mb3591|M.bovis_AF2122/97            ALDRLVRQLPDHTALIAE---DRRFTSTELRDAVYGAAAALIALGVEPAD
Rv3561|M.tuberculosis_H37Rv         ALDRLVRQLPDHTALIAE---DRRFTSTELRDAVYGAAAALIALGVEPAD
MUL_4126|M.ulcerans_Agy99           ALDRLVRRLPNHDALVTD---ERSFTVSELNDEVYRAAAALIELGVKPAA
MAB_4377c|M.abscessus_ATCC_199      NFERIARAHPDVGALVDVSG-DRRWTYRELDAEINRVARGLMSLGVAAGD
MLBr_02546|M.leprae_Br4923          LPAMPARRSPHRAALIDEEG---TLTYKELDRAAHALANGLIAKGVRGGD
                                                   .            ::       *  *    :  . 

Mvan_4135|M.vanbaalenii_PYR-1       VVAMQLPNWREAAVTFWASAFLGAVVVPIVHFYGRRELAHIMATAKPRVF
Mflv_2523|M.gilvum_PYR-GCK          VVALQLPNWREAAVTFWASAFLGAVVVPVVHFYGRKELAHILTTAKPRVF
MSMEG_4774|M.smegmatis_MC2_155      VIAFQLPNWMEAAAAFWATSFLGAVTVPIVHFYGRKELAHILSTAKPKVF
TH_2816|M.thermoresistible__bu      VIAFQLPNWVEAAMTFWASAFLGAVVVPVVHFYGRKELGHILRTARPKVF
MAV_2638|M.avium_104                AVAVQLTNRVECAVAYQAVLLCGAVLVPIVHIYGMAEVAFVLDQSAAKVL
MMAR_0303|M.marinum_M               VVSFMLPNWHEAAVIYLASTLAAMVANPVLPSLREHELRFILEDAGSRMI
Mb3591|M.bovis_AF2122/97            RVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVL
Rv3561|M.tuberculosis_H37Rv         RVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVL
MUL_4126|M.ulcerans_Agy99           RVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVL
MAB_4377c|M.abscessus_ATCC_199      RVGIWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTL
MLBr_02546|M.leprae_Br4923          GIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVI
                                     :..   *    .    .    .     :       :            :

Mvan_4135|M.vanbaalenii_PYR-1       VTAEEFGRMRYQPDLC-GDVAVV-GLVG--AAHPAAG-NEHAFEQLLADE
Mflv_2523|M.gilvum_PYR-GCK          VTTAQFGRLQFHPDVC-AGVPIV-ALVGDGPDSGADG-GWEPFEDLLAAE
MSMEG_4774|M.smegmatis_MC2_155      LTTERFGRMSFQPDLC-AQVPIV-GLVG-----------ESSFTDLLAER
TH_2816|M.thermoresistible__bu      ITAAEFGRMRYQPDLC-ADVPIV-GVVG-----------QHGFDDLVADE
MAV_2638|M.avium_104                IMPERHGSIVYSKRLQ-DLSRID-SLQHVVMLDAEPGEGYLAWSQLDTPA
MMAR_0303|M.marinum_M               FAPADFRGHDYTSMLRRVAAQLP-SRPEVIEVRGQCPDGVSTFQSLLVGR
Mb3591|M.bovis_AF2122/97            FAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALD
Rv3561|M.tuberculosis_H37Rv         FAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALD
MUL_4126|M.ulcerans_Agy99           FAMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGT-DTG
MAB_4377c|M.abscessus_ATCC_199      ICAKAFKSSDYVA-MASQVMPDAPGLRDVVFIGTSDWTELVAGAERVTET
MLBr_02546|M.leprae_Br4923          IYDDEYTKVVSKAEPALGKLRALGVNPD---EEEPPGSTDETLAELIARS
                                    .    .                                            

Mvan_4135|M.vanbaalenii_PYR-1       PMAG-TVAADPAAPTLIAFTSGTTRDPKGVIHSHQTLSCETR---QLLEN
Mflv_2523|M.gilvum_PYR-GCK          PMAG-TVAADPAGPALIAFTSGTTRDPKGVIHSHQTLSFETR---QLLEN
MSMEG_4774|M.smegmatis_MC2_155      PMSG-TLDTDPAAPALIAFTSGTTRDPKGVIHSHQTLSCETR---QLLAN
TH_2816|M.thermoresistible__bu      PMTG-TLATDPAGPALIAFTSGTTRDPKGVIHSHQTLTFETR---QLLAN
MAV_2638|M.avium_104                ARYR-RPAVAADDVCLLLYTSGTTSAPKGVQHTNNTVLAEQRTMPALLAG
MMAR_0303|M.marinum_M               ETAAPLPTADPDAVRMVLYTSGTTGRPKGVLHTHNSIHALICQIRDHWMV
Mb3591|M.bovis_AF2122/97            AVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKI
Rv3561|M.tuberculosis_H37Rv         AVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKI
MUL_4126|M.ulcerans_Agy99           AVTARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKI
MAB_4377c|M.abscessus_ATCC_199      ALRARMSQLSNTDPINIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQL
MLBr_02546|M.leprae_Br4923          SSAP--APKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPF
                                                    :  *****  .**.                    

Mvan_4135|M.vanbaalenii_PYR-1       YPPDRGRQLTATPVGHFIGMLGAFLIPVLEGAPIDLCDV-WDPGRVLKLI
Mflv_2523|M.gilvum_PYR-GCK          YPPDRGRQLTATPVGHFIGMLGAFLIPVLEGSPIDLCDV-WDPGRVLQLM
MSMEG_4774|M.smegmatis_MC2_155      YPPNRGRQLTATPVGHFIGMVGAFLIPVLEGAPVDLCDV-WDPAKVLRLM
TH_2816|M.thermoresistible__bu      YPPDRGRQLTATPVGHFIGMVGAFLIPVLEGAPIDLADV-WDPGRVLRLM
MAV_2638|M.avium_104                KPDD--VSLVTFPPGHIAG-VGSMLRPLLSGARTVFMDG-WDPARAVEVV
MMAR_0303|M.marinum_M               EPGD--GFLVASPIAHIGGSIYAFECPLLLGTTAVLLDR-WDADRAVQLM
Mb3591|M.bovis_AF2122/97            TSDD--RYLCINPFFHNFGYKAGILACLQTGATLIPHVT-FDPLHALRAI
Rv3561|M.tuberculosis_H37Rv         TSDD--RYLCINPFFHNFGYKAGILACLQTGATLIPHVT-FDPLHALRAI
MUL_4126|M.ulcerans_Agy99           TADD--RHLCINPFFHNFGYKAGILACLQTGATLFPHLT-FDPLRTLQAI
MAB_4377c|M.abscessus_ATCC_199      QAGD--RLCIPVPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEAI
MLBr_02546|M.leprae_Br4923          RAHE--VTLLPAPMFHALGYLHATLAMFL-GSTLVLRRR-FKPATVLEDI
                                     . :        *  *  *   .       *:        :..  .:. :

Mvan_4135|M.vanbaalenii_PYR-1       ESDGLSIGGGPPYFVTSLLD--HPDFRPEHLRRFKTVGLGGSTVPAAVTQ
Mflv_2523|M.gilvum_PYR-GCK          ETEGLSIGGGPPYFVTSLLD--HPQCRPEHVRRFKTVGLGGSTVPAAVTR
MSMEG_4774|M.smegmatis_MC2_155      ESDGLSIGGGPPYFVTSLLD--HPDFADRHLARIRTVGLGGSTVPAAVTR
TH_2816|M.thermoresistible__bu      EAEDISIGGGPPYFVTSLLD--HPDCTPEHLARFKTVGLGGSTVPTTVTR
MAV_2638|M.avium_104                HRFGVTCTAGTPFHLAGILD--LGDTG-DKLASLREFLVGAAPVAEEIGR
MMAR_0303|M.marinum_M               TSKRCTHMAGATPFLEQLLA--AAQRAGTRLPDLKFFVCGGASVSPSLIR
Mb3591|M.bovis_AF2122/97            ERHRITVLPGPPTIYQSLLD--HPARKDFDLSSLRFAVTGAATVPVVLVE
Rv3561|M.tuberculosis_H37Rv         ERHRITVLPGPPTIYQSLLD--HPARKDFDLSSLRFAVTGAATVPVVLVE
MUL_4126|M.ulcerans_Agy99           ERHRITVLPGPPTIYQTLLD--HPARDDYDLSSLRFAVTGAATVPVVLVE
MAB_4377c|M.abscessus_ATCC_199      ERERCVGVYGVPTMFIAMLA--DPGFAHRDLSTLRTGIMAGSVCPVEVMK
MLBr_02546|M.leprae_Br4923          EKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELAT
                                               .     :*           :  ::    ..:     :  

Mvan_4135|M.vanbaalenii_PYR-1       RLTDLG--LFVFRSYGSTEHPSITGSR-PDAPEVKRLFTDGNVRPGVEIR
Mflv_2523|M.gilvum_PYR-GCK          RLSDLG--MFVFRSYGSTEHPSITGSR-PSAPEDKRLFTDGDARPGVEIK
MSMEG_4774|M.smegmatis_MC2_155      RLADLG--IFVFRSYGSTEHPSITGSS-PSAPEGKRLYTDGNPRPGVEIR
TH_2816|M.thermoresistible__bu      RLAELG--MFVFRSYGSTEHPSITGSG-PAAPEEKRLYTDGNPRPGVEIR
MAV_2638|M.avium_104                RAAQAG--ISTFRSYGATEHPTVTGEH-EGQPQWARLGTDGKPLPGSEIR
MMAR_0303|M.marinum_M               CATDYFDKAVVTRVYGSTEVPVTTIGA-PDSS-AHAAATDGRVG-AADVK
Mb3591|M.bovis_AF2122/97            RMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELR
Rv3561|M.tuberculosis_H37Rv         RMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELR
MUL_4126|M.ulcerans_Agy99           RMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELR
MAB_4377c|M.abscessus_ATCC_199      RCIDEMHMAGVAIAYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIEIK
MLBr_02546|M.leprae_Br4923          RALEELG-PVIYNMYGSTEIAFATIAG--PKDLQINSATVGPVVKGVKVK
                                       .          ** **                   * *      .::

Mvan_4135|M.vanbaalenii_PYR-1       LGED-----------GEIFSRGPD--LCLG---YTDD-ELTARAFDDDGW
Mflv_2523|M.gilvum_PYR-GCK          LGPD-----------GEIFSRGPD--LCLG---YVDD-DLTAQAFDEDGW
MSMEG_4774|M.smegmatis_MC2_155      LGPD-----------GEIFSRGPD--LCLG---YTDD-ALTAKAFDDEGW
TH_2816|M.thermoresistible__bu      IAED-----------GEILSRGPD--LCLG---YTDD-ALTARAFDDDGW
MAV_2638|M.avium_104                IVGSD-GTDCPIGIGGEVVVRGPD--QFIG---YQDS-ALNTEAFTDDGW
MMAR_0303|M.marinum_M               LVAG------------EIRVRGPQ--MLVG---YRHP-EDEAGSFDAQGY
Mb3591|M.bovis_AF2122/97            IADD-----------GEVLLRGPN--VMVG---YLDDTEATAAAIDADGW
Rv3561|M.tuberculosis_H37Rv         IADD-----------GEVLLRGPN--VMVG---YLDDTEATAAAIDADGW
MUL_4126|M.ulcerans_Agy99           IGPDT----------GEVLLRGPN--VMLG---YLDDPRATAAAIDADGW
MAB_4377c|M.abscessus_ATCC_199      IVDPNSGETVQRGQSGELCTRGYS--VMLG---YWNDEAHTREVLDTDGW
MLBr_02546|M.leprae_Br4923          ILDDS----------GKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIIDGL
                                    :               :   **      :*     .           :* 

Mvan_4135|M.vanbaalenii_PYR-1       YRTGDVGVLDDDGYLTITDRKADVIIRGGENISALEVEEVLLAMPAVAEA
Mflv_2523|M.gilvum_PYR-GCK          YHTGDIGVLDEDGYLTITDRKADVIIRGGENISALEVEEILLGMPAVAEA
MSMEG_4774|M.smegmatis_MC2_155      YRTGDVGFLDDDGYLTITDRTADLIIRGGENISALEVEEVLLGIPGVIEA
TH_2816|M.thermoresistible__bu      YHTGDIGVLDDDGYLTITDRKADLIIRGGENISALEVEEVLLGMPAVAEA
MAV_2638|M.avium_104                FRTGDLGHLDAHGRLTITDRIKDVIIRGGETISSGQVEEVLNAHPAVADG
MMAR_0303|M.marinum_M               FRTGDLGHWVDDEYLVVTGRAKDIIIRNGENISPKEIEDILITHPGIADV
Mb3591|M.bovis_AF2122/97            LHTGDIGAVDQAGNLRINDRLKDMYICGGFNVYPAEVEQVLARMDGVADA
Rv3561|M.tuberculosis_H37Rv         LHTGDIGAVDQAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMDGVADA
MUL_4126|M.ulcerans_Agy99           LHTGDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADV
MAB_4377c|M.abscessus_ATCC_199      MHTGDLAVMRDDGYCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDV
MLBr_02546|M.leprae_Br4923          LSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEA
                                      :**:.         : .*  :: : .* .: . ::*:.:     : : 

Mvan_4135|M.vanbaalenii_PYR-1       VVVAAPDARLGEHTAAVLRIREGQSMPALGDVREHFKQAGVATQKWPEEL
Mflv_2523|M.gilvum_PYR-GCK          VVVAAPDERLGEHTAAVLRIRDGHVMPSLDDVRAHFRAAGAATQKWPEEL
MSMEG_4774|M.smegmatis_MC2_155      IVVAAPDARLGERVAAVLRTRSGAPLPTLDDVRAHFERVGIARQKWPEEL
TH_2816|M.thermoresistible__bu      VVVAAPDPRLGERTAAVVRVKPGHAMPTLDEVRDHFERTGVARQKWPEEL
MAV_2638|M.avium_104                VAVAAPDSRYGDVVAAVVVLKPGYALN-LDDLRAHFAASGLARQKTPERL
MMAR_0303|M.marinum_M               AIVGLPDDRTGERACAVIVAAAD-PPPGLPGVRAFLEGAGVARFKIPEQV
Mb3591|M.bovis_AF2122/97            AVIGVPDQRLGEVGRAFVVARPG-TGLDEASVIAYTREH-LANFKTPRSV
Rv3561|M.tuberculosis_H37Rv         AVIGVPDQRLGEVGRAFVVARPG-TGLDEASVIAYTREH-LANFKTPRSV
MUL_4126|M.ulcerans_Agy99           AVIGIPDHRLGEVGRAFIVARPG-FNLDEKSVIDYTREH-LANFKAPRSV
MAB_4377c|M.abscessus_ATCC_199      HVVGVPDEKYGEELCAWVRMRPDRVVIDAVAIRAFASGR-LAHYKIPRYV
MLBr_02546|M.leprae_Br4923          TAIGVDDKEWGARLRAFVVKKQD-ATIDEDAIKAYVRDH-LARYKVPREV
                                      :.  * . *    * :    .        :  .      *  * *. :

Mvan_4135|M.vanbaalenii_PYR-1       HRVPEGQDFPRTASGKVQKFVIRQQLAAGELSAIATGQE--
Mflv_2523|M.gilvum_PYR-GCK          HRVPEGQDFPRTASGKVQKYVIRQQVAAGMHGVVAASQK--
MSMEG_4774|M.smegmatis_MC2_155      HHVPDGQDFPRTASGKVQKYRVRQAVRNPAAVMDIATSAN-
TH_2816|M.thermoresistible__bu      HEVS---DYPRTASGKVQKYRVRQSIAEIAAAQQ-------
MAV_2638|M.avium_104                AIVD---ELPRTSLGKVRKAQLRSDHFGAARR---------
MMAR_0303|M.marinum_M               VIWD---HLPKNHAGKIVKHRIKAALMKAEQ----------
Mb3591|M.bovis_AF2122/97            RFVD---VLPRNAAGKVSKPQLRELG---------------
Rv3561|M.tuberculosis_H37Rv         RFVD---VLPRNAAGKVSKPQLRELG---------------
MUL_4126|M.ulcerans_Agy99           RFVD---TLPRNAGGKVVKPQLRELA---------------
MAB_4377c|M.abscessus_ATCC_199      HVVE---SFPMTVTGKVRKIEMRQQTIQIFGLPEPGRTDEQ
MLBr_02546|M.leprae_Br4923          IFLE---ELPRNPTGKVLKRELRDFEVH-------------
                                             * .  **: *  ::